Document Z4Mk3a1wNpYMje8rrbQxrzEgV

R&S 002975 1 Hillhouse Site PO Box No 4 Thornton - Cleveleys Blackpool FY5 4QD Telephone (0253) 861 63Direct line (Secretary '861370) (0253) 861444 Switchboard 6 632Extension Number Facsimile (0253) 864687 Telex 67483 Iciplast Clvlys Imperial Chemical Industries PLC MEDICAL DEPARTMENT CONFIDENTIAL To all recipients of ASL Register Your ref Our ref 3B/BGS Date 6 March 1986 Dear Colleague REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1986 I regret that due to a typing error an amendment is needed in Table 1 (Page 30) of the Register recently sent to you. Against the year 1980 would you please alter the figure 0 to read 10. The total, of course, remains correct. With apologies Yours sincerely B BENNETT M.A. M.B.,B.Ch.,B.a.Q. D.Obst.R.C.O.G. D.I.H.,M.F.0.M. I IVES. ANGIOSARCOMA CASES CONFIDENTIAL WPX/ASL - ASL ADDRESS CIECOLAXICN OF REGISTER R&S 002976 ADAMS Dr A Ross Air Products, Allentown, Pa, USA BASHAW DrIMM Norsk Hydro, Newton Aydiffe, IK BAND Dr P R Cancer Control Agency of British Colunbia, Vancouver, Canada BARNES Jnr W C Monsanto, St Louis, Missouri, USA BARR Dr J T Air Products, Allentown, Pa, USA BARRAT Dr G AECRP, Comuentry, France BAXTER Dr Peter EMAS, London, IK BEADPRE M Govemnent of Quebec Cancer Registry, Canada EENECH Dr M Naphtachimie, Lavera, France BENNETT Dr B ICI Hi11house, UK BERTAZZI Dr P Inst of Occupational Health, Milan University, Italy BESCHE Dr Dynamic Nobel, Troisdorf, Germaiy BISHOP Dr C EMAS, Bootle, UK BORRELLI F E Georgia Gulf, Delaware City, USA BOXER R W Formosa Plastics, Delaware City, USA BURGESS Mr David ICI Americas, Wilmington, Delaware USA BiREN Dr David Kemanord, Stockholm, Sweden CARTER Dr J T EMAS, London, IK CELIA Mr C Enichan Polimeri, Milan, Italy CHANCE Mr M ICI Runcorn, IK CLAUS Mr P G ARC, Brussels, Belgium QAXTON Mr H Norsk Hydro, Newton Aydiffe, UK OONEASSCT Dr J C Chloe Chimie, Saint-Fons, France DAVIES Mr J G ICI, Everberg, Belgiim (2) D SLOWER Dr Solvay & Cie, Brussels, Belgiun DE VOS Mr A J ICI Everberg, Belgiun Dim DrHH B F Goodrich, Akron, Ohio, USA DOLL Sir Richard Imperial Cancer Research Fund, Oxford University, IK sDQMBRCWaCI L Dow Chemical, Midland, Michigan, USA DUPONT Mr G ARE, Brussels, Belgium EMGNGER Mr H VKE, Frankfurt, Germany ERFST Dr W Berufsgenossenschaft der (hanischen Industries, Numberg, Germany FALK, Dr H Chronic Diseases Div, US Dept of Health & Hunan Services, Atlanta, USA FERGUSON Dr D M ICI Americas, Wilmington, Delaware, USA FORMAN Dr D Imperial Cancer Research Fund, Oxford University, IK ERASE R W DiversiTech General, Akrcn, Ohio, USA FRIEEEL Dr H P Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germaiy GOLBERG Prof L Duke Univ Medical Center, Durham, North Carolina, USA GOSZTONYI Jnr Dr R E Termeco Chemicals, Piscataway, New Jersey, USA QOTTEHiAN R T The Vinyl Institute, New York, USA HARRIS Dr W D Uniroyal Inc, Middlebury, Connecticut, USA HILL Dr G B Alberta Cancer Board, Edmonton, Canada HUIMAN Dr D W Diamond Shamrock Carp, Dallas, Texas, USA HDCERERDr RK BF Goodrich, Cleveland, Ohio, USA LDDGSCN Mr J EMAS, Bootle, IK HOGG Dr W A Imperial Oil Ltd, Sarnia, Ontario, Canada SWARD Dr J K University of Otago School of Medicine, Wellington, New Zealand HUMPHRY Dr N F ICI Australia, Melbourne, Australia JAUVERT Mr J Chloe Chimie, Paris, France JERVIS Mr H R ICI M111 bank, London IK KARRH Dr Bruce Dupont, Wilmington, Delaware USA KREUGER Dr R A BF Goodrich, Akron, Ohio, USA LALDDE Dr J P Solvay, Brussels, Belgiun LAIHAM Dr John Dew Chemical Europe, Horgen, Switzerland LAURENCE Mr J SPI, New York, USA LAURENCE-JONES Sir Christopher, Chief Medical Officer, ICI, London IK IfEDrFI Victoria Hospital, Blackpool, Lancs, IK T FI,BACH Prof WC University of Bonn, West Germany IEVEQUE Dr G CDF Chimie, AZF, Bully-les-Mines, France LEVISCN Dr D A St Bartholomew's Hospital, London, UK LEWIS Dr P Chemical Industries Association, London, UK LOUVTER Mr Solvay, Brussels, Belgiun LUSSAIO Dr T Atochem, France 2- - WFX/ASL - ASL .ADDRESS,2 R&S 002977 MAHLARD Dr J M Medizinsche Abteilung, Luzern, Switzerland MALHOTRA Anna Statistics Canada, Ottawa MALTONI Prof C Institute di Oncologia, Bologna, Italy MATTRF prof Lo Medil-Anic-S, Milan, Italy MATEUSSI Dr R Montedison, Milan, Italy MIDDLETON D Norsk Hydro, Newton Aycliffe, UK M3KKA Mr Neste Oy, Espoo, Finland tCNTESAND Dr R IARC, Lyons, France MCfTTI Dr A A Duperial SAIC, Buenos Aires, Argentina MUNN Dr A Mantanto, Brussels, Belgian MUNDZ MOUTCN Dr M Rio Rodano, Madrid, Spain MacSHEEN Prof RNM Western Infirmary, Glasgow, Scotland NAKAMJRA S Japanese FVC Association, Tokyo O'SULLIVAN Dr JJ ICI Runcorn, UK OLSON H G VC Safety Association, Louisiana, USA OWEN Dr R Trades Union Congress, London, UK PADDLE Dr G M ICI Central Medical Group, Alderley Park, LK PAGLIALUNGA Dr S Montedison, Milan, Italy POPPER Dr Hans Mount Sinai Medical Carter, New York, USA POSSBEEG Dr J Whcker-Chemle, Munich, Germany HJECH Dr A M Atochem, Brlgnoud, France FURDHAM Dr J Canadian Centre for Occupational Health & Safety, Hamilton, Canada RAMBADD Dr J RP Recherches, Antcny, France RAMSES F Norsk Hydro, Porsgrunn, Norway RICHARD Dr P Rhone Poulenc, Roussillon, France ROBSON Mrs D Saskatchewan Cancer Foundation, Regina, Canada RODRIGUES Dr MJF ICI, Sao Paulo, Brazil ROUSH Dr G Monsanto, St Louis, Missouri, USA RUTY Dr J Atochsn, St Auban, France SALG Dr J NIOSH, Cincinnati, USA SARAOCI Dr R IARC, Lyons, France SCHEFFERS Dr M L DSM/CVMD, Geleen, Holland SOlLfftK Dr H University of Manitoba, Winnipeg, Canada SEROME Dr D ' Diamond Shamrock, Dallas, USA SHAH Dr Has CMA, Washiigtan DC, USA SIGRIST Dr J Shell Chimie, Berre L'Etang, France 9CTH Dr E Division of Environnental Health, World Health Organisation, Geneva, Switzerland SMITH Dr P M Llandough Hospital, Penarth, UK SPIKEAS Dr R NCI/NIH, Bethesda, Maryland, USA STAFFORD Dr J Somerset, UK SIAHECKER Mr BASF, ludwigshafen, Germany TAMBURRO Prof CB University of Louisville, USA TER HAAR Dr Gary Ethyl Corporation, Batcn Rouge, Louisiana, USA TERWIESCH Dr B Chemlsche Werke Huls, Kreis Recklingheusen, Germany THERIAULT Dr Gllles FfcGill University, Montreal, Caruria THIESS Prof Dr AM BASF, Ludwigshhafen, Germany THIIS-EVENSON Dr E Norsk Hydro, Porsgrunn, Norway THM'SON Dr D H Cancer Treatment & Research Foundation, Halifax, Nova Scotia, Canada TORDOIR Dr W Stall, An Dot Haag, HoHarri VAN DER MERWE Dr H J AECI, Sasolburg, South Africa WALLACE J R Esso, Sarnia, Ontario, Canada WALEMOE H BF Goodrich, Cleveland, Ohio, Usa WEJDLUE S 0 Kemanord, Stockholm, Sweden WHEELER Dr D J ICI Hillhouse, IK HHEFIER R N Union Carbide, South Charleston, USA WHISTDN Dr J ICL Hillhouee, UK WHITE K H Duperial, Buenos Aires, Argentina WILUBKI 0 Electrochemical Industries, Acre, Israel WILLIAMS Dr DMT BP Chemicals, Penarth, UK WILSON Prof R Harvard University, Canbridge, Massachusetts, USA WRIGHT Dr A P IQ Wilton, UK YORK J ICI Evertarg, Belglun From; Dr B Bennett, Medical Department, Imperial Chemical Industries Pic Hillhouse Site, PO Bax 4, Thornton-develeys, Blackpool FY5 4<p, UK. ?s'-ruarv 1986 R&S 002978 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE PREFACE: Acknowledgments, significant changes and comments REVIEW DATE 1 JANUARY 1986 1. The new cases in the Register are the following : France Germany UK 18 23,24, 25, 26, 2? 11, 12 2. There are amendments from the previous Register against the following cases: Germany 21, 22 US 36, 38 3. I would like to thank Dr De Sloover, Dr D H J Williams and Dr Friedel for informing me of new cases. 4. For the case corrections I would like to thank Dr Friedel, Mr J T Barr and Mr R W Frase. 5. For other corrections and information, thanks to Dr D Forman, Mr J T Barr, Mr T H Sutherland and Mr N F Humphry. 