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ATTACHMENT TO LETTER OF 1/18/05 3M FLUOROCHEMICAL SUBMISSION AZ2r no I 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Multiple Chemicals o "Inter-Species Comparison of Mechanisms Fluorochemical Toxicity following Intraperitoneal dosing of perfluorooctanesulfonate (PFOS, T-6295) or ammonium perfluorooctanoate (APFO, T-6889) in Rats and Guinea Pigs and oral dosing of N-ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316) in Rats," 3M Medical Department Corporate Toxicology, DT15-A, May 24, 2004. 2. Molecular Biology Study: <Q6-/9>3a- Final Report, "Comparative Molecular Biology of Perfluorooctanesulfonate (PFOS, T6295), N-Ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316), N-Ethyl perfluorooctanesulfonamide (N-EtFOSA, T-6868), Perfluorooctanesulfonamido acetate (FOSAA, T-7071), and/or Perfluorooctanesulfonamide (FOSA, T-7132) of in [sic] Rats and Guinea Pigs following Oral dosing," 3M Medical Department Corporate Toxicology, DT-15-B, May 25, 2004. Amendment to Final Report, "Comparative Molecular Biology of Perfluorooctanesulfon ate (PFOS, T-6295), N-Ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316), N-Ethyl perfluorooctanesulfonamide (N-EtFOSA, T-6868), Perfluorooctanesulfonamido acetate (FOSAA, T-7071), and/or Perfluorooctanesulfonamide (FOSA, T-7132) of in [sic] Rats and Guinea Pigs following Oral dosing," 3M Medical Department Corporate Toxicology, DT-15-B, July 16, 2004 (revising page 59). 3. Cell Proliferation Study: a. cZ2-/?0U- Final Report (except for in-life appendix), "Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; 3M T-6295.16), andN-Ethyl Perfluorooctansulfonamide (N-EtFOSA; 3M T-7091.1) in Rats," Charles River Laboratories, TRC 1132-100, August 9, 2000 (amended November 8, 2004). In-Life Appendix, "Cell Proliferation Study with N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; 3M T-6295.16), andN-Ethyl Perfluorooctansulfonamide (PFOSA; 3M T-7091.1) in Rats," Therlmmune Research Corporation, TRC 1132-100, May 2, 2000 (Appendix 1 to full report). ^OrM7A- "Evaluation of the Northwest Bioanalytical Method Validation Reports for PFOS and Related Analytes in Human Serum or Plasma in Meeting the Requirements of the FDA CONTAIN NO C 3 ATTACHMENT TO LETTER OF 1/18/05 3M FLUOROCHEMICAL SUBMISSION Bioanalytical Method Validation," Quality Associates, Inc., Q A I405-503, December 31, 2001. POSF Perfluorooctanesulfonyl fluoride 1. "Bladder cancer in Perfluorooctanesulfonyl Fluoride Manufacturing Workers," Bruce H. Alexander (University of Minnesota), November 21, 2004. PFOA Perfluorooctanoate ffCff i . "Ammonium Perfluorooctanoate: Age Effect on the PFOA Plasma Concentration in PostWeaning Rats Following Oral Gavage," Paul M. Hinderliter (DuPont), DuPont-15302, December 2, 2004.