Document YjJqaxw7pywbJK9Dm5xgp4Mjn

Fur example, In rats rocai . ing asbestos fLbors by Intratracheal Injec tion fibroslo cf characteristic typo is vloible to oarly aa one month after injootion; for quartz dust tho latuut poriod iu two moutho or more. 1 Tims, tho dovolopment of nodular fibroals duo to iuhuled ailicu lags bo*i hind tho deposition of duet to a greater extont than^doe a tho evolution of tho diffuse ronction to aabostos. This results in a difforouco in the degroo of progruoaion which follows tormination of expoauro to dust. For example, on dlacontiuuing exposure, tho nodules of silicosis beooua larger, to a limited extent, for a considerable period cf .time, wherea3 tho fibrosiu of aubostoaio inoroaaoa for only a short time. Subsequently, the aobostotio fibrosis contractoj this proooss often distorts tho adjacent v > \ '' pulmonary tiscuo ar.d nay rosult in a - progressive interference with cardio- i* renpiratory function. Asbootoale Codies. Tho peculiar structure known as tho asbostoeis body or "ourioun body" is a spooific concomitant of asbastosis^,^,'^. The typical body it a golden-yellow, beaded or hauatratod rod which may be either straight or curved (figs. 2 and 3). Often one or both ends are bulbouo like a dumb-bell. Tho bodies vary considerably in longth, and dimensions up to 260 microns havo been rooordod. .. It is believed that asbootoals bodies are duo to a deposit of protein and iron pigment of tissue origin upon the eurfaoo of inhaled fibors 6, `^Cloyno, S.H.t 'Iho Formation of the AsbeatoBla Body in the Lung. Tuborcle 12: 39B, 1931. - 7. Gloyno, S.R.i Tho Asbostoals Body. Lanoot. 1351, June 26, 1932. -7-