6. I should be very grateful if all recipients of the Register could continue to keep me fully informed of any new cases, or, if they should hear of other Companies who have acquired a case of ASL, it would be much appreciated if I could be notified by the appropriate person. It is extremely helpful if new information is supplied in tabulated form, using the headings in the Register as far as possible, 7. I would like to thank the many people who have suggested research topics, and should be grateful if I could be kept up to date. 8. I shall be happy to supplyto any recipientof the Register a copy of the Paper "Exposure toVinylChloride andAngiosarcoma of theLiver: a report ofthe Register of cases" by Dr David Forman,myself. DrJohn Stafford and Sir Richard Doll, published in the British Journal of Industrial Medicine, November 1985 (42: 750-753) Dr Brian Bennett M dical Department Imperial Chemical Industries pic Hillhouse Site P O Box 4 Thornton-Cleveleys Blackpool FY5 4QD England R&S 002979 IMPERIAL CHEMICAL INDUSTRIES PLC UPX/ASL_2 - LANGIOCASES,4 Index Table Sequence Belgium Canada Czechoslovakia LIVER ANGIOSARCOMA CASES (REVIEW DATE - I JANUARY 1986) Page 1 2-3 4 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) Page 42 43 France Germany Italy 5-8 9-14 15 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Case6 (Table 9) 44 45+46 Japan Norway Sweden 16 Canadian PVC Producers - Start-up Dates vs ASL Cases 47 (Table 10) 17 East European PVC Producers - Start-up Dates vs ASL Cases 48 18 (Table 11) UK USA Yugoslavia Incidence of Cases per annum (Table i) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Latency Periods (Table 4A) 19-21 22-28 29 30 31 32 33 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Australasian PVC Producers - Start-up Dates (Table 14) 49 50 51 Distribution of Latency Periods (Table 4B-4H) 34-40 An Geographical Incidence (Table 5) 41 - R&S 002980 IF*** , | itlCHM IMPERIAL CHEMICAL INDUSTRIES FIX LIVER Angloearcoaa Cases - (Review Date i 1 January 1986) WPX/ASL_2 - LANtUOCASES.6 1 2 1 4 56 7 a 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE MO MANX OB INITIALS OATS or RUTH CUHTAHY FACTORY FIRST VC EXPOSURE DATE Of DIAGNOSIS ACE AT DIAGNOSIS TEARS OF EXPOSURE TO D1 ACNOS IS TEARS Of EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIHATED EXPOSURE LEVEL OCCUPATION OTHER CAREER II1CHL1CIITS OTHER COHHENTS EI.CIUH 01 12.01.13 Solvay Jeneppe 00.07.SR 00.05.76 63 ia i; 29.06.76 e High Autocleaner Driller In a Hepatic testa 14 yra foundry In Oct 1974 1958-1968 U yte) were unreal. exposed to Fulywurker Faraer Ret Ired 200 pp* lyre <15 yra) Feb 1975 for S fire Work In glass Hospitalised per day Ind. 4 cheat- Hay 1976 and cel Industry certainly Comp 1ete under 500 pja Clinical and career details In, 6 to are given In a 9* paper by atit ocl avee 1964-1t>2_ Hub let et el In Arch. Belg. exposed to Med. Soc., * 50-200 Hpa ITyg. Ned. S hre per Trev. Ned. day In Leg. 2 5a* 1977 pages autoclaves 601-622 1972-i7l' exposed to 50-200 ppa In auto clave roo* i$7i-ioo-- PI* 1975- 50 ptm RETIRED 1 Feb 1975 02 SR 29 09 60 Solvay Jaaappe 20 OR 62 00.10.79 19 17 9 23 10 S3 Tea OR.62-03. 63 01.67 -10.71 * 200 pi** Rli/day 04.63-12. 66 200 p|U Autocleaner Flreaan since 5 yra 5 ache 10 71. Operator 3 yra 9*1 La. let el go July 7 91 Thoracic pain 07.79. Hepatic tests slLercd 10.79. Positive ecltog rapliy 11.79. Hepslectoay 02.60. Clieaotbei epy. Inforaatlon given In letter 12 Nov 1964 fro* Dr Oe Slouver. R&S 002981 h|a 2 CANADA Sheet 1 1 2 3A IMPERIAL CHEMICAL INDUSTRIES Pl.C LIVEN Angiosarcoma Ciui - (Review Date! 1 Jen 1986) All datea uae UK ayelem DAY - MONTH ~ YEAR WPX/ASLJZ - LANG IOCASKS,7 66 7 a 9 10 1L 12 13 14 15 16 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF mm * CANADA 01 15.12.13 COMPANY FACTORY FIRST VC KEFOSURR DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER UiGHLICHJS OTHER COMMENTS SIIAUI1 IlGAN 1944 1966 4L !L " 02.09.55 Yea Reactor cleaner Operator Smoker polymer lea Lion 02 06.03. IA 19A3 1967 43 14 14 21.12.67 Yea Maintenance, Operator millwright, plpef]tter Worked overtime Smoker 03 26.08.19 19AI 1962 42 21 20 23.03.62 Yea Operator, foreman Worked overtime Non-smoker 04 06.04.19 1946 1967 48 22 22 21.01.68 Yea Reactor cleaner Operator, foreman, water cooling uii i i Worked overtime Smoker 06 07.06.11 1944 196S 57 24 06 05.07.68 Yaa Reactor cleaner Water cooling unit Worked overtime Smoker 06 16.12.19 1947 1971 61 24 23 10.04.71 Yea Reactor cleaner Maintenance, ul llwrlgHt Worked overtIme Smoker * 07 09.11.19 1946 1972 63 26 25 24.12.72 Yea Reactor cleaner Machine eliop operator and poly unit Worked overtime Smoker 08 13.06.20 09 19.07.21 1961 1973 53 12 05 12.06.73 Yea 211946 1974 53 26 04.09.74 Yea Reactor cleaner Maintenance machine aliop In plant 25 yre! Smoker Furnace op, pi pefltter maintenance Worked overtime Smoker Paper by Dr t DELORME la luilia d'Autoala psthologlqua Parle, 1971 Vol 23 No 2 ppl05-ll4 elalaa thle caaa had both a Hepatoma and ASL simultaneously. r&S 002982 Vl 3 CANADA Sheet 2 1 134 INFERIAL CHEMICAL INDUSTRIES PLC LIVER Aogloaarcowa Ceaea ~ (Review Date: 1 Jen 1986) PAY ~ MONTH ~ YEAR All date* use UK Byslee WPX/ASL_2 - LANC1UCASKS, 8 i6 7 S 9 10 11 12 13 14 15 1 16 COUNTRY AM) R EftHENCE NO NAHE OH INITIALS DATS OP 11 ITU COMPANY FACTORY PIHST VC E1P0SUHE DATS OP DIAGNOSIS ACE AT DIAGNOSIS TEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEYEI. OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS CANADA 10 16.05.li 1933 1976 61 23 14 00,04.77 Yea Reactor cleaner Furnace op. ealutenance, packaging E*-awoker R&S 002983 Pag# 4 CZECHOSLOVAKIA IMPERIAL CIIEHICAL INDUSTRIES PLC LIVER Angioaarcoaa Caaea - (Review Dates l Jan 84) MPX/ASL_2 - LANtilOCASeS,9 ft1 a 3 4 67 a S 10 n 12 1) U 15 16 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIACNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS C2KCHflSlX>VAKIA tit 2ft.06.ZB State Co Novaky 01.07. 57 24.12.73 45 16 16 24.12.73 Yea Autoclave Cl eerier LAKC letter of 1-4-82 giving detail* froa Prof A David of Centre Ind Hygiene and Occ disease*. 02 06.07.27 State Co Novaky 01.11.50 17.11.64 37 14 15 26.11.64 Yea Autoclave Cleaner IAKC letter of 1-4-82 gave eonewhal altered Jatea for title ceae. 1 have accepted the changes eluce the datea cone fron Prof A David of the Centre of Industrial Hygiene and Occupational Dlaeaaea. Hy detea cone originally fron NIOSH. R&S 002984 Paga 5 PRANCE Sheet i IMPERIAL CHEMICAL INDUSTRIES PLC LIVER iD|Uurcou Cite! - (Review Dete: 1 Jen 86> WPX/ASL_2 - LANCIOCASES.IO 1 2 1 4 56 7 S 9 10 11 12 11 14 15 16 COUNTRY AND REFERENCE NO NAHE OR INITIALS DATE OF I1RTH COMPANY FACTORY PIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS TEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLICUTS OTHER COMMENTS FRANCE 01 H 15.04.24 RP Route- 00.01,46 IS.02.67 41 21 19 19.02.67 Yu* High Autoclave illon worker end cleener 19 yrc Ref. Ravler el al Arch. Mai. Prof. 1 10 n' 1 Nov 75 P 171-177 02 SIM 01.06.11 PCUK Brlgnoud 06.07.59 15.01.75 61 16 12 24.01.75 Yee High 2 yre on Itallan Ref. (NIOSIl no eonoaer origin G gooneton el coaaent) 10 yre on al NouvelJe polyner- preeee leatlon aedicule " 5 Nov 1977 p 7)5 01 NAV 06.01.20 RP St Pone 00.00,46 15.01.75 55 29 29 29.06.75 Yee High Pulyworker VCH production Kef. Rety et 10 yra ae 1 6 yre al Arch. Hal. autoclave Tta!lan POW Prof. 1 37 n` cleaner Shepherd, 6 June 7f Coapoundtng Sawyer, Mu eon p 551-555 1 yra 04 HOR 27.01.27 PCUK Brlgnoud 19.10.49 16.01.76 49 26 26 04.01.76 Yee High ttonoaer production worker S yra PVC (11tralIon 1 fl yre 05 S 29.Ok.IS PCUK Brtgnnud IS. 01.65 11.05.76 IS 11 11 11.05.76 Yee High Polyworker 11 yra 1 )Thoracotony Ref. P Courier* 9th Feb 1976 et al 'Senalne coatal dee huepltaux angloaercoaa 10 Septeehre 2)Sclut Jgraphy 1976 found ASL Previouely had l)Uae*orrIiage hone fro* ASL angloaarcona 4 )Klght Alao Nepatectony Pillchouekl et al La Nouvulle Preeee Medicale 7th July 1979 1 P*Ru2LU5 1 R&S 002985 Pari i FRANCE IMPERIAL CHEMICAL INDUSTRIES FLC LIVER Au,lourcou C.1*. - (ft.vl.w D.t.s 1 J.u 19At) WE/ASL_! - LANCIOCASES,M ' 1 1 4 56 7 8 * 10 U 12 11 14 15 16 country AND tit titact. NO NAME Ot INITIALS OATS OP NINTH COMPANY FACrOMT FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEAIS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFJRMAT10N ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER 11 ICilLICHTS OTHER COMMENTS FRANCK 06 Pa 14.04.34 PCUK Rrlgnoud 01.01.56 12.08.76 42 18 11 |].09.76 Yea Moment te (1958-1960) (NIGSH aayi 12.09.76) 2 yra flltratIon 10-11 yra palyworker and work* lab? Thla nan Led AOL prior to AS. Ann. de Hal. Prof. July *77 p 646 A 6. AOL waa found In L97I five yra before ASL OJ C1R 16.04.17 IF St Auban 01.07.10 AfUr 48 26 22 02.07.76 Yea High Plant lore- 1972-6 aJnln Died of dith (NIOSH ao an In aectloa in aeptlcaeula N10SH COMB (It) pulyaer- St Auban Snail liver lira laatloa lealon found 00.07.76 after autopay 08 s 01.04.14 Solvay Tavaux 23.01.17 01.12.73 42 19 19 10.01.77 Yea HaJurata 6 yra packer 4 autoclave clnr 14 yra autoclave worker Nad been tunnel worker prevtouely 09 RFX 00.10. U IF St Foal 10.01.48 26.04.76 6) 28 28 25.12. 