Document YD5QKQgGq6brXQb7JvYJKLYK8

or HOesrcnaarndez Scaheezs, McTcoa.:rgRaoVrabeneterSstcsFhalnVaenUaxakDdtiCe/DrIOClUCIDSIUCUESISPEUEAPSPAIEAUPUUSASS@U@GESEEPGPPAEAA,P,AC,haSreleecdislAaJuosnrreDirfCyeI,rU@SEbPEeAPrMAtAUIeLS@iEEsPPCAAIG,UOSVEEEPPAAU,S@EPA SBaurbbjaercat LSeAcBzyrequest Pris Fat Ro P D VPaenrfeisusoar,ooactttaancchiecdacisida(rPeFqOuAe)s.t foWr eanwiSllAwBorrekviwietwhoSfaABsprtealfimtionaarsysiesmkbalsestehsesfmoernmtalofsubmission. "Thank you for your help. 8s CONTAIN NC CB! Science Advisory Board Proposed Project $13 BE 1. Project Titl/e Subject: Preliminary Risk Assessment of Perfluorooctanoic Acid 2. Requesting Organization /Office: Office of Pollution Prevention and Toxics (OPPT) 3. Requesting Official: Oscar Hemandez, Director, Risk Assessment Division, OPPT 4. General Ranking: High within the Agency; High within OPPTS; High within OPPT 5. Applicable Goal, Objective, and Subobjective: Goal 4,432, 6. Legal Obligation / Directive (if any): Toxic Substances Control Act (TSCA) 7. Endorsement by other offices: Not Solicited 8. Program Contact: Jennifer Seed, OPPT/RAD (403M), 202-564-7634, US EPA, 1200 Pennsylvania Ave., NW, Washington DC, 20460 (9O.PBPac)ktgorouunndedr:standAhseaplatrhtoanfdtehneveifrfoorntmebnytatlheiOsfsfuiesceproefsPeonltleudtiboyn fPlrueovreoncthieomnicaanldsTionxtihceswake osfulufnoenaxtpeesct(ePdFtOo)x,icoOlPogPiTcahlaasnbdeebnioiancvceusmtuilgaattiinognpdeirsfclouvoerroioecstawniotihc raecsipdecatntdo iptes rsfallutosr(oPocFtOaAn)e.. OdaPtPedTFreeblreuaasreyda20p,re2l0i0m2i,noarnyMDarracfth H2a8,za2r0d02A,ssaensdsimsesnuteodfaPmeirnfolruocroororcetcatnioonictAoctihdatadnodcuItmseSnatltso,n a`Anpdriol b1s5e,r2v0e0d2.thaTthbatlodordafmtoansisteosrsimnegndtaitnadsiucagtgeedstpeodtewnitidaelspsryestaedmeixcptoosxuirceittyoatnhde cgaernceirnaolgenicity, puonpduelrawtiaoyn,onalobtehiteratenldopwoilenvteslsa.ndIttahlastofnuorttehde,r hdaotwaevweoru,ldthabteaadvdaiitliaobnlael wtiotxhiicintay smtautdtieersowfemroenths. toxicoloNguicmaelrsotuusdiesstuidniersodceonntdsucatneddmboynkienyduss,trbyioomnonPiFtoOrAinagnsdtuitdsiessalotsfhwaovrekeirnsclaunddedthe general sUtSudpioepsulhaatvieons,hoepwindtehmaitoPloFgOyAstiusdaielss,o ahnigdhlbyiopmeornsiisttoernitnginstthuedieensovifrtohnemewniltdalinfdedionetshenoUtS. These pheyrdsriosltyeznet,inphhoutmoalnysze, oisrnboitodmeegtraabdoeliuznedderaenndviharsonamheanltfallifceoonfdisteivoenrsa.l yPeFarOs.AiTs haelsboiohmiognhilytoring stthuedsioeusrhcaevseasndhopwanthtwhaatysitofisepxrpeossenutreinatrheeugneknneroawln.USTopxoipcuollaotgiiocnaalnsdtutdhieeswiilndlrifoed.entAstapnrdesent, dpreivmealtoepsmehnatvael/srheoprwondutchattiveexptooxsiucrietyt,olPivFerOtAoxciacintyreasunldt ciannacevra.rietyofeffects including OPPT dGeitveernmitnheadt tPhFeOnAeedis tporecsoenndtuicntatheisgeknaesrsaelssUmSenpt.opuTlhaitsiopnraelnidmiitnsatroyxriicsokloagsisceaslsmpreonftile, pLleaycdeisgecmepllh)asoibsseornvetdheindetvheelcoapnmceenrtablioraespsraoydsucatreivtehoeungdhpotitnotsb.e dTihreecttluymoorrsin(dliirvecre,tlpyarneclraetaesd atnod 2 the activation of scientific debate. PPAR. The relevanceofthis mode of The ILS! Risk Science Institute, under action to humans is currently under a cooperative agreement with EPA, has wfoorrkmsehdospe.veTrahlewroirskkgarsoseuspssmteontasosfesPsFtOheAstwaitlelobfetehxetsecnideendcetowhinicclhudweitlhebesypsrteesmeinctetdoxaitcaitpyuabnldic cancer data once there is resolutionofthis issue. m10a.rgWinhoyf tehxepoSsAurBeS(hMoOuEld) Rapepvrioeacwh.thiSsinPcreojtehcetr:e isTnhoisinpfroerlmiamtiniaornyavraisiklaabslseeosnsmtehnetsuotuirlciezeodra wpahtihcwhayw(esr)eoafvahiulmabalne efxorpotshuergee,nethrealprheulmiaminnaproypurliasktiaosnseasnsdmwenetreofavPaiFlOabAleutfiolriztehdesreatrutmoxliecvoellosgy Srteuldeiveasn.ceS,inScAe Bthirsepvrieelwiaminndacryomrimseknatssies sbsemienngtsiosuoghft.hiAghscpireinotriiftiycawliltyhsroeusnpdecatstsoesAsgmeennctywould play an important role in the analysisof options by the program offices. 11. Type of SAB Activity Requested: Peer review. t1h2e. uTseenotfasteivreumChdaartgaea:s aRemveiaeswuorfeotfheinptreemliamlidnoasrey;r(ibs)k tahseseussseomefnstewriutmh slpeevceilaslfcrmopmhpaasriesntoanl (a) paonsismiabllseaMsaOEsu;rr(odg)atoethfeorralsesvuelmsptiinoonfsfstphraitngw;er(ce) mthaeds.eoAfmtohreedadtetaatiolepdrocvhiadregea wrialnlgbeeof negotiated with SAB ata later date. 13. Tentative Schedule and Committee: Winter, 2003. Environmental Health Committee. 14. Principal Interested and Affected Parties: FTleuloormoeproslRyemseeraMracnhuPfraocgtruarme,rsStGartoeuopf, West Virginia, Region 3 15. Budget: Tashseesdsemveenltopwmaesntdoonfethbiys OprPePliTmisnciaernytirsitsskdausrsiensgsmFeYnOtIan-dFYth0e2.bacAkngreosutinmdahtaezda3rd FTEs were required. No intramuralo extramural funds were used. 16. Past Peer Reviews: None 17. the fQoulalloiwtiyngMcaonmapgoneemnetnsto/fQtuhaelOiftfyicAes'ssuqruaalnictey:syTshtiesmp:rienltiemrinnaalrbyraasnscehsrsemveinetw,harsebvieeewn through through the management hierarchy, including Division and Office review. 18. Preparer: Jennifer Seed, OPPT/RAD, 202-564-7634 Date: September 23, 2002