Document Z4o14L27Nwma2o7yagXNDXYQJ

1UCKMAN LABORATORIES INTERNATIONAL.INC Ra I'i. (aa UAAM Maw 129*NORTH Hc OAH MULtVARD/ttWMS TtWCUtt KR Ui ITIIWR IIP) ITMUCiTTkfSt-MIlMU AOORESS*ULA* Daember 8,1971 Htarin| Clerk Department of Health, EAicitioii, end Welfare Room 6-28 5600 FUhen lane RoekviBe. Maryland 20152 Dear Sir: Burkman Labontoriaa, lac, bat aocad the comment* (Tneniiminnir ifjhi Rood and Brae Adminiegaocn m die Mml Rl/irter node* ^r*k* * pan 20915-20916, and it wipriaed that paint* eontuining watCMohibk barium arc included in the propoiad nfulatioB ia aactioB 19li(aK2Ktt)> Hue prepoetd regulation pertain* to the tone mml* lead, antimony, anaaie. cadmium, mercury, and mUnhm which an coaddmbly non baaardoat tbaa barium. To oar bnooladai. dm low bam no icportod iaataneaa of tonic effect* to children or other partone related to dm jnganion of paint fibna tout*tog barium compound*. TV* tonicity of compouada of badun, coppar, mutiny, teknium, cadmium, antimony, manic, aad land baa boea in*atigBtad by &. A. J. Lehman of dm Rood and Drag Adminisoadea. A coop of Sr. Lehman1* papar it induaad at appendix A. Hi* paper ikon that barium chloride fad to rati for 104 trookt at dietary coneanoaciona of 2,000 para per mfflioD did not product any pom afiect or dame damage. IWlowmt lava! ofbarium chloride dm mi actually ebtarved to produce mot* t&ca or Hum damage era* 10,000 para per affion or one percent of barium chloride in the diet. Ia emmet, copper chloride, mercuric aerate, pheuylaimcuricacetete.ieleninm.mdmlumcklcrid*. and aiitjmooytrionide produced from code eraat at from on* half (antimony irioxidt] to one two hundredth (mercuric acetate and pbanyhntrcnrfc eccmu) of tha cooccatratioa of berinm chloride. The difference* Tba edmmimmdon ofbotfam chloride to dam far M traakt at dm rate of20 m. pm kg. of body wright produced no groat avidanca of hmry. U cempuriiee, 043 nm. par m. oflead acratv hfllad me dam b S3 weak*. Thl* non by Lehman, b tba Rood and Dng AdmbUtaodon'a owe labor*mriar dm doflobnly dm tb* water tohblr barium chloride bat a low level ofchronic toridey. An emminerion of the toricnlngy Baemtute farther confine* that dm acute toridciaaof meet eoloble berinm canfemd nr* rairidtrahty km dmn thoee of lead, antbaooy, antnic. ftp* V~: 4^ caeATivmr eoBowncucTOHiM dC^ jgwsijii. ; r'vy 0007-SWP-036430 N21805 Hearing Otrk Department of Health, Education, and Welfare cadmium, mercury, and aelemium compounds. The most striking and the most important difference between berium and tbe tonic metal* bated in tection 191.5 is that barium it not a cumulative poison. It docs not accumulate in the bone, muscle, kidney, or other name. It is actually turned more rapidly than calcium. Antimony, artenic, lead, cadmium, mercury, and jejenium da accumulne in the body. Them metals cause tonic effects whta ingested in imdl quantities over long periods ol c o m. The hasardt caused by this cumulativt effect arc well known. The indicated metals thus are mrioua contaminants in the environment, and chert hat been increasing worldwide concern about them, particularly during the peat lew years. The metals which have cumulative toxic effects are the only ones which hove ever been (band to be haaerdoui ia paint films. A child does not consume large antnririai of paint film during a 24-hour period. Toxic effects from lead end arsenic in paint films have batorically been related to the repeated ingtatioa of msell quantifier of pome films over weeks or even* months. If the mgeition of lent quantities of paint fibs were a problem, die Food end Drug Administration would hare to include is aoctioo lld a number ofother metals in addition to water-soluble barium. Tbaie would include amc, eoppar, cobalt, chromium, and molybdenum. * la addition, dit ns* of such oqpnk enmpoandt oa sadism tetrachloropheaatt tod sodium puMschlotopheaaco and poniblv ocher sow mfemblcMoa cuirently baiog developed for the peat industry should abo be included is Ac prnpnmd taction 191.5. Zinc oxide is e widely need paint ragmsat Although nine oxide ie not eppredehly watm solnhlt. it is roluhlt in dSutt mineral add mch aa that present in the stomack. Oae widriy used lafveoee book on clinical toxicology (2) (eoe attached Reference Liec) amtot aa follows for sine oxide: 'Tbe usually U.S.P. grade kaabigb