Document YGjG565za544YQd0B7dnyL5LD
tREQUEST for standard toxicology studies AT BUSHY RUN RESEARCH CENTER >
Ta
Mr. RC. Myers gjjhy Run Research Center
rd 4 Mellon Road
Export PA 15632
Asm: N*m
Sponsoring Piuixian
Dept /L+$--------------------- - Location (city) &&IL jfcfTtL
A---------
Charge to Account No.
~9'fVO
Tachnology Manager &JjCyj/ATX4UJte /
Lio* f.J.&t*. /2 U/kru
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Page 1 of 9 33.17
. '
BUSINESS
w"'tCONFIDENTIAL
complete copies op this poem
MUST i SENT (BY THE SUBMITTER. TO:
A. Dr. Bryan Ballantyne Technical Center (3005) South Charleston, WV 25303
B. Dr. W.C. Kuryla Technical Center (3005) South Charleston, WV 25303
C. Dr. E.R. Homan Bushy Run Research Center RD 4 Mellon Road Export, PA 15632
D. Sponsoring Division HS & EA Manager
Name:
Loe : , i><*J/kl/Lr
TESTS REQUESTED (Standard procedures, other tests require specific protocols. Please contact the Corporate
Applied Toxicology Dept, for advice and guidance.)
RECEIVED
1 RANGE FINDING: O Acute Oral
Other,
3. IN VITRO:
_
19- Ames (Salmonella) Test
AUG 2 4 1984
40
O Acute Percutaneous Acute inhalation O Skin Irritancy
D Eye Irritancy
2 KNOWN PROCEDURAL REQUIREMENT (circle).
O Gene Mutation (CHO)
^NGI rr.
D Chromosome Exchange (SCE)
D Chromosome Damage (Micronucleus)
DNA Damage (UDS)
D Macrophage (RAM) test
0KD, FHSA. DOT. FIFRA. TSCA. RCRA, Other.
Other
PLEASE PROVIDE THE FOLLOWING INFORMATION, IT IS NEEDED IN ORDER TO
i EXPEDITE WORK ON THE REQUESTED STUDIES.
' `u
PRODUCT/COMPOSITION NAME: acs NOMENCLATURE:l-UtfScyOcft,/
`J</}&ryi `I,
7-t(V- /. *>)
:i 4.taut A3 86- 87-0
**->*"*. fi7*z
11 chemical synonyms/alternate/trade names:
! STRUCTURAL FORMULA OR COMPOSITION OF MIXTURES:
iJ O^O*
C,y
0H
;1
;DISTRIBUTION OF REPORT: A Standard divisional distribution list will be used unless otherwise requested (seepages).
IMC USE)
ACKNOWLEDGEMENT OF SAMPLE RECEIPT
Received
* PC Sample n^ _ /'J ? `
b Cl'
By
S
ucc
062541
3338
j CHEMICAL INFORMATION
Report 47-182
Appendix 2
Fage2 of 9
1
1. sample PURITY/COMPOSITION:
TjUu&Z.
Analytical test method employed*
______
(Send copy of available data, source and location of analytes.)
Percent Composition
^*7fUtyCb~
lu+jL* (a
brfHl tk/>ur&Z*am ^( uu*./J*^*1*
kutii ' AtU.
Amounts and identities of known impurities: Amount of unidentified impurities: Test material: %
2. REQUIRED SAMPLE QUANTITY:
Acute Tests:
In vitro Tests: 4 ounces
1. 32 ounces for full series of tests
2. 16 ounces for chemicals with known high toxicity
3. 2 ounces for irritancy tests only
NOTE: To reduce problems involving disposal of unused amounts of the sample. Supply only the amount specified above
3. PHYSICAL CHARACTERISTICS: (Give all which are known):
Gas.
x/ Liquid.
