Document YGB99RNqXZE0MwX0yZgbV2Y9D

HFM - 003509 Race Chinese Hawaiian Filipino Japanese Caucasian 1960-64 19.9 11.8 8.8 6.1 4.9 1968-72 12.3 17.0 18.4 6.3 9.4 1 -vK . the remaining cell types was follicular ma, the encapsulated subtype with minimal (18 percent), medullary (three percent), vascular and capsular invasion is charac anaplastic (three percent), sarcoma (less terized by a 10-year survival rate that is than one percent), lymphoma (two per almost twice that of non-encapsulated, cent) and other (11 percent) (Table III). primary, operable follicular carcinoma.: Follicular carcinoma has a peak incidence The survival rate in women as reported in the fifth decade of life, and occurs with by the End Results Group of the National greater frequency in women. Anaplastic Cancer Institute was consistently better carcinoma tends to be diagnosed at a later than that noted in men (Table V). During age than the differentiated carcinomas, 1955-1964, 54 percent of women as con and occurs about equally in men and trasted with 39 percent of men were diag women. Russell et al.22 found a differen nosed as having localized disease. Relative tiated component in all anaplastic carci survival rates at five and 10 years in men nomas, and concluded that the undiffer and women decreased with increasing age entiated foci were derived from the more (Thble VI). Women and the younger age differentiated papillary and follicular groups are characterized by a higher prev elements. It is reasonable to assume that alence of papillary and follicular carci in the bimodal age-incidence curve evi nomas and earlier stage of disease.24 Rel denced by women, the first mode is com ative survival rates at three and five years prised predominantly of papillary and, to for women-and men have improved sub a lesser extent, follicular carcinomas, and stantially between 1940-1949 and i960- the second mode is comprised of predom 1964: If these data can be generalized, inantly anaplastic and, to a lesser extent, then the declining age-adjusted mortality papillary and follicular carcinomas. in the face of increasing age-adjusted in The prognosis in patients with thyroid cidence since 1950 in the United States has carcinoma is variable and correlates with occurred because of more significant histologic type, extent of disease, age at gains in survival and in average duration diagnosis and sex. The survival rate for of disease. papillary carcinoma is significantly higher Medullary carcinoma or solid carcino than for follicular carcinoma, and is low ma with amyloid stroma is typified by a est for the spindle and giant celt carcino lack of follicular and papillary differen mas (Table IV).22-22 In follicular carcino- tiation; colloid formation and radioiodine 30fit tVVtl? tA cancer journal for clinicians Type Total No. % All races Mate No. % Female' No. % Papillary carcinoma Follicular carcinoma Medullary carcinoma Anaplastic carcinoma Lymphoma. Sarcoma Othert Total number of patiema 1434 403 . 59 65 34 4 236 64 18 3 3 2 <1 11 2225 100* 364 61 98 16 28 5 21 4 11 2 1 <1 74 1? 595 100 1070 307 31 34 23 3 162 1630 66 19 2 2 1 <1 10 - 100 Type Papillary carcinoma Follicular carcinoma . Medullary carcinoma Anaplastic carcinoma Lymphoma 7 Sarcoma Othert Total No. % 1334 358 56 55 33 4 218 65 17 3 3 2 <1 11 White Male No. % 344 62 85 15 28 5 21 4 11 2 1 <1 67 12 Female No. % 990 66 273 18 28 2 34 2 ' 22 2 3 <1 161 10 Total number of patients 2058 100* 657 100 1501 100 Type TotalNo. % Black Male No. % FemaleNo. % Papillary carcinoma Follicular carcinoma Medullary carcinoma v . Anaplastic carcinoma Lymphoma.: Sarcoma : , Othert 63 62 .' 11 41 40 33 11 41 3 3 '-- " -- '-- -- ' 1 1' -- -- ---- ---- 14 12 5 19 52 7 55 29 31 3 :7 3 -- v1 -.:/; 1 : -- .. -- 9 10 Total number of patients 121 100* 27 100* 94 100 : tOther Includes carcinoma or adenocarcinoma (not otherwise specified), carcinoma simplex, clear cell adenocarcinoma, squamous carcinoma and malignant neoplasm (not otherwise specified). *Does not total .100 percent because of rounding. VOL. 28. NO. 2 MARCWAPRll. 197 .... i'iV 7'7 8301 6963 73 7:.::