Document Yr22rOnGqbG83JqKqaXmvNg2N

\. 'tuLi'il'u-al BIO-TEST 2u atvii&i, 9hc. &> MONSANTO COMPANY STATUS SUMMARY TWO-YEAR CHRONIC ORAL TOXICITY OF AROCLOR 1242 IN BEAGLE DOGS I. Outline of Investigation A. Type and Length; B. Animal Species Tested: C. Number of Animals: D. Starting Date: E. Status of this Report: F. Organization: Two-Year Chronic Oral Toxicity Pure-Bred Beagle Dogs 32 May 23, 1969 33 weeks (January 12, 1970) Group Control Test I Test II Test III . Number of Animals Male F emale 44 44 44 44 Dietary Level of Aroclor 1242* .... . (PPm) None 1 10 100 * Voluntary oral ingestion; ad libitum feeding of graded levels of test material in diet. DSW 034218 STLCOPCB4018043 DinluiOitol B I O - T E S T Ic ' laiMicl, 9mc. II. Results A. Body Weights Mean body weight gains (kg) after 33 weeks of testing are as follows: Males F emales Control 2.9 2. 7 Test I 4.4 3. 0 Test II 2. 0 2.4 Test HI 3.7 2.3 Body weight values for the Untre ated Control Group and the three test groups compare favorably. B. Food Consumption Average food consumed per week (g/kg of body weight) during the first 33 weeks of testing is as follows: Males F emales Control 265 278 Test I 272 269 Test II 232 268 Test m 254 261 No significant abnormalities have been noted at any of the levels tested. C. Reactions No untoward behavioral reactions have occurred at any levels tested thus far in the investigation. DSW 034219 STLCOPCB4018044 r HtuLidual BIO-TEST <. aivu&t, 9nc. 3 D. Mortality No fatalities have occurred at any levels tested. E. Hematologic Studies. Blood Chemistry Studies and Urinalyses The results of these determinations, conducted at the 1, 3 and 6 month periods, have revealed no significant abnormalities at any levels tested. db January 15, 1970 OSW 034220 STLCOPCB4018045