Molecular Wt. Density (liquids) ____ LdJiJ___(
Solid. ^---------
pH (aqueous sol.) Freezing point"V ACr *C Boiling point 3jVuC( 1 led/A*--_________ c
Flash pointlif. C
(Tag. dosed cup)
PowderGranular
Vapor Pressure (@ 3 temp, between 15* and 150*0 1. --*r.0>\Z*C 2. mm@ C 3. mm@ "C
4. SOLUBILITY: Solvent Water
Percent Solution *3T.r"-o eS
Acetone Ethanol Dimethylsulfoxide Vegetable Oil Other (specify)
5. STABILITY: (Check appropriately):
Shelf Life Light sensitive Temp, sensitive . Oxidizes Polymerizes^
< 6 mo; yes; yes; yes;
-- yes;
l/--- > 6 mo. f _ no li no
_ no _ no
Known solvent Incompatibility (specify)
Am/
.
UCC 062542
fV
l
Report 47-182 Appendix 2
Page 3 of 9
'3359
HANDLINGrSTORAGErOISPOSAL INFORMATION:!
1 acrOMMENDEP PRECAUTIONS FOR HANDLING*: U& AM* f&M S&/J AJJ) /&&*
'Enclose UCC (or other company) Material Safety Data Sheet if available.
Any unusual fire or explosion hazards: Mb_______________
Any chemical incompatibilities (materials to avoid): >TTfo/j4
/faJA
2 SPECIAL PERSONNEL PROTECTIVE EQUIPMENT NEEDED: Ul/fiA /ZlftTZO ArtfrH tomi.h -At&- mjA&Z_______________________________________________________________
3 RECOMMENDED INACTIVATION/DECONTAMINATION PROCEDURES):
< RECOMMENDED STORAGE CONDITIONS:
Temperature (Check appropriately):
Room Temp. _____ _________
Refrigerate____________________
freeze _______________
< 208 C < 0eC
SAMPLE DISPOSAL: (Check appropriately)
0 Return unused sample to:
Special Conditions Required (Check appropriate^)' Under N gas Dessicator Other_____
u'CC 062543
Report 47-182 Appendix 2 Page 4 of 9
|>^HER PERTINENT INFORMATION!
The following information will be useful in determining or confirming the necessity of specific toxicity tests
i. Proposed use of material (circle):
Industrial Product
Food
Drug
Other use (specify):
Intermediate
Home Use
Experimental
Cosmetic Packaging (specify Food. Drug. Cosmetic)
2. Potential hazard route(s) (circle): Other (specify):
Inhalation
3. Form shipped in commerce (circle): Solvent or Vehicle composition:
Solid
Gas
Suspension or Slurry
ATTACHMENTS (TO BE PROVIDED BY SUBMITTER): * * Analytical data for sample. * - Material Safety Data Sheet of sample material (if available). * - DOT shipping information (if applicable).
DISTRIBUTION LIST: Unless indicated below, the standard distribution list for the sponsoring division will be used Please use the following divisional distribution list for the final study report
WCK/M*r S3
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062544
MATERIAL SAFETY DATA SHEET
EFFECTIVE DATE: *--"**,982
" 3341 Report 47-162 . t, Appendix 2 Page 5 of 9
PRODUCT NAME: CHEMICAL NAME: FORMULA:
SAKE LITE Cycloaliphatic Epoxy Amin ERL4221, ERL4221G
1.4-Epoxyeyclohexyl methyl1.4-Epoxycyelohexyl cerboxylete
CHEMICAL FAMILY:
ClH*o4
MOLECULAR WEIGHT:
Diepoxide 252.30
SYNONYMS;
--
"department OF TRANSPORTATION
HAZARD CLASSIFICATION SHIPPING NAME
None Nor.s
CAS I 2386-87-0
CAS NAME 7'0xabicydo[4.1.0]haptana-&carboxylic acid, 7-oxabicyc1o(4.1.0]hept-3-ylmethyl titer
JL PHYSICAL DATA
BOILING POINT. 760 mm 101.325 kPa
364 *C (669 *F) Extrapolated FREEZING POINT
Sett to glass below --20*C(-4 *F)
SPECIFIC GRAVITY (H.O 1)
1.175 at 25/25 *C
VAPOR PRESSURE *1 20 *C
<0.001 kP# <0.01 mm Hg
VAPOR DENSITY (air s 1)
PER CENT VOLATILES BY VOLUME
Nil
SOLUBILITY IN WATER. % by wt. at 20
EVAPORATION RATE (Butyl Acetate * 1)
0.05
<0.01
APPEARANCE AND ODOR
Low viscosity liquid: characteristic odor.
