Document YppYo8kpMXg4BYnN6EdM65q0

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W. WASHlNGTON^t). C. 20009 (202) tMfcALS LavC RESEARCH SEP28 1377 September 27, 1977 TO; Vinyl Chloride Technical Panel SUBJECT: I- The Chemistry and Biogenesis of the S-Containing Metabolites of Vinyl Chloride in Rats II. Comparative Mammalian Metabolism of Vinyl and Vinylidene Chlorides in Relation to Oncogenic . Potential Gentlemen: Mr. R. N. Wheeler has thoughtfully made available the subject technical papers which he received from Mr. J. Stafford of ICI. Your copies of these papers are enclosed. The contribution by Dr. David E. Hathway on the elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway (reference Subject II) was well received at the Symposium on Comparative Metabolism and Toxicity of Vinyl Chloride Related Compounds (NIEHS, Bethesda, Maryland). Sincerely, JTS:ec Enclosures J. T. Seawell Project Manager Vinyl Chloride Research vvc OOOOOA522