Document Z3YQg57Vq2ZZk9jpdnM68wZJ

PLAINTIFF'S EXHIBIT For Information.Only - Not for Publication ' Kettering Laboratory University of'Cincinnati THE PROJECT ON CARCINOGENICITY PROPOSED EPIDEMIOLOGICAL STUDIES Progress Report for The Subcommittee on Carcinogenicity of the API Medical Advisory Committee April 23, 1950 Revision - May 1$, 195>0 SC-API-2056 Appendix Page 3 Detailed Clinical Record (To be completed in duplicate) (One copy to be retained by the Medical Director) I. Identification Data A. Code Number - All identifying data (Name-Address) to be retained in the office of the Medical Director. B. Age (Year bora) C. Sex D. Race E. Marital Status P. Etaployment Status H. Clinical Data A. Dates 1. First Symptom 2. First Visit to Physician .3 First Diagnosis Ij.. First Treatment or Hospitalization .5 Death B. Clinical and Pathologic Diagnosis - List of tumors to be reported which will be placed on the reverse of record. This list is not exhaustive but comprises the great majority of terms usually used. When there is doubt concerning the malignant nature of a tumor, it should be reported. Appendix. Page If. Carcinoma - Sarcoma 1 and any term of which one Epithelioma f of these words is a part. Endothelioma J Acanthoma Astrocytoma Brain Tumors Chorioma Chloroma Cholesteatoma Embryoma Ependymoma Ganglioneuroma Glioma Granulosa Cell Tumor (Ovary) Hypernephroma Hodgkin's Disease Leukemia Lymphoma Lympho s arc oma Llnitis Plastica (Stomach) Melanoma Meningioma Myeloma ' Medulloblastoma Mesothelioma. Mixed Tumor Neurocytoma Oligodendroglioma Pinealoraa Syncytioma Seminoma Sympathoblas toma Spongioblas toma Teratoma Thymoma Paget's Disease (Breast) Wilms' Tumor (Kidney) Ewing's Tumor (Bone) Grawitz' Tumor (Kidney) C. Primary Site and Stage D. Treatment Advised and Received E. Complications - Metastatic Sites III. Pnusual Exposure to Possible Carcinogens - Including estimates of Degree, Type and Length of Time (As elicited by the Physician) List which will be placed on the reverse of the record. A. Physical Agents 1. Trauma 2. Radiant Heat 1. Solar Rays a. Ultraviolet Rays 5. Radioactive Substances or Roentgen Rays B. Inorganic Substances 1. Arsenic 2. Chromates C. Organic Substances 1. Aromatic Amines 2. Tar or Pitch . Soot . Creosote and Anthracene Oils * For Information Only - Not for Publication .AMERICAN PETROLEUM INSTITUTE SUBCOMMITTEE ON CARCINOGENICITY Minutes of Meeting April 23, 1950 Hotel Sherman Chicago, Illinois Members Present Associates Present Mclver Woody (Chairman) Marshall Clinton T. M. Frank A. E. Hoag J. P. Holt (Rep. by R. E. Eckardt) T. Kelly J. W. Long M. N. Newqulst Chas. A. Swan L. 0- Crockett Allan E. Dooley R. W. Faulk R. M. Landon H. P. Lankelma K. 0. Mackenzie (Rep. by H. R. Warrick) R. M. Shepardson Members and Associates of Medical Advisory Committee W. 0. Armstrong V. C. Baird F. F. Boys Kleffer Davis E. K. Linder E. P. Luongo B. B. Reeve E. R. Ware E. W. Adams R. D. Bent R. C. Cole T. E. DeVllliers L. M. Henderson C. A. Neilson F. M. Watkins Quests N. W. Bolyard - Standard Oil Co. (Ind) Philip Drinker - Harvard School of public Health J. W. Hammond - Humble Oil and Refining Co. Howard Hansen - Esso Standard Oil Co. A. W. Horton - University of Cincinnati W. C. Hueper - National Cancer Institute, Bethesda. Md. R. A. Kehoe - University of Cincinnati R. C. Page - Standard Oil Co. (N. J.) J. J. Phair - University of Cincinnati H. G. S. van RaAlte - Shell Oil Co., Curacao, N. Ant. W. E. Smith - New York University D. V. Stroop - American Petroleum Institute P. M. Waddlll - Phillips Petroleum Co. Total in attendance - 44 -2- Members Absent L. E. Curtis V. R. Levis Associates AbBent L. C. Beard, Jr. H. Q. M. Fischer The minutes of the November 10, 1949 meeting were approved. Dr. A. W. Horton presented a progress report, copies of which had been sent to all members and associates on April 11. This report was supplemented by a series of lantern slides showing poten cies of some of the oils which have been tested. Vith respect to the analytical phases. Dr. Horton stated that many compounds had been Isolated but very few had been identified as yet. Perylene, 4-methyl pyrene and chrysene have been definitely Identified as constituents of high-boiling catalytically cracked oils. Dr. Horton described the data which was to be submitted for publication