^2z*3C3folY*,!sLw Bl. INGREDIENTS .
MATERIAL
% TLV (Units)
HAZARD
BAKEUTE Epoxy Resin ERL4221. ERL4221G 100 Not esteblished
Slight skin end eve irritsm
iti tv. FIRE AND EXPLOSION HAZARD DATA
flash point
(lest method(s))
245* F, Pensky-Martens Dosed Cup 400 F, Cleveland Open Cup
flammable limits in air, v. by volume ----- -- ----I -
Not determined i .--1.--. _____ ._UNonvalalile Fluid)
1
J (Nonvolatile Fluid)
EXTINGUISHING MEDIA
Use weter spray, carbon dioxide, dry chemical, alcohol-type or universaltype foams applied by manufacturer's recommended technique.
SPECIAL fire fighting PROCEDURES
Don't spray pool fires directly, e solid stream of water directed into hot burning liquid can cause frothing. Use supplied breathing air and protective clothing.
WUSUAL FIRE AND
explosion hazards
Hazardous polymerization may occur, due to heat from exposure to a fire.
EMERGENCY PHONE NUMBER
304/744 3487
Thi iv*ib*f it BVBtlfbit d*vt, ntgpiii. rv6ER0i. **0 fcolid*yt
` C*r*iO* CerDOranOR M<#*i 1A11 IN* tf*1* C*NtBn#d N*rt*R *rt <Clw*l *N0 tNt 0*hint tB*f*tB*0 *f (NOB* I RwB'f** *p*rt| *fRr*."5 IN* f*iu'15 0* in* 1*4*1
MCI** tN*tt*lssitPkOHtw^git#llwj^*mFDfrtBF*B*PtlBfiRtoi^NieNWNtONCaPNia*C*YpF*1*pP'*6iMm**#0Bl*ipoR*l6tli1v TN#s *t* *M*i*0 SOAP'S *0 yOM* C*^t>9*'**'Dv
U*ai>OP|.BnO
Ry MB*eUN*B*aBt8*NdtNtOPm*1tNm4,ilM0*l*fm)F**MvtN* WB*MOD*lRBCCOFa*A&*
Silt* ano<OlBU#*5B*3<*9w,B>'Or k
UNION CARBIDE CORPORATION SPECIALTY CHEMICALS AN0 PLASTICS DIVISION OLD RIDGEBURY ROAD. DANBURY. CT 06817
NOTES TO PHYSICIAN
There ii no specific antidote. Treatment of overexposure should be directed at the control of symptoms and the clinical condition.
ucc
062546
Report 47-162 Appendix 2 Page 7 of 9
334
UNSTABLE
STABLE
7REACfivifYOATA :r;.~ ,;
CONDITIONS TO AVOID
None
^COMPATIBILITY pnaltrieletoavold)
Acids, strong bun, amines.
HAZARDOUS combustion or DECOMPOSITION products
Burning can produce CO and/or CO,.
HAZARDOUS POLYMERIZATION
May Occur
Will not Occur
CONDITIONS TO AVOID
Acids, strong bases, amines.
r VII. SPILL OR LEAK PROCEDURES
STEPS TO BE TAKEN f MATERIAL IS RELEASED Oil SPILLED
Collect for disposal. Avoid discharge to waterways; see Section IX.
WASTE DISPOSAL METHOD
Dilute with an inert solvent and incinerate in a furnace where permitted under appropriate Federal, State, and local regulations.
r VIII. SPECIAL PROTECTION INFORMATION
RESPIRATORY PROTECTION (Specify type)
None required in normal use.
VENTILATION
Genaral (mechanical) room vantilation is expected to be satisfectory.