77 Yea Vary High PoJymer- 10 yra In Operated 4.76 1940*1966 laatlon Leaaer operator, eulphuric for removal of acid factory, tuMuur from Expoeure autocleaoer, atorekeeper A liver and 1966*1976 aut oclave general died after Maintenance service* aecoiul eurglcal operation for blllo bronchial f latula Paper by Dr Rety et al lu Archtvea de Ha ladee Profeaalonala Vol 40 Ho 6 1979 pagea 741-1. R&S 002986 r| 1 1HFK1IAL CHEMICAL 1NLHJSTMF.B fUC WFX/ASL_Z - LAMCIOCASES.I2 PBAMCB Sheet 3 LIVEE Angiosarcoma Cases - (Hevlsw Datei 1 Jan 1986) 1 1 3 4 &6 ? 8 ft 10 11 12 13 14 15 16 COUNTRY AND BEFXEENCE MO NAME OB INITIALS BATS OP NINTH COMPANY PACTQHY PIBST VC EXPOSUBE BATE OP DIAGNOSIS ACE AT DIAGNOSIS YEANS OP EXFOSUHE TO DIAGNOSIS HEARS OP EXFOSUHE DATE OP DEATH HISTOLOGICAL C0NPIHMAT10N ESTIMATED EXPOSURE LEVEL OCCUPATION GTNtitt CAHEEK HIGHLIGHTS OTUEH COMMENTS fftnca 10 n vr L 24.05.19 HP 11.01.11 IIP St Pons 00.13.56 10.01.18 5ft 21 St Pons 00.01.41 n.os.ji ii ..... fJ 21 10.01.38 Yea Ji 11.11.70 Yea High High Autoclave cleaner 10 yre lu median leal engineering Industry 1946-1956 1941-19(0 polymerieatlon gene rat purpose worker 1946-1972 VCH aynlliesle (HCl 6 Acetylene) Foreman (agent de maitrlae) 1972 retired Uied of pulmonary embolism 5 days after surgery ii Tortr FCUE Brliuud 09.01.49 00.01.79 65 Jo 13 19.01.11 Solvay Tavaux ii.o4.ti li.04.1* 44 16 14 HJ Dl-M-74 ChlM Chtmle (lovMrly *P) St Poms iUs oo.o).a 17 "Ii 2) 2i.6t.V4 Yea 13 12.Oft. 79 Yea 36 I9.07.tl taa High Very High 1943-1973 and Intermitt ently 1935-1979 Monomer product Ion end polymer- iaatIon mtcra tor Autocleaner 2 yre aa cycle 2 yre. mechanic. Auto- 10 yra as operator enamellet lu 9 yre* aaaltary ware Copolymers manuCacture 4 yre 1943-1935 1975-1979 All types of maintenance Jobe on work manufacture 4 malntamanci la VCH Poly Process __________ Cigarette Banker uni 11 1974. Ill all of 1977 due to Oesophageal varices. Surgical Intervent ion 25.05.79 (right heMteclomv) R&S 002987 ri 8 FRANCE Sliest A IMPERIAL ClIEHICAL INDUSTRIES PLC LIVES Angloaarcuea Cases ~ (Review Date; 1 Jan 1986) WPX/ASL_2 - LANCIOCASESJl l 2 1 A SA 7 a 9 10 11 12 11 14 15 U couttfar and reference HO NAMB OR INITIALS OATS OF IIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HJCtl LIGHTS OTHER COMMENTS France is DEF 03.01.17 Chios St Fens 07.07.11 28.09. 62 45 27 27 Alive Yea High-20 yr Autoclave Chlaie (foraerly Moderate 7 yra cleaner 1955-1962 V) autoclave operetor 1962*1982 J C Couteeaol Letter of 5 10 1983 it CIM 13.07,21 Chios QiUU (Foraerly *> SI Fona I7.10.AI 05.01.63 61 A1 38 01.04.82 Yea HJgh-33 yra Polymerisat Moderate* ion Process Low ~ 5 yra Han Maintenance Worker Health A Safety Agent Retired Jan 1979. J C Contaeeot Letters of 5 10 1983 and 25 7 84. 17 NAR 22.02.21 Chios Chlals (Foraerly RF) St Fona 17.06. AS 01.04.81 60 1A 28 01.04.81 Yea High 21 yra Autoclave Cleaner 1946-1971 Other sectors ut St Fona Factory 197|1976 Ret 1 red 01.01.79 J C Cuntueaot Let Ler of 5 JO 1981 I& n IA.07.A2 Solway Tavsux 09.09.82 21.01.6A A2 21 21 27.12.84 21.03.84 High-12 yre Autoclave Low - 9 yra Cleaner O9.03.8A Right Hepatectuuy 05.05.8424.09.84 cheuotherapy for limgetaetaeJe i part la) reelaelon. 08.84 * liver iecurrenre. 10.84 - lung; evolutIon of the disease R&S 002988 r|a 9 GERMANY Sheet I IMPERIAL CHEMICAL INDUSTRIES PLC LIVER An|loiarcMi Caaea - (Review Date: 1 Jen 1986) WPX/ASL_2 - LANCIOCASES.14 1 23 jr COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH 4 COMPANY 36 7 B 9 10 11 12 13 14 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOI.OCICAL CONFIRMATION kSTLMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS GERMANY 01 00,00.30 Dynastt Troledorf 01.10.36 19.09.61 38 12 12 25.01.69 Yea (HIOSU) PoIyworker 02 00.00.11 Dynastt Troledorf 14.10.57 25.09.70 39 13 11 14.12. 71 Ye. (MIOSII) Polymarker tn 00.00.30 Dynastl Rhelnfel- 09.06.32 00.03.73 43 21 16 10.10. 73 Ye. (HIOSU) FI 11Ing den peetietde Reported under nun polyser- aeroeol cane leatloo will. VC workere In NIOSLI Hat or 31.3, 77. Thle of course la atrlctly correct. However 1 wonder whether till a on hud high exposure to VCH In hi a can filling uperat lea? 04 00.00.30 Wacker Burg- 16.04.57 26.11.74 44 17 17 25.11. 74 Ye. (NIOSH) 200-500 pps Polyworker A 1958 uaa ClInlcal ha ueen but high teeporary autocleaner detail* lu during 1 yr autocleaocr fur 1 yr paper by autocleaner Gokel et al Virchow* Arch A Path 1976 172 p 195-203 R&S 002989 Page 10 GRRHANV Shaat 2 IMPERIAL CHEMICAL INDUSTRIES PLC LIVKI iaiiourcHt Cm at,* - (Itvlex Bttii 1 Jan >986) WXJASL_2 - LANClOCASES.ti 1 2 3 6 36 7 s 9 10 U 11 13 14 15 16 COUNTRY A NO REFERENCE NO HAKE OB 1HIT MLS DATE Of B1BTH COMPANY PACTOBY P1BST VC Eirosuts OATS OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO D1ACNOS IS YEARS OP EEPOSUBE DATE OP DEATH HISTOLOGICAL CONFIRMATION EST[HATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS GERMANY OS (NIOSH glvea aa Cae* 06) 00.00,36 ILoechet Prenfcfurt 02.04.60 10.12.73 3a 11 05 16.12.74 Yea (NIOSH) 06 (NIOSH glvea i Case OS) 0) 00,00.31 1,01111 Ualdehut 16.11.62 00.00. 76 43 00.00.26 Hacker Rurghaueen 15.04.54 12.11.75 49 13 11 09,01.75 Yaa 21 21 L3.ll.75 Yea (NIOSH aaya 12) EG Cheale aa ye 'clieelatry laboratories Jo Ike Techno logical Beaearch Departaeiu ' (NIOSH aaya aaalatant factory cheat at which Bay he wrong translation) PVC - Manu facture Shift Leader PVC Manu facture ami all work Incl auto clean log 12 yra (1954-66) foreman Tech Dev 8 yra (1967-1975) Conf1raed Reported under non-polyaerlaatlon workera In HIOSJI llat of 31.1.77 and 1. 76. 1 dou1 l think ibla la a correct claaalfleet Ion by NIOSH. The Ban aey have been Involved In VCM potyaerlaatleu In pilot plant or In aln plant. OB 00.00,17 Dynaalt Troiadorf 19.07,54 06.04.75 56 20 20 25.12.75 Yea ! Polyworker 1 i R&S 002990 page GERMANY MbH 3 MHIUL CUBICAL INDUSTRIES PIC LIVES Aa|toMrcuH Cihi - {Review Dtia: 1 Jan 1)86) WPX/ASL_2 - LANC10CASfcS.it 1 2i e COUNTRY AMD REFERENCE NO HAHe OR INITIALS DATE Of IIRTH A COMPANY 5A 7 S 9 10 It 12 13 14 FACTORY FIRST VC exposuse DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTJHATED EXPOSURE LEVEL OCCUPATION 13 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS GERMANY 09 00.00.34 CWU Karl 20.02.61 16.06.76 41 13 13 24.03.70 Yea lllgli peak* 12 yra poly worker Incl 171 auto clave cleaning Control rooia 1 jrr 10/76 Confirmed Average expoeure flrat 9 yra 150 ppa, occ 1000 ppm. Next 3 yra av, 75 ppm. La at yr av 35 ppm 10 (kiosk |ivu c*i in OO.OO.It CWH Marl 01.01.61 00.01.77 40 16 10 07.03.77 Yu High peake 10 yre poly worker Incl 172 auto clave cleaning Average eapoaure flrat 9 yra 150 ppm, occ 1000 pp. Last yr av 75 ppm. CUII letter of 2i.04.7S H (NIOSN lives me Can* 10) 12 00.00.29 Hacker Burg- 10.10.S3 2S.06.77 47 21 22 2B.06.77 Yea High 3 yra auto hausen clave cleaner 19 yra filter operator 00.00.31 Dynami t TroleAorf 00.00.61 00.10.77 39 16 6 07.10.77 Yea 7 PVC Manu facture Autoclave worker for 6 yra R&S 002991 P|< 12 GERMAN! Sheet 4 ) COUNTRY AHO REFERENCE MO 2 ----- i------ NAME OR INITIALS GATE OF BIRTH 4 COMPANY IMPERIAL CHEMICAL INOUSTKIIS PLC LIVER Angloaercoae Caaea - (Review Data; 1 Jan 1966) MFX/ASl.Jf - LAHUIOCASES,! 7 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE OF DIAGNOSIS i ACE AT DIAGNOSIS 4 TEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE It DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL u OCCUPATION 15 OTHER CAREER menu curb 16 OTHER COMMENTS GERMANY U IS (NIOSII give* thla Cam 11) 16 OO.OO.14 Lonaa Hal dehut 00.00.60 06.04. 76 61 IB 14 19.05.76 Yea Not an Angloiarcoai In hla latter of 21 12 61, Mr Frledel eald thla uaa a Flatteueplthelfcaralnoa Per Speleerohre (a carclnoaa of t lie oeaophague) not attribut able to VCK 6 not recognlaed aa an Joduetrlal diaeaea 00.00.29 Hacker Burgheuee* IS.10.51 os. 10.7a *4 25 25 21.10. 