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' ww DuPont-11418 TRADESECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 3 of 5 Laboratory Project ID: DuPont-11418 T e st G u id e l in e s: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (AUG-1998) AUTHOR: Susan A . MacKenzie, V.M.D., Ph.D., D.A.B.T. \ S tu d y Co m p l e t e d o n : August 1,2003 PERFORMING L a bo r a to r y : E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 W ork Request Number Service Code Number \ Page 629 of 1602 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D u P o n t-11418 APPENDIX D INDIVIDUAL FOOD CONSUMPTION -630Company Sanitized. Does not contain TSCA CBl H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL FOOD CONSUMPTION Critical Dates EXPLANATORY NOTES Day 72 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Body weights and clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section; Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Day 90 Last day of test substance administration for male and female rats designated for one-month and three-month recovery periods. Day 91 Last day of body weight and food consumption data collection for male and female rats designated for the subchronic toxicity evaluation. Last day of test substance administration for male rats designated for the subchronic toxicity evaluation. Day 92 Male rats designated for the subchronic toxicity evaluation were sacrificed. Last day of test substance administration for female rats designated for the subchronic toxicity evaluation. Day 93 Female rats designated for the subchronic toxicity evaluation were sacrificed. Day 126 Last day of body weight and food consumption data collection for rats designated for the one-month recovery period. Last day of food consumption data collection for rats designated for the three-month recovery period. Day 127 Male and female rats designated for the one-month recovery were sacrificed. Day 182 Male and female rats designated for blood fluorine level evaluation were sacrificed. Abbreviations mg/kg = mg/kg/day g/anm/day = grams/animal/day Note_ Absence of data indicates the animal was not alive at the time of data collection. -631 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day GavageStudy in Rats with One-Oeneration Reproduction Evaluations Study : t a H B B m a l e Food Cons. g / anni/ day Day 7 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 665081 26.0 26.5 30.0 27.0 23.3 30.5 27.9 28.2 26.2 24.1 28.6 24.7 23.5 27.0 28.5 28.3 25.7 25.9 23.0 29.5 27.6 24.7 27.0 25.5 29.3 26.6 28.2 31.1 27.3 24.4 26.1 30.5 26.3 24.2 27.3 25.1 25.6 29.2 26.1 Food Cons. g /anm /day Day 14 Food Cons g/anm /day Day 21 26.6 26.9 29.6 31.0 24.9 31.0 29.1 29.5 26.6 26.4 29.6 27.7 24.7 27.8 28.8 31.0 27.3 27.4 24.6 31.2 28.9 27.8 30.9 27.1 28.3 26.9 28.2 33.3 28.4 26.1 28.1 31.3 25.5 25.6 29.0 26.5 26.0 31.0 26.8 ' 28.9 27.5 30.3 33.2 26.7 32.8 31.5 33.3 27.6 29.0 30.7 30.1 25.9 29.9 31.9 33.3 29.3 26.8 26.0 31.1 32.1 28.1 32.2 27.4 29.9 27.0 28.4 34.0 28.3 25.1 29.6 30.6 27.7 26.3 30.9 27.6 26.6 30.4 27.1 In d iv id u a l Food Consumption Food Cons. g/anm /day Day 28 Food Cons. g/anm /day Day 35 Food Cons g/anm /day Day 42 28.0 29.8 30.9 32.4 26.7 32.7 29.4 33.9 28.0 27.9 29.2 30.1 25.6 27.6 31.3 32.9 29.5 27.6 25.5 32.7 31.9 27.6 33.0 27.6 29.5 27.0 28.5 32.8 29.7 25.7 26.7 30.4 27.4 26.9 32.7 25.8 26.7 31.1 27.3 29.2 29.0 33.1 32.5 28.5 31.0 29.5 34.1 29.4 28.7 32.2 32.9 28.2 27.9 33.2 31.9 27.9 27.1 26.4 33.7 31.3 26.5 32.8 26.7 29.6 57.0 28.7 33.3 30.1 26.0 27.6 30.5 27.8 26.6 32.1 25.1 26.6 30.7 27.0 27.2 27.4 30.7 29.1 24.1 27.8 25.9 28.8 27.7 25.1 29.6 31.1 29.0 26.4 33.5 31.8 29.3 26.4 25.5 29.4 31.7 24.5 33.7 27.5 30.2 27.0 28.9 33.4 30.2 25.0 27.0 28.9 27.0 26.2 32.3 27.2 25.7 30.0 27.4 Company Sanitized. Does not contain TSCA CBI - 632- ) D u P o n t-11418 Food Cons, g/anm /day Day 49 Food Cons, g/anm /day Day 56 Food Cons. Food Cons. g/anm/day g/anm/day Day 63 Day 70 30.2 30.9 33.8 34.4 29.6 31.2 30.2 32.3 29.2 27.7 27.1 29.9 27.5 26.0 32.6 31.2 30.5 24.0 26.2 31.5 31.5 26.8 34.8 26.8 28.8 27.1 30.5 34.5 29.6 24.3 26.2 30.4 28.3 25.8 32.0 27.3 25.8 31.5 26.8 28.5 30.4 34.3 31.1 28.6 33.8 29.0 32.0 30.2 24.7 28.5 31.2 27.9 27.7 33.8 33.2 28.9 27.2 26.1 31.0 30.5 27.4 33.7 27.4 29.9 28.5 3<hl 33.4 29.3 25.3 26.9 30.0 27.1 28.5 31.1 25.3 26.3 30.6 28.6 29.5 31.4 34.6 31.1 27.2 36.6 28.9 31.2 29.9 28.9 30.8 31.1 27.2 26.8 34.7 35.2 30.0 27.3 27.5 32.1 32.2 28.0 31.6 26.5 28.7 27.7 31.8 31.6 30.5 25.6 28.9 29.8 28.9 27.5 33.2 26.1 25.4 30.9 28.2 28.6 31.1 31.9 32.5 25.4 31.7 31.7 31.9 31.5 26.8 31.0 30.5 26.7 24.8 32.5 32.8 28.0 28.6 26.9 31.8 33.2 26.5 31.9 26.5 28.5 25.9 28.6 30.7 27.9 24.9 25.7 26.1 26.6 21.7 32.6 25.7 26.5 31.8 27.7 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: a le In d iv id u a l Food Consumption Food Cons. g /am n/day Day 7 Food Cons. Food Cons. g/amn/day g/anm/day Day 14 Day 21 Food Cons. g/anm /day Day 28 Food Cons. g/anm /day Day 35 Food Cons. g/anm /day Day 42 Male, I 0 mg/kg 665159 665043 665064 665121 665106 665008 28.9 28.1 26.2 24.4 28.1 27.3 28.7 29.9 28.3 25.9 29.1 27.6 31.3 30.3 29.6 28.1 31.9 31.2 31.4 31.4 31.1 29.4 31.6 30.9 31.9 30.6 29.0 29.1 31.2 29.4 31.0 31.3 25.0 30.6 30.5 30.1 Company Sanitized. Does not contain TSCA CBI - 633- DuPont-11418 Food Cons. g/anm /day Day 49 Food Cons. g/anm /day Day 56 Food Cons. g/anm /day Day 63 Food Cons g/anm /day Day 70 29.7 32.5 27.2 30.5 33.0 31.2 30.9 32.8 26.0 29.5 32.5 32.7 30.7 31.4 24.9 29.4 31.1 31.9 28.8 31.8 23.7 29.8 32.3 28.1 H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations Study Food Cons. Food Cons. g/anm/day g/anm/day Day 7 Day 14 Male, I I I 10 mg/kg Food Cons g/anm /day Day 21 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 .665156 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 29.2 31.0 29.5 28.7 26.2 25.0 28.4 26.3 27.8 25.2 27.5 27.5 24.5 28.0 22.0 27.9 26.3 26.0 26.2 29.2 26.5 28.2 25.2 25.1 27.0 24.5 26.0 26.6 28.9 23.5 25.8 26.6 27.5 25.7 27.5 28.5 32.6 29.7 29.6 26.5 26.1 29.3 27.7 28.5 25.9 18.0 27.2 24.5 28.6 23.8 27.9 28.0 26.8 28.3 28.8 25.7 29.1 25.3 26.5 28.6 26.7 24.7 28.2 29.8 23.0 27.3 27.2 30.1 27.2 28.7 ' 31.1 35.1 31.2 30.7 28.5 27.8 30.7 29.3 31.8 28.5 25.1 29.8 26.4 30.7 25.8 28.4 30.2 29.6 31.2 27.1 25.2 27.7 27.1 25.9 28.4 26.4 25.0 29.4 32.9 25.5 27.8 28.8 31.6 28.2 30.5 In d iv id u a l Food Consumption Food Cons, g/anm /day Day 28 Food Cons, g/anm /day Day 35 Food Cons. g/anm/day Day 42 32.1 36.5 33.4 30.5 26.8 28.2 31.8 29.3 32.0 28.8 25.6 30.9 26.1 30.2 27.4 30.4 29.8 31.4 32.5 29.0 25.7 28.9 28.0 25.8 30.0 27.0 27.8 30.2 34.6 25.6 27.9 29.9 31.7 29.8 30.8 32.2 36.2 34.0 31.8 26.5 27.7 32.0 27.8 30.4 30.2 24.7 27.9 24.6 28.3 26.7 28.2 28.5 28.7 31.1 29.3 26.0 28.2 27.8 27.4 29.2 26.5 26.2 30.6 33.7 27.0 28.5 30.6 30.7 27.8 30.5 30.5 33.4 31.2 26.9 26.4 25.9 27.9 26.2 31.2 26.1 25.6 28.7 25.7 28.7 27.2 27.5 27.6 27.2 32.2 30.3 26.8 27.5 25.5 25.0 28.9 26.9 25.2 29.2 32.3 26.7 26.7 29.0 30.7 28.2 29.4 Company Sanitized. Does not contain TSCA CBI - 634- DuPont-11418 Food Cons. g/anm /d a y Day 49 Food Cons. g/anm/day b a y 56 Food Cons. g/anm /day Day 63 Food Cons g/anm /day Day 70 33.5 36.7 37.2 30.9 27.9 28.2 30.3 27.8 30.9 25.7 23.6 30.7 24.1 28.8 27.0 28.7 29.7 28.1 33.2 30.4 28.2 26.1 27.9 26.3 31.2 29.4 25.6 30.8 35.1 26.0 27.9 30.6 31.3 30.0 32.1 33.7 37.6 28.0 31.1 25.3 28.6 31.6 25.5 30.5 27.1 21.5 30.8 26.0 27.7 28.0 30.3 29.2 28.0 31.6 30.6 27.4 27.2 27.3 24.9 30.8 28.0 27.0 30.3 31.9 25.7 27.0 30.2 32.5 29.2 31.2 33.4 35.0 35.8 30.5 27.9 27.8 30.9 26.3 30.8 28.3 23.3 30.4 25.7 29.2 29.7 30.5 31.0 29.6 32.3 30.9 26.6 28.3 28.2 26.6 30.5 28.8 27.1 31.8 34.3 28.1 28.2 30.8 33.2 30.0 31.9 34.7 35.0 33.4 30.6 27.3 29.6 31.5 26.2 31.6 28.2 23.8 30.0 25.4 29.9 29.6 29.9 30.0 29.0 31.1 31.5 28.3 27.0 25.7 26.2 30.5 26.8 25.1 30.8 33.2 26.5 24.9 29.5 33.8 29.3 30.8 ) H-25425: Subchronic Toxicity 90-Day^avageStudj in Rats with One-Generation Reproduction Evaluations Study : H h l f l C a le Food Cons. Food Cons g / arm/d ay g/anm /day Day 7 Day 14 Male, V 100 mg/kg Food Cons. g/anm /day Day 21 In d iv id u a l Food Consumption Food Cons, g/anm /day Day 28 Food Cons. g/anm /day Day 35 Food Cons, g/anm /day Day 42 665122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 6651 665055 665066 665039 665003 665088 665147 29.1 28.3 32.1 26.6 22.2 24.1 27.9 30.9 24.8 24.4 25.0 28.4 28.4 28.1 27.0 26.8 27.4 28.4 24.1 27.3 29.1 25.0 29.8 24.2 27.3 26.4 28.6 28.8 23.4 26.8 25.4 29.6 27.6 21.2 27.0 27.4 28.7 33.2 26.6 21.9 26.3 29.2 32.2 24.9 23.5 24.3 28.1 29.3 27.7 29.9 27.1 28.0 23.2 25.2 26.6 30.6 24.4 29.3 25.2 29.1 26.5 28.4 29.6 28.9 27.7 26.0 29.0 28.7 21.2 27.2 ` 29 2 28 5 37 0 28 5 23 9 27 6 30 6 33 9 26 8 25 4 26 9 29 2 29 6 29 5 33 6 27 4 29 3 27 4 26 7 27 2 31 0 25 9 32 2 26 9 28 7 27 6 28 1 30 8 28 6 27 3 26 1 29 3 30 6 22 4 29 5 32.4 29.6 37.8 29.7 25.6 26.9 31.8 33.7 29.7 25.9 25-9 28.5 30.4 27.5 31.3 28.1 30.3 26.9 26.6 26.8 32.9 26.7 33.5 27.0 31.2 27.3 29.1 32.6 28.2 29.0 28.6 26.1 31.5 23.2 29.7 33..1 30..8 35..7 30..6 26..2 29..0 32..0 36..2 29..9 26..0 27..7 30..3 31..2 29..7 35..0 30..5 30..8 26..8 25..5 27,.8 31..1 24..8 31,.7 24..7 30.,9 28..5 28..0 30,.7 28..1 27..9 27..0 27..1 30..1 22,.1 28..8 30..4 25..8 30..7 29..4 25,.0 26..3 28..0 31..1 25..4 23..2 27..8 28..4 30..4 28.,7 34..9 30..4 29..6 26..7 24..6 25..3 30..9 24..5 30..8 25..1 31..7 29,.3 27..7 29 .2 27,.7 26..5 26 .4 28..5 31..6 23 .3 30..8 Company Sanitized. Does not contain TSCA CBI - 635- DuPont-11418 Food Cons. g/anm /day Day 49 Food Cons g/anm /day Day 56 Food Cons. Food Cons g/anm/day g/anm/day Day 63 Day 70 31.1 29.4 34.8 33.8 26.9 24.5 31.7 34.6 27.4 24.8 24.6 31.1 30.7 26.8 34.1 28.1 30.0 26.1 24.0 25.9 30.2 25.4 31.2 24.3 30.3 28.2 27.6 30.5 27.0 25.8 27.9 27.9 29.4 23.3 29.8 31.8 29.0 31.9 32.8 27.9 28.6 33.0 34.4 30.2 22.7 26.2 30.1 31.6 27.1 34.8 28.0 29.0 25.6 23.5 25.8 29.8 23.2 30.5 24.6 31.1 27.5 26.1 29.2 26.1 25.5 28.4 26.5 30.5 23.5 28.2 30.8 28.1 33.3 31.6 26.6 27.3 29.4 33.8 29.5 23.4 27.7 30.2 30.5 27.4 36.3 29.9 28.8 26.6 24.5 27.3 30.7 22.7 31.1 24.4 31.3 29.2 27.3 31.7 26.8 25.3 28.4 27.8 30.8 25.2 29.3 31.3 29.7 32.4 33.2 27.5 27.3 31.4 33.9 31.0 25.0 26.5 30.8 31.0 27.9 37.5 29.0 28.8 24.5 23.7 15.4 32.6 20.9 31.0 24.7 29.9 29.0 28.4 30.2 26.0 24.9 26.8 26.2 28.9 25.0 29.7 )) H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations s tudy Food cons. g/anm /day Day 7 Food Cons g/anm /day Day 14 Male, VII 1000 mg/kg 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027' 665084 665142 665118 665108 665024 66505 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 665095 28.6 26.8 25.9 26.2 27.6 24.6 23.4 27.1 28.4 25.2 23.3 25.3 24.3 26.5 23.2 25.7 26.0 25.6 22.7 26.0 25.5 26.6 26.2 23.7 28.1 27.7 28.9 29.6 28.2 25.4 26.9 26.9 28.1 23.5 28.2 23.6 27.2 25.4 23.1 29.1 26.6 26.6 27.5 29.3 25.1 24.1 27.5 30.3 27.4 24'.9 25.8 24.8 27.0 23.4 27.8 26.4 25.6 24.9 25.9 25.5 29.5 28.7 24.0 27.7 31.0 30.6 28.3 29.7 26.6 29.3 28.9 30.9 24.1 27.8 25.8 28.4 27.9 25.3 Food Cons. g /anm /day Day 21 In d iv id u a l Food Consumption Food Cons, g/anm /day Day 28 Food Cons, g/anm /day Day 35 Food Cons, g/anm /day Day 42 30.3 29.0 27.2 28.0 32.8 24.9 26.7 28.2 31.1 28.7 26.6 28.4 27.2 30.7 24.3 31.4 29.3 25.0 25.8 28.0 28.3 33.4 29.0 26.1 28.6 33.4 31.5 30.8 30.6 28.1 26.0 30.8 29.0 24.8 28.4 27.6 30.1 28.4 24.6 31.9 28.4 27.4 28.6 32.3 25.8 27.5 27.6 30.5 28.4 26.6 29.6 26.6 30.0 24.6 30.3 27.1 25.2 27.0 28.7 28.6 32.3 29.1 25.7 30.2 33.1 32.0 31.0 30.9 26.8 27.3 31.8 29.3 25.5 27.9 28.8 30.5 27.9 26.4 30.3 28.5 29.1 29.2 32.2 27.8 29.8 27.6 31.2 27.7 27.4 30.7 26.5 29.5 25.2 30.2 28.5 24.2 26.7 27.7 26.5 30.3 27.7 23.5 26.8 32.5 30.6 31.0 30.5 25.3 27.5 31.3 28.2 26.2 28.9 27.2 30.8 29.4 26.0 28.5 27.3 26.0 27.0 29.4 25.4 26.9 28.6 29.0 26.0 28.6 30.3 26.8 30.2 25.2 31.3 26.8 26.2 27.3 29.9 28.0 31.3 29.4 23.0 26.5 31.0 32.6 30.9 28.9 26.9 29.3 32.4 29.9 26.1 27.5 27.1 32.9 28.4 25.7 Company Sanitized. Does not contain TSCA CBI - 636- DuPont-11418 Food Cons. g/anm /day Day 49 Food Cons g/anm /day Day 56 Food Cons. Food Cons g/anm/day g/anm/day Day 63 Day 70 29.9 29.8 28.9 31.1 33.7 28.3 32.1 29.6 32.5 31.1 30.4 32.2 28.4 29.0 25.4 32.6 25.8 24.3 27.3 29.8 29.0 34.7 30.6 24.9 25.9 32.1 33.9 33.1 30.0 27.3 30.9 34.1 30.4 25.4 28.1 26.9 32.9 29.0 25.6 28.1 28.2 26.2 30.1 32.7 27.9 30.4 28.6 30.4 29.1 25.9 31.6 27.9 27.4 24.5 31.5 26.0 23.7 27.6 30.0 28.0 30.8 29.6 23.5 27.2 30.4 32.5 30.7 29.1 27.8 32.1 32.2 26.8 25.2 28.3 22.8 30.9 26.4 26.3 29.8 30.9 28.9 32.4 35.0 26.8 28.4 29.2 29.5 29.4 25.8 29.7 26.2 28.6 23.7 31.1 26.0 24.9 27.4 28.0 28.2 33.1 29.7 23.6 26.6 32.4 32.6 30.4 31.1 27.1 .31.1 31.5 31.0 25.2 28.9 24.5 29.7 28.6 26.2 31.4 30.3 27.8 29.1 34.9 27.2 28.5 29.0 30.6 26.4 27.0 30.8 26.5 30.0 24.6 30.6 26.9 24.6 27.1 28.5 28.8 33.7 24.2 23.3 26.5 30.9 30.6 31.3 31.3 27.5 29.7 33.9 31.4 25.5 27.8 25.0 30.8 28.6 27.5 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations tudy :V H IH jH IH (n a le Food Cons. g /anm /day Day 7 Food Cons. g/anm /day Day 14 Male, VII 1000 mg/kg 565031 665146 665062 665138 665112 665007 27.8 28.5 27.4 23.1 26.4 28.3 29.7 29.3 29.5 22.9 28.4 28.3 Food Cons. g/anm /day Day 21 30.5 30.7 30.3 25.5 28.8 31.0 In d iv id u a l Food Consumption Food Cons. g/anm /day Day 28 Food Cons. g/anm /day Day 35 Food Cons. g/anm /day Day 42 30.6 29.5 28.2 26.1 28.6 30.7 30.3 30.2 31.0 25.5 29.7 30.2 31.2 30.0 32.3 25.8 28.1 32.0 Company Sanitized. Does not contain TSCA CBI - 637- DuPont-11418 Food Cons. Food Cons. g / aran/day g/arm /day Day 49 Day 56 Food Cons. g / aran/day Day 63 Food Cons g / aran/day Day 70 31.6 31.6 34.9 26.9 27.8 32.5 29.3 29.9 31.5 24.9 27.7 30.7 31.4 32.3 31.6 26.9 28.8 32.8 30.8 33.8 31.6 25.6 29.6 31.8 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Da^javage StiMy in Rats with One-Generation Reproduction Evaluations Study e Food Cons. g/anm /day Day 77 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 665081 28.5 29.3 32.3 32.2 26.5 31.8 30.7 32.6 30.5 24.5 30.0 30.9 24.8 25.8 32.7 26.8 25.9 30.2 27.7 Food Cons. g/anm /day Day 84 28.7 28.1 31.3 28.5 23.6 31.4 28.9 32.1 30.1 24.Q 25.8 28.2 25.6 24.6 31.0 25.2 26.0 28.3 25.6 Food Cons. g/anm /day Day 91 26.0 28.2 33.8 28.8 24.1 30.5 27.7 31.5 30.6 25.2 25.2 26.3 27.8 25.0 28.9 23.8 23.9 26.5 22.3 In d iv id u al Food Consuaption Food Cons. g /anm /day Day 98 Food Cons. g/anm /day Day 105 Food Cons g/anm /day Day 112 27.0 26.6 30.0 24.9 24.4 24.6 29.6 26.1 25.6 25.9 32.2 30.7 Food Cons. Food Cons. g/anm/day g/anm/day Day 119 Day 126 26.8 25.9 31.8 29.3 26.5 25.6 30.8 27.1 -638- DuPont-11418 ) H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations S t u d y :H p M H B l K n a l e Individual Food Consumption Food Cons. g/anm /day Day 77 Food Cons. g/anm /day Day 84 Food Cons. Food Cons. g/anm/day g/anm/day Day 91 Day 98 Food Cons. g/anm /day Day 105 Food Cons. g/anm /day Day 112 Male, I 0 mg/kg 665159 665043 665064 665121 665106 665008 28.3 30.5 24.6 30.0 34.0 33.3 29.5 31.2 23.2 29.1 33.5 30.2 27.2 25.7 23.1 27.4 32.5 32.3 27.6 26.2 25.5 29.1 32.9 29.9 30.2 28.1 ' 26.2 30.2 33.9 30.5 29.8 30.3 25.9 31.2 34.6 30.3 Company Sanitized. Does not contain TSCA CBI - 639- Food Cons. Food Cons, g/anm/day g/anm/day Day 119 Day 126 30.2 31.8 27.1 30.1 33.6 32.0 29.4 30.8 26.8 28.8 34.4 32.8 D u P o n t-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y :lM M B n a le Food Cons. , g/anm/day Day 77 Male, I I I 10 mg/kg Food Cons. g/anm /day Day 84 Food Cons g/anm /day Day 91 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 665032 . 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 34.4 34.5 32.2 11.9 26.9 26.6 34.0 26.6 30.8 27.3 23.0 30.4 25.6 29.7 29.1 33.1 34.6 32.3 31.4 26.6 26.9 33.1 27.6 30.5 27.7 22.6 28.0 24.1 27.1 29.3 . 