Document YrZ6L28apVKyBXbkLJ4rEkRJK

Virtual conference Page 1 o f2 SA EWT-A. CM Efrurope Search engine Find User : Anonymous 1 t-ogin Forum Upload presentation User registration FAQ 1329. Cancer prevalence in subjects exposed to alkylated substances (PFAS) A uthor: James Dahlgren Perfluorooctanonic Acid (PFOA) is a man-made perfluorooctaned chemical, which is also referred to as C8. PFOA is a key ingredient agent in the production of Teflon and other fluorochemical products and is biopersistent and bioaccumulates. There has been documented chronic exposure to PFOA of the residents near a plant using PFOA and other fluorinated contaminants. Our aim was to compare cancer distribution and cancer prevalence rates in a PFOA-exposed population (residents) to that of the industry cancer registry data from an occupational exposed population and finally to the general population (SEER). We performed a questionnaire on 599 residents living near a PFOA using manufacturing plant operated by Dupont. Cancer registry data from the PFOA Dupont workers was made available through discovery in pending litigation against Dupont and was not previously made available to the scientific community for review. The SEER data was used for comparison to the general population. The overall cancer prevalence rate is higher In the PFOA-exposed population when compared to the general population. Comparison of cancer prevalence rates for the industry cancer registry data, resident data and SEER is shown in Table 1. Our findings indicate that the PFOA exposed residential population and PFOA-exposed workers have elevated cancer prevalence (Table 1). Prostate cancer in the residents was proportionately elevated among young age males. Cervix and uterine cancer rates In women were also higher in the resident population compared to the U.S. general population. The distribution of cancers in the residents and workers is different than expected. Of note are the findings of elevated prevalence rates of atypical cancers such as Non-Hodgkin's, Leukemia, and Multiple Myeloma. This data suggests that exposure to PFOA may alter cancer distribution In exposed populations (worker and residents) and may be an important risk factor for an excess of cancer cases. Author Post Replyj Vif+r>-//nra m i 7iin ua py/ve/index n 1 in ?a = to n ic& X = 1 3 2 9 & Message webmaster : Kamil Strakos 4/28/2004 CANCER PREVALENCE IN SUBJECTS EXPOSED TO PERFLUOROOCTANONIC ACID (PFOA) James Dahlgren MD1, Ayman B 1. UCLA School of Medicine. Ibrahim MD1'2'\ Raphael Warshaw2, 2. Comprehensive Health Screening Services, Harpreet Takhar MPH3 -0 3. Dahlgren Medical Group forIluilrfxv'jraHttc Acid iPFOAi chenucaL alM'H'Uirci! in i i l H I'KJA is j key incrvdi* sgiiM in the prnductHta 'JTcfliwti mJ rahar ihn'r.vFeroicai product jrul u i'KV'i.Tuflcfti jiW buvttcasniitek*. There fu i hn drwumcaicd chrome expn.<*re m PFOAoi'ihc rcsklrnu cars plum wing PFOA tnd>Hlier llurmrau-O onnuminMis. O v aim erje *compar tMtrr tisirihutmn and cancer prevalence mi in a Pi'OA<etpnMd pnpelai* i resMieatsi tothai i>FiNti irhlutry cancer registry >bti Irnru sa ncciqsixxial apeted population and foully hvike^ywrsl pnpulawniSEEfU We(vrformcl>t qtsesiiMiaairr on WV resklents living near a PFOA ism* manufocniripp ptax operand by Onpnar. Cancer npsu y data teni the PFOA exposed Oupom workers was nude available Ihrnugh discovery in pdukag litigatfemagain Dupont and ww not previously i-- a available totho aeteotifle commnity for review. ThaHF.EAdate weit forcnnparUnu to the general population. The overall cancer prevalence mic is higher m the PFOA-swpoeed population whencompand w ihc general pnputaiiM. Cerapomon of cancer prevalenceRKci fne ihe industry cuteer registry data. resident dau and SEIiR i* riiowni Table I Our findmga imlicnK that the PFOA exposedreikkatinl pnpiUannn and PFOA-epnMd workers have elevated cancer prevalence tTaMe 11. Proeuka cancer n ike rettderus was pmportwnwty elevated among yenng males. Ccrvia and uterine cancer rales in woman were alee higher in the resident population compand to die VX general The d)0nMiMMnfcaaevrs |n ike residents ami workers itdinfeiml bun expected. Ofmie srv rhefosdtagxefefevatadprrraknec mat at atypical caneen iK k aaNna-Hodgkift'slympiMma. Leukemia, and Multiple Myeloma. This data suysed ten poeurc to PFOA may altercancer diruibunwi inexposed populations (workers aod residentsI andmay be an impon risk reme Cman exeeai o f canear cuci- Results Aro P FO A LovolS leKtbl 17-4.3 Location Liio HocUng. OWo 2 0.4*3.9 LubKk. WV 3 0.25*0.37 Tuppon PteUte, Ohio 0 0.06-0.13 Botpeo, Oh 5 0.03*0.1 Mason, WV 6 0.06-0.07 Pomoroy, ONo 1 0*5.0 OuponL WtMNnBlon Wort B 1.75-1.87 G E Plagte 9 0.05-8.8 68 Private Welte WVA 6 J2 2 ________________ * Mimateti an 1* pcopte per household N-'A N Applicable kieiwalwMa 4200 3700 4800 6000 4200 1000 WA N/A 68 Reputation* 11760 10360 13440 16800 11760 2800 2200 700 190 FIg*rc 2. Overflew of Washington te tu PhuM ' Hatedno SEER Fin Malignant Primary Ftur 1 Washington Work