76 Yea I Autoclave cleaner and worker. Drier operator. Laier aliift leader 00.00.21 Dynaatt Trotad or f I0.01.SS o7.oa.7a 55 24 20 o7.oa.7a Yea High Autoclave (Laibach ASL and worker till auapected Hepatocellular 1964. ASL at Carclnoaa Leader and Fab 1975 deter laparotoay) F U Seat letter of 30c 1. June I960 encluelog data f roa Hr H P Fried*! of 6G Gheale F U Beat letter of 30th June I960 eocloelng data f roa ti P Frledel ot 6G Clieale wlthdrawjng thla caae Anglosarcoaa conflraed 09/79. Suae detail of thla A also caae* 9, 13, 15, 16 A 17 given In ttKIJ Report for 1976 Angloaarcotaa conflraed, lull detalla of lllncaa a luce March 1973 given In NHU Med Inap Rep for 197B. Different detail* given lo VC Aa aocIdled Dlaeaae by l.elbacti and Huadraa^b^?le)r. R&S 002992 rge u StNHANY Sheet S IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Aailoiarcoai Uh - (l*vlw Daces I Jan 1986) UPX/ASLJ2 - l AHGIOCASKS,I 6 1 2 3 4 S6 7 a 9 10 11 12 13 14 15 16 COUNTRY AMD REFERENCE MO NAME OR INITIALS OATR OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIACNOS1S YEARS OF EIPOSURB TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS CERHAHY w (MlOSH glvae a Cane 1 5) IS 19 20 21 22 00*00.32 Dynamic Troiedorf 01.11.61 14.08.76 41 16 H 28.06.78 Yea High Autoclave ho Angluearconu worker coni 1 rated. Annual report of the North Rhine Uebtphel la Hedlcal Inspectorate for 1976 pagee 347-377 give* full detalla. Vinyl chloride dlaeaae d1agnoaed 02-02-73. Oeaophageal varlcea. Radiologically conflraed aero oo.oo.n Hoecbat Cendorf 00,00.S5 2S.ll.Ti a a 21 75.12.79 Yea Autoclave oateolyala. Worker 00.00.2S OyaHtt Trolsdorf 1^.10.54 o6.oi.ti si is 18 22.02.80 Ye* Nigh Autoclave Hetaetaelng Worker ASL Dr Beache letter of 13-04-82 tu Or U C F Adana oo.oA.it DynaMt Troledorf 14.01.61 00.04.60 a i4 1* ii.io.eo Yea High Autoclave llaeaanglo Worker Endotliellcea of liver wJcLi He teat eaea Dr Beache letter of 13-04-62 u Dr W C F AJuna 00.0&.13 Dynualt Troledorf 01.01.62 00.09.14 66 16 13 H.oi.ao Yea High Autoclave pronounced Haenanglo Hoiker anJ clinical Endothell one worked In 1 lvcr of liver wl ill drying elntp cyatoaa) Dr Beache letter uf 1 3-04-62 in Dr W G P Adana 00.00.21 DjfbmU Troledorf 15.10.61 2t.oa.ao 59 19 U 06,12.81 Yea High Autoclave Chargehand, Dr Bcache Neteateelng Marker eubaequent1y latter uf ASL Foreman 13-04-62 lo Dr W C F Adana R&S 002993 1 Page * * GERMANY Sheet 6 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angloeercoaa Caeea ( Rev Date; I Jan 1986) UPX/ASL_1 - LAMCiUCASES>l9 I 2 3 4 S6 7 s 9 10 11 12 13 14 15 16 country and REFERENCE NO NAME OR INITIALS DATE OF BIRTH CERKANY 23 IIP 00*00.27 COMPANY Weaker FACTORY 8urg~ hauaen FIRST VC EXPOSURE 1953 DATE OF DIAGNOSIS 26.01.79 AGE AT DIAGNOSIS 61 YEARS OF EXPOSURE TO DIAGNOSIS 24 YEARS OF EXPOSURE DATE OF DEATH 21 19.09.81 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER IllUJI LIGHTS Yea High Cheat airy <OUO Vim) Worker - OTHER COMMENTS Prof Get) 1 gk 1 etatee nctaataalaed. Prledel letter 19.04.65 24 IIL 00.00.2S U.ck.r Burg- 1969 11.I0.S2 64 13 12 2 fl. 05. B3 Yea High Autoclave hauaan ('300 pp) Cleaner Prof Eder (Munich) letter 22.08.U3. Frledel leLlei 19.04.B5 is E.Sch 00.00.2) We clear Burg- 1960 hauaeo 20.09. SI 5S 21 1) 14.01.S3 Yea High Pulyclave Worker and Autoclave Cleaner Prof Selnalr (Munich) Frledel letter I9.04.S5 16 FH 00.00.11 CUU Mad 195) 14.06.76 54 22 22 22.U.S2 Yea High Polyworker di route ilepatltle (Lelbach). Frledel letter 19.04. B5 27 UR 00.00.20 OjroMlt Troiadorf 1965 IS.OI.S3 55 IS IS 02.03.84 Yea High Autoc1 eve Cleaner till 1972 L.elbach. FrJedel letter 19.04.B5 R&S 002994 Page 15 i my IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angioear (Review Data: 1 Jan 1966) WPX/ASL_2 - LANCIOCASES. 1 2 3 4 S6 7 a 9 to u 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF HATH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH IIISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION ITAI-T 01 I.C IS. 06. 34 FANSAC Hire 00.00.65 19.04.71 36 06 03 16.04.71 lYee (On HIOSH Vanlca supple mentary Hal) PVC Reg extrude! OTHER CAREER II1CHUC1ITS OTHER COMMENTS Prlaary tumour may have been pericardium. Not homo geneous with other cases, a a*** 02 SE 13.U.29 Honcad loon For to 00.00.37 13.12.71 43 15 06 27.12.72 Yaa Harghera Polyworker * a* 0) VC 14.03.20 Solvey Farrar* 00.01.33 10.07.75 55 22 2t 10.07. 75 Yaa High Autocleaner 1972-5 did 6 yre (1953- a variety of 61) Autoclev Juba operator Including 12 yre (1961 PVC pecking. 72) ** 04 FI 20.07.37 ANIC Savanna 00.04.59 00.01.01 43 11 21 30.01. SI Yea 12 yre - l yr - Never cleaned Vary Ulgh Monomer operator autoclaves. Sea paper by M 3 yre - CUIAPFENO el Nou-smoker. Medium 20 yra - al Med Lavoro Consumed Autoclave Vol 6 (1962) little 4 yre - operator 6 pp 555-563 alcohol. No Low other duLlee AOL. In wuapens * ion polymer- 1 eat Ion. Area Foreman In eame Dept eloce 1975. OS C Danaela 19.03.37 FANSAC Hi ra 00.00.67 07.03.R3 Vanlca 46 16 a 06.04. S3 Yaa Medium-T High Rag extruder 1967-1975 Commercial Dept 19761903 S PagllaUinga telex at 2 Aug I9S3 * Sea Mai tonI Had dt Lavoro 6S p445, 1974. Further detaJIe In latter from Or Hanuaaao of IARC on April let 19B2. ** Also oea Maltoni and koedlMlla In Acta Oncologic* Vol 1 >9ftO pagee IS - 49. R&S 002995 Page 14 JAPAM IMPERIAL CHEMICAL [MHIITRIBS FLC LIVER Angloeercoea Caaea - {Review Date: l Jan 1986) WPX/ASL_2 - I.ANCIQCASES.21 1 2 3 4 54 7 S 9 10 1 1 12 13 14 15 lb COUNTRY AMD REFERENCE HD NAME OR INITIALS DATE 0E BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH 11 (STOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREEN lit CM LI CUTS OTHER COMMENTS JAPAN 01 Toaojl Mori 01.OS.22 Hltaul Nagoya Toatau (do coawui by Jap PVC Aaaoc) 00.04.53 * 24.10.75 a 53 02 SO 02.0fl.3S 00.II.3S 10,OB.74 37 a 22 17 13 24.10.75 13 10.OS.74 Yea Yea PVC Aaaoc 13 yra auto aaya not clave known. cleaner * Japan 1964 - Tlaea aaalgned to Indicated different on 25.10.75 work alnce eapoaurea had 111 often at healtH 3000 ppa up to 1974 Hot known In pot year-- lent ton work Includlug autoclave cleaning Japan Tlaeu 25.10.75 A Japaneae PVC Aaaoc letter of 31.03.7B Japaneae PVC AeaociatLon latter of 3L.01.7S * In hla letter of let April 1912 Date of dlagnoala Age of dlagnoeJe Yeare of eipoaure 21-06-74 52 22 Honteeano of 1ARC aaya Japaneea Kioietry of Labour give R&S 002996 tafte I J NORWAY IMPERIAL CHEMICAL INDUSTRIES PLC LIVEN AngtoearcoBe Caaee - (Review Date! 1 Jen 1966) WF)t/ASL_2 - LANGIOCASES.22 1 2 24 2 `. I e 9 10 n 12 11 14 12 16 COUNTRY AND REFERENCE HO NAME OR EXIT IAE.S DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE Of DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMHENrS NORWAY 01 AH 22.12.12 Norsk Hyd ro Herojra 00.01.20 ii.12.n 26 22 21 04.OL.72 Yea High fureadn A Autoclave supervisor Cuntlraed I>y Or TIi 1 la* Evanaen uf Nil. At APME Mia uf 9 June 19JS Mr P Ranguea stated that AN had been a enter of a start-up lean. VCH A PVC were Bade In suae building. The VCH use Bade from acetylene R&S 002997 r*t i SWEDEN IMPERIAL CHEMICAL IHOUSTKIES PLC LIVER An|ioircoM Ctiti - (Review Datei I Jen 1966) VPX/ASL_2 - LANGIOCASES,23 1 2 3 4 56 7 s 9 10 n 12 13 14 15 16 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF RUTH COMPANY TACTOAT FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS QP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE 1EVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS SWEDEN a 01 NU 23.06.27 Kewanord Su citl aval J 14.06.51 20.10.70 41 ! 16 20.10.70 Tea Polyuorker A 02 EL 27.U.U Keaanord Sondavail 00.01.45 00.06.72 61 27 27 16.OS.72 Yea III Rh VCM product Ion Hr SJoel lii'e letter of 26 HarOi 1976 couftra* RL wee e aonoaer worker wlio woe Heavlly eipowed. probably even aore ao then a noraal reactor cleaner 03 HE 10.06.10 Keaanord Snnd avail 00.05.47 16*01.76 65 29 21 19.01.76 Yea High Polymarker 04 AL 16.11.14 Keaanord Sundevell 00.00.46 12.05.77 62 11 11 12.05.77 Yea 01 Eh 1946-1956 palyeer- leatlon worker (12 yre) 6 1956- 1977 foreaLaii (19 yin) In flrat 12 yre of eaployaeul had been heavily expound. lu 1974> liver abnormallly and necroela diagnoaed. Data conflrated In Dr C Ryren letter 1 6. 6. 77 to CEPfC OS 12*01,19 Keaanord Sundavall 11.05.64 22.11.60 61 16 16 22.11.60 Yea High - 1964-1970 6 Yaara Lew - centrifuge operator 10 Year* 1970-1960 drier operator Letter of 2nd Nov 1961 from Dr David Ryren la hfa l.tt.r of lat April l*2, Or Hontaaaoo of MIC aaya to Sued..