Document Z8pDkvjOrnVMKwrvK2bo3YX1Z

Corporate Toxicology Study Outline July, 1998 ARIG-0227T To Title: FC-129 Preliminary ADME Screen in Rats `Timeline: In Life Start Date: 7/13/98 In Life End Date: 7/17/98 `Purpose: This study is designed to `provide preliminary information on theabsorption, distribution, metabolism and excretion (ADME) of FC-129. Significance: The. results of this ADME screen will be comparedtothe test results from similar studies on other compounds. O`pbajretcitcuilvaer(tsh)e: fTohremaotbijoenctoifvepeirsstios.treanpti`dmleytasbcorleietensF.C-129 for its ADME characteristics, in Protocol: Charles River Rats /Sprague Dawley/CD/ 415-475 ey 6 males Single dose, oral gavage 0 and 5 mg/kg eICndoimvmiedrucalilayllhyouasveaidlainblmeactearbtoifliiesdmLcaabgoersatory Rodent Diet #5002 (PMI Feeds, St. Louis, MO) ad libitum eWater ad libitum Urine and feces collected days 1, 2,3and 4 post dose. Necropsy day 4 post dose Liver and sera collected Analysis for parent compound and suspected `metabolites by Kris Hansen, `Ph.D., 3M Environmental Technology and Safety Services. `Sponsor: 3M Specialty Chemicals Division. Principle Investigator / Locat/iCoostn: Andrew Seacat/ 3M Strategic Toxicology Laboratory Report: Mean concentrationsof FC-129 and its `metabolites in the collected tissues for each group will be analyzed for differences `between means and considered significant at the p=0.05 level. 000511 -