Document YrMpQ7m5eE4Yx6q0vE6qzqr4N

AR226-2759 Haskell .1ASKELL I. E. du Font de Nemours and Company and Induscrial Medicine Laboratory for Toxicology 19711 Elkton Road, Newark, Delaware --------------------J LABORATO&Y REPORT NO. 1007-oU n Study Initiated/Completed io/i/ao - ii/3/yu .Material Submitted by Washington Works Parkersburg, W. Va. ORAL LD50 TEST IN RATS Procedure; The teat material, used ae received, was administered by of 10 young adult Crl:CD8 ititragastric intubation in singia Finding Study dosee to a group was conducted to determine the initial dose (Bale rats* A Range level for cha LD50 test.** The surviving rate were weighed and observed during a 14-day recovery period and t^hen sacrificed. Resultgi Dose (mg/kg) 25,000 Average Body Weight (g) 2A2 Average Doae (ml) Mortality Ratio,... 0/10 LD5Q_ ___ > 25,000 ag/kg Clinical Signa ' 25.UUU ng/kg Congestion and slight initial weight lose (1 rat) after aoaing. SummarylUljli i i ih'iy Inn in single Iniililly iiiilirii mlinl uliiiil i 11 ill niiiiMl1 l 11 11111111)' lulul t rog/kg of doses. Its LD50 The is greater than .'5,01)0 only clinical signs observed were Cri;GD Bale rate body weight, the maximum feasible dose. congestion and slight weight loss in one rac. ,1001^'" - -1 H-aed.O08"0 Santt*10 iCeatR131^ * ocher Name(ajt ** A Range Finding Study was run from 670-25,000 nig/kg ai.d produced no deaths. Report by': // -P /'/7 .,/L. an^^-rHf il.-^^c.-ji^:-^ Lon Hinckle Technician l^v^y Appcoved by; ^^yJLf L Gerald L Katnnedy Chief, Acuca lavescigaciona Section LH;jrg Study Director: 0. L. ^nrct--^laaTuaaeuda^A^i_f_l&Dcacaefflf^lheei:r "'RReepooortr^M^b.^lOOiOT"^^ Dashiell 22, 1980