30.6 34.3 31.1 30.1 27.1 24.8 33.8 25.4 30.2 26.5 21.1 28.3 19.9 24.9 26.1 In d iv id u a l Food Consumption Food Cons, g/anm /day Day 98 Food Cons. g/anm /day Day 105 Food Cons, g/anm /day Day 112 Food Cons, g/anm /day Day 119 Food Cons. g/anm /day Day 126 > DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 640- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Oeneration Reproduction Evaluations Study Food Cons g /anm /day Day 77 Male, V 100 mg/kg 665122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 29.7 28.9 30.7 34.1 25.1 22.2 31.1 32.3 29.0 23.2 25.8 29.2 29.8 26.3 NM Food Cons. g/anm /day Day 84 Food Cons. g/anm /day Day 91 In d iv id u a l Food Consumption Food Cons. Food Cons. g/anm/day g/anm/day Day 98 Day 105 Food Cons. g/anm /day Day 112 Food Cons. g/anm /day Day 119 Food Cons g/anm /day Day 126 30.1 28.7 31.7 32.9 26.0 25.3 30.4 30.0 28.2 23.4 25.5 27.1 27.8 26.5 33.3 28.7 26.1 26.8 27.5 25.5 21.7 27.5 28.9 28.0 22.5 25.0 26.3 28.7 27.3 34.0 Key: NM = N ot M e a s u r a b l e ; f e e d e r w e i g h t n o t r e c o r d e d . - 641- DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations Study e Food Cons. Food Cons. g/anm/day g/anm/day Day 77 Day 84 Male, VII 1000 mg/kg Food Cons. g/anm /day Day 91 In d iv id u a l Food Consumption Food Cons. Food Cons. Food Cons g/anm/day g/anm/day g/anm/day Day 98 Day 105 Day 112 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118 665108 665024 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 665095 29.4 26.7 25.4 31.0 29.1 26.5 29.2 25.1 30.5 23.0 23.9 30.5 25.0 27.1 22.9 24.7 30.8 28.6 26.0 28.5 30.7 25.4 28.1 32.9 24.8 27.2 28.7 31,5 27.8 25.3 27.1 24.3 27.6 23.0 ,, 29.7 29.5 27.2 29.1 32.5 25.4 26.6 26.6 30.5 30.1 22.0 22.9 28.8 28.7 23.5 24.6 30.2 26.3 25.8 24.9 28.5 25.5 23.0 24.4 28.7 27.1 27.7 27.6 28.4 29.1 29.2 25.1 30.1 28.9 28.2 Food Cons. Food Cons, g/amn/day g/anm/day Day 119 Day 126 25.3 30.1 29.0 27.5 26.1 32.1 29.1 26.3 -642- DuPont-11418 H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations male In d iv id u al Food Consumption Food Cons. g/anm /day Day 77 Food Cons. Food Cons. g/anm/day g/anm/day Day 84 I Day 91 Food Cons. g/anm /day Day 98 Food Cons. g/anm /day Day 105 Food Cons. g/anm /day Day 112 Male, VII 1000 mg/kg 665031 665146 665062 665138 665112 665007 30.1 33.8 32.2 26.0 26.7 31.3 27.8 30.9 32.3 22.0 25.7 30.7 26.2 30.2 29.8 27.0 26.5 30.8 29.4 32.3 32.1 26.3 26.7 31.0 31.2 30.7 29.1 28.8 28.4 30.5 31.3 33.1 32.7 24.8 28.5 30.8 Company Sanitized. Does not contain TSCA CBI - 643- Food Cons, g/anm /day Day 119 Food Cons, g /aran/day Day 126 32.4. 32.8 33.1 26.4 26.8 30.7 31.0 32.9 34.3 26.7 28.7 31.5 DuPont-11418 H-25425: Subchronic Toxicity PO-Da^pavage StudyinRats with One-Generation Reproduction Evaluations Study Food Cons. g/anm /day Day 7 Female, I I 0 mg/kg 665211 665271. 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 18.9 18.5 20.6 17.1 18.9 17.8 21.3 18.4 19.7 19.5 18.4 18.4 13.7 18.8 19.2 17.0 20.2 18.9 18.2 17.4 20.1 17.0 21.4 19.6 19.7 22.3 18.2 18.8 18.5 18.6 18.1 19.7 20.6 18.2 17.1 17.4 18.7 16.8 19.2 Food Cons. Food Cons. g/anm/day g/anm/day Day 14 Day 21 21.6 19.6 20.6 18.1 21.2 19.0 22.3 22.0 21.2 18.8 19.9 18.6 15.8 19.4 20.1 19.2 22.8 19.3 20.1 19.0 23.4 18.0 23.7 21.8 21.2 22.0 21.4 21.1 18.8 18.9 18.1 19.3 21.1 20.4 20.6 19.7 18.9 17.4 20.5 ` 25.1 20.5 22.9 20.1 22.3 20.1 22.8 21.0 21.7 19.3 21.2 20.5 16.1 22.1 22.6 19.9 22.9 21.2 21.8 21.3 22.7 19.7 25.8 21.2 19.1 20.9 19.9 21.4 18.9 21.6 17.7 22.0 21.5 19.4 20.9 19.8 19.0 19.1 21.2 In d iv id u a l Food Consumption Food Cons. g /anm /day Day 28 Food Cons. g/anm /day Day 35 Food Cons. g/anm /day Day 42 25.4 20.0 22.3 20.5 22.6 21.4 27.4 20.2 22.5 21.2 22.6 20.0 15.7 21.4 22.5 19.1 22.1 22.4 21.3 21.7 23.3 20.5 25.5 22.1 21.8 22.1 20.9 22.4 18.5 21.0 17.2 22.4 21.1 21.3 21.9 19.8 18.8 27.7 22.0 24.7 19.0 22.6 20.8 21.4 20.8 23.2 22.9 23.2 19.5 22.3 18.7 . 15.4 20.3 21.1 19.1 20.8 19.6 22.7 18.8 22.9 20.4 23.5 22.1 22.5 21.9 20.8 21.7 19.7 22.1 18.1 22.0 21.3 22.4 23.5 18.7 21.6 19.9 24.8 24.1 20.3 20.8 17.7 19.7 19.1 20.6 20.1 18.6 18.1 22.8 21.1 16.9 21.6 20.9 20.1 21.7 18.3 21.1 20.0 22.0 18.6 24.3 20.5 21.9 21.4 22.7 21.7 20.4 20.6 16.3 21.0 20.4 19.5 21.8 20.3 19.4 18.1 21.9 Company Sanitized. Does not contain TSCA CBI - 644- D u P o n t-11418 Food Cons. g /anm /day Day 49 Food Cons. g/anm /day Day 56 Food Cons. g/anm /day Day 63 Food Cons. g/anm /day Day 70 28.4 20.1 22.2 19.9 22.3 20.6 23.9 21.8 21.3 19.0 23.9 21.4 14.8 20.5 20.1 19.4 20.8 20.7 21.8 20.4 22.7 19.2 23.4 20.5 22.6 21.3 21.4 20.9 19.7 24.2 18.9 21.1 19.5 21.9 22.7 19.0 18.8 19.7 23.6 26.6 20.1 23.5 18.4 20.7 19.4 24.1 20.7 20.3 20.2 21.7 19.4 15.0 19.4 19.0 17.5 19.2 19.8 20.1 18.5 20.6 17.7 20.1 20.6 22.5 18.9 21.8 20.8 19.8 21.3 16.6 20.3 18.0 21.3 23.4 18.7 19.7 18.5 22.1 23.2 21.0 20.3 17.7 20.2 18.9 23.7 20.0 22.1 21.3 22.2 19.2 15.7 20.6 19.8 18.9 20.5 20.2 21.7 18.9 23.0 19.1 22.1 20.5 22.6 19.7 22.0 21.9 19.9 22.0 17.5 23.2 19.1 21.7 23.5 20.2 22.5 19.9 20.7 24.0 20.8 21.6 18.3 20.8 18.6 21.9 18.9 18.3 20.8 20.9 19.6 15.2 20.0 19.8 19.6 18.9 20.0 21.3 18.4 21.4 19.4 22.2 20.3 23.3 19.1 23.5 21.3 17.8 21.0 16.6 17.1 19.8 20.5 20.6 20.0 20.6 21.0 19.6 )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations -------- a r ----------- --% -------------------------------- -- ---------------------------------------------------------------- S tud y ; B H H 9 em In d iv id u a l Food Consumption Food Cons. Food Cons. g/anm/day g/anm/day Day 7 Day 14 Food Cons. Food Cons. Food Cons. g/anm/day g/anm/day g/anm/day Day 21 Day 28 Day 35 Food Cons. g/anm /day Day 42 Female, I I 0 mg/kg 665228 665260 665189 665204 665327 665203 21.5 20.2 22.5 18.8 18.2 15.7 23.5 16.4 21.4 20.7 18.5 16.9 * 25.6 26.6 21.9 19.7 20.3 18.0 24.6 22.6 24.2 19.7 19.9 18.6 24.0 22.7 22.7 19.8 20.5 17.8 24.1 22.9 20.6 19.3 20.3 19.4 Company Sanitized. Does not contain TSCA CBI - 645- DuPont-11418 Food Cons. g/anm /day Day 49 Food Cons. g/anm /day Day 56 Food Cons. g/anm /day Day 63 Food Cons g/anm /day Day 70 23.3 21.6 23.5 20.3 20.8 18.7 22.0 22.3 21.4 18.4 20.0 18.2 20.8 23.6 22.8 19.2 18.8 18.6 21.9 21.0 20.4 17.9 19.2 16.6 H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations Study: ) Food cons. Food Cons, g/ ama/day g / aim/ day Day 7 Day 14 Fem ale, IV 10 mg/kg Food Cons. g/anm /day Day 21 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 18..4 16..3 18..0 18..0 2 0 . 8 19..1 20..9 19..0 16..8 18..1 18.. 5 19..4 18..7 17..8 18,.2 16..9 18,, 9 21,.4 18..4 20.. 6 19..4 16.,8 17..6 20..1 18..8 19,.2 22..4 20..1 17,. 6 16.. 6 18..1 18..5 16..9 14..2 18..3 20..3 17..8 21..0 20..2 21..7 19..9 21..8 19..8 17..1 20..4 20..5 20..9 19..5 19..3 19..9 17..5 20..3 22..7 20..2 23,.0 20..9 21..7 21..4 21..1 19..6 21..1 24..7 24..5 19..2 17..6 20,.6 19..4 17..2 17,.3 19,.4 21..4 19..7 19.,4 19..7 22.,9 21..2 21..4 19.,1 17.,2 19..1 20..5 21..7 18.,9 19..4 19..4 16..4 19..6 25..2 23..1 23..1 22..2 20..5 20..1 22..3 17..6 20..2 25..0 24..0 19..1 16..2 19..9 20..5 19..7 18..4 19..1 In d iv id u a l Food Consumption Food Cons g/anm /day Day 28 Food Cons g/anm /day Day 35 Food cons, g/anm /day Day 42 21..8 19,,4 2Q.,5 21.,0 22.,6 21..7 23..9 21.,3 21..6 20..8 21..6 22.,2 21.,8 19.,6 21..6 20..1 20..6 26,,8 22..1 21..6 24..0 19..0 19..9 23,.0 19..9 21..2 25,.8 25..1 20..8 17,.0 20,.9 19..8 20..6 18,.3 19..8 21,.3 19..6 22..9 19..5 23..5 22..1 16..4 20..4 19,.3 21..7 22..2 22..8 21..2 19..9 20..5 17..7 19..8 24..9 22..6 20,.9 24..7 20..2 20,.3 21,.8 17..9 20,.4 32,.7 24..7 22,.8 19 .0 18 .0 19..3 19 .3 19 .5 18 .4 20.3 18.6 19.6 19.8 21.3 19.4 21.4 18.0 21.3 18.9 22 ..1 21.9 20.0 20.4 20.9 17.3 19.8 24.8 23.1 22.5 23.9 21.5 21.6 24.0 20.6 20.5 24.0 23.6 22.6 16.6 19.5 22.9 18.0 19.0 20.1 Company Sanitized. Does not contain TSCA CBI - 646- D u P o n t-11418 Food Cons. Food Cons g/anm/day g/anm/day Day 49 Day 56 Food Cons. Food Cons g/anm/day g/anm/day Day 63 Day 70 23.4 20.6 21.5 19.5 23.3 19.3 21.6 19.0 21.7 21.2 21.5 22.0 19.4 19.9 21.4 18.3 18.3 26.2 25.0 23.2 23.8 20.0 21.0 22.5 17.6 20.0 23.6 22.5 22.3 15.3 20.6 21.1 18.5 17.5 20.3 19.4 19.7 19.7 18.8 20.9 19.1 21.7 19.8 19.7 20.7 21.3 19.7 19.6 19.3 21.6 16.9 20.6 24.8 23.6 20.9 22.2 18.0 18.8 22.8 19.7 19.2 22.9 21.7 24.0 16.1 19.7 19.3 18.4 19.2 19.0 20.4 19.2 21.0 20.3 21.9 20.9 21.7 18.7 13.1 19.6 22.5 20.6 19.5 19.6 21.4 18.1 20.8 22.8 23.2 22.5 23.0 19.2 19.9 24.8 19.2 19.5 20.8 19.1 22.9 15.9 20.0 21.5 17.5 20.6 20.6 19.3 18.4 21.2 20.7 22.4 18.5 22.3 17.9 21.4 19.. 5 22.1 22.1 19.3 20.8 21.1 17.5 20.2 20.8 21.7 21.1 21.1 18.4 17.4 21.7 19.2 19.7 20.7 18.4 20.1 16.4 18.4 18.3 15.7 19.9 18.9 > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study ) _______ Food Cons. g/anm /day DaY 7 Food Cons. g/anm /day Day 14 Fem ale, VI 100 mg/kg Food Cons g/anm /day Day 21 665295 665251 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233 665216 665266 665270 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 20.6 18.1 17.4 18.4 18.4 21.6 17.6 19.9 17.9 18.2 19.0 19.0 16.9 19.0 19.4 15.1 18.4 20.0 17.3 17.5 19.4 21.2 20.4 22.0 20.5 18.2 21.5 22.9 19.4 19.2 19.1 19.2 21.1 18.0 20.1 ' 20.8 20.8 20.4 18.6 19.6 21.8 19.3 22.0 18.2 20.4 22.2 20.0 17.6 18.9 21.9 12.5 18.5 20.5 17.8 19.3 21.2 23.1 19.4 21.3 21.8 20.0 21.0 25.1 21.9 18.2 21.1 20.2 22.2 18.2 20.3 * 21.2 19.5 20.7 17.8 20.5 22.2 19.9 21.1 19.3 20.4 19.5 21.2 20.5 17.9 21.6 15.0 21.0 20.7 17.8 19.4 21.5 24.4 22.1 36.0 20.8 19.6 20.0 25.1 21.1 17.7 19.7 19.8 21.3 19.0 21.3 In d iv id u a l Food Consumption Food Cons. g/anm /day Day 28 Food Cons. g/anm /day Day 35 Food Cons g/anm /day Day 42 22.1 19.6 20.5 17.2 20.0 22.4 19.1 23.8 18.4 20.4 23.8 22.3 21.2 19.4 21.2 16.4 19.5 23.8 18.7 19.9 22.2 24.4 21.9 22.7 20.7 19.6 21.3 23.3 20.8 18.0 20.4 19.1 24.1 17.2 20.8 21.5 21.7 22.0 19.8 20.5 20.4 20.1 22.7 19.1 20.7 22.6 23.1 20.7 18.9 22.3 16.5 21.0 22.9 18.3 19.3 21.2 23.7 20.9 23.4 21.4 18.7 19.5 22.9 19.7 18.5 20.8 19.0 24.1 16.8 20.1 21.8 18.9 18.7 17.7 19. 20.7 19.1 19.4 17.8 19.7 24.6 21.9 21.2 18.9 22.1 16.6 20.5 22.0 18.7 18.8 20.6 22.4 22.8 25.3 22.3 18.7 21.0 22.6 21.0 18.3 20.8 20.1 27.3 15.5 20.7 Company Sanitized. Does not contain TSCA CBI - 647- DuPont-11418 Food Cons. g /aran/ day Day 49 Food Cons g/anm /day Day 56 Food Cons. g/anm /day Day 63 Food Cons g/anm /day Day 70 23.7 23.0 21.8 19.1 21.2 21.9 22.6 23.1 20.2 20.3 22.8 22.2 20.6 19.7 21.5 16.0 20.8 23.0 19.7 20.2 21.3 26.2 19.9 25.9 21.6 22.7 20.1 22.3 22.3 18.9 20.9 21.0 23.5 16.5 21.3 21.7 20.8 19.8 18.5 19.9 22.1 20.2 23.4 16.1 18.2 22.3 21.2 18.6 17.8 21.7 16.2 18.1 21.1 17.7 18.9 20.9 22.6 22.4 24.0 20.0 15.2 21.1 20.6 20.3 16.0 20.5 18.9 23.9 15.2 18.6 21.6 21.4 20.1 18.3 20.2 20.3 19.0 21.0 17.8 15.3 21.7 22.1 19.7 17.4 20.1 17.8 20.7 23.0 17.6 20.6 21.3 21.9 19.9 23.9 22.4 19.6 22.4 19.7 21.1 17.4 19.6 19.9 22.0 14.8 20.6 21.2 22.9 20.8 17.4 19.7 19.3 18.8 36.7 17.8 17.2 21.4 21.6 20.1 18.8 21.1 14.8 20.1 21.7 16.9 19.6 21.4 21.9 20.8 24.6 23.4 19.5 20.4 22.7 20.7 17.0 20.3 20.6 23.8 15.2 21.1 H-25425: Subchronic Toxicity 90-D a^iav ag e Study in Rats with One-Generation Reproduction Evaluations S tu d y Si ifem Food C ons. Food Cons g/anm /day g/anm /day Day 7 Day 14 Fem ale, V III 1000 m g/kg 665234 665242 665183 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172. 665194 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665288 665282 665275 665229 665237 665209 665335 1 9 .9 1 8 .6 1 6 .9 1 8 .8 1 9 .5 1 7 .2 1 9 .4 19.3 1 9 .2 1 8 .8 1 8 .7 1 9 .3 2 0 .1 2 0 .2 1 7 .5 1 4 .8 1 9 .7 1 8 .6 1 7 .7 2 1 .4 2 1 .2 1 9 .7 2 1 .1 19.3 1 8 .2 1 8 .0 17.3 1 9 .6 2 1 .7 1 7 .1 1 8 .6 1 7 .4 2 1 .1 2 1 .9 1 9 .7 19.3 1 8 .0 1 9 .1 1 7 .3 1 8 .8 2 0 .4 1 8 .3 1 9 .7 2 0 .3 1 8 .0 1 9 .5 2 0 .6 2 0 .7 1 8 .6 1 9 .0 2 0 .6 1 9 .2 2 0 .4 1 6 .6 1 4 .4 2 0 .3 1 7 .6 1 7 .8 2 0 .2 2 3 .8 2 1 .2 2 1 .7 2 0 .1 1 8 .6 1 8 .8 1 8 .8 2 1 .3 2 2 .9 1 9 .0 1 9 .0 1 9 .0 2 1 .1 2 1 .4 2 0 .6 2 0 .5 2 0 .1 2 0 .2 1 8 .9 Food Cons. g/anm /day Day 21 In d iv id u a l Food Consum ption Food C ons. Food Cons g/anm /day g/anm /day Day 28 Day 35 Food Cons. g/anm /day Day 42 2 1 .5 2 3 .5 1 9 .0 1 9 .7 1 9 .9 1 8 .8 2 1 .0 2 0 .8 2 1 .3 1 8 .8 2 0 .2 2 0 .1 2 0 .1 2 0 .5 1 9 .1 1 5 .6 2 2 .1 2 0 .5 1 8 .6 2 0 .9 2 4 .3 2 1 .6 2 3 .7 2 0 .9 1 8 .5 1 9 .6 1 8 .8 2 0 .9 2 4 .1 1 9 .7 1 8 .0 1 7 .0 2 2 .5 2 0 .2 2 0 .2 1 9 .7 2 0 .3 2 0 .6 1 7 .5 2 2 .4 1 9 .6 1 8 .2 1 8 .8 1 9 .0 1 9 .6 2 0 .5 2 1 .3 2 1 .5 1 7 .9 2 0 .0 2 0 .4 2 1 .2 2 1 .0 1 8 .1 1 6 .1 2 1 .1 2 0 .3 1 9 .6 2 2 .5 2 5 .7 2 2 .5 2 3 .8 2 1 .2 1 8 .3 1 9 .5 1 9 .1 2 0 .5 2 3 .9 2 0 .7 2 0 .4 1 8 .5 2 2 .3 2 3 .7 1 9 .8 1 9 .7 2 0 .6 2 1 .3 1 7 .3 2 2 .1 1 8 .9 1 9 .2 2 2 .4 2 0 .7 1 9 .3 2 0 .5 2 0 .9 2 2 .5 2 0 .0 1 9 .4 2 1 .8 1 9 .4 2 0 .2 1 8 .7 1 5 .5 2 3 .2 2 1 .2 2 0 .9 2 2 .6 2 4 .5 2 1 .1 2 2 .9 1 9 .2 1 7 .9 1 6 .7 1 9 .0 2 0 .8 2 4 .0 1 9 .4 1 8 .6 1 7 .8 2 1 .6 2 3 .4 2 0 .6 1 9 .8 2 0 .0 1 9 .2 1 7 .8 1 9 .3 20.1 1 9 .5 1 9 .0 1 8 .6 1 8 .1 1 9 .5 2 0 .7 20.6 1 7 .6 2 1 .7 20.1 20.8 2 0 .4 2 1 .5 12 62 ..26 2 2 .4 2 1 .5 2 4 .5 2 6 .6 2 1 .5 2 4 .4 1 9 .2 1 7 .5 1 8 .7 20.2 1 9 .8 2 2 .5 1 9 .0 2 0 .7 1 6 .9 2 1 .7 21.8 21.8 1 9 .5 20.0 1 9 .6 1 7 .9 Company Sanitized. Does not contain TSCA CBI -648- D u P o n t-11418 Food Cons. g/anm /day Day 49 Food Cons g/anm /day Day 56 Food Cons. Food Cons g/anm /day g/anm /day D ay 63 Day 70 2 3 .1 1 9 .7 2 0 .6 2 2 .6 2 1 .1 2 0 .6 2 4 .2 2 2 .5 2 5 .1 2 0 .7 2 0 .1 1 9 .9 1 9 .4 2 0 .2 1 8 .1 1 4 .4 1 9 .0 1 8 .6 2 0 .6 2 3 .3 2 5 .4 2 3 .4 2 3 .1 2 1 .2 1 8 .5 1 7 .6 1 8 .6 2 0 .6 2 5 .2 2 1 .1 2 1 .3 1 7 .4 2 1 .8 2 2 .2 2 0 .1 1 8 .9 1 9 .6 2 0 .2 1 8 .3 2 1 .8 2 1 .2 1 8 .2 2 0 .2 1 9 .3 1 8 .6 2 1 .2 2 0 .5 2 3 .7 1 8 .2 2 1 .2 1 8 .6 1 8 .1 1 9 .4 2 1 .1 1 6 .0 2 1 .2 2 0 .9 1 9 .3 2 2 .1 2 2 .1 2 3 .5 2 4 .0 1 9 .1 1 8 .2 1 7 .5 1 7 .2 1 8 .0 2 3 .5 1 9 .7 2 0 .9 1 8 .5 2 1 .4 2 0 .5 1 9 .5 1 9 .9 1 8 .8 1 9 .9 1 8 .3 2 1 .6 2 0 .9 2 0 .6 1 9 .7 2 1 .4 1 8 .2 2 0 .1 1 9 .0 2 2 .8 1 9 .8 2 2 .0 1 9 .0 2 3 .3 . 19.7 1 8 .1 1 5 .6 1 9 .5 1 8 .9 1 9 .4 2 1 .7 2 3 .5 2 3 .3 2 2 .6 2 0 .5 1 6 .8 1 7 .9 1 7 .9 2 1 .0 2 3 .8 1 8 .8 1 9 .8 1 8 .1 2 2 .1 2 2 .2 2 1 .1 1 9 .6 1 9 .7 1 9 .2 1 9 .3 2 1 .1 2 1 .2 2 0 .8 2 0 .7 2 0 .1 1 9 .1 2 1 .9 1 9 .5 2 4 .9 2 0 .3 2 3 .1 1 6 .9 1 9 .7 1 9 .9 2 0 .0 1 7 .5 2 1 .2 2 1 .5 2 1 .0 2 3 .3 2 4 .6 2 2 .9 2 1 .9 1 9 .1 1 6 .8 1 7 .8 1 9 .4 1 8 .0 2 4 .3 1 9 .7 1 8 .3 1 8 .2 2 0 .4 2 0 .1 2 2 .1 2 0 .1 2 1 .5 2 0 .3 1 9 .8 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study In d iv id u a l Food C onsum ption Food Cons. g/anm /day Day 7 Food Cons. g/anm /day Day 14 Food Cons. g/anm /day Day 21 Food Cons. g/anm /day Day 28 Food Cons. g/anm /day Day 35 Food Cons. g/anm /day Day 42 Fem ale, V III 1000 m g/kg 665303 665328 665299 665255 665213 665280 1 7 .4 18.3 1 9 .8 1 9 .6 1 9 .5 2 1 .4 1 5 .8 1 8 .2 1 9 .2 2 1 .0 2 0 .6 2 2 .3 1 8 .9 1 9 .8 1 7 .7 2 2 .1 2 1 .3 2 5 .4 1 8 .5 1 8 .6 1 8 .2 2 0 .6 1 9 .9 2 3 .1 1 6 .7 1 9 .1 1 9 .3 2 1 .6 2 1 .5 2 4 .3 1 8 .6 1 9 .6 1 8 .5 2 3 .8 1 9 .5 2 4 .1 Company Sanitized. Does not contain TSCA CBI - 649- DuPont-11418 Food Cons. g/anm /day Day 49 Food Cons. g/anm /day Day 56 Food Cons. g/anm /day Day 63 Food Cons g/anm /day Day 70 1 8 .5 1 9 .5 1 8 .4 2 1 .7 2 0 .5 2 4 .8 1 8 .8 2 0 .1 1 7 .5 2 0 .1 1 9 .1 2 4 .1 1 9 .1 1 9 .6 1 7 .8 2 1 .1 2 1 .0 2 3 .7 1 9 .1 2 0 .0 1 7 .8 2 1 .9 2 2 .0 2 4 .8 Company Sanitized. Does not contain H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations Study Food Cons. g/anm /day Day 77 F em ale, XI 0 m g/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 2 4 .3 1 9 .2 2 1 .8 1 7 .7 1 9 .7 1 8 .7 2 1 .5 2 0 .3 2 0 .8 2 4 .0 2 3 .1 1 9 .9 1 5 .1 2 0 .3 1 8 .8 1 9 .9 1 9 .5 1 8 .9 2 3 .9 2 0 .1 Food Cons. Food Cons. Food Cons. Food Cons. Food Cons, g/anm /day g/anm /day g/anm /day g/anm /day g/anm /day Day 84 Day 91 Day 98 Day 105 Day 112 2 2 .7 1 8 .2 1 9 .8 1 6 .9 1 8 .9 1 8 .9 2 0 .0 1 9 .7 2 1 .4 1 9 .5 2 2 .5 1 8 .4 1 4 .2 1 9 .3 1 9 .1 ` 2 3 .9 1 8 .8 2 1 .8 1 8 .1 1 9 .4 1 8 .5 2 2 .4 1 9 .2 2 2 .6 2 0 .4 2 0 .0 1 7 .3 1 5 .4 1 9 .8 1 7 .0 * * 2 1 .0 1 8 .7 1 8 .7 1 9 .2 2 0 .7 2 0 .4 1 8 .3 1 9 .0 1 8 .8 2 0 .4 2 0 .4 1 9 .8 1 8 .6 2 1 .4 1 9 .3 2 3 .9 2 0 .8 1 9 .2 2 0 .0 2 2 .2 2 3 .0 1 9 .7 2 0 .9 2 0 .1 2 3 .1 Food Cons. Food Cons, g / anm /day g/anm /day Day 119 Day 126 21 .3 19 .9 20 .0 22 .2 24 .2 21 .9 20..4 20 .6 21..4 21..1 D u P o n t-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study ) In d iv id u a l Food C onsum ption Food Cons. g/anm /day Day 77 Food Cons. g/anm /day Day 84 Food C ons. Food Cons. g/anm /day g/anm /day Day 91 Day 98 Food Cons. g/anm /day Day 105 Food Cons g/anm /day Day 112 F em ale, I I 0 m g/kg 665228 665260 665189 665204 665327 665203 2 2 .8 2 1 .2 2 0 .4 1 9 .7 2 0 .1 2 2 .3 2 3 .6 2 0 .5 1 7 .9 2 1 .1 2 2 .2 2 2 .9 1 9 .2 1 7 .4 1 8 .7 2 1 .0 2 4 .6 2 1 .2 1 8 .5 1 9 .8 2 3 .5 2 8 .6 2 0 .4 1 9 .7 2 0 .2 2 1 .6 2 8 .4 2 1 .5 2 0 .5 2 0 .4 Company Sanitized. Does not contain TSCA CBI -651 - Food Cons, Food Cons, g / aran/day g / aran/day Day 119 Day 126 2 6 .5 2 6 .7 2 2 .8 1 8 .0 1 9 .1 2 7 .3 2 6 .1 2 2 .5 2 0 .7 2 0 .1 D u P o n t-11418 >) H-25425: Subchronic Toxicity 9 0 -D a ^ javage Study in Rats with One-Generation Reproduction Evaluations_____ Study flH jH H H H B fern Food Cons. Food Cons. g/anm /day g/anm /day Day 77 Day 84 F em ale, IV 10 m g/kg Food Cons. g/anm /day Day 91 In d iv id u a l Food C onsum ption Food Cons. g/anm /day Day 98 Food Cons. g/anm /day Day 105 Food Cons. g/anm /day Day 112 Food Cons. g/anm /day Day 119 Food Cons g/anm /day Day 126 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 66533 665294 665244 665258 2 1 .3 1 7 .5 2 0 .8 1 9 .6 2 3 .7 2 0 .4 2 2 .4 1 9 .3 2 1 .2 1 9 .4 2 1 .6 2 1 .1 2 0 .2 2 0 .3 2 2 .4 1 9 .7 1 9 .0 2 0 .1 1 8 .1 2 3 .5 2 0 .2 2 0 .0 1 8 .6 2 0 .9 2 1 .6 2 2 .4 2 0 .9 1 9 .2 1 9 .7 2 1 .7 ` 2 0 .0 1 8 .8 1 8 .8 1 6 .6 2 3 .2 1 9 .4 2 0 .1 1 8 .3 1 9 .2 2 1 .3 2 0 .1 1 8 .4 1 7 .9 1 8 .7 2 0 .3 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 652- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study : Food Cons. g/anm /day Day 77 Food C ons. ' Food Cons g/anm /day g/anm /day Day 84 Day 91 Fem ale, VI 100 m g/kg 665295 665251 665300 665340 665259 665341 665199 665238 665250 6651.70 665313 665233 665216 665266 665270 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 2 1 .9 2 2 .5 2 1 .0 1 8 .6 2 0 .5 2 0 .0 2 0 .5 2 1 .4 1 7 .6 2 1 .1 2 1 .4 2 2 .8 1 8 .4 1 8 .4 2 0 .4 2 3 .1 2 1 .2 1 9 .7 1 7 .0 1 9 .1 1 9 .8 1 8 .9 2 2 .8 1 6 .5 1 9 .6 2 3 .0 2 1 .2 1 9 .7 1 8 .5 2 1 .5 1 8 .9 1 7 .7 1 8 .8 1 7 .2 1 8 .1 1 7 .6 1 7 .1 2 0 .0 1 6 .0 1 8 .4 1 9 .8 1 8 .8 1 7 .1 1 7 .9 1 8 .5 In d iv id u a l Food Consum ption Food Cons. g/anm /day Day 98 Food Cons. g/anm /day Day 105 Food Cons. g/anm /day Day 112 Food Cons. g/anm /day Day 119 Food Cons g/anm /day Day 126 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 653 - H-25425: Subchronic Toxicity 90-Da^Gavage Study in Rats with One-Generation Reproduction Evaluations Study Food Cons. g/anm /day Day 77 Food Cons. g/anm /day Day 84 Fem ale, V III 1000 m g/kg Food Cons g/anm /day Day 91 665234 665242 665183 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191. 