Document Z4Qj55VeNgYE40ardDmL4mojZ

AR 226 _ 0647 PFOS Acute Toxicity - | 000025 ---------------- Subject: November 14, 1974 irc: EH.. AJ.. BDeivrinnbyaum- -23262-028-28 3C.0DG.l LKlaazuesrte- -23263=63-a1 3F1LAA.l PUbeenlder-gr2a2s0s-28- 220-28 0: D. R. RICKER - COMMERCIAL CHEMICALS - 236-2B FM: J. E. LONG - MEDICAL DEPT. - TOXICOLOGY SERVICES = 220-28 primarAyttasckhiend irprleiatsaetiofnindandcopeiyees iorfrittahetiornepoarstssesosnmentthse Conducted with your EC=95 (T-1117) by WARF Institute. of alFbCi-n9o5rwaabsbitfsounudndetro btehenosnt-uidyrrictoandtiitnigontso utthieliszkeidn. Ntohesitgensst oafnidmealrsmalatiarnryittaitmieondwuerriengobtsheervsetdudyinpearniyodo.f irritaTthiinsgprtoodutchte weayses foofundalbtionobermaibnbiimtaslluyndetro mtiheldlsytudy tcoondtihtationosf tuhteiliczoendj.unctTihveaeocuilnartheirrsiixtattieosnt waansimallismitaetd Noone,contjweunntcyt-ifvoaulr,irarnidtatfioorntyw-aesighotbsehrovuerds aptostth-eins7t2ilhloautrion. texaatmiionnatwieorne. obsNoervseidgnsinofanycoorfneatlheoptaecsittyaniormalisriadatlaniyrritime during the study period. upon cFolnutsahcitngsthhoeuldeyeasrrweistth/rpelveenrtsye otfhewaitrerritaitmimoendipartoe-ly cess. producPtremcaayutibeonairryritlaatbienlgtetxoteysehso.uld indicate that this SAgeoLamAn ) : 000026 bee: EH.. JA.. DBeivrinnbyaum- 2=362-2208-2E CJ.. GD.. LKlaazuesrte- -2362-363-A1 3P.l AA.l PUpeenlder-gr2a2s0s-2E- 220-28 NOTE FOR 3M COPIES: 7-117 = FC-95, CC#7410-16 October 24, 1974 WDrA.RFDoInnasltdituL.teHarris BP.i0o,logBiocxal259D9epartment maaison, WI 53701 Dear Dr. Harris: labeleUdndeTr-11s1e7partaoteyoucrovelra,borIataomryf.orwPalredaisneg ocnoemsi3dMersamtphilse dtuoctbeeyae rierqruietsatt/iaounthoanrdizpartiimoanryforskWiAnRFirrIintsattiitounte astosescso-nments with this sample. pleaseIninosrtdielrltoonea-stseesnsthtohfe eoynee girrarmitoaftiotnestpotseanmtpilael,into tehyeelicdonjsuhuntctifvoarlomseacsoefcosnidxaanldbitnhoenraebxbaimtisn.e thHeoldtestthe escyoerseatforoneo,cul2a4,r 4i8r,ritaandtio7n2 ahocucrosrdpinogst-tionsttheillpartoicoenduraend of Draize. tationForpottehnetipaulr,poaspeployf afsisvees-tseinntghstheofporniemargyrasmkionf itersrtisskaimnpletestto siintteasc.t (Adtry24andanwdet7)2 haonudrsabproasdte-dap(pdlriycaatnidonw,et) etxaatniionneacthceordsiknign ttoestthesiptersoceadnudrescoofreDrfaoirzed.ermal irriin theOurneaprufrfcuhtausree.order for $200 will be forwarded toryau this mWaetttehra.nk you for your assistance and cooperation in Sincerely yours, JEL:mn - JM.ediE.calLonDge,paSrct.mDe.nt ManSaegrevri,cesToxicology 000027 : -------------------------- ec. e. E. J. Deviny JC..GD. LKlaazuesrte 236-24 223366--134 Fa Subject: Toxicity Testing of FC-95, CC 7410-16 october 16, 1974 20: J. E. Long - Toxicology - 220-2E FROM: D. Ricker ~- Comm. Chems. - 236-2B As per your suggestion, please arrange to have the following studies conducted on FC-95: 1) Primary Skin Irritation Assessment 2) Eye Irritation Assessment. BEd _ PIlewaislel lseetndmeyouknoawsuanmdpelre wohfatFCT-95Ro.tothbiesusteedstifnogr wtihlils tbeestdionnge.. Thank you DR:al Se . : 000028 Ra WN WARF INSTITUTE, INC. - eBppe os re smie te lens ano0 coe nfidenoMmtAnobDousInscS.aOreNNno,treeWfeyIreSnbCceeOMfoNotdShsIANwhrkO.Hth wireensusGucotrtioatthieonIoime hineantyivfoersm REPORT Sample: 71-1117 ARF No. 4102871 Date Received: 10-31-74 Submitted by: 3S.i 5C.omtpoannyg St. Paul, Minnesota 55101 Testing requested: SEvkein IrIrrriittaattiioonn Conclusion: inrhrietyUaentdieofrnirtiihtneadteicxoonnodfistcsioeorvneossansogfpecz8i.e0fr0io,edfo5rt.3h3eb,optrh3o.dd3u5rcytanahdnadszweeartopraapitpmla1,ircya2t4s,ikoinn4s8 an Honours respectively. to theTheeveprroduct is not irritating to the skin and is irritating Report. approved by: Signed . and for WARF Institute, Inc. Date: November 