*. National Board of OS Health giro a 20-02-J0 aa data of dlegnoela for Cat 01 and 15-OW2 lor Caaa 02, R&S 002998 fill 19 Bluet I IMPERIAL CHEMICAL INDUSTRIES PLC LIVER JUtgloaarcoe Ceeea - (Review Pete; 1 Jan 1986) WPX/ASL_2 - LANC10CASES.24 1 Jl COUNTRY AND REFERENCE NO 2 NAME OR IH1TULB 3 DATE OF BIRTH 4 COMPANY 36 1 R 9 10 11 13 13 14 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIACNOS IS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS me 01 UJ 20.04.01 1C1 muhMii 04.04.44 03.12.73 71 28 22 03.12.72 Yea 300 ppe 1944-7 VCM (Fes 4 (Foe 6 1947-8 Drier Collier Collier 1948-61 paper eaye paper Autoclave 23.12. 72) aye operator 23.12.72) 1961-66 Drier Lee and llarry l.enret 29-06074 pages 1316-8 Dubious 03 fabrication caae 03 AJW 03.06.32 BP Barry 00.02.66 00.12.74 37 09 3.3 24.12. 74 Yea High Autoclave cleeuer Eapoeure Halted to 2.66 - 9.69 04 JSt 23.06.30 ICI HI Uhouee It.Ot.M 00.06.79 39 25 18 12.10.79 Yea Hedliie- 54-5 Pre-war 11 eh hlgh Ragging Plant packer HH-4S er.y 55-6 vehicle Drier Plant tea Intenence 56-58 1945-54 Autoclave f 1 all packer worker 58-61 ChargetuiiiJ Drier Plant 61-72 Fo reauu C 2/3 Plu.it R&S 002999 Pi| 20 UPEIIAL CHEMICAL IMPOSTS IE S FLC WPX/ASL_2 - LAHCIGCASES,2S Shut 2 LIVES Aagtoearcoae Cihi - (levlew Petes 1 Jen 1906) 1 i --s-- -----------(----------- 5 i -----------T 1 5 10 11 12 li 14 15 li COUNTRY AND REFERENCE NO UR 0& NAME Ot INITIALS JK DATE OP BIRTH 30.03.14 COMPANY BP FACTORY Berry FIRST VC EXPOSURE DATE OF DIAGNOSIS 08.01. SI 00.10.79 ACE AT DIAGNOSIS YEARS OP EXPOSURE TO ` DIAGNOSIS YEARS OF EXPOSUSE DATE OP DEATH 61 20 21 19.11.79 HISTOLOGICAL CONFIRMATION EStIHATED EXPOSURE LEVEL OCCUPATION 1951-52 Polycleaner 1952-55 Later 1955-60 Polyfloor 1960-64 Poly ChargebauJ 1964-70 Charging operator 1970-72 Drier operator OTHER CAREER HIGHLIGHTS OTHER COMMENTS Oi CEP tut M *rry mi as.oi.to IT75 it li o4.6i.m 0? RGB 26.04.20 BP Berry iiii 00.00.00 to . (J. - 4.1 13.M.60 7 yre Poly Floor Operator 5 yra Creaaar on Poly Floor Polycleener 1963-5 Recovery 1965-19JJ 06 vm aa.oi.M BP Berry l4.04.S0 27.11. SI if il 24 25.12.81 1950-1956 500 ppe 1 968-1974 200 pp* 1950-51 Autoclave operator 1938-1948 Motor Mechanic 194 8-1950 1951-1957 Cite r gee an autoclave Operator on Acetylene Production but 1 ding 1957-1974 Shift mtjiervl aor autoclave Plant building Never cleaned autoclave* but aupervleor1a Job entalled entering autoclave* to Inspect thee R&s 003000 ri* n UK jbwt 1 l 2i COUNTRY AND RIFEREWOE j NO UK 09 NUS OR INITIALS EJCP DATE OP RUTH 07.05.25 4 company BP 5 FACTORY Barry IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Aagtoaercoma Caeee - (Review Dates 1 Jan 1966) 4j I 5 10 It FIRST VC EXPOSURE DATE OF ACS AT DIAGNOSIS OIACNOSU YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATS OF DEATH 15.02.30 02.03.01 SB 33 29 24.02.61 12 HISTOLOGICAL CONFIRMATION Yaa WP*/ASL_2 - LANCIOCASES426 n l4 IS ESTIMATED EXPOSURE JEVKL OCCUPATION OTHER CAREER HIGHLIGHTS HedliM Polyworker 1 year* ou Acrylonitrile Realn Plant. Alao prior to 1950. 4 yeara RAP maintenance. 3 yeara aocor car palutahop. 2 yeara In Craving Dok.5. 16 OTHER COMMENTS )0 CJT 04.04*47 BP Barry 27.04.66 01 05 64 37 IS 4.2 16.05.04 Yea 111 Hh - n Polycleaner Heavy goude Information soothe (500 1966-67. vehicle driver given In ppm). Lou- Sprayerdrler until final letter 10 aoutha bagger 1967- illnea. 1 0.06.04 f nil (50 pp). 60. Blow ttrDHJ He d lies - down Willlaaa 21 aootha *t ripper (200 ppa) operator 1960-70. LI Cil.P 0fl.05.lS BP Barry 19.12.65 02.06.S5 57 19 16 02.06.05 Yaa 111 rIi Polycleaner 1965 -69 1965-60. Had 69-79 Service Lou 79-02 operator 6 0-69. PoJy Operator 69-79. Leading Hand 79-82. 12 JT 24.01.37 IC1 IlilJhouee 16.09.57 03.06.S5 40 28 2ft 06.12.05 Yea Low 1957-59 Spare aao, High 59-74 bagging Low 74-05 floor 1957-59. Autoclave Operator 1959-85 Letter of 04.06.05 Dr Paul Sul ill and letter of 04.06.65 Dr MD Evaue OeaopHageal haemorrhage due to oeeophageal varlcea due to Angloaarcoaa of liver Let ter 26.06.85 Dr F I Lee R&S 003001 ri* 22 USA Sheet I IMPERIAL CHEMICAL INWSfAIES PLC LIVES Angloaercoaa Cm sea - (Review Detei I isn 19H6) UK ayatea of ilet.es DAY - MONTH - (AS WPX/ASL_2 - LAWC1UCASRS,I7 2 3 4 36 7 0 9 10 11 12 13 14 15 COUNTRY Akl> REFERENCE MO NAME OR INITIALS DATE OP BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS 16 OTHER COMEHl'S USA 01 Earl l7.10.13 BPG Louis 09.I2.4S 03,03.73 49 24 2 l 03.03. 71 Yes Parks ville 02 H.OI. JJ RFC Louis 13.11.35 00.03.70 17 14 13 27.09.71 Yea ville (HIOSH ays 2S. 09.71) Pot Cleaner (Block Jans 1974) p 53 History given Rolling Stone In Anna]a NY Art ACAD SCIENCES Ref l NY Acad Vul 329 (1979) of Sc Syep page 190 In 1974 Paper by Alao Block fi R Cottlue ot Jans 1.7.74 OSJtA e si Pot Cleaner (Cf Slock) Ref 1 Also block JAMA 1.7.74 p SJ 03 Edwant 25.03.13 RPC Louis 2S.11.45 19.12.73 30 20 ZS 19.12.73 Yea Dinwiddle ville 04 15.01.24 RFC Louis 06.07.52 19.OS.67 43 15 15 07.01.6S Yea ville Pot Cleaner (Cf Block) Louisville Courier Journal 02-09-B0 Pot Cleaner (Cf Block) Ref 1 Also Block Ref 1 Also Block 03 23.01.12 RPC Louis 19.06.44 09.04.64 32 20 20 09.04.64 Yea ville 06 Ray 23.11.20 RFC Auatln Jones! Louis ville 17.01.62 00.02.74 45 12 12 24.07.75 Yea Pot Cleaner (Cf Block) US Air Force Pot Cleaner (Cf Block) Ref 1 Also Block Ref 1 + Louisville Tinea 23.7.75 Retired April 1974 Alao Block 07 Chsrlaa 03.05.22 UCC S Charle 27.OS.44 00.00.6S 45 24 17 23.03.6S Yea T Reerc ston Ref 1 OS 06.05.20 Good year Niagara 07.10.44 00.00.61 43 13 15 29.00.61 Yea Ref 1 R&S 003002 hga 21 USA ai>Mt 2 IMPERIAL CHEMICAL INDUSTRIES PLC LIVER Angtosarcoaa Cases - (Review Dale: 1 Jan 1986) UR ayetee of dates DAY - MONTH - YEAR UPX/ASL_2 - LANCluCASeS'2 8 1 2 1 A 5A 7 a * 10 11 12 1) 14 IS COUNTRY AMD REFERENCE NO NAME 08 INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HI8TOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL 0 CCU PA 1` |()tf OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS USA 09 Rayaond OB.ll.ll BPC Louis- 28.05. AS 01.0). 74 4) 29 24 11.01.75 Yea 2000 ppa Cattle'* villa Finger! Ref 1 hue wrong figures re flret eapoaure. Loulvvll1e Tines 29.10.74, 12.1.75, 10.1.76 10 16.06.11 Goodyear Niagara u.oa.si 00.OS.68 SS 17 17 10.OS.68 Yea Ref 1 11 27.OS.OS Goodyear Niagara LA.10.46 00.01.70 61 23 2) 16.01.70 Yea Kef 1 12 Francis A 17.11.18 FIreel one Pottatowa 13.07.49 02.OS.69 SO 20 19 02.OS. 69 Yea High 10 yra 10 yra aa Utility 4 Ref l + letter Bsc heart Pa reactor op. Service op. of 26 April (not cleaner Bagger 1978 fro* - separate Dryer up. Russell A Park creu cleaned St ripping op. to J T Seawall autoclaves) 1 yra prior of MCA service Jn tyre plant 11 Richard 01.11.21 UCC S Charle 11.12,42 00.OS. 74 52 12 26 07.04. 74 Yea 2000 pp* Eduard ston Clendenla Charleston Dally Hall 21.7.75 14 Never diag nosed aa angloaarcoea of liver. Inform ation given In letter 22 May 1964 f ron J A Salg. 1 5 Accountant ASL ' No evi dence of VCH exposure. R&S 003003 rt 14 USA Sheet 3 IMPERIAL CHEHICAL INDUSTRIES PLC LIVER Angiosarcoma Gaaea - (Review Date) 1 Jen 1966} UK by it lea of datea DAY " MONTH - YEAR UI*X/ASL_2 - IANC10CASES.29 . 3 3 4 36 7 B 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OP RUTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIClILICHfS OTHER COMMENTS USA 16 Jamae 04.11.27 RPC Loule- OR. 03.30 00.00.69 41 19 04 27.03.69 Yea Howard vllle 1951-4 VCH polymer isation Prim 1954 Table 4 in onwards In Wagoner Army auJ other Testimony to service. US Senate 46-50 Army Coni1 reed In H N Jobnaon lir 07.0a.76 Louie* Tee 17 Peerenboem 06.03.31 RPC vllle 23.06.33 11* 10. 74 43 19 19 16.10.60 on 11.10.74 but no poac-aortaa 16.10.80 Dr H H Jolmaim letter of 24.2.81 con firmed death 6 years after <11**noala 18 Charlie 23.04.36 RPC Arthur Avon Lake 13.09.54 00.00.73 46 21 13 02.11.75 Tea 1 3 yra Navy autocleaner 8 yra on fatal Tyre Store plastic leer 6 Carboaet operation Confirmed In H N Johnnou Itr 07.08. 76 Also Rolling Slone mag. I 5.01.76 19 Virgil 00.00.13 ucc S Charle 00.00.43 19.06. 75 60 33 32 06.04.76 Yee 200u ppa Ctirlai lea ston HI Ulamaport Sun Gazette 21 June 1973 Charles! on Dally Mall 21. 7. 75 20 31.08.17 Goodyear Niagara 00.00.53 30.01.76 58 21 18 30.01.76 Yea HIOSM letter of 23.10.79 21 Cheater 02.09.09 UCC S Cliarle- 00.12.46 Early 77 67 30 22 02.01.77 Yea Hinkle aton 28 yre with UCC at SC Retired Neua releeee 23.2. 