Document YjEZDd3kZOpzM4gXqaE8V1N1D

32. Ross, D., Siegel, D., Schattenberg, D. G., Sun, X. M. M., and Moran, J. L. Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: Identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ.Health Perspect., 104 Suppl. 6: 1177-1182, 1996. 33. Tunek, A, Platt, K. L., Bentley, P., and Oesch, F. Microsomal Metabolism of Benzene to Species Irreversibly Binding to Microsomal Protein and Effects of Modification of This Metabolism Mol.Pharmacol., 14: 920-929, 1978. 34. Irons, R. D., Greenlee, W. F., Wierda, D., and Bus, J. S. Relationship between benzene metabolism and toxicity: a proposed mechanism for the formation of reactive intermediates from polyphenol metabolites. Adv.Exp.Med.Biol., 136A: 229-243, 1982. 35. Andrews, L. S., Sasame, H. A, and Gillette, J. R. 3H-benzene metabolism in rabbit bone marrow. Life Sci, 25: 567-572, 1979. 36. Andrews, L. S., Lee, E. W., Witmer, C. M., Kocsis, J. J., and Snyder, R. S. Effects of toluene on the metabolism, disposition and hemopoietic toxicity of benzene. BiochemPharmacol., 26: 293-300, 1977. 37. Ross, D. Metabolic basis of benzene toxicity. Eur.J.Haematol., 57 Suppl. 60: 111-118, 1996. 38. Eastmond, D. A, Smith, M. T., and Irons, R. D. An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure. Toxicol.Appl.Pharmacol., 91: 85-95, 1987. 39. Rickert, D. E., Baker, T. S., Bus, J. S., Barrow, C. S., and Irons, R. D. Benzene disposition in the rat after exposure by inhalation. Toxicol.Appl.Pharmacol., 49: 417-423, 1979. 40. Irons, R. D., Neptun, D. A, and Pfeifer, R. W. Inhibition of lymphocyte transformation and microtubule assembly by quinone metabolites of benzene: evidence for a common mechanism J.Reticuloendoth.Soc., 30(5): 359-372, 1981. 41. Pfeifer, R. W. and Irons, R. D. Alteration of lymphocyte function by quinones through a sulfhydryl-dependent disruption of microtubule assembly. Int.J.Immunopharmacol., 5(5): 463-470, 1983. 42. Irons, R. D., Stillman, W. S., Colagiovanni, D. B., and Henry, V. A Synergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating factor in vitro. Proc.Natl.Acad.Sci.USA, 89: 3691-3695, 1992. 43. Eastmond, D. A Induction of micronuclei and aneuploidy by the quinone-forming agents benzene and O-phenylphenol. Toxicology Letters, 67: 105-118,1993. 44. Irons, R. D. and Stillman, W. S. Cell proliferation and differentiation in chemical 109 SH ELL-MCCLU RG-059554