665231 665288 665282 665275 665229 665237 665209 665335 1 9 .4 1 9 .6 19.3 2 1 .1 1 8 .9 1 9 .7 2 1 .6 2 0 .5 2 2 .6 2 0 .2 2 1 .6 1 9 .6 ' 2 0 .9 2 0 .6 1 8 .9 2 1 .5 2 1 .6 1 8 .7 2 1 .7 1 8 .9 1 9 .2 2 0 .5 1 8 .7 2 2 .3 19.8. 2 5 .0 2 0 .0 1 7 .7 , 1 9 .8 - 18.8 1 9 .0 2 0 .0 1 9 .3 1 9 .6 1 7 .8 1 7 .2 1 9 .7 2 0 .2 2 1 .2 1 9 .3 2 0 .5 1 9 .2 1 8 .1 1 8 .9 1 8 .6 21.3 20.6 1 8 .1 2 0 .4 19.3 1 8 .8 1 8 .7 21.8 2 1 .4 1 9 .2 21.6 1 9 .3 2 0 .7 1 9 .0 20.0 21.2 1 6 .3 1 8 .3 1 8 .5 1 8 .1 1 6 .4 In d iv id u a l Food Consum ption Food Cons, g/anm /day Day 98 Food Cons, g/anm /day Day 105 Food Cons. g/anm /day Day 112 2 1 .4 20.8 21.1 1 9 .2 20.0 21.2 1 7 .7 20.8 2 4 .1 2 0 .7 2 0 .5 20.6 2 2 .4 1 8 .0 2 3 .1 2 3 .6 22.6 2 1 .5 1 9 .4 20.2 1 8 .4 Company Sanitized. Does not contain TSCA CBI -654- Food Cons. Food Cons. g/anm /day g/anm /day Day 119 Day 126 DuPont-11418 2 4 .3 2 0 .0 2 0 .8 1 8 .0 1 9 .0 2 1 .1 1 7 .7 2 1 .8 2 3 .8 2 2 .7 2 0 .9 2 3 .2 1 9 .7 1 7 .1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study:] [fem In d iv id u a l Food C onsum ption Food Cons. g/anm /day Day 77 Food Cons. g/anm /day Day 84 Food Cons. g/anm /day Day 91 Food Cons. g/anm /day Day 98 Food Cons. g/anm /day Day 105 Food Cons g/anm /day Day 112 F e m a le , V I I I 1000 mg /k g 665303 665328 665299 665255 665213 665280 2 0 .8 1 9 .0 1 6 .7 1 9 .7 2 0 .0 1 7 .4 1 5 .7 1 8 .1 1 5 .4 1 9 .5 1 9 .4 1 7 .2 2 0 .5 2 0 .1 1 8 .5 2 1 .1 2 4 .3 1 7 .5 Company Sanitized. Does not contain TSCA CBI -655- Food Cons, g/am n/day Day 119 Food Cons, g/anm /day Day 126 1 8 .4 1 7 .3 1 7 .3 2 0 .9 1 9 .8 1 7 .7 DuPont* L1418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Qne-Generation Reproduction Evaluations_____________ DuPont-11418 APPENDIXE INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY RECORDS -656Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY RECORDS Critical Dates EXPLANATORY NOTES Day 72 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Body weights and clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section; Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Day 90 Last day of test substance administration for male and female rats designated for one-month and three-month recovery periods. Day 91 Last day of body weight and food consumption data collection for male and female rats designated for the subchronic toxicity evaluation. Last day of test substance administration for male rats designated for the subchronic toxicity evaluation. Day 92 Male rats designated for the subchronic toxicity evaluation were sacrificed. Last day of test substance administration for female rats designated for the subchronic toxicity evaluation. Day 93 Female rats designated for the subchronic toxicity evaluation were sacrificed. Day 126 Last day of body weight and food consumption data collection for rats designated for the one-month recovery period. Last day of food consumption data collection for rats designated for the three-month recovery period. Day 127 Male and female rats designated for the one-month recovery were sacrificed. Day 182 Male and female rats designated for blood fluorine level evaluation were sacrificed. -657Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study Sex Group Animal % In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation MI 665047 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ight S a c rific e d by design MI 665049 G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , L e ft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MI 665070 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design MI 665130 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t S a c rific e d by design MI 665076 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight H air L oss, Forepaw, B ila te r a l S a c rific e d by design Company Sanitized. Does not contain TSCA C8I -658 - R ecords Days 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -35,42-92 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -6 3 37 92 70-92 92 D u P o n t-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations stu d y : a le Sex Group Animal In d iv id u al C lin ic a l o b serv atio n s and M o rtality O bservation MI 665015 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , L e ft Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t S a c rific e d by design MI 665068 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight H air L oss, Forelim b, L eft H air L oss, Forepaw, L eft S a c rific e d by design MI 665148 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight H air L oss, Forepaw, B ila te ra l S a c rific e d by design MI 665016 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MI 665086 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l f o r C lin P ath , L eft Company Sanitized. Does not contain TSCA CBI -659- Records Days 0 -3 5 ,4 2 -9 2 37 92 92 0-35 37 92 42-92 42-92 92 0 ,9 1 -9 2 37 92 7 -3 5 ,4 2 -8 4 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -9 2 37 ) DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : tale DuPont-11418 In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal MI 665086 MI 665023 O bservation Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P ath , R ig h t S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Days 92 92 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 Eye O b serv atio n s, Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, L eft B led v ia O rb ita l fo r C lin P ath, R ight 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 MI 665072 S a c rific e d by design G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 MI 665151 Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , B ila te r a l Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 140 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 6 1 ,1 8 2 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 1 2 6 ,1 7 5 -1 8 2 Eye O b serv atio n s, Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft B led v ia O rb ita l fo r C lin P ath , R ight 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 D isch arg e, Eye r ig h t, B lack 140-161 MI 665164 H air Loss, Face, R ight S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 133-168 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 Company Sanitized. Does not contain TSCA CBI -660- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : sale Sex Group Animal MI 665164 * In d iv id u al C lin ic a l ob serv atio n s and M o rtality O bservation Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P a th , R ight MI 665154 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b se rv a tio n s, B led v ia O rb ita l fo r C lin P a th , L e ft Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t MI MI MI MI MI MI MI 665144 665104 665044 665141 665135 665005 665075 S a c rific e d by design G e n e r a l o b s e r v a t i o n . NO A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Removed from s tu d y G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Company Sanitized. Does not contain TSCA CBI -661 - D u P o n t-11418 R eco rd s Days 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 4 0 .1 6 1 , 182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 4 0 .1 6 1 , 182 182 0-70 72 0-70 72 0-70 72 0-70 72 0-70 72 0-70 72 0-70 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study a >ale In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b se rv a tio n Days MI 665075 Removed from stu d y 72 MI 665091 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 MI 665040 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 MI 665069 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 MI 665029 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 MI 665000 Removed from stu d y . G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 72 0-70 Removed from stu d y 72 MI 665166 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 MI 665012 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0 M isshapen O b serv a tio n s, T a il 7-70 Removed from stu d y 72 MI 664996 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-63 H a ir L oss, Forepaw, B ila te r a l 70 Removed from stu d y 72 M I 664994 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 -662- DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ---------- m -- 1.-,, ----------------------------------------------------------------------------------------- Sex Group Animal In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation MI 665046 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y MI 665021 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Removed from stu d y MI 665087 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y MI 665079 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y MI 665042 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight A ccid en tally k ille d MI 665098 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design MI 665149 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight MI 665081 S a c rific e d by design \ G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MI 665159 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Company Sanitized. Does not contain TSCA CBI - 663- R eco rd s Days 0-70 72 0-70 72 0-70 72 0-70 72 0-127 127 127 0-127 127 127 0-127 127 127 0-127 127 127 0-127 DuPont-11418 Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study ' ile In d iv id u a l C lin ic a l O b serv atio n s and M o rta lity Records Sex Group Animal O b s e rv a tio n Days MI 665159 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 S a c rific e d by design 127 MI 665043 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 S a c rific e d by design 127 MI 665064 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 S a c rific e d by design 127 MX 665121 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 0-127 127 MX 665106 S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 127 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 S a c rific e d by design 127 MI 665008 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 H yperreactive S a c rific e d by design 77-127 127 - 664- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-DayGavage Study in Rats with One-Generation Reproduction Evaluations Study ^ A n a l e Sex Group Animal M III 665053 In d iv id u a l C lin ic a l O bservations and M o rta lity Records O bservation Days G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-7 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft 37 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 92 H air L oss, F orelim b, B ila te ra l . 28-35,42-92 H air L oss, Forepaw, B ila te r a l 1 4 -3 5 ,4 2 -9 2 S a c rific e d by design 92 M III 665074 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-7 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft 37 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight H a ir L oss, Forepaw, B ila te r a l 92 1 4 -3 5 ,4 2 -9 2 S a c rific e d by design 92 M III 665128 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0 -7 ,9 1 -9 2 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft 37 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t 92 H air L oss, Forepaw, B ila te ra l 1 4 -3 5 ,4 2 -8 4 S a c rific e d by design 92 M III 665080 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0 -3 5 ,4 2 -7 0 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft 37 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t G eneral T eeth O b serv atio n s, C lipped 92 77-92 D ia rrh e a , Brown 77 -665- ) DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study lale Sex Group Animal In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation M III M III 665080 664993 S a c rific e d by design G e n e ra l o b s e rv a tio n , No a b n o rm a lity D e te c te d Eye O b servations, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design M III 665131 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia o r b ita l fo r C lin P ath, L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t S a c rific e d by design M -III 665060 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design M III 664995 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b serv atio n s,B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight H yperreactive S a c rific e d by design M III 665136 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b se rv a tio n s, B led v ia O rb ita l fo r C lin P a th , R ig h t Company Sanitized. Does not contain TSCA CBI - 666- Records Days 92 0 -3 5,42-92 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -7 7 37 92 84-92 92 0 -3 5 ,4 2 -5 6 ,9 1 -9 2 37 92 ) D u P o n t-11418 H-25425: Subchronic Toxicity 90-D ayGavage Study in Rats with One-Generation Reproduction Evaluations t udy M B H k i d e Sex Group Animal M III 665136 M III 665033 M III 665132 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation H air L oss, Forepaw, B ila te ra l S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B ledv ia O rb ita l fo r C lin P ath, L e ft Eye O b serv atio n s, B ledv ia O rb ita l fo r C lin P ath, R ight S acrificed by resig n G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b serv atio n s, B ledv ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B ledv ia O rb ita l fo r C lin P ath , R ig h t D ischarge, Nose, B lack H a ir L o ss, For&Limb, B i l a t e r a l H air L oss, Foresaw , B ila te ra l M III 665156 S ta in F u r/S k in , S h o u ld e r, B i l a t e r a l , Brown Sw ollen O b serv a tio n s, Face S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design Company Sanitized. Does not contain TSCA CBI -667- DuPont-11418 R eco rd s Days 63-84 92 0 -3 5 ,4 2 -9 2 37 92 92 0 ,7 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 4 0 .1 6 1 , 182 8 5 6 -7 0 ,7 7 -8 4 ,9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 ,9 1 , 9 8 .1 0 5 .1 1 2 .1 1 9 - 182 175-182 8 ,1 4 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 4 0 .1 6 1 , 182 182 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study:] tale ) Sex Group Animal M III 665061 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight M III 665145 Eye O b serv atio n s, C orneal O pacity, R ight D isch arg e, Nose, B lack D isch arg e, Eye r ig h t. B lack S t a in F u r/S k in , F o re lim b , B i l a t e r a l , Brovm S a c rific e d by design G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b se rv a tio n s, B led v ia O rb ita l f o r c L in P a th , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight M ill 665019 S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight M III M III 665153 665037 S a c rific e d by design G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Company Sanitized. Does not contain TSCA C8I - 668- DuPont-11418 R eco rd s Days 0 ,7 ,14-21,28 ,35-42 108 3.9.22.34.55.76.89.93.97.101.115.140.161, 182 168-182 147 147-161 49,56-70,77-84,91,98,105,112,119-182 182 0 ,7 ,14-21,28,35-49,56-70,77-84, 91.98.105.112.119- 182 108 3 .9 .22.34.55.76.89.93.97.101.115.140.161, 182 182 0,7 ,14-21,28,35-49,56-70,77-84, 91.98.105.112.119- 182 108 3.9.22.34.55.76.89.93.97.101.115.140.161, 182 182 0-70 72 0-70 Company Sanitized, Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : lale In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days M III 665037 Removed frcm s tu d y 72 M III 665163 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70. Removed from stu d y 72 M III 665001 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M III - 665126 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y 0-70 72 M III 665125 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-49 Eye O b se rv a tio n s, E nophthalm