in "Cancer Research". The potency curves of oils 8 and 9 (see Table I of Dr. Horton*s report) would be Included as being typi cal examples of the oils being studied. In the discussion which followed, many of the members and associates voiced a request that a complete and detailed report be prepared by Dr. Horton. It was pointed out that such a report would be of particular benefit to new members and associates. Dr. Horton's report was accepted and approved. Mr. R. M- Shepardson described the work of his company on the development of a quick laboratory test for measuring the potential carcinogenicity of petroleum products. As a numerical expression of potential carcinogenicity, the number of days required for 50 per cent of the mice to develop tumors after discarding all mice which had died -3- without tumors, has been tentatively chosen. Of 64 samples tested to date, a satisfactory correlation has been found between the biological tests and the ultra-violet absorption measured at 360 mu on the por tion of the sample separated by distillation and boiling between 65O0 and 950 F., when correcting for difference in viscosity, mid-boiling point and concentration of the 650-950 F material. This study is being continued on a larger number of samples. The subcommittee expressed its thanks to Mr. Shepardson for his presentation. Dr. R. E. Eckardt reported on some of the work* being done at Memorial Hospital. Cancers have been produced in two monkeys out of six who had been painted with a high-boiling oil twice a week for about five years. This is the first time that skin cancers have been produced experimentally in monkeys. Dr. Eckardt reporting on washing experiments Bald that re sults to date indicate that washing offers some protection but not absolute protection. With groups of 30 mice, application of the oil and washing after five minutes resulted in a reduction in the number of tumors and no cancers after one year. Washing the mice one hour after application produced tumorB in four mice and cancer in one mouse of the group of thirty. Washing the mice six hourB after appli cation resulted in the development of cancer in three mice. In a group of sixty mice which were painted with only one application of a high-boiling oil, tumors were produced in two mice * See attached copy of paper "Experimental Analysis of the Carcino genic Activity of Certain Petroleum Products" for additional informa tion on this work. and cancers In two additional nice. The first tumor appeared after 92 days and the first cancer after 274 days. No tumors or cancers appeared In a control group on 100 mice. This subcommittee expressed Its thanks to Dr. Eckardt for his presentation. Dr. J. J. Phalr presented a progress report on the epidemio logical study which he plans to get under way about July 1, 1950. Dr. Phalr distributed mimeographed copies of his report. During the discussion It was brought out that, to date, there have been no cases of skin cancer in which the employe has claimed that exposure to these high-hoiling oils was the cause. Dr. phalr*s report was accepted and approved with the under standing that the word "approved" would be changed to "needed" where it fits the context of the report. Dr. H. Q. S. van Raalte told about a fishing village on the Island of St. Martin where the Inhabitants, all of Danish ancestry, can trace their ancestry back about 200 years on the island. He stated that most of the men develop skin cancers by the time they reach age 40. Most work at fishing and handle tarred nets and tackle. A few who have worked in the refinery or at Aruba apparently have not had skin cancers. Dr. W. C. Hueper (National Cancer Institute) said that he had talked to a nurse in an asphalt shingle plant in the western part of the United States and that the nurse had reported cases of cancer on the dorsum of the hands. Dr. Hueper said that a petroleum asphalt -5- was being used and that it would be well to keep an eye on this ma terial with respect to both producers and consumers. The subcommittee recommended to the Medical Advisory Com mittee that it should approve: . 1. Publication of the report as described by Dr. Horton in his letter of April 7* 1950 to D. V. Stroop. 2. The proposed epidemiological study as described by Dr. Phair. Mclver Woody, M.D. Chairman Allan E. Dooley Secretary