7, 1974 l Chief PA atl holoT giste /TT oxicologist . : J-- 000029 Co co WlMWADAIRSOFN,IWNISSTCIOTNUSTINE,INC. Sample: T-1117 Primary Skin Irritation: WARE No. 4102871 wuendrerMahebotbuhsioesdd:chionAwlibaniddniovliidbruiatabulbmi.tsscrTewheeenrehbauositertdowmafsocragceltsihipspaenddworffker.domvatTthheeery back and flanks of the animal. Five tenths of one gram of vith gauge patch and tape to Maintain contact with the skin. test material was placed in intimate contact with the skin on prepared test sites (intact-wet; abraded-wet), and covered aATanfnoddtettrhtheheea sc3d244aelgerahenoedhuerl7oo5fcvo.nhetorauyrcRttehaerdmepiaaenrdgiiasonndgd,sveerduteehsemeadtacwkotaevosnerdiearntgegeacsriomnriwdneeaerdtet7a2hcreceomMproorvduieirdsnmgary in leritation score. Results: ANniimnbaelr Ons2ibrab4ded rHouarsded Uns2Abrba2ded rHouarsded Average 31 :i53 a11nosniotetsedreiardrinteagtaitoinve Primary skin irritation score: 0 Scale for Evaluation of Skin Reaction Erythema and Eschar Formation Score Edema Formation Score MDSleoifdgiehnrteadteeerrytytothhesememavaere erythema 21 3 DsleifPpgidhnrtecdeepdetedimeviamea)(b(aerdegleys 1 Seveesrcehareryftohremmaatiotno slight 4 Moddeerfaitneiteedermiasin(ga)re|a 2 raised 1 mm) 3 Semvoerree etdheamna1 (mrma)ised ` SShcionreieoqiutaaltsiosnunionfdexeryStqhueamlas aanvderaegdeemaofre2a4diannggs.72 hour scores. 006630 Lo a WHMWADAIRSOFN,INWISSTCIOTNUSTIEN, INC. Sample: T-1117 ARF No. 4102871 Primary Skin Irritation: vnearerhMaebotbuhisoeedd:chinoAwlibaniddniovliidrbiuatabulbni.tsscrveTeehrneehbauoistretdovmafsocragceltshiipspaenwddorffker.domwTaththeeeyr b2a0c5k% Bantderfilaalnkswasofplthaecedaniimnali.ntiFmiavetetceontnhtsactofwiotneh gthreamskofin oeAAninthepeirrhe'Sepahaarrd2e4eedgrpheooteuteresntofcoasnneidtrtayecsttthaep(empiaenrttioaaoncdmdt,a-idenrtdythe;aemianacwboarvcsaeodrneitrdnae-gccdstorrywwd)iee,trdheaantcrdhecemoocrvodsevikdiennrg.ed BStooianchheierrsie54taattsainobanet7o5swc.ohroeu.r"Reraedaidnignsgwseruesedtakteondeatgaeirnminaet t72hehopurrismary Results: AnNiitmpaelr bis24 Usonusrbsraded Una2Abrade2brouarsfed Average 1z3 i a1n1o'snivoetsedreirarditnaetgiaoinve 3: Primary skin irritation score: 0 Scale for Evaluation of Skin Reaction Erythema and Escher Formation Score Edema Formation Score SDMeiotidigennretadteereyrttyhhtehsmeeamvaere erythema 213 sDleifigiihnrtceedpetdeiedvmeiamea)(b(aerdegleys 1 SevaecrheareryFtohremmaatiotno slight 4 Moddreearfiaistneeidtee1dmremim)sain(ga)r|ea 2 3 Sevneorree etdheamna1 (mrma)ised ` SrcoereteaqutalisosnuminofdexeryStauhaelmsa aanvderaegdeemoafre3a4dianngds.72 hour scores. . L031 no WE WARF INSTITUTE,INC. . -~ MADISON, WISCONSIN Sample: T-1117 WARF No. 4102871 Eye Irritation: placedMetihnoad: coAldlualrtsuaclhbinnoatrabtbheitsaniofmaltshecNoeuwldZmeoatlanrdubWhtihteeirveayreise.ty wOenree hSitaneTtnuet5orhhnsoeaolfTeyiewba,absimtitslrhelewaiadlositthaeecwrreceodru(dn0itf.nr1ogreagetmtoaecdfhotrheeyseusbosslcstiaeadlrsnev)ceedo.fofasscTthoeaesrticsnoegnstaurcfboeoslirt.oandnacmAetaogwseaetshreiteoisntestshtotefillseidx cornea, iris and the bulbar and palpebral conjunctivae at 1, 24, 48 and a72cuhmoiuirasteadfteirscehyaezgienstaixlelaftliaosnh.edAnFyromrestihedueeyeofeatcheh ftiesnte tmhaetyeriaarle asncodred. Aemingstration: Concentration of test sample: as submitted Diluent or solvent: none Special ashing: none Results: NRoambbbei:t GpcCiotryneaKfsi Iris RefinesscoCnhjeumnocstiisvaDischarge 13z1 000 000 o00 2z2 111 11i hour 54 : 0a a 000 000 :22 111 111 1 hour eye irritation score: 8.00 3z1 aa0 000 000 2z2 z11 i11 hours :54 0oa 000 000 :3: :zi z11 24 nour eye irritation score: 9.33 0 3z1 000 000 000 I12 002 000 hours :54 0a0 000 ;00 111 o11 100 48 nour eve irritation score: 3.33 72 hour eye irritation score was zero. All readings were negative. 000V32