us, L e ft 56-70 D isch arg e, Nose, B lack 70 D isch arg e', Eye l e f t . B lack 56 Removed from stu d y 72 M III 665017 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-49 H air L oss, ?orepaw . B ila te ra l 56-70 Removed from stu d y 72 M III 665071 G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0-70 Removed from s tu d y 72 M III 665032 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed from s tu d y 72 M III 664997 G e n e r a l o b s e r v a t i o n , . No A b n o rm a lity D e te c te d Removed from stu d y 0-70 72 -669- ) D u P o n t- 1 1418 I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________ ___________________________ DuPont-11418 In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days M III 665110 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M III 665041 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 H air L oss, F orelim b, B ila te ra l 7-70 H air L oss, Forepaw, B ila te ra l 7-70 Removed from stu d y 72 M III 665058 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M III 665113 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c te d Removed from stu d y 0-70 72 M III 665056 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-35 H air L oss, Forepaw, B ila te ra l 42-70 Removed from stu d y 72 M III 665025 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-7 H air L oss, Forelim b, B ila te ra l 14-70 H air L oss, Forepaw, B ila te r a l 14-70 Removed from stu d y 72 M III 665038 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M III 665006 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d H air L oss, F orelim b, B ila te ra l 0-7 14-70 Company Sanitized. Does not contain TSCA CBI - 670- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: m ale Sex Group Animal M III 665006 M III 665167 M III 665020 In d iv id u a l C lin ic a l O bservations and M o rta lity R ecords O bservation Days H air L oss, Forepaw, B ila te r a l 14-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-35 H air L oss, F orelim b, B ila te ra l 49-70 Wound, S u p e r f i c i a l , F o re lim b , B i l a t e r a l 42 Removed from stu d y 72 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -671- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : lale In d iv id u a l C lin ic a l O bservations and M o rta lity Sex Group Animal O b s e rv a tio n MV 665122 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , h e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design MV 665155 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MV 665073 G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design MV 665089 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MV 665119 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MV 665137 G e n e r a l o b s e r v a t i o n . No A b n o r m a li t y D e t e c t e d Company Sanitized. Does not contain TSCA CBI -672- R eco rd s Days 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5,42-92 37 92 92 0 -3 5,42-92 37 92 92 0 -3 5,42-92 37 92 92 0 -3 5,42-92 D u P o n t-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study:, lale In d iv id u a l C lin ic a l O bservations and M o rta lity Sex Group Animal O b s e rv a tio n MV 665131 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MV 665103 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design MV 665143 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, R ight S t a in F u r/S k in , F a c e , Brown S a c rific e d by design MV 665054 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design MV 665035 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b se rv a tio n s, B led v ia O r b ita l f o r C lin P a th , R ig h t H air L oss, Forelim b, B ila te ra l S a c rific e d by design Company Sanitized. Does not contain TSCA CBI -673- Records Days 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 37 92 49-92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -7 ,3 5 ,4 2 -9 2 37 92 14-28 92 DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study:! ale Sex Group Animal MV 665048 In d iv id u al C lin ic a l O bservations and M o rta lity O bservation G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b se rv a tio n s, B led v ia O r b ita l f o r C lin P ath , R ight MV 665030 D isc h a rg e , Eye r i g h t, Red S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P ath , R ig h t MV 665028 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a li t y D e t e c t e d MV 665052 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight D isc h a rg e , Eye r ig h t, B lack Found dead in cage. G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design Company Sanitized. Does not contain TSCA CBI -674- DuPont-11418 R ecords Days 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 175 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 4 0 .1 6 1 , 182 182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 4 0 .1 6 1 , 182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 91,98 101 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 105-108 108 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 4 0 .1 6 1 , 182 182 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study DuPont-11418 Sex Group Animal 665150 665116 665034 665051 665083 665124 665078 665036 In d iv id u a l C lin ic a l O bservations and M o rta lity Records O bservation Days G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,9 8 ,1 05,112,119,161-182 Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P ath , L e ft 108 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 D isch arg e, Eye r ig h t. B lack 133-154 D isc h a rg e , Eye r i g h t, Red 126 S a c rific e d by design 182 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0 -56,70 D isc h a rg e , M outh, Red 63 Company Sanitized. Does not contain TSCA CBI - 675 - Company Sanitized. Does not contain TSCA CBi H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : tale In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days MV 665036 S ta in F u r/S k in , F ace, Red 63 Wet F u r, F orepaw , B i l a t e r a l 63 Wet F u r, C hin 63 Wet F u r, N eck, V e n tra l 63 Removed from s tu d y 72 MV 665085 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 MV 665092 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed from s tu d y 72 MV 665004 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from s tu d y 0-70 72 MV MV 665140 665114 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Removed from stu d y G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Removed from stu d y 0-70 72 0-70 72 MV MV 665139 665111 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Removed from stu d y G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Removed from stu d y 0-70 72 0-70 72 MV 665055 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d H air L oss, Forelim b, L eft 0-7 28-70 -676- DuPont-11418 H-25425: Subchronic Toxicity -9-0--D-ay--G-a-v-ag-e-S-t-u-d-y-in--R-a-ts-w--ith--O-n-e--G--en-e-r-at-io-n-R--ep-r-o-d-u-ct-io-n--E-va-l-u-at-io-n-s-------------------- -----------------------------D--u-P-o-nt---11-4-1-8 St udy e Sex Group Animal MV 565055 MV 665066 MV 665039 MV 665003 MV 665088 MV 665147 In d iv id u a l C lin ic a l O b serv atio n s and M o rta lity Records O bservation Days H air L oss, Forepaw , L eft 14-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-42 H air Loss, Forelim b, B ila te ra l 49-70 Removed from s tu d y 72 G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d t Removed from stu d y 0-70 72 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from s tu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from s tu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-7 H air L oss, Forepaw, B ila te r a l 14-70 Removed from s tu d y 72 Company Sanitized. Does not contain TSCA CBI -677- Company Sanitized. Does not contain TSCA CB1 H-25425: Subchronic Toxicity 90-DayR avage Study in Rats with One-Generation Reproduction Evaluations_____________ Study -m 3 Sex Group Animal M V II 665160 In d iv id u a l C lin ic a l O bservations and M o rta lity Records O bservatipn Days G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0 -3 5 ,4 2 -9 2 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 37 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 92 S a c rific e d by design 92 M V II 665096 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0 -3 5 ,4 2 -6 3 ,' Eye O bserv atio n s, B led v ia O rb ita l fo r C lin P ath , B ila te r a l 92 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 37 Comments, compound on l i p s 69 M V II 665082 S a c rific e d by design G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft 92 0 -2 1 ,4 2 -9 2 37 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 92 Wound, S u p e r f i c i a l , M outh 28-35 S a c rific e d by design 92 . M VII 665107 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-35 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 37 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 92 H a ir L o ss, Abdomen, C audal 42-92 H a ir L oss, Perineum 77-92 M V II 665152 S a c rific e d by design G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 92 0 -3 5 ,4 2 -9 2 - 678- DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y lale In d iv id u a l C lin ic a l O bservations and M o rta lity Sex Group Animal O b se rv a tio n M V II 665152 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design M V II 665120 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S t a i n e d C a g e b o a rd , R ed, FROM URINE S a c rific e d by design M V II 664999 G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d Eye O b se rv a tio n s, B led v ia O r b ita l f o r C lin P a th , L eft Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ight s a c rific e d by design M V II 665026 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b se rv a tio n s, B led v ia O r b ita l f o r C lin P a th , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design M VII 665162 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design M V II 665027 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Company Sanitized. Does not contain TSCA CBI -679- R eco rd s Days 37 92 92 0 -3 5 ,4 2 -4 9 37 92 55-92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -9 2 37 92 92 0 -3 5 ,4 2 -9 2 DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study:] lale Sex Group Animal M V II 665027 M V II 665084 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design \ G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight H a ir L oss, Forepaw, B ila te r a l M V II 665142 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft B led v ia O rb ita l fo r C lin P ath , R ight M V II 665118 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft B led v ia O rb ita l fo r C lin P ath, R ight M V II 665108 S a c rific e d by design G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft Company Sanitized. Does not contain TSCA CBI - 680- D u P o n t-11418 R eco rd s Days 37 92 92 0 ,7 ,1 0 5,112,119-182 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 ,9 1 , 98 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 91,98,10 5 ,1 1 2 ,1 1 9 -1 8 2 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 182 0 ,7 ,9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 108 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y :' lale Sex Group Anim al M V II 665108 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight M V II 665024 H air L oss, Forepaw, B ila te r a l S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t M V II M V II M VII M V II M V II M . V II 665050 665134 665022 665105 665102 665161 S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Rem oved fro m s t u d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d H air L oss, Forepaw, B ila te r a l Removed from stu d y G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y Company Sanitized. Does not contain TSCA CBI -681 - DuPont-11418 R eco rd s Days 3 ,9 ,2 2 ,3 4 ,.5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 14-21 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 91,98,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 4 0 ,1 6 1 , 182 182 0-70 72 0-70 72 0 -7 ,2 1 -4 9 1 4 ,5 6 -7 0 72 0-70 72 0-70 72 0-70 72 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y j lale In d iv id u a l C lin ic a l O bserv atio n s and M o rta lity Records Sex Group Animal O b se rv a tio n Days M V II 665133 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 -7 ,4 9 -7 0 H air L oss, Forepaw, B ila te r a l 14-42 Removed from stu d y 72 M ' V II 665157 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M V II 665093 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M V II M V II 665059 665123 G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y 0-70 72 0-70 72 M V II 665018 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 M . V II 665065 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 M V II 665063 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M VI1 665090 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M V II 665057 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from s tu d y 72 - 682- DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y :' lale In d iv id u a l C lin ic a l O bservations and M o rta lity R ecords Sex Group Animal O b s e rv a tio n Days M VII 665011 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M V II 665109 G e n e ra l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 0-63 H a ir L oss, H indlim b, R ight 70 Removed from stu d y 72 M V II 664998 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 M V II M V II 665077 665158 G e n e r a l' o b s e r v a t i o n . No A b n o rm a lity D e te c te d Removed from stu d y G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t 0-70 72 0-127 127 M V II 665002 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P a th , R ig h t 127 0-127 127 M V II M V II 665067 665095 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P a th , R ight H yperreactive S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 0-98 127 105-127 127 0-127 127 -683- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study Sex Group Animal In d iv id u a l C lin ic a l O bserv atio n s and M o rta lity Records O bservation Days M VII 665095 S a c rific e d by d esig n 127 M VII 665031 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t 127 S a c rific e d by design 127 M V II 665146 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-91 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 A ggressive B ehavior 105-127 H air L oss, Nose 98-127 S a c rific e d by design 127 M V II 665062 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-7 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 H air L oss, Forelim b, B ila te ra l 21-127 H air L oss, Forepaw, B ila te r a l 14-127 H air Loss, S houlder, B ila te ra l 105-127 H air Loss, S houlder, R ight 49-98 S ta in F u r/S k in , F a c e, Brown S a c rific e d by design 105-112 127 M V II 665138 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 0-127 127 S a c rific e d by design 127 M V II 665112 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-127 -684- ) DuPont-11418 )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____ Study Sex Group Animal M V II 665112 M V II 665007 In d iv id u a l C lin ic a l O bservations and M o rta lity Records O bservation Days Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t 127 S a c rific e d by design 127 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 S a c rific e d by design 127 .) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -685- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : :em In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal F II 665211 O bservation G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Days 0 -3 5 ,4 2 -9 3 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight 93 F II 665271 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 93 0 -35,42-56,70-93 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft 38 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight 93 D isc h a rg e , Eye l e f t , Red 63 S a c rific e d by design 93 F II 665178 G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0 -3 5 ,4 2 -9 3 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft 38 Eye O b se rv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t 93 S a c rific e d by design 93 F II 665317 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 -3 5 ,4 2 -9 3 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, L e ft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t 93 S a c rific e d by design 93 F II 665230 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 -3 5 ,4 2 -9 3 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 S a c rific e d by design 93 - 686- ) DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluaiions S tu d y :! I f ein In d iv id u a l C lin ic a l O bservations and M o rta lity Sex Group Animal O b s e rv a tio n F II 665225 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design F II 665114 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design F II 665319 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight A rches back du rin g handling S a c rific e d by design F II 665221 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t S a c rific e d by design F il 665278 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b se rv a tio n s, B led v ia O r b ita l f o r C lin P a th , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight H yperactive Company Sanitized. Does not contain TSCA CBI -687- Records Days 0 -3 5 ,4 2 -9 3 38 93 93 0 -3 5 ,4 2 -9 3 38 93 93 0 -2 8 ,4 9 -9 3 38 93 35., 42 93 0 -3 5 ,4 2 -9 3 38 93 93 0 -7 ,28-35,42-93 38 93 14-21 D u P o n t-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y :' :em DuPont-11418 Sex Group Animal F II 665278 F II 665176 In d iv id u a l C lin ic a l O bservations and M o rta lity R ecords O bservation Days S a c rific e d by design 93 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 7 5 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft 108 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 2 6 ,1 4 0 , 1 6 1 ,1 8 2 D isch arg e, Eye l e f t . B lack 182 F II S a c rific e d by design 665283 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 91', 9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 Eye O b serv a tio n s, Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft B led v ia O rb ita l fo r C lin P ath, R ight 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 2 6 ,1 4 0 , 1 6 1 ,1 8 2 F II 665297 S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1,98,105,112,119-182 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, B ila te r a l 101 Eye O b serv atio n s, Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, L eft B led v ia O rb ita l fo r C lin P ath, R ight 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 1 5 ,1 2 6 ,1 4 0 ,1 6 1 , 182 F II 665301 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,9 8 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L eft 108 Company Sanitized. Does not contain TSCA CBI - 688- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : em Sex Group Animal F II 665301 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S t a in F u r/S k in , F a c e , Brown S a c rific e d by design I I 665269 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight F II F II F II F II F II 665220 665334 665257 665175 665336 H yperreac t iv e D isc h a rg e , Eye r i g h t, Red S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d H air L oss, F orelim b, B ila te ra l H air L oss, Forepaw, B ila te r a l Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Company Sanitized. Does not contain TSCA CBI -689- DuPont-11418 R eco rd s Days 3,9,22,34-, 5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 2 6 ,1 4 0 , 1 6 1 ,1 8 2 1 0 5 ,1 1 2 ,1 1 9 -1 8 2 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,9 8 ,1 0 5 , 1 1 2 ,1 1 9 ,1 3 3 -1 8 2 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 2 6 ,1 4 0 , 161,182 7 7 -8 4 ,9 1 126 182 0-7 ,4 9 -7 0 28-42 14-42 72 0-70 72 0-70 72 0-70 72 0-70 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study em In d iv id u a l C lin ic a l O bservations and M o rta lity R ecords Sex G roup Animal O b s e rv a tio n Days F II 665336 Removed from stu d y 72 F II 665192 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F II 665232 G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F II 665307 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F II 665246 G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d H a ir L oss, Abdomen, R ig h t H air Loss, F orelim b, R ight Removed from stu d y 0 -28,49-56 63-70 35-42 72 F II F II 665289 665264 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d H air L oss, Forelim b, B ila te ra l 0-70 72 0-14 28-70 H air Loss, Forepaw, B ila te r a l Removed from stu d y 21-70 72 F II 665185 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F II 665206 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 -690- D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study In d iv id u a l C lin ic a l O b serv atio n s and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F XI 665306 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed Erom s tu d y 72 F II 665226 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F II 665198 G e n e ra l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 0-42 D isch arg e, Eye r ig h t, B lack 56-70 D isc h a rg e , Eye r ig h t, Red 49 Removed from stu d y 72 F II F II 665249 665284 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 72 0-70 F II 665240 Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 72 0-70 Removed from stu d y 72 F II 665201 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ig h t 127 S a c rific e d by design 127 F II 665197 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 0-105 127 S ta in F u r/S k in , D o rsal Body, Red 112-127 S a c rific e d by design 127 -691 - ) DuPont-11418 Company Sanitized. Does not contain TSCA CBl H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations tu d y In d iv id u a l C lin ic a l O bservations and M o rta lity R ecords Sex Group Animal O b s e rv a tio n Days F II 665256 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 S a c rific e d by design 127 F II 665323 G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0 -9 8 ,1 1 2 -1 2 7 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ig h t 127 Ear tw itch . B ila te ra l 105 A rches back du rin g h an d lin g 105 S a c rific e d by design 127 F .II 665276 G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ig h t 127 S a c rific e d by design 127 F II 665228 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 S a c rific e d by design 127 F II 665260 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-2 8 ,4 2 ,7 0 -9 8 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ig h t 127 H air L oss, Forelim b, B ila te ra l 105-127 H air L oss, Forelim b, R ight 49-63 H air Loss, S a c ral, B ila te ra l 126-127 H air L oss, Neck, V en tral 126-127 S t a in F u r/S k in , F a c e, Brown 105-127 -692- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study :em In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F II 665260 A rches back during handling S a c rific e d by design 35 127 F II 665189 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 S a c rific e d by design 127 F II 665204 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 ,1 2 6 -1 2 7 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 H a ir L o ss, Abdomen, R ig h t 91-119 H air L oss, F orelim b, B ila te r a l H a ir L oss, Forepaw, B ila te r a l 63-119 7-119 Ear tw itch . B ila te ra l 105 A rches back du rin g handling 105 S a c rific e d by design 127 F II 665327 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-119 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 H air Loss, Forelim b, R ight S a c rific e d by design 126-127 127 F II 665203 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-72 Removed from stu d y 72 -693- DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study :em In d iv id u a l C lin ic a l O b serv atio n s and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F IV 665308 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0 -3 5 ,4 2 -9 3 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 S a c rific e d by design 93 F IV 665215 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 -3 5 ,4 2 -5 6 ,7 0 -8 4 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O bserv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 H yperactive 91-93 Ear tw itch . B ila te ra l A rches back during handling 6 3 ,9 1 63,91 S a c rific e d by design 93 F 'IV 665277 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0 -2 8 ,4 9 -9 3 Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P ath , L e ft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin Path, R ight 93 H air L oss, Forepaw, L eft 35,42 S a c rific e d by design F IV 665241 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 H air L oss, F orelim b, B ila te ra l H air L oss, Forepaw, B ila te ra l 2 8 -3 5 ,4 2 -9 3 1 4 -3 5 ,4 2 -9 3 - 694- DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : Ifem In d iv id u a l C lin ic a l O bserv atio n s and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F IV 665241 E ar tw itc h . B ila te r a l 7 F IV 665236 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 93 0 -35,42-93 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin Path, L eft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 93 S a c rific e d by design 93 F IV 665324 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r d i n P ath , R ight 93 D isch arg e, Eye l e f t , B lack 21-28 H air L oss, F orelim b, B ila te ra l 63-93 H a ir L oss, Forepaw, B ila te r a l 7 -3 5 ,4 2 -9 3 S a c rific e d by design 93 F IV 665332 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 -1 4 ,4 2 -9 3 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 H air L oss, Forepaw, B ila te r a l 21-35 S a c rific e d by design 93 F IV 665239 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, L eft 0 -3 5 ,4 2 -9 3 38 Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P ath , R ig h t 93 - 695- DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y ! DuPont-11418 In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F IV 665239 S a c rific e d by d esig n 93 F IV 665182 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 -3 5 ,4 2 -9 3 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L eft 38 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight 93 S a c rific e d by design 93 F IV 665268 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-35,4 2 -5 6 ,7 0 ,8 4 -9 3 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight H yperactive H yperreactive Ear tw itch , B ila te ra l A rches back d u rin g handling 93 77 63 77 77 F IV 665218 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 93 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 91,98,1 0 5 ,1 1 2 ,1 1 9 -1 8 2 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 108 3 ,9 ,2 2 ,3 4 ,5 5 ,7 6 ,8 9 ,9 3 ,9 7 ,1 0 1 ,1 1 5 ,1 2 6 ,1 4 0 , 161,182 F IV 665309 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 7 5 -1 8 2 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L eft 108 Company Sanitized. Does not contain TSCA CBI - 696- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : [fern In d iv id u a l C lin ic a l O bservations and M o rta lity Sex Group Animal O b se rv a tio n F IV 665309 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P a th , R ig h t F IV S t a in F u r/S k in , H ead, Brown S a c rific e d by design 665177 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , D eft Eye O b se rv a tio n s, B led v ia O rb ita l, f o r C lin P a th , R ig h t F IV 665202 S ta in F u r/S k in , H ead, Brown S t a in F u r/S k in , N eck, Brown S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b serv a tio n s, Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, D eft B led v ia O rb ita l fo r C lin P ath, R ight F IV 665235 S a c rific e d by design G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, L eft B led v ia O rb ita l fo r C lin P ath , R ight F IV 665212 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Company Sanitized. Does not contain TSCA C8I -697- ) DuPont-11418 R eco rd s Days 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 1 6 1 ,1 8 2 119-168 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,98,105,112 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 1 6 1 ,1 8 2 119-182 133-182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 182 0-70 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study flH H M H H E e m In d iv id u a l C lin ic a l O b serv atio n s and M o rta lity Records Sex Group Animal O b se rv a tio n Days F IV 665212 Removed from s tu d y 72 F IV 665180 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-21 H air L oss, F orelim b, B ila te r a l 28-70 Removed from s tu d y 72 F IV 665292 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F IV 665137 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-7 H a ir L o ss, Abdomen, L e ft 63-70 H air L oss, Forelim b, B ila te ra l 14-70 H air L oss, Forepaw, B ila te ra l 14-70 Removed from stu d y 72 F IV 665205 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 -1 4 ,4 2 -7 0 H air L oss, Forepaw, B ila te r a l 21-35 Removed from stu d y 72 F IV 665263 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F IV 665210 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 H air L oss, Forelim b, B ila te ra l 14-70 H air L oss, Forepaw, B ila te ra l 7-70 Removed from stu d y 72 F IV 665131 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 - 698- ) DuPont-11418 Company Sanitized. Does not contain TSCA H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study S l j ^ H e n i In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Anim al O b se rv a tio n Days F IV 665181 Removed from stu d y 72 F IV 665248 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-28 H air L oss, Forelim b, B ila te r a l 49-70 H air L oss, Forepaw, B ila te r a l 35-70 Removed from stu d y 72 F IV 665293 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-28 H air L oss, Forelim b, L eft 49-70 H a ir L oss, H indlim b, L e ft 35-70 H air Loss, Inguen, L eft 49-70 H air Loss, Side, L eft 35-70 Removed from stu d y 72 F IV 665329 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-21 H air L oss, F orelim b, B ila te r a l 28-56 H air L oss, Inguen, L eft 42-70 Removed fro n stu d y 72 F IV 665290 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F IV 665253 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-28 H air L oss, Forepaw, B ila te r a l 49-70 S t a in F u r/S k in , S h o u ld e r,B i l a t e r a l , Brown 35-70 Removed from stu d y 72 O CD ) DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ Study em TS In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F IV 665286 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed from s tu d y 72 F IV 665281 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c te d 0-70 Removed from s tu d y 72 F IV 665186 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c te d 0-70 Removed from s tu d y 72 F IV 665330 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c te d 0-70 Removed from s tu d y 72 F IV 665294 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y 0-70 72 F IV F IV 665244 665258 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y 0-70 72 0-70 72 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -700- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____ t u d y H H H H H k em In d iv id u a l C lin ic a l O bservations and M o rta lity Sex Group Animal O b se rv a tio n F VI 665295 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , L e ft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P a th , R ight S a c rific e d by design F VI 665251 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design F VI 665300 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b se rv a tio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t S a c rific e d by design F VI 665340 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight H air L oss, Forepaw, B ila te r a l S a c rific e d by design F VI 665259 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t S a c rific e d by design Company Sanitized. Does not contain TSCA CBI -701 - R eco rd s Days 0 -3 5 ,4 2 -9 3 38 93 93 0 -3 5 ,4 2 -9 3 38 93 93 0 -3 5 ,4 2 -9 3 38 93 93 0-35,4 2 -4 9 ,9 1 -9 3 38 93 56-84 93 0 -3 5 ,4 2 -9 3 38 93 93 D u P o n t -11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y Sex Group Animal F VI 665341 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design F VI 665199 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight S a c rific e d by design F VI 665238 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t H a ir Loss', F o re lim b , B i l a t e r a l H air L oss, Forelim b, R ight Ear tw itch , B ila te ra l A rches back d u rin g handling S a c rific e d by design F VI 665250 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight H air L oss, F orelim b, B ila te ra l H air L oss, Forelim b, L eft Company Sanitized. Does not contain TSCA CBI -702- Records Days 0 -3 5 ,4 2 -9 .3 38 93 93 0 -3 5 ,4 2 -9 3 38 93 93 0 38 93 3 5 ,4 2 -9 3 7-28 49 49 93 0-14 38 93 2 8 -3 5 ,4 2 -9 3 21 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study Sex Group Animal F VI 665250 F VI 665170 F VI 665313 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation H air L