Document Z44a9oB1qBj1vB52bzr11Nqv8

* ' J. i % { Review on VCM and PVC Executive Committee Meeting March 11-12, 1974 DRAFT f | A U* I. l*1 Incidence of Cancer (Angiosarcoma of liver). ! 8 proven cases - 6 Goodrich, 1 Carbide, 1 ICI - 7 dead, 1 still alive - 7 PVC manufacture, 1 VCM manufacture TCA Study has not revealed other significant findings todate on causes of death. For 131 deaths in vinyl workers, had 26 cases of other cancer. Incidence of 19.8% compares with national average (1967 males) 16.2%. Final report due 4/15. Industry to look into (either individually or through TCA) medical background of all cancer cases or other sus picious disease. Ethyl has five to. investigate further (3 from Baton Rouge in TCA study). Brain, kidney, cirrhosis at Baton Rouge; gall bladder at Louisville; pancreas at Houston. II. Incidence of Liver Disease Original Goodrich information - 55 of 270 showed abnormal liver function--4-7 more than minor. f, Speculation - Germany - 68 serious cases. Some of which may develop to cancer^ Controversy - liver toxicology vs cancer. MCA trying to investigate detail. NIOSH "experts on liver" concluded 3/2, there is no predictive test. Reported BFG thinks a transpeptiddse measurement coupled with liver scaning may be fruitful. Needs proof in prospective studies or animal studies. I. Monitoring <^^7^ ^ ^ 3 ff*** y. General area .monitoring at Baton Rouge and Houston -c Site sele^fcecl monitoring performed in compounding @ Baton : A a* v,rt . .Rouge and Tiptonville,/bottle molding' @ Louisville, pipe i\ m*9 * v#* Vw^extrusion @ Columbia -|u\ Personnel monitoring week of 3/11 resin manufacture 8 Baton Rouge - *4/ Site selected and/or personnel monitoring planned for other ^ ' /l-Va areas including Greece. Estimate 2-3 months to get suf- i ficient data for confidence in characterization of work |^ EC- 2116 j ( j rr IV. Work Practices in PVC Manufacture DOL rejected AFL/CIO petition for temporary emergency standard. Industry group (MCA) presented proposal to NIOSH on 2/27 Got perfunctory reception and little discussion Main points of controversy were: jyw --.,(1) protection for reactor entry - union wants full . {'T ' protection regardless of conditions (2) limits on monomer content in resin not needed since standard will deal solely with manufacture - NIOSH (3) second thoughts on inclusion of control value on basis may be misinterpreted - NIOSH and union / Group met to redraft on 3/7. Detail unknown ^ ^ x (* fA I r f f V. Other Activities I ! X. Amalgamated Meat Cutters have raised problem of meat cutters asthma. Union met with Borden and Goodyear, possibly Filmco, have contacted Ethyl. Calling meeting 3/13 to present proposal.for study by Selikoff. Borden called meeting of entire interested industry on 3/1 at MCA. Plans underway for study under MC7, expect to re fuse to sponsor union study as too.broad. Probable MCA budge4 $150-200M. No pr.oration schedule decided. Ethyl sh^re could be S10-20M. 2. MCA-VCM group soliciting funds for studies in metabolism and teratology. Budget $80M-Ethyl*s share $4.8M 3. MCA-VCM to ask TCA to continue follow up on "lost" persons from epidemiology study. $5M from available contingency funds. 6-8 months allowed. 4. SPI feeding and food extraction studies in process of funding. Detail? Ethyl budget anticipated $6M/yr. for three years. 5. Consumer Product Safety Commission investigating aerosol use. May get on other non-food uses. 6. Rumblings re interest by Selikoff on possible pneumoconiosis from PVC dust. Unions could attempt to involve NIOSH and/or OSHA. c*A' 7. A by invitation only meeting on VC pathology is scheduled for 5/10 in New York. Pushed by Selikoff, through New York Academy of Sciences and American Cancer Society sponsors. MCA is in on planning. Will be papers and discussion. Publication of proceeding is planned. EC- 2117