Document Yjn1g5a7VrdwdONORGERgLokE

AR226-2887 kl E. I. du Pone de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 571-80 MR NO Other Codes Study Initlated/Completed 7/15/80 - 7/18/80 Material Submitted b CD&P Dept. Jackson Laboratory EYE IRRITATION TEST IN RABBITS Procedure: One-tenth milliliter of undiluted test material was placed into the right conjunctival sac of each of 2 male albino rabbits.** After 20 seconds, 1 treated eye was washed with tap water for 1 minute. The treated eye of the other rabbit was not washed. Observations of the cornea, iris and conjunctiva were made with a hand-slit lamp at 1 and 4 hours, and at 1, 2, and 3 days, Fluor-i-strip* stain and a biomicroscope were used at examinations after the day of treatment. Results : Dose Treatment Ocular Effects Cornea Iris Conjunctiva 0.1 ml Not Washed undiluted test material Localized slight cloudiness at 1 hr. None Redness: Mild - 4 hrs. SwellingsSlight 1-4 hrs. Discharge:Copious - 1 hr, Moderate - 4 hrs (Hema8tix* +). 0.1 ml Washed undiluted test material None None Redness: Mild 1 hr.-l day. Swelling:Slight - 1 hr. Discharge:Mild - 1 hr. Company Sanitized. Does net contain TSCA CBI 1 S u m m a r y transient slight corneal cloudiness, mild to slight conJune copious discharge and no Iritis when tested in the eye of a rabbit. This eye returned to normal within 1 day. An eye dosed with the compound and promptly washed had mild to slight conjunctivitis and no corneal or irltic effects. This eye was normal within 2 days. This material is a mild ocular irritant. In the event of contact, flush eyes copiously with water. Approved by: ___________ Gerald L. Kennedy Chief, Acute Investigations Section PA:jrg Study Director: 0. L. Dashiell .Date Issued: July 30. ,1980 Report 2- - Company Sanitized. Doss noi coniata TSCA CBs I