oss, Forepaw, B ila te r a l S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft E y e O b s e r%v a t i o n s , B le d v i a O r b i t a l f o r C l i n P a t h , R i g h t S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight F VI 665233 D isch arg e, Eye r ig h t. B lack H air L oss, Forepaw, B ila te r a l H a ir L oss, Forepaw, L e ft Wound, S u p e r f ic ia l, NeckS a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, E nophthalm us, R ig h t Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight Eye O b serv a tio n s, C orneal O p acity , R ight H air L oss, Neck, R ight Company Sanitized. Does not contain TSCA CBI -703- DuPont-11418 R ecords Days 2 1 -3 5 ,4 2 -9 3 93 0 -3 5 ,4 2 -9 3 38 93 93 0 ,7 ,1 4 ,2 8 ,3 5 -4 9 ,5 6 ,7 7 -8 4 ,9 1 ,9 8 ,1 0 5 ,1 1 2 , 119,133-154 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 126 6 3 -7 0 ,1 8 2 161-175 21 182 0 ,7 ,1 4 ,5 6 -7 0 ,7 7 -8 4 ,9 1 ,9 8 ,1 0 5 ,1 1 2 ,1 1 9 -1 4 0 147-182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 147-182 2 8 ,3 5 -4 9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ em Sex Group F VI F VI ' In d iv id u a l C lin ic a l O bservations and M o rta lity Animal O b se rv a tio n 665233 Wound, S u p e r f i c i a l , Neck S a c rific e d by design 665216 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight F VI 665266 H air L oss, Forepaw, B ila te ra l S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P a th , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight F VI 665270 S ta in F u r/S k in , Head, Red S t a in F u r/S k in , N eck, Brown S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S t a in F u r/S k in , H ead, Brown S t a in F u r/S k in , N eck, Brown Company Sanitized. Does not contain TSCA CBI -704- DuPont-11418 R eco rd s Days 21 182 0 ,4 2 -4 9 ,5 6 -7 0 ,7 7 -8 4 ,9 1 ,9 8 ,1 0 5 ,1 1 2 , 119-182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 7 ,1 4 -2 1 ,2 8 ,3 5 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 ,9 8 ,1 0 5 ,1 2 6 -1 7 5 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 112,119 182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 91,98 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 119-182 1 0 5 ,1 1 2 ,1 1 9 -1 8 2 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F VI 665270 S a c rific e d by d esig n 182 F VI 665338 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c te d 0-70 Removed from stu d y 72 F VI 665219 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F VI 665267 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F VI 665325 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 F VI 665331 Removed from stu d y G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 72 0-70 Removed from stu d y 72 F VI 665217 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F VI 665227 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F . VI 665262 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-42 H air L oss, Forelim b, R ight 49-70 S ta in F u r/S k in , S h o u ld e r, B i l a t e r a l , Brown 56-70 Removed from stu d y 72 F VI 665247 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 -705- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : :em In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F VI 665243 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-14 H a ir Loss', F o re lim b , B i l a t e r a l 56-70 H air Loss, F orelim b, R ight 49 H a ir L oss, H indlim b, L e ft 42 S t a in F u r/S k in , S h o u ld e r, B i l a t e r a l , Brown 21-70 Removed from stu d y 72 F VI 665312 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F VI 665298 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from stu d y 0-70 72 F VI 665207 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-28 H air L oss, Forelim b, B ila te ra l 35-70 Removed from stu d y . 72 F VI 665273 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F VI 665274 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F VI 665272 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F VI 665195 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 -706- ) DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : sex Group Animal F VI 665314 F VI 665316 F VI 665173 In d iv id u a l C lin ic a l O bservations and M o rta lity Records O bservation Days G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0-70 Removed from s tu d y 72 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from s tu d y 72 DuPont-11418 Company Sanitized. Does not contain TSCA C8I - 707- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study:' :ent Sex Group Animal In d iv id u a l C lin ic a l O bservations and M o rta lity Records O bservation Days F V III 665234 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0 -3 5 ,4 2 -9 3 Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P ath , L e ft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 S a c rific e d by design 93 F V I I I 665242 G e n e r a l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 0-35 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 H air L oss, F orelim b, B ila te ra l 56-93 H air L oss, Forepaw, B ila te ra l 42-93 S a c rific e d by design 93 F V I I I 665183 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-35 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin Path, B ila te ra l 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 H air L oss, Forepaw, B ila te ra l 42-56 H a ir L oss, Forepaw, R ight 63-93 F V III 665261 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 93 0 -3 5 ,4 2 -9 3 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 93 S a c rific e d by design 93 F V I I I 665291 G e n e ra l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0 -3 5 ,4 2 -9 3 -708- DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : :em Sex Group Animal F V ili 665291 F V ili 665337 F V ili 665333 F V ili 665200 F V IH 665310 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L eft B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design G e n e ra l' o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design G e n e ra l o b s e r v a t i o n . No A b n o rm a lity D e te c te d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight Ear tw itch , B ila te ra l A rches back during handling S a c rific e d by design Company Sanitized. Does not contain TSCA CBI - 709- Records Days 38 93 93 0 -3 5 ,4 2 -9 3 38 93 93 0 -3 5 ,4 2 -9 3 38 93 93 0 -3 5 ,4 2 -9 3 38 93 93 0-35,4 2 -7 0 ,8 4 -9 3 38 93 77 77 93 DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : DuPont-11418 In d iv id u a l C lin ic a l O bserv atio n s and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F V I I I 665326 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0- 35, 42-93 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L eft 38 Eye O b se rv a tio n s, B led v ia O rb ita l f o r C lin P a th , R ig h t 93 V III 665302 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 93 0, 7 , 14- 21, 28, 35- 49, 56-70 Eye O b se rv a tio n s, E nophthalm us, R ight 154-182 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, B ila te r a l 161 . Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft 108 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 3 , 9 , 2 2 , 3:4 , 5 5 , 7 6 , 8 9 , 9 3 , 9 7 , 1 0 1 , 1 1 5 , 126,140 , 182 Eye O b serv atio n s, C orneal O pacity, R ight 119-182 Eye O b serv atio n s, Dark, R ight 77- 84 , 91:, 98 , 105,112 D isch arg e, Eye r ig h t, B lack 126 V III 665179 S a c rific e d by design G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 182 0, 49, 56-70 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 108 3, 9, 22, 34, 55, 76, 89, 93, 97, 101, 115, 126, 140, 161,182 H a ir L oss, Forepaw, B ila te r a l S ta in F u r/S k in , S h o u ld e r, B i l a t e r a l , Brown 7 , 14- 21-,28, 35-42 77- 84, 91, 98, 105, 112, 119-182 S t a in F u r/S k in , S id e , R ig h t, Brown 126-182 S ta in F u r/S k in , S id e , R ig h t, Red 112,119 Company Sanitized. Does not contain TSCA CBI -710- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : Sex Group Animal F V III 665179 F V III 665287 In d iv id u a l C lin ic a l O bservations and M o rta lity O bservation S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , L e ft Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight F V III 665172 S a c rific e d by design G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, L e ft Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight F V III 665194 H air L oss, Forelirab, B ila te ra l S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv atio n s, Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , L eft B led v ia O rb ita l fo r C lin P ath , R ight F V III F V ili F V ili 665296 665193 665320 S a c rific e d by design G e n e ra l o b s e r v a t i o n . No A b n o rm a lity D e te c te d Removed from stu d y G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Removed from s tu d y G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Company Sanitized. Does not contain TSCA CBI -711 - D u P o n t-1 1418 R ecords Days 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,1 7 5 -1 8 2 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 7 7 -8 4 ,9 1 ,9 8 .1 0 5 ,1 1 2 ,1 1 9 -1 6 8 182 0 ,7 ,1 4 -2 1 ,2 8 ,3 5 -4 9 ,5 6 -7 0 ,7 7 -8 4 , 9 1 .9 8 .1 0 5 .1 1 2 .1 1 9 - 182 108 3 .9 .2 2 .3 4 .5 5 .7 6 .8 9 .9 3 .9 7 .1 0 1 .1 1 5 .1 2 6 .1 4 0 , 161,182 182 0-70 72 0-70 72 0-70 Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y ; em In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b se rv a tio n Days F V III 665320 Removed from stu d y 72 F V I I I 665315 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0 ,1 4 -7 0 Ear tw itch , B ila te ra l 7 Removed from s tu d y 72 F V I I I 665318 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F V I I I 665279 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 F V III 665224 G e n e r a l o b s e r v a t i o n , No A b n o r m a li t y D e t e c t e d Removed from stu d y 0-70 72 F V I I I 665254 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from s tu d y 72 F V I I I 665245 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 F V III 665322 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Removed from s tu d y ' 0-70 72 F V I I I 665214 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-56 H air L oss, F orelim b, L eft 63-70 Removed from stu d y 72 F V III 665321 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d Removed from stu d y 0-70 72 -712- DuPont-11418 Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study ;em Sex 'G roup A nim al F V III 665171 F V III 665265 F V III 665169 F V III 665191 F V III 665231 F V III 665288 F V III 665282 In d iv id u a l C lin ic a l O bservations and M o rta lity R ecords O bservation Days G e n e ra l o b s e r v a t i o n . No A b n o rm a lity D e te c te d 0-70 ' Removed from stu d y 72 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d \ Removed from stu d y 0-70 72 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n . No A b n o r m a li t y D e t e c t e d 0-70 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a li t y D e t e c t e d 0-98 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 S t a in F u r/S k in , F a c e, Brown 105-127 S a c rific e d by design 127 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-70 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , B ila te r a l 127 H air L oss, Forelim b, B ila te ra l 98-127 H air L oss, Forelim b, R ight 77-91 H air L oss, Forepaw, B ila te r a l 77-127 S t a in F u r/S k in , F a c e , Brown 105-127 S a c rific e d by design 127 -713- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : :em In d iv id u a l C lin ic a l O b serv atio n s and M o rta lity R ecords Sex Group Animal O b s e rv a tio n Days F V I I I 665275 G e n e r a l o b s e r v a t i o n , No A b n o rm a lity D e te c te d 0-14 Eye O b se rv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 H air L oss, Forelim b, B ila te ra l 35-127 H air L oss, Forelim b, R ight 21-28 H a ir L oss, Forepaw, B ila te r a l 21-127 H air Loss, Shoulder, L eft 126-127 H air L oss, S houlder, R ight 119 S a c rific e d by design 127 F V III 665229 G e n e ra l o b s e r v a tio n . No A b n o rm a lity D e te c te d 0 -2 8 ,9 1 -1 0 5 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 H yperactive S t a in F u r/S k in , H ead, Brown 35-84 112-127 Ear tw itch , B ila te ra l 35 A rches back du rin g han d lin g 35 S a c rific e d by design 127 F V I I I 665237 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-91 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath, R ight 127 H air L oss, F orelim b, B ila te r a l 98-127 H air L oss, Forepaw, B ila te r a l 119-127 S a c rific e d by design 127 F V I I I 665209 G e n e ra l o b s e r v a tio n , No A b n o rm a lity D e te c te d 0-127 - 714- DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S tu d y : if em In d iv id u a l C lin ic a l O bservations and M o rta lity Records Sex Group Animal O b s e rv a tio n Days F V III 665209 Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 S a c rific e d by design 127 F V I I I 665335 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0-127 Eye O b serv atio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 F V III 665303 S a c rific e d by design G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight 127 0-70 127 H air L oss, Forelim b, B ila te ra l H air L oss, Forepaw, B ila te r a l S t a in F u r/S k in , D o rs a l Body, Brown S a c rific e d by design 77-127 77-127 119-127 127 F V III 665328 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath, R ight M ass S i d e , L e f t , M ass # 1 , N o t U l c e r a t e d , 1 . 0 cm 0-84 127 98-127 M ass S i d e , L e f t , M ass # 1 , N o t U l c e r a t e d , 0 . 5 cm S a c rific e d by design 91 127 F V III 665299 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d Eye O b serv a tio n s, B led v ia O rb ita l fo r C lin P ath , R ight H yperactive 0 -5 6 ,7 0 -1 2 7 127 63 S a c rific e d by design 127 F V I I I 665255 G e n e r a l o b s e r v a t i o n . No A b n o r m a lity D e t e c t e d 0 -2 8,42-72 -715- ) DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gayage Study in Rats with One-Generation Reproduction Evaluations Study Sex Group Animal F V III 665255 F V III 665213 F V III 665280 In d iv id u a l C lin ic a l O bservations and M o rta lity R ecords O bservation Days Ear tw itch . B ila te ra l 35 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-72 Removed from stu d y 72 G e n e r a l o b s e r v a t i o n , No A b n o r m a lity D e t e c t e d 0-72 Removed from stu d y 72 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -716- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX F INDIVIDUAL OPHTHALMOLOGY OBSERVATIONS -717Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Study: [Eyes In d ividual Ophthalmology O bservations Sex Group Animal O bserv atio n MI 665047 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d MI 665049 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665070 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665130 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665076 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665015 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665068 .No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665148 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665016 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d MI 665086 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d MI 665042 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665098 No O p h th a lm o lo g ic a l A b n o rm a litie s D e te c te d MI 665149 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665081 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665159 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d MI 665043 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665064 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d MI 665121 R e tin a , R e tin a l D egeneration Focal , R ight MI 665106 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d MI 665008 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d DuPont-11418 Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 -718Company Sanitized. Does not contain TSCA C8I o. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Study: lyes Sex Group Animal M III 665053 M III 665074 M III 665128 M III 665080 M III 664993 M III 665131 M III 665060 M III 664995 M III 665136 M III 665033 Ind iv id u al Ophthalmology O bservations O b serv atio n No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d DuPont-11418 Days 87 87 87 87 87 87 87 87 87 87 -719Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Study: re s Sex Group Animal MV 665122 MV 665155 MV 665073 MV 665089 MV 665119 MV 665137 MV 665103 MV 665143 MV 665054 MV 665035 Ind iv id u al Ophthalmology O bservations O b serv atio n No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d DuPont-11418 Days 87 87 87 87 87 87 87 87 87 87 -720Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Study: !yes Individual Ophthalmology O bservations Sex Group Animal O bserv atio n M VII 665160 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d M VII 665096 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d M VII 665082 No O p h th a lm o lo g ic a l A b n o r m a l i t i e s D e t e c t e d M VII 665107 No O p h th a lm o lo g ic a l A b n o r m a l i t i e s D e t e c t e d M VII 665152 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d M VII 665120 No O p h th a lm o lo g ic a l A b n o r m a litie s D e te c te d M VII 664999 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d M VII 665026 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d M VII 665162 No O p h th a lm o lo g ic a l A b n o r m a litie s D e te c te d M VII 665027 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d M VII 665158 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d M VII 665002 No O p h th a lm o lo g ic al A b n o rm a litie s D e te c te d M VII 665067 No O p h th a lm o lo g ic al A b n o rm a litie s D e te c te d M VII 665095 No O p h th a lm o lo g ic a l A b n o rm a litie s D e te c te d M VII 665031 No O p h th a lm o lo g ic a l A b n o rm a litie s D e te c te d M VII 665146 No O p h t h a lm o l o g ic a l A b n o r m a l i t i e s D e t e c t e d M VII 665062 No O p h t h a lm o l o g ic a l A b n o r m a l i t i e s D e t e c t e d M VII 665138 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d M VII 665112 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d M VII 665007 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d DuPont-11418 Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 -721 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations S t u d y :| yes Individual Ophthalmology O bservations Sex Group Animal O bservation F XI 665211 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665271 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665178 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665317 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665230 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665225 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665174 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665319 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665221 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665278 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 655201 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665197 R e tin a , R e tin a l D egeneration F o c a l, L e ft F II 665256 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665323 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665276 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665228 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665260 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F ' II 665189 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F II 665204 No O p h t h a l m o l o g i c a l - A b n o r m a l i t i e s D e t e c t e d F II 665327 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d DuPont-11418 Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 -722Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Study, yes Individual Ophthalmology O bservations Sex Group Animal O b serv a tio n F IV 665308 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F IV 665215 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F IV 665277 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d F IV 665241 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F IV 665236 No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d F IV 665324 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F IV 665332 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F IV 665239 No O p h t h a lm o l o g ic a l A b n o r m a l i t i e s D e t e c t e d F IV 665182' No O p h t h a lm o l o g ic a l A b n o r m a li t ie s D e t e c t e d F IV 665268 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d D u P o n t-11418 Days 87 87 87 87 87 87 87 87 87 87 -723 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Study Eyes Sex Group Animal F VT 665295 F VI 665251 F VI 665300 F VI 665340 F VT 665259 F VI 665341 F VI 665199 F VI 665238 F VI 665250 F VI 665170 Ind iv id u al Ophthalmology O bservations O b serv atio n No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d DuPont-11418 Days 87 87 87 87 87 87 87 87 87 87 -724Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Study: [Eyes In d iv id u al Ophthalmology O bservations Sex Group Animal O bserv atio n F V I I I 665234 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665242 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665183 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665261 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665291 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665337 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665333 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665200 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665310 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665326 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 6652B8 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665282 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665275 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 565229 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665237 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665209 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665335 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665303 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665328 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d F V I I I 665299 No O p h t h a l m o l o g i c a l A b n o r m a l i t i e s D e t e c t e d DuPont-11418 Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 . 87 -725 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 NANCY M. BROMBERG, VMD, MS, DACVO EYE CLINIC FOR ANIMALS 6119 MASSACHUSETTS AVE BETHESDA, MD 20816 STUDY INFORMATION: Study N( H # 25425 Species: Rat Study Director: SUE MACKENZIE OPHTHALMOLOGICAL EXAMINATION SUMMARY Examination Date: January 10,2003 METHODS: Indirect Ophthalmoscopy following 1% Tropicamide m ydriasis Sex G roup# A nim al# Observation M ale I 665121 Focal retinal degeneration OD Fem ale II 605197 Focal retinal degeneration OS CO M M EN TS/D ISCU SSIO N: Two (2) animals, one m ale and one fem ale, were identified w ith an area o f retinal degeneration in one eye. As both animals were in the control group, these findings are considered inconsequential. No compound-related abnormalities were identified, -726Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 APPENDIX G INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH -727Company Sanitized. Does not contain TSCA CBI Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb G rip S tren g th Animal Number F o re lim b G rip S t r e n g th (kg) Mean of T rial 1 T rial 2 T rial 3 3 T rials M a le , G r o u p I - 0 m g / k g / d a y - BASELINE H indlim b G rip S t r e n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 0.56 0.74 0.47 0.61 0.60 0.51 0.76 0.57 0.60 0.62 0.41 0.62 0.52 0.69 0.63 0.44 0.66 0.57 0.73 0.57 0.56 0.66 0.61 0.67 0.48 0.68 0.71 0.59 0.76 0.69 M a le, G roup I I I - 10 m g / k g / d a y - BASELINE 0.51 0.67 0.53 0.66 0.57 0.54 0.71 0.58 0.70 0.63 0.43 0.30 0.27 0.40 0.49 0.37 0.27 0.40 0.41 0.43 0.31 0.33 0.29 0.42 0.55 0.42 0.27 0.35 0.55 0.31 0.36 0.38 0.25 0.44 0.42 0.42 0.37 0.39 0.43 0.37 0.37 0.34 0.27 0.42 0.49 0.40 0.30 0.38 0.46 0.37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 0.49 0.52 0.59 0.66 0.62 0.63 0.51 0.59 0.60 0.65 0.58 0.66 0.62 0.75 0.50 0.76 0.60 0.59 0.48 0.76 0.56 0.80 0.68 0.75 0.47 0.78 0.61 0.51 0.64 0.56 M a l e , G ro u p V - 100 m g / k g / d a y - BASELINE 0.54 0.66 0.63 0.72 0.53 0.72 0.57 0.56 0.57 0.66 0.31 0.37 0.32 0.43 0.34 0.42 0.33 0.30 0.46 0.43 0.43 0.39 0.39 0.36 0.32 0.37 0.43 0-27 0.46 0.50 0.36 0.41 0.30 0.41 0.45 0.43 0.37 0.20 0.37 0.44 0.37 0.39 0.34 0.40 0.37 0.41 0.38 0.26 0.43 0.46 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 0.64 0.72 0.63 0.69 0.63 0.78 0.53 0.52 0.63 0.47 0.62 0.70 0.65 0.70 0.76 0.73 0.68 0.64 0.50 0.41 0.72 0.71 0.56 0.69 0.70 0.78 0.71 0.51 0.63 0.53 0.66 0.71 0.61 0.69 0.70 0.76 0.64 0.56 0.59 0.47 0.23 0.32 0.43 0.40 0.39 0.27 0.32 0.38 0.23 0.33 0.28 0.34 0.32 0.50 0.31 0.24 0.34 0.34 0.23 0.37 0.27 0.32 0.31 0.57 0.27 0.28 0.32 0.36 0.27 0.37 0.26 0.33 0.35 0.49 0.32 0.26 0.33 0.36 0.24 0.36 -728- DuPont-11418 )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb Grip S tren g th Animal Number F orelim b G rip S tre n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials M a le , G ro u p V I I - 1000 m g / k g / d a y - BASELINE T rial H indlim b G rip S tr e n g th (kg) T rial 2 T rial 3 Mean o f 3 T rials 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 0.53 0.73 0.67 0.37 0.61 0.51 0.44 0.58 0.47 0.53 0.59 0.61 0.53 0.39 0.57 0.67 0.56 0.62 0.55 0.58 0.62 0.65 0.55 0.34 0.58 0.63 0.70 0.53 0.63 0.59 0.58 0.66 0.58 0.37 0.59 0.60 0.57 0.58 0.55 0.57 0.41 0.44 0.44 0.25 0.49 0.32 0.45 0.36 0.35 0.32 0.38 0.33 0.42 0.28 0.42 0.43 0.44 0.34 0.28 0.29 0.46 0.42 0.36 0.23 0.43 0.28 0.40 0.42 0.34 0.28 0.42 0.40 0.41 0.25 0.45 0.34 0.43 0.37 0.32 0.30 DuPont-11418 Company Sanitized. Does not contain TSCA CBI 729 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb G rip S tren g th Animal Number F o re lim b G rip S t r e n g th (kg) Mean o f T rial 1 T rial 2 T rial 3 3 T rials M ale, G roup I - 0 m g /k g / d a y - Week 13 H indlim b G rip S tr e n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 1.87 1.36 1.96 1.40 1.10 1.00 1.81 1.21 2.14 1.30 1.56 1.29 2.18 1.30 1.58 1.42 1.69 1.29 2.30 1.78 1.36 1.26 0.90 1.40 0.82 0.99 1.83 1.94 2.21 2.00 M ale, Group I I I - 10 m g /k g /d a y - Week 13 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 1.58 1.10 1.45 0.71 0.85 1.70 2.48 1.71 1.14 1.65 1.45 1.11 1.50 1.98 1.35 2.20 2.10 1.88 1.51 1.70 1.39 1.37 1.61 2.03 1.47 2.56 2.43 1.53 1.96 1.79 M ale, Group V - 100 m g /k g /d a y - Week 13 1.60 1.30 1.68 1.37 1.17 1.14 1.78 1.48 2.22 1.69 1.47 1.19 1.52 1.57 1.22 2.15 2.34 1.71 1.54 1.71 0.77 0.75 0.62 0.72 0.78 0.75 0.74 0.79 0.61 0.76 1.10 0.55 0.60 0.95 0.82 0.96 0.66 0.65 0.79 1.17 0.86 0.66 0.51 0.79 0.89 0.77 0.68 0.60 0.78 0.88 0.78 0.78 0.90 0.82 0.61 0.76 0.78 0.81 0.53 1.12 0.60 0.79 0.50 0.78 0.88 0.56 0.76 0.80 1.00 0.77 0.85 0.95 0.68 0.84 0.65 0.93 0.61 0.72 0.73 1.15 0.74 0.73 0.54 0.76 0.85 0.69 0.73 0.73 0.80 0.80 0.91 0.76 0.73 0.87 0.69 0.88 0.68 0.73 0.68 1.15 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 0.81 1.66 1.01 1.40 1.40 2.41 1.67 1.63 0.82 1.44 0.90 1.66 1.39 1.62 1.46 2.61 1.96 1.75 1.16 1.53 0.71 1.90 1.48 1.72 1.74 1.87 1.71 1.69 1.47 1.52 0.81 1.74 1.29 1.58 1.53 2.30 1.78 1.69 1.15 1.50 0.51 0.59 0.86 0.59 1.03 0.50 0.70 1.12 0.61 0.83 0.69 0.51 0.60 0.59 0.77 0.68 0.65 0.84 0.57 0.85 0.50 0.41 1.00 0.95 1.32 0.80 0.92 0.86 0.66 0.96 0.57 0.50 0.82 0.71 1.04 0.66 0.76 0.94 0.61 0.88 -730- D u P o n t-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u a l Forelim b and Hindlimb G rip S trength Animal Number F o re lim b G rip S tr e n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials M a le , G ro u p V I I - 1000 m g / k g / d a y - Week 13 H indlim b G rip S tr e n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 1.09 1.47 1.47 1.44 1.47 1.46 1.14 1.51 1.60 1.41 1.45 1.44 1.77 1.54 1.67 1.3.4 1.16 1.71 1.55 1-00 2.14 1.60 1.35 1.39 1.79 1.78 1.19 1.30 1.68 1.64 1.56 1.50 1.53 1.46 1.64 1.53 1.16 1.51 1.61 1.35 0.76 0.76 0.78 0.51 0.69 0.61 0.82 0.63 0.68 0.56 0.71 0.68 0.60 0.47 0.77 0.55 0.68 0.87 0.95 0.94 0.77 0.88 0.83 0.64 0.56 0.69 0.60 0.91 0.92 0.52 0.75 0.77 0.74 0.54 0.67 0.62 0.70 0.80 0.85 0.67 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -731 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb G rip S trength Animal Number F o re lim b G rip S t r e n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials Male, Group I - 0 m g/kg/day - Recovery H indlim b G rip S t r e n g th (kg) Mean o f T rial 1 T rial 2 T rial 3 3 T rials 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 1.60 1.34 1.45 2.11 1.17 1.40 1.95 1.62 2.30 1.66 1.50 1.10 1.47 1.89 1.36 1.09 2.10 1.98 2.42 1.78 2.01 1.43 1.25 1.20 1.43 1.03 1.88 1.76 2.20 1.59 Male, Group V II - 1000 m g/kg/day - Recovery 1.70 1.29 1.39 1.73 1.32 1.17 1.98 1.79 2.31 1.68 0.77 0.64 0.50 0.70 0.52 0.46 0.81 0.87 0.71 0.68 0.64 0.56 0.45 0.60 0.72 0.42 0.75 0.81 1.00 0.73 0.82 0.56 0.61 0.80 0.71 0.43 0.76 0.84 0.86 0.78 0.74 0.59 0.52 0.70 0.65 0.44 0.77 0.84 0.86 0.73 665002 665007 665031 665062 665067 665095 665138 665146 665146 665158 2.00 2.10 1.40 1.62 1.85 1.04 1.08 1.03 1.37 1.24 2.01 1.97 1.43 1.61 1.91 1.17 1.18 0.83 1.20 0.84 2.09 1.80 1.50 1.14 1.56 0.96 0.90 0.84 1.07 1.30 2.03 1.96 1.44 1.46 1.77 1.06 1.05 0.90 1.21 1.13 0.95 0.59 0.63 0.51 0.51 0.65 0.70 0.62 0.42 0.46 0.82 0.69 0.52 0.59 0.61 0.71 0.59 0.61 0.43 0.52 0.71 0.69 0.57 0.65 0.63 0.60 0.61 0.67 0.60 0.75 0.83 0.66 0.57 0.58 0.58 0.65 0.63 0.63 0.48 0.58 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -732- Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb G rip S tren g th Animal Number Forelim b G rip S tre n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials F e m a l e , G ro u p I I - 0 m g / k g / d a y - BASELINE H indlim b G rip S tre n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 0,.61 0,.36 0 .53 0 .40 0 .37 0 .31 0 .42 0 .36 0..45 0 .46 0..65 0..39 0,.52 0..42 0..41 0..31 0..50 0..47 0..48 Q.. 4 3 0..52 0..36 0..64 0..42 0..37 0..37 0..50 0..50 0..59 0..56 n a l e , G ro u p IV - 10 m g / k g / d a y - BASELINE 0..59 0..37 0..56 0..41 0..38 0..33 0..47 0..44 0..51 0..48 0..33 0..38 0..36 0..22 0..28 0..37 0..32 0..32 0..41 0..35 0..32 0..32 0..32 0..29 0..29 0..37 0..40 0..32 0..31 0..36 0..39 0..36 0..33 0..35 0..31 0..41 0..42 0,.41 0..41 0..33 0..35 0..35 0,. 3 4 0,.29 0.. 29 0,.38 o ,.38 0,.35 0-. 3 8 0,.35 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 0 .49 0 .41 0,.34 0,.38 0,. 4 7 0..51 0..57 0,.24 0,.40 0,.46 0..57 0..40 0..48 0..51 0,.52 0..45 0..50 0..60 0..42 0..52 0..47 0..57 0..43 0..31 0..43 0..58 0..40 0,.61 0..32 0..59 F e m a l e , G ro u p VI - 100 m g / k g / d a y - BASELINE 0..51 0..46 0..42 0..40 0,.47 0..51 0,.49 0..48 0..38 0..52 0,.27 0..30 0,.29 0 .26 0 .30 0 .32 0..32 0..37 0..32 0..50 0..25 0..27 0..25 0 .27 0,.37 0,.38 0..28 0..43 0..44 0..46 0,.20 0..37 0..28 0..36 0..46 0..36 0,.44 0..38 0..30 0..43 0,.24 0,. 31 0..27 0..30 0..38 0..35 0,.35 0,.39 0..35 0..46 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 0.23 0.48 0.53 0.68 0.36 0.34 0.73 0.56 0.40 0.54 0.27 0.37 0.41 0.63 0.30 0.56 0.81 0.47 0.26 0.53 0.28 0.32 0.37 0.57 0.28 0.66 0.71 0.39 0.41 0.63 0.26 0.39 0.44 0.63 0.31 0.52 0.75 0.47 0.36 0.57 0.25 0.26 0.36 0.27 0.32 0.35 0.34 0.31 0.24 0.33 0.22 0.26 0.32 0.27 0.38 0.38 0.41 0.30 0.27 0.28 0.25 0.26 0.43 0.29 0.48 0.34 0.47 0.43 0.25 0.37 0.24 0.26 0.37 0.28 0.39 0.36 0.41 0.35 0.25 0.33 -733- ) DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb Grip S trength Animal Number T rial Female, Group V III F o re lim b G rip S t r e n g th (kg) T rial 2 T rial 3 Mean o f 3 T rials 1000 m g / k g / d a y - BASELINE H indlim b G rip S tre n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 0.41 0.32 0.47 0.43 0.41 0.59 0.42 0.54 0.41 0.71 0.53 0.39 0.36 0.43 0.44 0.59 0.56 0.50 0.50 0.. 