77 R&S 003004 2S USA M>at * IMPERIAL CHEMICAL INDUSTRIES PLC LX Wit Aiir to aercoms Gaaca " (Review Date; 1 Jan 1986) UK ayatem of date* OAK - HONTU - YEAR WPX/ASL_2 - LANC|OCASES,)0 COUNTRY AHO REPERENCE MO KAHK OR INITIALS DATE OP BIRTH FIRST VC EXPOSURE PAIR OP DIAGNOSIS ACE AT DIAGNOSIS VeARS Of EXPOSURE TO DIAGNOSIS TEARS Of EXPOSURE DATE Of DEATH HISTOLOGICAL COtffIRHATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS USA Loulavilla 11.07,47 00.01.74 29 23 24^ CSiarlaa Edward Moore 00.00.23 I7.0i.l? Great American dtnlcil Company UCC PJ tchburg 0fi.09.5S Maas. S Charlaaton 1939 oi.oOJ I *705777 50 IS 38 tht Removal from reglater confirmed la R Kanlnakl latter of 5 November I960 U 106.04.73 I.uuUvII le Tinea 26.I.76 said be Una the lOtii AS vta i* st Sella Lane of wtiuu 0 had died by 26.1.74 In his letter of 16.09.01 Or M H Johneoi conflrmu tlila I a tire cstttt described liy De nn a (ter famhurro ( Yau In Peb I 900 An J Medicine Vat 70 n2BJ 24l (N10SII aay* 26) iJ.6i.tJ Cholangloaarcoma (R Eamlnakl 26/2/79) He d I urn to high for 24 yra 1941-65 non- 1937-39 wee H M Wheeler aolvent off aod on vinyl reein abmirer letter of 10.a.77 to unit and 1939-41 nay .1 Stafford dI ape rat on have been aIvea detail* vinyl realite eapoaed aa Roae Kanlnakl unit first reuctur letter of i fitter 1 cleaner 26/2/79 helper, tlien 1943 became R Kanlnakl alii ft ahlft fitter (5 Nov 1900) utility man 1946 became biiggeeta that ahlft utility MlOSH will man r tain on 26.04,65 reglater sinci employment viu thlfi neoplaam terminated may he aaaocl* ateJ with ASL, t H Wheeler letter of 20/2/79 and Roae Kamlnakl lettcra of 26/2/79 and 3n\J" R&S 003005 fi|# 26 USA Sheet 3 IMPERIAL CHEMICAL INDUSTRIES PLC UVU Aogloeercoeu Cease ~ (Review Dates 1 Jta KS86) OK eyates of dales OAK ~ HONTH - YEAR VPX/ASLJ1 - LANCIOCASES.31 1 23 COUNTRY AND REFERENCE NO USA NAME 0B INITIALS DATE Of B1BT1L 26 Jolio Barry 02.07.21 ti J L 11.0).It Forrest 28 29 30 UYN 11.04.11 11.10.07 0 21.0).11 n Ofl.11.23 A COMPANY 3 FACTORY 6 msx VC EXPOSUBE AFC Louis 03.10.67 ville ucc S Charle 01.07.41 ston ucc ucc S Charle 00.08.44 ston S Charle 00.05.42 ston Tenneco Fleslngtoii 11.06.64 Cbcaleils UCC S Charle 11.OS.44 ston 7 DATE OP DIAGNOSIS 00.00.77 (up to 2 years after death) io.ii.la 01.ll.tl 00.03.80 30.12.80 01.08.SI a ACE AT DIAGNOSIS 52 (death) 62 i\ >2 56 si 9 YEABS OP EXPOSURE TO diagnosis to YEARS or EXPOSURE n DATE OP DEATH 20 (death) i a t1.02.75 ii 20 25.11.78 (NIOSH aaya 27 and C Dally Hall 25) u ii 03.11.78 ii 16 01.03.80 i? 15 10.11.80 n 01.04. B2 12 13 14 HISTOLOC1CAL COMF1EHATION ESTIMATED EXPOSURE 1EVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS Tea Tea Yea Yea Yes Yea Expo tied In Various Jobs R Kasluekl oae degree in PVC Lo 22 plants froa letter of 26/2/79 and cheat cal a cold roos to Prof. Tasburro but sain paste letter of exposure recovery to 9/1/79 was to VCM. PVC charging probably operator to high paste charging, lit August 1965. Terslodted eaployaeut High Jan 1966 Operator to t0.10.76 Exposure In B N Wheeler bulk and 1tr of 4 Jan dlepersfou PVC 1979 and anufac1ure Charleston Dally Mall 30.11.76 and B Kaalnakl 26/2/79 R Kaslnakl letter of 6/4/79 R Kaslnakl Leitera of L9ih June I960 6 5th Nov 19 B0 6 - Unknown Maintenance 9 - HlnJeal Hechanlc 6 yra E1aewhere l 4 r Bo 11 er liutiue Operator 9 yra High (But Cheslcal Pro. 1438 to Dr Dacey not sa high Operator In 1976 AlIphat1c letter aa reactor charge Cheslcal* 16.10.fll and cleaner reactor operator and U N Hheuler would experience) fros July t976 letter of to date 4.11.81. Worked ea Foresan Also Dr Dacey Labourer Aliphatic letter of froa Cheslcal 07.03.81 re June 1941 Operation date of death. to May 1946 and say Lave cleaned reectora In Lliat tlse R&S 003006 Ng 27 USA jhMt 4 IMPERIAL CHEMICAL INDUSTRIES LIMITED LIVER Anglnaercoma Cases - (Review Date; 1 Jen 1966) UK system of dates DAY - MONTH - YEAR UPX/ASL_2 - LANU[OCASES,32 1 2 3 4 36 7 6 9 10 II 12 13 14 15 16 COUNTRY AND REFERENCE MO NAME OR INITIALS OATS OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OP D1ACHOSIS ACE AT DIAGNOSIS YEAES OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COHHENfS US 11 C W Cl roue 22-02-06 Hofleet) to prlhgf lel< 1 13-10-51 Heae 00-07-79 71 US 31 S Parguaon 06-10-27 Jnr RFC LoutavllL 09-09-54 ll-OS-R2 34 US 34 Hr Syria* 29-01-34 BFC Loulavlll 1955 03-11-62 46 US 31 Ufl 36 09-01-12 UCC S Charle 23-07-44 ston 16-07-63 71 27-00-32 The General Aahtab Tire end Ule Rubber Co 11-06-56 21-06-63 50 26 14 17-03-80 An autopry The death 1940-1951 (In PVC wee dona and certlflcete Various Johe autoclave Immediate gave In polymer area) cauae of Hr Giroux' manufacture death Riven ueual BUTVAR re occupation LUSTREX 'Angiosarcoma as kettle 1951-1964 operator Various John In In and 'chemicals around PVC Industry * autoclaves 1964-1973 Various clerical joba In PVC polymer! eat! an fee!lity/ Retired 01-03-71. Information given In letter of 24 February 1962 from Dr Halter C Barnee of Ho nee ii to Springfield to Dr A Munn of Houaanto Eu rope. 26 26 Alive Yea Hultlple jo be Including Poly Operator + Polvclesoer. Prof Tauborro letter of 12 Aug 1962 * Dr H H Johnson letter of 26 Peb 1963. 27 10 04.06.63 Yea Poly Operator + Autoclave Cleaner 1955-65. 1965 left RFC to become a Clergyman. Dr H N JoJuison letter of 3 Nov 1962, 26 Feb 1963 and 9 Aug 1964. 39 14 16-07-63 Yea High from 1944 to 1955. Medlue from 1955-1958 Dr Dacey letter of 5 Sept 1963. 27 27 Alive Yee Moderate 1956-56 labourer 1956-57 prod helper 1957-70 operator 1970-75 electrician 1975-present operator H U Lsundrle letter of 12 Sept 1963; spotted at medical Hay 1963. Testing commenced Hay 1963 R&S 003007 r( 28 USA Shoot 7 1 IMPERIAL CHEMICAL INDUSTRIES LIHITKO LIVE1 Amgloaarcoaa Case* - ( Review Data: 1 Jan 1986) % 2 3 4 36 1S 9 10 11 UK eyatem of date DAT - MONTH - YEAR WPX/ASb_2 - LANCIOCASES.33 12 13 H 15 16 COUNTRY AMD lEFfRENCE NO NAME OB INITIALS DATE OP E11TU COMPANY FACTORY FIRST VC EXPOSURE DATS OP DIAGNOSIS ACE AT DIAGNOSIS TEAKS OP EXPOSURE TO DIAGNOSIS YEABS OP EXPOSUSE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COHHENTS US 37 Hr J 29 OS 19 BTC Loula- 1953 OS OS 64 34 31 23 06.06.84 Ye* High Hoiked Payton vllla regularly in PVC area. In the early daya was a reactor cleaner 1953-75. Information given In letter 09.08.84 from Dr H N Juhnaon US 38 JUS 28 OS 22 Ai r Calvert 00.02,S3 19.01.84 SI 20 30 38.10. S3 Yea High Normal pro- Product! cup 1963-1982 greaalon fro* helper to aenlor O|erator, cleaned reactor*, tripping and recovery well aa charging operator. ThrumLo cytopenla and 1 eukopeolti alnce 1978. Gold treatment for arthrltl* 1976. Under Dr1a cure about 6 month* before death, had paaaed standard physical exam ination 3 monthe earller. J Barr letter* of 32.10 . 64 4 23/01/85. R&S 003008 Pill 19 YUGOSLAVIA IMPERIAL CHEMICAL INDUSTRIES PLC LIVES AAglourcuM Cimi - (Review Ditei I Jan 1986) UPX/ASL_2 - LANCIOCASES.34 1 2 3 A s6 7 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE date of DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS YUGOSLAV 1A 01 U5.04.14 Jugo Spile 00.00.5) 08.04.73 59 20 20 08.04.73 Yea Vlall SARIC at al papa r Env Heal tit PerupectIva Vol 17, pp J 89-192 1976 02 15.11.31 Jugo spin 00.00.50 12.07.7) 42 2) 18 12.07.73 Yes* Vlall 03 21.12.31 Jugo Split 04.06.54 U. 01.76 45 22 22 11.01.76 Yea* Vlall 04 11.06.30 Jugo split 15.12.58 03.09.76 48 20 18 03,09.78 Yea Vlall VCH Production VCH P reduction Mn hla letter of 3 Oct 1978, Or Splrtaa of NllJSH cliangtsd tlie statue of Case 02 to VCH production eaployee. Dr Splrtas alao not!fled a new Case 03 alao a VCH production worker Koue KaalnaH Letter of 19th June 1980 and 1ARC letter of I April 1982 Page 30 Incidence of ASL Cases Per Annum TABLE R&S 003009 (Review Rate - 1 Jan 1986) Iff#1 &***-&'-*''* 2 The 1977 total includes US case 24 which is a Cholangiosarcoma. 3 The 1982 total does not Include US 33 and F 15 who are alive. 