Document YGam68vJ3757b3wNGy8N8G9Dy

3M General Offices 3M Center St. Pal, MN 55-144-1000 g-em. - o u s t il t s 612 733 1110 0601 --ri A&2.Z6 _ ioy 37 3 June 7, 2001 /hV ^ ~-.h3 Document Processing Center (7407) ATTN: Section 8(e) Coordinator Office of Pollution, Prevention and Toxics US Environmental Protection Agency 401 M Street, SW Washington, D.C. 20460 Contain NO CBI Re: TSCA 8(e) Supplemental notice for Sulfonate-based and Carboxylic-based Fluorochemicals-Docket numbers 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-0381-0394; 8EHQ-0598-373 ^CORRECTIONS to May 15, 2001 Notice Dear Docket Coordinator: 3M submitted an 8e notice dated May 15, 2001, for the above subject with incorrect chemical descriptions in the tables. Attached is a corrected first page of that notice (corrections highlighted in blue). PFHS should be described by the formula: CF^SCV PFOSA should be described by the formula: CsFnSOzNFL M f. Please contact Dr. Larry Zobel at 651-733-5181 for additional questions relative to this notice. Manager, Corporate Product Responsibility EPA-OTS 000811821L D001121L l May 15, 2001 Document Processing Center (7407) ATTN: Section 8(e) Coordinator Office of Pollution, Prevention and Toxics US Environmental Protection Agency 401 M Street, SW Washington, D.C. 20460 *CORRECTIONS to May 15, 2001 Notice made June 5, 2001 Re: TSCA 8(e) Supplemental notice for Sulfonate-based and Carboxylic-based Fluorochemicals-Docket numbers 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-0381-0394; 8EHQ-0598-373 Dear Docket Coordinator: 3M recently completed analyses of several fluorochemical compounds in individual, stored human sera. We have previously reported results of perfluorooctane sulfonate for human sera from pooled samples.'1,2) In the current analyses, individual samples were measured for sulfonate-based and carboxylic-based compounds. Table 1 represents samples of 599 individuals from 23 different states in the U.S. in the age span 2-12. These samples were drawn in 1995. Table 2 represents over 600 individuals from six blood banks across the United States, focusing in the age span 20-69. These samples were drawn in 2000. 3M will send a final report on these analyses to the EPA in the near future. Table 1. Summary of Samples Drawn in 1995, Ages 2-12 Compound A verage M edian 9 5 "1p e r c e n tile PFOS C8F17S 0 3- 43.5 ppbw 36.7 ppb 90.2 ppb *PFHS C6Fl,S 0 3- 15.0 ppb PFO<3AA 4.4 ppb C ,F 17S 0 2N(CiH5)- 3.8 ppb 3.7 ppb 71.3 ppb 10.4 ppb CH2CO2 M570 C8F 17S02N (C H 3|- 3.4 ppb 1.8 ppb 12.5 ppb CH2CO2 *PFOSA <LLOQ <LLOQ cLLOQ C8F 17S 0 2NH2 M556 3.0 ppb 2.5 ppb 7.3 ppb CsFnSOiNH- c h 2c o 2PFOA C7F15C 02- 5.6 ppb 5.1 ppb 10.2 ppb (a) ppb is parts per billion; (b)<LLOQ is less than the lower limit of quantification Range 6.7-515 ppb <LLOCT-712 ppb <LLOQ-23.8 ppb <LLOQ-48.0 ppb <LLOQ <LLOQ-19.1 ppb <LLOQ-56.1 ppb Table 2. Summary of Blood Bank Samples Drawn in 2000, Focusing on Ages 20-69 C o_m__p_o_u_njd Aa-v-e--r-a--g-e- M edia--n n95c,thh --p.e..r.-c-e-n-tile PFOS C8F17SOj- 43.7 ppb 35.8 ppb 90.5 ppb *PFHS ` 2.9 ppb 1.6 ppb 9.6 ppb c 6f 13s o 3- PFOSAA 3.0 ppb 1.4 ppb 7.6 ppb CsFnSOjNCCjHs)- CH2CO2 M570 1.8 ppb 0.9 ppb 5.3 ppb CsFnSOjNCCHj)- CH2CO2 *PFOSA <LLOQ cLLOQ cLLOQ c 8f 17s o 2n h 2 M556 cLLOQ cLLOQ cLLOQ Range cLLO Q -1656 ppb cLLOQ-66.3 ppb cLLOQ_60.1 ppb cLLOQ_19.0 ppb cLLOQ cLLOQ-12.9 ppb % TT J CsFnSOjNHc h 2c o 2' PFOA C7F15C 02` 5.6 ppb 4.7 ppb 12.9 ppb <LLOQ-52.3 ppb Section 8(e) Coordinator May 15, 2001 Page 2 Please contact me at 651-733-5181 for additional questions relative to the above analyses. Sincerely, N Larry R. Zobel, MD MPH Staff Vice President & Medical Director 3M Medical Department (1) Letter to TSCA 8(e) Co-ordinator, May 15,1998 (2) Perfluorooctane Sulfonate: Current Summary of Human Sera and Toxicology, January 21, 1999 3 Re: TSCA 8(e) Supplemental notice for Sulfonate-based and Carboxylic-based Fluorochemicals-Docket numbers 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-0381-0394; 8EHQ-0598-373 ^CORRECTIONS to May 15, 2001 Notice Be: 8e Committee G. McCarney H