PROTECTIVE GLOVES
Plastic
l EYE j PROTECTION
OTHER PROTECTIVE EQUIPMENT
Eye bath and/or safety dtower.
IX. SPECIAL PRECAUTIONS
PRECAUTIONS TO BE TAKEN IN HANDLING AND STORING
Safety glasses
Avoid contact with ayes, skin, and clothing. Wash thoroughly after handling. Do not take internally.
I OTHER PRECAUTIONS
Nxni UII-SM
FOR INDUSTRY USE ONLY
This product is essentially insoluble in water. It is resistant to rapid biodegradation end mey be toxic to aquatic life. Avoid discharge to natural waters.
UCC 062547
PnntM in US.A
3344
Report 47-182 Appendix 2 Page 8 of 9
UNION CARBIDE CORPORATION
WOAlTv POkWBWa COMPOBTEBOVBON
RECEIVED
SEP 121984
W.CHENGLER
P.D BOX B70. BOUMD BROOK NJ OBBOS WLfR-ONt laoiijat-BBoo
September 6, 1984
Mr. W. C. Hengler Bushy Run Technical Center RD4, Mellon Road Export, Pennsylvania 15832
Dear Mr. Hengler:
Infrared spectra have been run on the samples of cycloaliphatic epoxides that you returned to me recently. The spectra are enclosed for your files. The spectra that were obtained on these samples were compared with standard spectra for these products. In two cases, 4205 and 4299, comparisons were made with other samples of the these products that are being utilized in current laboratory programs.
Comparison of these various spectra by the infrared experts in our Analytical Croup {Dr. Clark and Mr. Lewis) led to the conclusion that the samples that you have are authentic samples of the UCC cycloaliphatic epoxides. Thus, the mutagenicity testing will be performed on valid samples of 4221, 4299, 4234, 4206 and 4205.
ends.
Very truly yours
RJCsmjk
cc:Dr. E. M. Clark, Mr. J. Lewis, Dr. R. . Plevan - DB
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334%
Report 47-182 Page 1 of 1
APPENDIX 3
Salmonella typhlmurlum
A. Historical Data on Spontaneous Reversion Rate* at BRRC As of June 30, 1984
Strain +/-S9 N Mean
Standard Deviation
Median
Range
IA98
-S9 98 18.2 +S9 98 25.6
TA100
-S9 98 123.1 +S9 98 101.5
TA1535 -S9 98 32.5 +S9 98 13.4
TA1537 -S9 98 4.3 +S9 98 5.0
TA1538 -S9 98 7.2 +59 98 15.0
5.02 7.40
26.89 17.86
13.61 7.34
1.90 2.61
3.72 5.41
18 7. 33 26 14, 44
120 61, 187 100 65, 137
32 7, 60 14 2, 35
4 1, 9 5 1. 13
7 2, 19 16 4, 29
T B. Historical Data on Postlve Control Values at BRRC As of January 26, 1984
Strain
Positive Control
+/-S9
N
Mean
>tandar<i Deviation Median
Range
TA98 NPD,10 yg -S9 84 877.1 166.73
870
2AA,10 pg
+S9
84 1434.2 327.54
1457
532, 1301 604, 2037
TA100 NZ, 10
-S9 84 1621.8 277.37 1696
2AA.10 pg +S9 84 1181.7 323.54 1201
869, 2069 475, 2225
TA1535 NZ, 10
-S9 84 1622.0 253.42 1666
2AA.10 V>g +S9 64
99.3
30.84
98
837, 2050 37, 182
1A1537 9AA.60 pg -S9 84 140.6 130.70 2AA.10 pg +S9 84 122.5 45.52
82 120
28, 489 36, 230
XA1538 NPD.10 pg -S9 84 1124.2 196.66 1168
2AA,10 pg +S9 84 532.0 230.61
486
573, 1582 146, 1249
S9- rat liver homogenate; NPD- 4-nitrophenylenedlamine; 2AA- 2-am"inoanthracene; NZ- sodium azide; 9AA- 9-alnoacrldlne.
VPC/rkk/0619B-l 11-08-84
UCC 062550