4 The 1983 total does not Include US 36 who is all^^) T TTUr 11 * r>T O 'TAP ` 1f R&S 003010 Page 31 Distribution of ASL Cases by Country TABLE___________ 2 USA W Germany France UK Canada Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway 35 AAA 26 AA 18 AAA 11 10 5 A AAA 4 AAAAA 4A 2 2 2 1 (Review Date - 1 Jan 1986) Total 120 * Omit ItOl - atypical case of PVC bag extruder. ** Includes GE03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholangloaarcoma & US 33, and 36; and F 15 who are alive. **** Includes one monomer worker. ***** Includes two monomer workers. i.e Western Europe Worth America Rest of World 67 45 8 Total 120 R&S 003011 Page 32 Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1986) (a) H Europe Of the 67 casea In W Europe, 57 have occurred in clusters at 11 factories. Of the 26 Cerman cases, 23 have occurred In clusters at 4 factories. ASL Cases Dynaroit, Trolsdorf, Germany Chloe Chimie (Formerly RP), St Fons, France BP, Barry, UK Wacker, Burghausen, Germany Kemanord, Sundavail, Sweden PCUK, Brignoud, France CWH, Marl, Germany IC1, Hlllhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium 11 8 8 7 5 5 3 3 3 2 2 57 NB: There are 32 pre 1962 PVC plants In W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 45 cases In N America, 38 have occurred at four factories out of a total of 54 factories:- In N America 43 plants have not had ASL cases. BFG, Louisville, US BFG, Shawlnigan, Canada UCC, S Charleston Goodyear, Niagara ASL Cases 14 10 10 4 38 NB: There are 28 pre 1962 PVC plants in N America; 11 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World The 8 ASL cases are believed to be in 1 cluster of 4 WPX/ASL 2 - LANGIOCASES,37 2 clusters of 2 cases. R&S 003012 Page 33 TABLE 4A (Review Date - 1 Jan 1986) Latency Periods (Years from first Exposure to Diagnosis) Country No of Cases Total Years Ave rage W Europe Belgium 2 35 17.5 France 18 459 25.5 Germany 26 495 19.04 Italy 4 74 18.5 Norway 1 22 22 Sweden 5 122 24.5 N America UK 11 254 23.09 k 67 1461 21.80 US 35 886 25.31 * Rest of World Canada 10 204 20.4 * 45 1090 24.22 Czechoslovakia 2 30 15.0 Japan 2 39 19.5 Summary Yugoslavia 4 8 85 21.2 154 19.2 W Europe 67 1461 21.80 N America 45 1090 24.22 Rest of World 8 120 154 2705 19.2 22.54 #* the countries with > 10 caBes France, UK and USA hav' average latency period above world average, Germany a nada ow world average. R&S 003013 Page 34 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1986) 0-9 yrs 10-14 yrs 15-19 yrs 20-24 yrs 25-29 yrs 30-34 yrs 35+ yrs Total Average Latency Period Belgium 2 2 17 .5 Canada 3 52 10 20.4 Czechoslovakia 11 2 15.0 France 1 4 3 5 2 3 18 25.5 Germany 5 9 9* 3 26 19.04 I taly 22 4 18 .5 Japan 1l 2 19.5 Norway 1 1 22 Sweden 2 21 5 24.5 UK I 4 42 11 23.09 USA 2 7 8 8 5 5 35 25.31 Yugoslavia 4 4 21.2 TOTAL 1 12 32 33 24 10 8 120 22.54 * Includes G 03 aerosol can filler WPX/ASL_2 - LANGIOCASES,39 (Review date I January 1986) TABLE 4C LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE LATENCY PERIOD (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 47 1939 38* 46 1940 244 34.86 45 1 37,21,37,41 7 44 2 32,38_______________________ 43 3 38,14,32 4 28,11,24,20,24,34,39 718 26.59 5 27,22,28,29 27 6 21,29,31,26,28,15,23, 30,35 39 __________ 7_ 29.24.29.28______________ 38 8 28,24,34 9 1950 30.26.20 458 24.11 26,22,31,19,23,14,33 19 1 19.28.17.28 34 ________________ 2_ 21**,15____________________ 33 3 25,22,23,22,20,31,22 4 21,21,25,25,21,28***, 22 725 21.97 5 22.23,24,14,19,21,27 33 27*** 24,28 6 21,12,27*** 29 7 19.17.15.13.16.28 28 8 18.18.15.17.20 9 1960 16,21 13.18.21 368 16.73 22 1 15,16,16,16,19,19,12 24 2_____________ _ 13.18.17.12.18__________ 23 3 16.17.20.21 4 16,17 5 11,19 6 9.18 180 16.36 11 19 _______________ 7_ 16 18 8 9 1970 1 13 13 VIOLA 14 ____________2_ 13 3 4 TOTAL 120 CASES 2706 120 22.55 MALTONI GOODRICH * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive. WPX/ASL_2 - LANGIOCASES,40 33 fio G> Page 36 (Review date 1 January 1986) TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE LATENCY PERIOD YEAR OF FIRST EXPOSURE LATENCY PERIODS IN WESTERN EUROPE NORTH AMERICA ROW 47 1939 38* 46 1940 45 1 37,41 21,37 44 2 43 3 38 4 28 32,38 14,32 11,24,20,24,34,39 5 27 22,28,29 6 21,29,31,33 26,28,15,23,30,35 39 7 29 24,29,28 38 8 28,34 24 9 30,26 20 1950 26,22,31 19 1 19,28 17,28 34 2 21** 15 33 3 25,22,22 23,31 4 21,21,25,25 21,28*** 5 22,23,24,27***24,28 14,19,21,27 6 21,12 27*** 29 7 19,17,15,13,28 28 8 18,18 15 9 16,21 1960 13,18,21 1 15,16,16,16,19,19 12 24 2 13,18,17,18 12 23 3 16,17,21 20 4 16 17 5 11,19 6 9,18 19 7 16 18 8 9 13 VIOLA 1970 1 2 MALTONI 3 TOTAL CASES 67 45 * Cholangiosarcoma ** Aerosol can filler *** US33 and 36; and F15 still alive WPX/ASL 2 - LANGIOCASES,41 23,14 22,20 22 16 17,20 8 JO 0 (/> oo 03 o cn TABLE 4E Page 37 (Review date 1 January 1986) PLANT START UP DATE LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) NO OF CASES AVERAGE LATENCY PERIOD LOUISVILLE USA SHAWINIGAN CANADA S CHARLESTON USA TR0ISD0RF W GERMANY 1940? 1941? 1939? 1954 12,14,15,19,19,20,24,27,28,28,28,29,29 31 11,12,14,21,22,23,24,24,26,28 24,30,32,32,34,35,37,38,38,39 12,13,16,16,18,19,19,21,23,25,28 14 10 10 11 23.07 20.5 33.9 19.09 30 8" (/) o o CO o cn WPX/ASL 2 - LANGIOCASES,42 Page 38 TABLE 4F (Review date 1 January 1986) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) R&S 003017 WPX/ASL 2 - LANGIOCASES,43 Page 39 (Review date 1 January 1986) TABLE 4G PLANT START-UP DATE LATENCY PERIOD OF ASL CASES NO OF IN SPECIFIC PLANTS(4-9 CASES) CASES AVERAGE PERIOD SUNDSVALL SWEDEN BRIGNOUD FRANCE 1945 1950 16,19,27,29,31 11,16,18,26,30 5 24.4 years 5 20.2 ST FONS FRANCE 1939 21,28,29,37,38,27,41,35 8 31.88 BARRY UK 1948 9,17,18,28,31,33,18,19 8 21.62 BURGHAUSEN W GERMANY 1933 17,21,22,25,24,13,21 7 20.43 NIAGARA USA 1947 15,17,21,23 4 19 SPLIT YUGOSLAVIA 1941 20,20,22,23 4 21.25 u (f) o o CO o 00 WPX/ASL 2 - LANGIOCASES,44 Page 40 (Review date 1 January 1986) TABLE 4H LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (4-9 CASES) WPX/ASL_2 - LANG10CASES,45 3D (/> O o CO o <o R&S 003020 Page 41 TABLE 5 (Review Date - 1 Jan 1986) Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 TOTAL Western Europe 1 1 1 1 4 1 3 6 6 6 7 5 6 5 1 6 4 2 66* ** North America 1 1 1 1 1 5 2 1 2 1 4 2 4 3 3 2 - 4 0 1 3 1 43** Rest of World 1 3 - 1 2 1 - - 8 Annual Total 1 l 1 1 2 1 5 3 2 3 5 8 5 11 11 9 10 5 10 5 2 9 5 2 117 Cumulative Total Key Events 1 2 3 4 6 7 12 15 17 20 25 33 38 49 60 69 79 84 94 99 101 110 115 117 Viola Malton1 Goodrich * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not Include US33, and 36; and F 15. All still alive. WPX/^_2 - LANGIOCASES,46 Page 42 (Review date l January 1986) TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) KEY | EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD Viola Maltoni Goodrich 1955 6 7 8 9 1960 1 2 3 4 5 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 Total FI G1 Swl G2 Nl,Sw2,UKl,It2 G3** G4.G5.UK3 F2,F3,G6,G7,G8,It3 B1,F4,F5,F6,F7,Sw3 F8,F9,G10,G11,G12,Sw4 F10,F11,G9,G13 ,G15 G16.G17 FI2,FI3,UK4,UK5,G18 UK6, UK7,G19,Sw5,G20,G21 It4,F14,UK8,G22,G23 G26 UK09,It5,F17,B2,G24,G25 UK10, FI6, F18, G27 UK11, UK12 66 .................... Cl C2 US8 C3 US5 Cz2 C4,C5,US4,US7,US10 US12.US16 US11 C6.US2 C7 C8.US1.US3.US23 C9.US13 US6,US9,US18,US26 US19.US20.US22, C10.US21.US24* US27.US28 Yl.Y2.Czl Japl Jap2,Y3 Y4 US17, US29, US30, US32 US31 US35. US34, US38 US37 43*** 8 * Cholangiosarcoma ** Aerosol can filler *** Does not include US33, and 36; and F15. All still alive. 3) (/) o o w oto WPX/ASL_2 - LANGIOCASES,47 Page 43 (Review date 1 January 1986' TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 Viola 70 pi 2 Maiton! 