Document Z4q5E13Y1xMb8wxGagJpb7ozZ

HEALTH EFFECTS, HANDLING, AND FIRST AID HEALTH AND ENVIRONMENTAL SCIENCES T.I.M.E, SYSTEM DR-0002-5310 HEX ACHL OROBE N Z ENE LATEST REVISIONS: 04/29/80 THIS INFORMATION APPLIES TO THE STATED MATERIAL AND MAY NOT APPLY TO DILUTIONS OR FORMULATIONS OF THE MATERIAL. CAS NUMBER; OOOOUB-74-1 OTHER IDENTIFIERS: K-00268B SYNONYMS: BENZENE, HEXACHLORO- F E RC HL ORO BEN Z EN E HCB PAGE 1 07/07/09 REPT Z CHEMICAL AND PHYSICAL PROPERTIES THESE DATA COMPILED FROM VARIOUS SOURCES AND NOT VERIFIED. ADDITIONAL INFORMATION IS AVAILABLE THROUGH YOUR SITE'S REACTIVE CHEMICAL PROGRAM. APPEARANCE: WHITE NEEDLES MOLECULAR WEIGHT: 284,80 BOILING POINT: 322 C MELTING POINT; 229 C (SUBLIMES) VAPOR PRESSURE: 1 MMHG @ 114.4 C FLASH POINT: 242 C STABILITY/REACTIVITY; VERY STABLE -- UNREACTIVE POTENTIAL HEALTH EFFECTS (REVISED:04/29/88) THIS SECTION INCLUDES POSSIBLE ADVERSE EFFECTS WHICH COULD OCCUR IF THIS MATERIAL IS NOT HANDLED IN THE RECOMMENDED MANNER. EYE: - ESSENTIALLY NONIRRITATING TO EYES. SKIN: - ESSENTIALLY NONIRRITATING TO SKIN. - A SINGLE PROLONGED EXPOSURE IS NOT LIKELY TO RESULT IN THE MATERIAL BEING ABSORBED THROUGH SKIN IN HARMFUL AMOUNTS. - THE LD50 FOR SKIN ABSORPTION IN RABBITS IS >2000 MG/KG. - REPEATED SKIN CONTACT PRESENTS A HAZARD DUE TO ACCUMULATION OF HCB IN THE BODY. INGESTION: - SINGLE DOSE ORAL TOX'ICITY IS LOW. - THE ORAL LD50 FOR RATS IS 3500 MG/KG. - ALTHOUGH SINGLE-DOSE ORAL TOXICITY IS PRESENTS A HAZARD DUE TO ACCUMULATION LOW, INGESTION OF SMALL OF HCB IN THE BODY. AMOUNTS * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED DOW USE ONLY DO 0 7 3 6 9 9 C O N F ID E N T ! 1> * ** HEALTH er-'F"EC T i, HANDLING, AND FI RST AID HEALTH AND ENVIRONMENTAL SCIENCES r.l.M.E. SYSTEM DR-0002-5310 HEXACHLOROBENZENE PAGE 2 07/03/89 REPT Z ACUTE INHALATION EFFECTS: - VAPORS ARE UNLIKELY DUE TO PHYSICAL PROPERTIES, - EXPOSURE TO DUSTS MAY CONTRIBUTE TO THE ACCUMULATION OF HCB IN THE BODY. SUBCHRONIC EFFECTS: - EXCESSIVE EXPOSURE MAY CAUSE NEUROLOGIC SIGNS AND SYMPTOMS. - REPEATED EXCESSIVE EXPOSURES MAY CAUSE ALTERED BLOOD/BILE PIGMENT METABOLISM (PORPHYRIA) AND LIVER, HONEY, SKIN, NERVOUS, SKELETAL, MUSCULAR AND IMMUNE SYSTEM EFFECTS. CHRONIC EFFECTS / CARCINOGENICITY: - HAS BEEN SHOWN TO CAUSE CANCER IN LABORATORY ANIMALS. - FOR HAZARD COMMUNICATION PURPOSES UNDER OSHA STANDARD 29 CFR 1910.1200, THIS CHEMICAL IS LISTED AS A POTENTIAL CARCINOGEN I ARC. PART BY NTP AND TERATOGENIC EFFECTS: - HAS CAUSED BIRTH DEFECTS IN LABORATORY ANIMALS ONLY AT DOSES TOXIC TO THE MOTHER. - HAS BEEN TOXIC TO THE FETUS IN LABORATORY ANIMALS AT DOSES NONTOXIC TO THE MOTHER. - TOXICITY TO THE NEONATE BUT NOT BIRTH DEFECTS HAVE OCCURRED IN OFFSPRING OF HUMANS KNOWN TO HAVE INGESTED TOXIC AMOUNTS OF HEXACHLOROBENZENE. REPRODUCTIVE EFFECTS: - IN ANIMAL STUDIES, HAS BEEN SHOWN TO INTERFERE WITH REPRODUCTION . - HCB IS BIOCONCENTRATED IN BODY FAT AND IS TRANSFERRED TO THE FETUS PLACENTA AND TO THE NEONATE VIA LACTATION. VIA THE MUTAGENICITY: - RESULTS OF IN VITRO ('TEST TUBE1) MUTAGENICITY TESTS HAVE BEEN NEGATIVE. - RESULTS OF MUTAGENICITY TESTS IN ANIMALS HAVE BEEN NEGATIVE. EXPOSURE GUIDELINES HEXACHLOROBENZENE: DOW BIOLOGICAL LIMIT GUIDE IS 150 PPB IN THE BLOOD. THERE IS NO GUIDELINE FOR AIRBORNE CONCENTRATIONS. r> OD * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED DOW USE ONLY 073700 HEAL > H F.FFECIS, HANDLING, AND FIRST AID HEALTH AND ENVIRONMENTAL SCIENCES T.l.M.E. SYSTEM DR-0002-53 10 HEX ACBLOROBEN ZENE PAGE 07/03/89 REPT L HANDLING PRECAUTIONS AND PROTECTIVE EQUIPMENT (REVISED:05/06/87) THESE RECOMMENDED PRECAT EONS ARE INTENDED FOR USE DURING NORMAL OPERATING CONDITIONS: EMERGENCY CONDITIONS COULD REQUIRE ADDITIONAL PRECAUTIONS. (FOR AN EXPLANATION OF THE LOW, MODERATE AND HIGH POTENTIAL EXPOSURE CATEGORIES OR SPECIFIC RECOMMENDATIONS FOR YOUR SPECIFIC OPERATION CONTACT YOUR INDUSTRIAL HYGIENST.) EYE LON MODERATE HIGH USE SAFETY GLASSES. USE SAFETY GLASSES. USE SAFETY GLASSES. SKIN LOW MODERATE HIGH NO PRECAUTIONS OTHER THAN CLEAN BODY-COVERING CLOTHING SHOULD BE NEEDED. USE PROTECTIVE CLOTHING IMPERVIOUS TO THIS MATERIAL. SELECTION OF SPECIFIC ITEMS SUCH AS GLOVES, BOOTS, APRON, OR FULL-BODY SUIT WILL DEPEND ON OPERATION. USE PROTECTIVE CLOTHING IMPERVIOUS TO THIS MATERIAL. SELECTION OF SPECIFIC ITEMS SUCH AS GLOVES, BOOTS, APRON, OR FULL-BODY SUIT WILL DEPEND ON OPERATION. INHALATION LOW MODERATE HIGH NO RESPIRATORY PROTECTION SHOULD BE NEEDED. USE AN APPROVED AIR-PURIFYING RESPIRATOR. USE AN APPROVED RESPIRATOR. SELECTION OF AIR-PURIFYING OR POSITIVE-PRESSURE SUPPLIED-AIR WILL DEPEND ON THE SPECIFIC OPERATION AND THE POTENTIAL AIRBORNE CONCENTRATION OF THE MATERIAL. INGESTION - AVOID INGESTION OF EVEN VERY SMALL AMOUNTS; DO NOT CONSUME OR STORE FOOD OR TOBACCO IN THE WORK AREA; WASH HANDS AND FACE BEFORE SMOKING OR EATING. WARNING PROPERTIES: - ODOR IS INADEQUATE WARNING OF EXCESSIVE EXPOSURE. VENTILATION - GOOD GENERAL VENTILATION SHOULD BE SUFFICIENT FOR MOST CONDITIONS. PROTECTIVE EQUIPMENT INFORMATION - THE FOLLOWING SHOULD BE EFFECTIVE PROTECTIVE CLOTHING MATERIALS: NEOPRENE, NITRILE BUTADIENE RUBBER. - THERE IS NO RESPIRATOR TEST DATA AVAILABLE FOR THIS CHEMICAL, DATA FOR RELATED CHEMICALS INDICATE THAT THE FOLLOWING SHOULD BE EFFECTIVE TYPES OF AIR-PURIFYING RESPIRATORS: ORGANIC VAPOR WITH DUST PREFILTER. * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED DOW USE ONLY c 073701 CONFTDFn tt Ht-Al 1H EFFECTS, HANDLING, AfJI) KHUiT AID HEALTH AND ENV I RON ME NT AL. SCIENCES T . I.M.E. SYSTEM DR-0002-5310 H E X AC HLORGBENZEME f'AOF- 4 07/03 '09 REPT / EMERGENCY TREATMENT AND MEDICAL NOTES REVISED:02/24/88) EYE - IRRIGATE IMMEDIATELY WITH WATER FOR AT LEAST 5 MINUTES, SK IN - WASH OFF IN FLOWING WATER DR SHOWER. INGESTION - INDUCE VOMITING IF LARGE AMOUNTS ARE INGESTED. CONSULT MEDICAL PERSONNEL. INHALATION - REMOVE TO FRESH AIR IF EFFECTS OCCUR. CONSULT A PHYSICIAN. NOTES TO PHYSICIAN: - INDIVIDUALS WITH CHRONIC OR LONG TIME EXPOSURE TO HEXACHLGROBENZENE SHOULD RECEIVE BIOLOGICAL MONITORING OF BLOOD LEVELS. - NO SPECIFIC ANTIDOTE. - SUPPORTIVE CARE. TREATMENT BASED ON JUDGMENT OF THE PHYSICIAN IN RESPONSE TO REACTIONS OF THE PATIENT. - REPEATED EXCESSIVE EXPOSURE MAY AGGRAVATE PREEXISTING LIVER AND KIDNEY DISEASE. END OF REPORT; FOR ADDITIONAL INFORMATION CONTACT: CHEMICAL HAZARD EVALUATION AND COMMUNICATION HEALTH AND ENVIRONMENTAL SCIENCES 1803 BUILDING, MIDLAND, MI 4B674 PHONE (517) 636--1909 DO 0 7 3 7 0 ? C O N F ID F N T T * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED - DOW USE ONLY 3>