purity, but aome technical grades contain s few tenths of 1% load. No aarimater of acute oral toxicity wore located, and it it aaanmed that so human fttaUtiei bavemaukad from ingmricn of th* pun oxide. Because it it soluble ie dilute mineral scid (presumably indudiog gastric juteo), it probably tharat to a bmitod txtant th* toxic acriosa of waccr-auihlo 'rise salts' (am latter)." Under Zinc Salta, Sclrihlc, u., Chloride, aul&te, acetate, the tame reference 12) tanas: "Although no logger recommended, dm euMata . baa baas used aa aa ematic drug {torn dots 0.MA gm.l. Toxiaty asd toxic actions an like thoee of coppw salts. Froducea writation or cottoSho ofthe alimentary ttset with pein. emesis, an. The chloride sppeen to be mon totruaive ead mort toxic then the sulfate. A few grams of Aa chloride hat Idled os aduh, wUo taeotow hot boos roperted afrar iagatrinn at 90 pa. Delayed iaariit hove boos netted to hmelrinai Mnwjgg nunc totetum oftaeaenphagu* and A lriaiah mfaraote book (I) ho* a tocameat os rise sad catrioneinarir "It bn 1 r aupeetad that ma%aanc tumors cosnis b%h coacesmdoas of aisc and that Dw I invadad by sMamaatts ian as lannaed Use osaaast of the sntovolvod ana* but low amounts of sloe is tha tumor ksK and that rinler ringgit of dm metal patten are teas ia i of the tercinagnit promn Some of ride mfannarion it contiediciory ead the tch fipthw eoadbnorios ui jovailhatina before e ipoclfic role of tine a ibe poetuleied " m .*?/*J** str V'>; 0007-SWP-000117756 Heariiy Clerk Department of Health, Education, end Weifart The publication Water Quality Criteria (J) summarizes the chemical constiruenu in the drinking water oandardt of the World Health Otniiication and the UJ. Public Health Service in tabular form. A copy of thia table i includedaa appendia 8. It ihould be noted chat the World Health Ot|aniaation doea not even establish maximum levels for barium but does set up standards for arsenic, cadmium, lead, and salaniam. The maximum allowable concentrations in drinking water aa established by the U.S. Public Health Service err as follows: Arsenic Barium Cadmium Land Selenium 0.05 mg. par liter XX) mg. per Uur 0.01 mg. per User 0.05 mg. per Kim 0.01 mg. pm liter Tbe emoam of mercury now establUmd as the maximum alloerabla concentration fat warm by the Eavbwaamaml Protection toncy to 0MB am. pm hear, luxiw it allowable at 90 dmm die cooctntratica of arsenic and had, 100 times toe comamerino ofcadmium and aciaaittra. and ZOO times the concentration of mercury. * Proposed mgularioo 1I1J would allew dm onreoricted urn of laid at concentration! of 0.5 percent of toe dried paint Bo even rhough lead it a cumulative poison and has caused daunt m soak symptoms in children who tarn auto pains fifaas mmaining load. On e comparable bests, water-soluble barium should then be allowed in prints u concentrations up so 10 percent of barium baaed on the drtod pabu fBm since die U.S. Public Health Sendee has established a maxuanm level in drinking nut at 30 times the level of bad. Aa mentioned earlier, the World Health Orpeicirion does nor awn eetablieh maximum lards for barium. Mercury wM be slinwerf u Oj OS percent of dried paint Sim. Using the tame reasoning as horn. a 200-faU inmaam In the tnlcrws far barium would ba 10 parceat haaad on the dried la dut awnobly, no bare presented evidence that the pseaeace of wciw-colubls barium oompouad^ia print^Sliat does am make the print 61m hoeardoue w chfldrm^Wamwoluble P*^ *-* le -- --VmM. jyJ -mI. .. A. mtkmm wli lurhiij U sfc. pwpesia ragnlatino Barfam comammdt potama the same order of magebuilt of roxieirv at sdne, which isawidaly naad aMtafia prints. Drinkbm water scaadarda forberhia aa aatabUdiad by dm UJ. PukKc Hmkb Smrlm also redact dut barium to muck Ism tunic than lead, mercury, sneak, cadmium. end erienhm. dm Vrned in dm m W- 5 C*" "V *x. U r , 0007-SWP-036432 0007-SWP-000117757 0007-SWP-000117758 UTERATUJU CITED 1. BrowniB|, E. 1961 Tojncity of Indimrio) Mtttk, p, 317, Buttciwortlu, London 2. Gkuos. M. N,, Gocttlin, R. E., tnd Hodft, K. C. 1957. OMeal TsBcolcgp of Commorciol 9ro4ueu, p. 203, Williams k Wilkins Co., Bokiiner* 3. Mdta, J. E., sad Wolf, H. W, IMS. Voter Qiolhy CriMrio, 2nd, d,, p. 91, CaUfornk Ststc Worn Qoolity Coaoro! Botrd, SaommcBto :.v t*'* t 4t- "i 0007-SWF-036434 0007-SWP-000117759