3 Frll,Frl6 Frl4 UK1 Sw2 Frl,Fr3,Sw4 Sw3 Fr9, Frl7 Frl2,Fr4 Fr7,Nl,UK8,UK9 Swl,UK5 G3** G15,It3,G26 G7,G8,UK4,G19 Gil,G16 ,G18 , Frl5*** G23.G28 FR10.G1 Fr8,G4,It2,G2 ,UK12 Fr6,B1 Fr2,It4 G5,G13,G25 G9,G10,G12,G17,G20,G22 G6,UK6,G21,B2 Frl3, UK7,Frl8 Sw5 Fr5,UKll UK3, UK10 It5 G24 US24* C3.US27 US13, US29 C2.US19 01^5,055,057,0328 .0335 C4,0S3,US9 C7,C9,058,0S11,0S21,US31 C6,OS22,US26 US1 US12 0S16 US10, 0532 US4 Y2, Cz2 CIO, US37 US18.0S33*** 0S2,US17,0S20,US34 Japl.Yl Y3 0536*** US23 Czl Jap2,Y4 C8 US6 OS38 US30 Total 67 45 8 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** DS33 and 36; and Fr 15 are still alive. WPX/ASL_2 - LANGIOCASES,48 a fio W o o N5 IO Page 44 WPX/ASL_2 - L&CIOCASES.49 TABLE 8 (Review date 9 January 1986) WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL GASES (OMITTING G03 & It.01) STAKIMJP COUNTRY NAME COMPANY NAME LOCATION ASL CASE NUMBER | YEAR OF YEAR 1931 1933 West Germany West Germany BASF Wanker Ludwigshafen Burghausen 1 1st Exposure l04,07,11,15,23,24 25!57,54,55,53,55,^60 1938 Italy Montecatini Anna 1939 France Rhone Poulenc St Fons 03,09,10,11,14, 146,48,56,41,43, 115,16,17 '55,41,48 1940 United Kingdom ICI Runcorn 1940 United Kingdom ICI 1945 Sweden Kananord Hillhouse 101,04,12 144,54,57 Sundsvall(Stockvik) 101,02,03,04,05~ 51,45,47,46,64 Switzerland Lonza Sins 1946 France 1947 Italy Rhone-Poulenc Rousillon Montedison Porto Marghera 01 02 46 57 1948 United Kingdom BP Chan Barry 03,05,06,07,08,09 66,51,62,63,50,50 10,11 66j65 West Germany Eils Marl 09,10,26 61,61,53 1949 Belgium 1950 France Solvay Puk Jemeppe Brignoud 01,02 02,04,05,06,12 58,62 59,49,65,58,49 France Rhone-Poulenc St Auban 07 50 Holland Shell Pernis Norway Norsk Heroya 01 50 1951 Italy Montedison Brindisi 1952 Italy Montedison Temi 1953 Austria Halvic Hallein France Solvay Tavaux 08,13,18 57,63,63 Italy Solvay Ferrara 03 53 Spain Rio Rodano Hemanl United Kingdom BIP Aydiffe West Germany Hoechst 1954 West Germany Dynamit Gendorf Troisdorf 18 55 01,02 ,08,12,16, 56,57,54,61,55,61, 17,19 ,20,21,22,27 54,61.62,61,55 1955 Spain Monsanto Iberia Monzon 1956 Spain Caiqsa Sabinanigo Hispavic Torrelavega 1958 West Germany Solvay Kheinberg 1960 Italy S C Ravenna 1960 West Germany Lonza Ravenna Waldshit 04 06,13 59 62,60 1962 Portugal Clres Oporto 1965 France Rhone-Poulenc Montlucon Italy Pozzi Ferrandina West Germany Wacker Cologne 1966 West Germany Hoechst Knapsack(Frankfurt) 05* 60 1967 France AID Chlmle Balan Spain Rio Rodano Miranda de Ebro Greece Esso Pappas Diavata Salonika 1968 Belgian Badiphll Antwerp 1%9 United Kingdom Vinatex Staveley Italy Runianca GayHari Sardlna 1970 Italy SIR Porto Torres Sar United Kingdom Ia Runcorn 1971 Italy S C Ravenna Ravenna Spain Hispavic Martorell Sweden Kemanord Stenungsund United Kingdom BP Chem Baglan Bay 1972 Finland Peksna Svartback Holland rm Beek TdTrixng 1976 France Soc Art D'vinyl Mazingarbe 1977 Spain Monsanto Iberia Tarragona laboratory worker in Research Department PAN5AC, Mira Venice, case not included (It 05), due not knowing start up date of doe Plant. R&S 003023 R&S 003024 Page 45 (Review date 1 January 1986) TABLE 9 USA FVC PRODUCERS - START-UP DATES vs ASL CASES SIAKT-UP COMPANY NAME LOCATION ASL CASE YEAR OF YEAR NUMBER 1st EXPOSURE 1939? *UOC S Charleston 07,13,19,21,24, 44,42,43,46,39, 27,28,29,31,35 41,44,42,46,44 1940? *BFG Louisville 01,02,03,04,05, 48,55,45,52,44, 06,09,16,17,22, 62,45,50,55,47, 26,33,34,37 47,54,55,53 1946? *UCC Texas City (Partially closed 1977) 1947 Goodyear Niagara Falls [08,10,11,20 46,51,46,55 1948 Firestone Uniroyal Pottstown Painesville 12 | 49 1950 Monsanto (closed 1975) Springfield 1 |32 51 (Qosed 1975 | 1952 Dew Midland (No FVC since c 1975) BFG Avon Lake 18 54 1953 BEG Deer Park (Formerly Diamond) 1954 General Tire Ashtabula |36 56 1956 Air Products (Qosed 1984) Pensacola | Atlantic Refining Brooklyn( Closed late 1960s) Borden Leominster (Closed 1984) Conoco Hebronville (Qosed 1975) BEG Niagara Great American Fitchburg 23 58 Plastics (Qosed 1983) Hooker Hicksville (Qosed 1980-81) Pautosoto Passiac (Qosed 1984) 1957 Atlantic Tubing Cranston (dosed 1967) 1958 Tenneco Keysor Century Remington NJ Saugus, Cal 130 | 59 1960 BEG Watson, Cal Air Products Calvert Qty 38 63 (closed Mwch 1982 Re-opened Octol xr 1983) Borden Illlopolis 1962 Tenneco Burlington NJ 1963 Conoco Aberdeen, Miss Stauffer Long Beach, Cal (Qosed 1982) 1965 Conoco ** Assonet, Mass (Qosed by Olin 1975 see below) 1966 Ethyl Georgia Gulf Baton Rouge (Qosed 1984) I Delawre City (Formerly Dianond) | General Tire/Pancas Mt Pleasant W Va 1 (Qoeed 1983) BEG Henry, 111 | | 1967 Stauffer Allied Delaware Qty (Sold to Formosa 1983) *** Painesville, 0 | (sold to Roblntech) Hooker Burlington NJ | 1968 Firestone Perryville (Qoeed 1982) 1969 BEG Pedrickton NJ Goodyear Plaquodne Un ** Assonet, Maas (Qocied 1975) (See above) 1971 (Formerly Conoco) Conoco Oklahoma Qty i WPX/ASL 2 - LANGIDCASES,50 Continued R&S 003025 Page 46 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1972 1973 COMPANY NAME Nat Starch Borden Robintech *** 1974 1975 1979 1983 Atlantic Tubing/ Tallyrand Shintech Certain-teed Georgia Pacific Tenneco Firestone Formosa LOCATION Meredosia, 111 Springfield ! Painesville, 0 (sold to Georgia Pacific who converted to polystyrene) Cranston RI (Closed ASL CASE NUMBER 1982) Freeport, Tex Lake Charles Flaquemine, La Pasadena, Tex Plaquemine Point Comfort, Tex YEAR OF 1st EXPOSURE 1 I r ! 1 1 i * My databank has no information on UCC before 1946 or BFG before 1950 ** Refers to same plant at Assonet ***Refer to same plant at Painesville. Allied plant never operated again for PVC after it was sold to Robintech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WPX/ASL 2 - LANGI0CASES.51 Page 47 (Review date 1 January 1986) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR COMPANY NAME 1943 (1941?) Goodrich LOCATION Shawinigan ASL CASE NUMBER YEAR OF 1st EXPOSURE 01,02,03,04,05 44,43,41,45,44, 06,07,08,09,10 47,46,61,46,53 1951 Monsanto La Salle (Closed 1! '75) 1957 Goodrich Welland 1966 Esso Sarnia 1979 Diamond Shamrock Alb Fort Saskatchewan WPX/ASL 2 - LANG10CASES,52 33 (/> o o 03 o to O) Page 48 (Review date 1 January 1986) J3 fio (/) 0 O w o M TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP COUNTRY NAME COMPANY NAME YEAR Pre 1939 East Germany State Company 1941 Russia State Comps 1950 Yugoslavia Jugo Vinil 1951 Czechoslovakia State Comps 1955 East Germany State Comps 1956 Rumania State Comps 1957 Poland State Comps Rumania State Comps 1958 1959 1961 1963 1965 1967 1969 1970 1972 1975 1976 1977 Rumania State Comps Hungary State Comps Rumania State Comps Yugoslavia Ohis Bulgaria State Comps Poland State Comps Russia State Comps Rumania State Comps Russia State Comps Yugoslavia Vinilplastika Czechoslovakia State Comps Russia State Comps Yugoslavia Hip Rumania State Comps LOCATION Schopau Vladimir et al Split Novaky Bitterfeldt Icechim Osweicim (Dwory) Tirnaveni Turda Risnov Berente Borsod Borzesti Skopje Varna Tarnow Djerjinsk Rimnicu Vilcea Volgograd Zadar Neratovlce Kalush Area Pancevo Rimnicu Vilcea ASL CASE NUMBER 01,02,03,04 01,02 YEAR OF 1st Exposure 53,50,54,48 57,50 WPX/ASL_2 - LANGIOCASES,53 Page 49 (Review date 1 January 1986) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP YEAR 1950 1951 1952 1951 1955 1956 1957 1960 1964 1966 1967 1968 1970 1971 1973 1974 COMPANY NAME Chisso Corp Kanegafuchi Kag Tekkosha Mitsui Toatsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichi Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahl Glass Toyo Soda 1975 1977 Central Kagaku Toyo Soda Unknown LOCATION Minamata Osaka Sakata Nagoya Yokkaichi Klkumoto Shibukawa Kambara Tckushima Uozu Takoaka Takeo Nishiki Naoetsu Ohmi Takasago Chiba Tokuyama Tokuyama Chiba Mizushima Tokuyama Mizushima Goi (Chiba) Kashima Kawasaki Sakai Chiba Kashima Yokkaichi Hayatsuki Sakata Yokkaishi Kawasaki Yokkaichi Kashima ASL CASE NUMBER YEAR OF 1st EXPOSURE 01, 02 53, 58 VPX/ASL 2 - LANGIOCASES,54 37 CO oo CO o IO 09 Page 50 (Review date 1 January 1986) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP COMPANY NAME YEAR 1953 Monsanto Mexica 1954 Policyd 1955 Geon Do Brazil 1956 Elchlor 1960 Electrochlor Viplastic 1961 Indupa 1965 (SOC Paramanga (1967 start up PET Columbiana 1966 Carburo De Col 1967 Plasticos Omega 1968 Primex 1970 Policasa Petro Dow 1971 Polimeros Mex 1975 Rico Chemicals 1976 Petroplas 1977 Indust Resistoc 1978 Huls Brasil Polychem Policyd 1979 PET Camacari LOCATION ! Lecheria (Mexico) | Mexico City (Mexico) Sao Paulo (Brazil) Sao Caetano (Brazil) Capitan Bermudez(Argentina) Mendoz (Argentina) Cinco Saltos (Argentina) Paramonga (Peru) ) Cartagena (Colombia) Medellin (Colombia) Mexico Puebla (Mexico) Managua (Nicaragua) Conception (Chile) St Martin Puebla (Mexico) Guyanilla (Puerto Rico) EL Tablazo (Venezuela) Tlazcala (Mexico) Cubato (Brazil) El Salvador Coatzacoalcos (Mexico) Camacari Bahia (Brazil) ASL CASE NUMBER YEAR OF 1st EXPOSURE | WPX/ASL_2 - LANGIOCASES,55 i DO (/> o o w ro to R&S 003030 Page 51 (Review date 1 January 1986) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP YEAR COMPANY NAME Mid 1950s ICI Australia 1960s B F Goodrich Late 1970s ICI Australia LOCATION Botany, Sydney Melbourne Laverton Melbourne ASL CASE NUMBER YEAR OF 1st EXPOSURE WPX/ASL_2 - LANGTOCASES,56