64 0.53 0.51 0.42 0.45 0.50 0.41 0.52 0.52 0.67 0.61 0.49 0.41 0.42 0.44 0.45 0.53 0.50 0.52 0.53 0.65 0.45 0.38 0.23 0.28 0.36 0.41 0.30 0.40 0.28 0.27 0.43 0.28 0.21 0.26 0.36 0.47 0.27 0.36 0.38 0.37 0.42 0.36 0.26 0.32 0.56 0.51 0.20 0.30 0.32 0.28 0.43 0.34 0.23 0.29 0.43 0.46 0.26 0.35 0.33 0.31 DuPont-11418 Company Sanitized. Does not contain TSCA CBI 734 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________ In d iv id u al Forelim b and Hindlimb Grip S tren g th Animal Number F o re lim b G rip S tr e n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials m a l e , Group I I - 0 m g /k g / d a y - Week 13 H indlim b G rip S tre n g th (kg) Mean o f T rial 1 T rial 2 T rial 3 3 T rials 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 0.98 1.53 0.86 1.12 1.30 1.10 0.90 1.12 1.51 0.60 1.22 1.88 1.28 1.40 1.37 1.61 0.81 1.24 1.05 Q.87 1.27 1.75 0.94 1.18 1.42 0.96 0.80 1.39 1.13 0.71 F e m a le , G roup IV - 10 m g /k g / d a y - Week 13 1.16 1.72 1.03 1.23 1.36 1.22 0.84 1.25 1.23 0.73 0.59 0.69 0.72 0.66 0.48 0.73 0.62 0.55 0.72 0.70 0.75 0.55 0.86 0.51 0.61 0.65 0.68 0.60 0.48 0.67 0.53 0.65 0.91 0.62 0.46 0.74 0.57 0.69 0.64 0.77 0.62 0.63 0.83 0.60 0.52 0.71 0.62 0.61 0.61 0.71 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 0.76 0.58 1.27 0.84 0.90 0.80 1.37 0.62 0.77 1.05 1.00 0.91 0.90 1.25 1.39 1.13 1.36 0.57 1.29 1.18 0.84 0.83 1.16 1.03 1.18 1.30 1.03 0.56 0.67 1.39 F e m ale , Group VI - 100 m g /k g / d a y - Week 13 0.87 0.77 1.11 1.04 1.12 1.08 1.25 0.58 0.91 1.21 0.40 0.50 0.64 0.76 0.56 0.68 0.71 0.60 0.61 0.78 0.42 0.73 0.66 0.77 0.68 0.72 0.75 0.65 0.66 0.89 0.50 0.60 0.69 0.67 0.75 0.61 0.61 0.50 0.67 0.87 0.44 0.61 0.66 0.73 0.66 0.67 0.69 0.58 0.65 0.85 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 1.00 1.38 1.65 1.16 1.00 0.72 1.80 1.25 1.10 1.23 0.83 0.96 1.73 1.16 0.77 1.12 1.61 1.65 1.18 1.41 0.71 1.23 1.63 1.34 1.32 0.73 1.83 1.25 1.00 1.30 0.85 1.19 1.67 1.22 1.03 0.86 1.75 1.38 1.09 1.31 0.42 0.53 0.53 0.43 0.56 0.62 0.78 0.59 0.56 0.67 0.60 0.61 0.54 0.55 0.62 0.68 0.78 0.61 0.45 0.67 0.56 0.49 0.72 0.68 0.50 0.52 0.88 0.57 0.68 0.77 0.53 0.54 0.60 0.55 0.56 0.61 0.81 0.59 0.56 0.70 -735- D u P o n t-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb G rip S tren g th Animal Number T rial Female, Group V III F orelim b G rip S tre n g th (kg) T rial 2 T rial 3 Mean o f 3 T rials 1000 m g /k g /d a y - Week 13 H indlim b G rip S tre n g th (kg) T rial 1 T rial T rial 3 Mean o f 3 T rials 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 1.25 1.25 0.99 0.58 0.94 0.80 0.68 1.21 0.81 1.54 1.50 1.46 1.11 0.44 1.13 0.79 1.33 1.38 1.33 1.58 1.60 1.49 1.25 0.76 1.38 0.68 1.44 1.47 1.14 1.60 1.45 1.40 1.12 0.59 1.15 0.76 1.15 1.35 1.09 1.57 0.58 0.80 0.51 0.43 0.71 0.70 0.75 0.62 0.42 0.60 0.61 0.77 0.51 0.78 0.60 0.69 0.74 0.56 0.57 0.47 0.51 1.00 0.50 0.42 0.69 0.76 0.52 0.71 0.62 0.74 0.57 0.86 0.51 0.54 0.67 0.72 0.67 0.63 0.54 0.60 DuPont-11418 Company Sanitized. Does not contain TSCA CBI 736 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u al Forelim b and Hindlimb G rip S tren g th Animal Number F orelim b G rip S tre n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials Female, Group I I - 0 m g/kg/day - Recovery H indlim b G rip S tre n g th (kg) T rial 1 T rial 2 T rial 3 Mean o f 3 T rials 665256 665323 665327 665189 665197 665201 665204 665228 665260 665276 1.26 0.62 0.55 1.39 1.11 0.74 1.01 0.69 1.05 0.73 1.46 1.01 0.46 1.32 1.07 0.97 1.17 0.70 1.20 0.61 1.45 0.71 0.65 1.16 1.34 0.94 1.04 0.81 1.15 0.60 Female, Group V III - 1000 m g/kg/day - Recovery 1.39 0.78 0.55 1.29 1.17 0.88 1.07 0.73 1.13 0.65 0.68 0.47 0.64 0.77 0.54 0.82 0.54 0.41 0.67 0.68 0.74 0.56 0.63 0.70 0.64 0.63 0.60 0.48 0.77 0.54 0.60 0.63 0.54 0.65 0.65 0.87 0.69 0.43 0.72 0.68 0.67 0.55 0.60 0.71 0.61 0.77 0.61 0.44 0.72 0.63 665209 obb^y 665237 665275 665282 665288 665299 665303 665328 665335 1.42 1.01 0.75 0.34 1.01 0.81 1.00 1.89 1.13 1.17 0.97 1.14 0.43 0.47 0.85 1.03 1.22 1.80 1.30 1.02 0.98 1.12 0.73 0.36 1.20 1.03 1.15 1.67 1.47 1.20 1.12 1.09 0.64 0.39 1.02 0.96 1.12 1.79 1.30 1.13 0.57 0.93 0.55 0.45 0.73 0.87 0.61 0.50 0.48 0.51 0.57 0.99 0.46 0.50 0.77 0.62 0.68 0.51 0.48 0.31 0.73 0.78 0.53 0.47 0.72 0.61 0.62 0.73 0.37 0.67 0.62 0.90 0.51 0.47 0.74 0.70 0.64 0.58 0.44 0.50 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI 737 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 APPENDIX H INDIVIDUAL SENSORY MOTOR FUNCTION OBSERVATIONS -738 Company Sanitized- Does not contain TSCA CBi H-25425: Subchrorc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 INDIVIDUAL SENSORY MOTOR FUNCTION OBSERVATIONS EXPLANATORY NOTES INDIVIDUAL SENSORY MOTOR FUNCION SCORING SYSTEM M a n ip u la tio n s in Open F ie ld A rea (Free-R oam ing S p a c e ): APPROACH & TOUCH: -1 = no r e a c t i o n 0 = normal 1 = in c re a se d re a c tio n (jumps away o r a tta c k s) AUDITORY STIMULUS: -1 = no re a c tio n 0 = normal re a c tio n (ra t flin c h e s or f lic k s ear) 1 = exaggerated re ac tio n (ra t jumps, flip s) TAIL PINCH: -1 = 0 ss 1- no response normal (turns toward s ite ) exaggerated response (vocalizations, rap id turning) M otor A c t iv it y M o n ito r: PUPILLARY RESPONSE: 0 = present 1 = absent DEFECATION: 0 ss a b s e n t 1 = present URINATION: 0 = absent 1 - present -739Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Sensory Motor Function Observations Male Rats/Group I: 0 mg/kg/day - Baseline MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 APPROACH& AUDITORY TOUCH STIMULUS 00 00 00 00 00 00 00 00 00 00 TAIL PINCH 0 0 0 0 0 0 0 0 0 0 PUPILLARY RESPONSE DEFECATION URINATION 0 10 001 000 0 11 0 11 001 0 11 0 00 0 10 001 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -740- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Male Rats/Group III: 10 mg/kg/day - Baseline Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 APPROACH & AUDITORY TOUCH ' STIMULUS 00 00 00 00 00 00 00 00 00 00 TAEL PINCH 0 0 0 0 0 0 0 0 0 0 PUPILLARY RESPONSE DEFECATION URINATION 0 00 0 00 001 0 11 0 11 001 001 001 0 11 0 11 D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -741- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Male Rats/Group V: 100mg/kg/day - Baseline Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 APPROACH & AUDITORY TOUCH STIMULUS 00 00 00 00 00 00 00 00 00 00 TAIL PINCH 0 0 0 0 0 0 0 0 0 0 PUPILLARY RESPONSE DEFECATION URINATION 0 11 001 0 11 000 0 11 001 0 11 00 1 0 11 0 11 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -742- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Male Rats/Group VII: 1000 mg/kg/day - Baseline Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 APPROACH & AUDITORY TOUCH STIMULUS 0. 0 00 00 00 00 00 00 00 00 00 TAIL PINCH 0 0 0 0 0 0 0 0 0 0 PUPILLARY RESPONSE DEFECATION URINATION 0 11 0 11 000 0 11 0 11 000 0 10 0 10 0 10 0 11 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -743- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Male Rats/Group I: 0 mg/kg/day - Week 13 Individual Sensory Motor Function Observations 'MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 APPROACH & AUDITORY TOUCH STIMULUS 00 00 00 00 00 00 00 00 00 00 TAIL PINCH 0 0 0 0 0 0 0 0 0 0 PUPILLARY RESPONSE DEFECATION URINATION 00 1 00 1 0 11 0 11 00 1 0 10 00 1 00 1 0 11 00 1 DuPont-11418 Company Sanitized. Does not contain TSCA CBl -744- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Male Rats/Group III: 10 mg/kg/day - Week 13 Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 APPROACH & AUDITORY TOUCH STIMULUS 00 00 00 00 00 00 00 00 00 00 TAIL PINCH 0 0 0 0 0 0 0 1 0 0 PUPILLARY RESPONSE DEFECATION URINATION 00 1 00 1 0 11 0 11 0 11 00 1 00 1 00 1 0 11 0 11 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -745- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Male Rats/Group V: 100mg/kg/day - Week 13 Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 APPROACH & ' AUDITORY TOUCH STIMULUS 00 00 00 00 00 00 00 00 00 00 TAIL PINCH PUPILLARY RESPONSE DEFECATION URINATION 0000 00 11 00 11 00 11 00 11 00 11 000 1 00 11 0001 00 11 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -746- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Male Rats/Group VII: 1000 mg/kg/day - Week 13 Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 APPROACH & AUDITORY TOUCH STIMULUS 0 0 0 0 0 0 0 0 0 0' 0 0 0 0 0 0 0 0 0 0 TAIL PINCH 0 0 0 0 0 0 0 0 0 0 PUPILLARY RESPONSE DEFECATION URINATION 00 1 001 0 11 00 1 0 11 001 000 00 1 0 11 0 11 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -747- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Sensory Motor Function Observations Male Rats/Group I: 0 mg/kg/day - Recovery MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665008 665042 665043 665064 665098 665106 665121 665159 665081 665149 a APPROACH & AUDITORY TOUCH STIMULUS 0 0, 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TAEL PINCH PUPILLARY RESPONSE DEFECATION URINATION 00 11 00 11 0 00 0 0000 0011 10 11 000 1 0 000 00 11 000 1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI 0Vocalization during handling -748- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________ ) DuPont-11418 individual Sensory Motor Function Observations Male Rats/Group VII: 1000 mg/kg/jlay - Recovery MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAEL PINCH RESPONSE DEFECATION URINATION 00 00 11 00000 1 0000 11 0000 11 0000 11 000000 0000 11 0 0 10 0 1 00 10 0 1 0 0 0 0 10 Company Sanitized. Does not contain TSCA CBl - 749- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female Rats/Group II: Omg/kg/day - Baseline Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 APPROACH & AUDITORY TOUCH STIMULUS 00 00 00 00 00 00 00 00 00 00 TAIL PINCH PUPILLARY RESPONSE DEFECATION URINATION 000 1 00 11 00 11 00 11 00 11 00 00 00 11 0 0 10 00 11 00 11 D u P o n t-11418 Company Sanitized. Does not contain TSCA O CO H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female Rats/Group IV: 10 mg/kg/day - Baseline Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 000000 00000 1 0000 11 00 0 0 10 0 00 0 00 0000 11 000000 0000 11 0000 11 0000 0 1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -751- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female Rats/Group VI: 100 mg/kg/day - Baseline Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 0000 11 0 00 0 10 0000 11 0000 11 00000 1 00000 1 00000 1 0000 11 0 00 0 0 0 0000 11 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -752- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Sensory Motor Function Observations Female Rats/Group VIII: 1000 mg/kg/day - Baseline MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 0 00 0 10 0000 11 000000 00000 1 0000 11 0 00 0 10 00000 1 0 0 0 0 10 0000 11 0 *0 0 0 10 D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -753 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female Rats/Group II: 0 mg/kg/day - Week 13 Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 00000 1 0000 I 1 00000 1 0000 11 00000 1 0000 11 000000 0000 11 00000 1 0 10 0 1 1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -754- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female Rats/Group IV: 10 mg/kg/day - Week 13 Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 00000 1 0000 11 0000 11 0000 11 000 0 11 00000 1 0000 11 00000 1 0000 11 00000 1 D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -755- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female Rats/Group VI: 100 mg/kg/day - Week 13 Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 0 10 0 11 000 0 11 0000 11 000000 00000 1 0000 11 0000 11 0000 11 0000 11 0000 11 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -756- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Sensory Motor Function Observations Female Rats/Group VIII: 1000 mg/kg/day - Week 13 MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 665209 0 0 0 0 1 1 665229 0 0 0 0 1 1 665237 0 0 0 0 1 1 665275 0 0 0 0 1 1 665282 0 0 0 0 1 .1 665288 0 0 0 0 1 1 665299 0 0 0 0 1 1 665303 0 0 0 0 0 1 665328 0 0 0 0 0 0 665335 a 0 0 0 0 1 1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI a Circling clockwise. -757- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female Rats/Group II: 0 mg/kg/day - Recovery Individual Sensory Motor Function Observations MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665256 665323 665327 665189 665197 665201 665204 665228 665260 665276 APPROACH & AUDITORY PUPILLARY TOUCH STIMULUS TAIL PINCH RESPONSE DEFECATION URINATION 000000 0 00 0 10 0000 11 00000 1 0000 11 0 00 0 0 0 0 00 0 0 0 0000 11 0000 11 0 0 0 0 1 1 D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -758- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Sensory Motor Function Observations Female Rats/Group VIII: 1000 mg/kg/day - Recovery MANIPULATIONS MOTOR ACTIVITY ANIMAL NUMBER 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 a b APPROACH & AUDITORY TOUCH STIMULUS 00 00 00 01 00 00 00 00 00 00 TAIL PINCH 0 0 0 0 0 0 0 1 0 0 PUPILLARY RESPONSE DEFECATION URINATION 0 11 0 11 00 1 000 0 11 0 11 0 11 0 11 000 000 DuPont-11418 Company Sanitized. Does not contain TSCA CBI a Mass, subcutaneous, left side. bCircling clockwise -759- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 APPENDIX I INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENT -760Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _________________ DuPont-11418 I n d iv id u a l M otor A c tiv ity : D u ra tio n o f Movement (se c) Anim al Number S u ccessiv e 10-M inute I n te r v a ls 12345 M a le , G roup I - 0 m g /k g /d a y - :BASELINE 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 432 235 358 296 425 257 374 214 353 168 363 259 412 269 370 244 399 286 420 344 7 262 81 201 85 182 33 62 176 285 8 8 7 117 113 0 1 1 1 99 29 1 1 40 0 1 0 13 18 0 M a le , G ro u p I I I - 10 m g /k g /d a y - BASELINE 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 379 108 2 1 3 455 298 299 173 48 439 333 37 1 28 427 254 270 84 6 446 381 263 323 229 473 414 113 1 1 436 294 34 2 1 470 377 268 75 24 368 252 242 188 4 369 300 153 237 50 M a le , G ro u p V - 100 m g /k g /d a y - BASELINE 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 394 273 204 3 10 353 239 132 1 0 463 382 215 150 6 382 188 0 9 0 415 363 323 155 10 332 141 5 0 0 452 421 353 241 342 393 266 251 63 1 484 379 218 21 1 375 310 271 305 153 M a le , G ro u p V I I - 1000 m g /k g /d a y - BASELINE 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 384 323 284 144 6 437 354 237 63 0 432 324 267 154 1 402 316 336 243 115 415 274 159 1 0 433 179 0 11 1 436 324 3 2 11 404 323 269 62 13 424 303 195 273 257 432 404 194 45 1 6 6 0 21 1 0 0 3 '4 10 1 1 3 3 18 229 2 1 3 5 0 6 10 10 1 6 0 22 11 0 16 16 4 0 0 2 8 7 2 130 0 T o tal 717 925 792 947 719 805 718 694 890 1149 494 1276 841 1059 1871 1004 768 1217 1059 1109 890 735 1226 580 1272 478 1831 985 1103 1430 1157 1095 1178 1412 851 632 783 1073 1582 1076 -761 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 I n d iv id u a l M otor A c tiv ity : D u ra tio n o f Movement (sec) Anim al Number S u ccessiv e 10-M inute I n te r v a ls 123 4 5 M a le, G roup I - 0 m g /k g /d a y - Week 13 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 426 388 237 293 298 320 302 269 239 206 405 275 147 285 173 396 234 229 123 186 355 245 232 229 169 450 315 188 279 92 386 340 175 245 147 373 321 275 273 272 388 397 345 324 314 372 313 250 365 265 M ale, G roup I I I - 1 0 m g /k g /d a y - Week 13 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 442 366 193 246 118 394 272 288 160 114 424 279 272 336 154 353 316 249 250 120 446 332 230 209 272 484 404 370 364 264 466 428 408 374 218 421 365 336 323 199 359 381 291 239 248 376 317 280 222 148 M a le , G roup V - 100 m g /k g /d a y - Week 13 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 382 283 348 265 297 366 240 226 181 215 385 261 201 235 205 393 341 316 286 249 475 326 219 283 141 321 240 283 242 203 313 317 276 190 300 415 241 228 227 229 484 425 408 445 359 336 169 218 140 151 M a le , G ro u p V II - 1000 m g /k g /d a y - Week 13 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 378 304 302 221 242 420 343 269 289 224 403 406 307 282 240 489 443 298 355 330 437 380 361 352 255 418 393 356 271 253 444 407 377 313 213 441 407 366 304 221 335 227 207 246 236 430 277 366 325 232 6 156 207 198 25 166 10 108 48 186 33 144 85 45 145 160 366 157 279 169 181 155 370 199 236 166 117 191 70 389 131 106 207 293 274 285 320 41 235 177 210 T o tal 1798 1543 1483 1193 1396 1334 1401 1562 1954 1598 1509 1313 1510 1433 1649 2252 2051 1923 1687 1524 1730 1598 1486 1821 1610 1406 1587 1410 2510 1145 1553 1752 1931 2189 2070 2011 1795 1974 1428 1840 -762Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 I n d iv id u a l M otor A c tiv ity : D u ra tio n o f Movement (sec) Animal S uccessive 10-M inute In te rv a ls Number 1 2 3 4 5 6 Group I - 0 m g/kg/day - R ecovery 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 449 291 249 219 203 113 397 309 224 310 251 211 276 141 185 156 173 93 414 278 136 164 18 152 305 260 237 224 206 154 418 371 291 351 143 237 442 239 262 232 163 207 376 212 280 233 197 211 444 325 197 285 223 215 251 196 196 159 125 142 !, G roup V I I - 1000 m g /k g /d a y - R e c o v e ry 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 396 273 187 54 159 111 443 390 328 305 258 27 274 276 130 154 35 67 440 274 249 263 276 252 435 316 297 235 340 261 469 380 317 315 280 288 381 270 265 296 3 121 527 453 335 235 7 29 478 334 300 328 239 121 309 240 185 171 157 115 T o tal 1524 1702 1024 1162 1386 1811 1545 1509 1689 1069 1180 1751 936 1754 1884 2049 1336 1586 1800 1177 -763 Company Sanitized. Does not contain TSC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _________________ DuPont-11418 In d iv id u a l M otor A c tiv ity : D u ra tio n o f Movement (sec) Anim al Number S u ccessiv e 10-M inute I n te r v a ls 123456 T o tal F e m a le , G roup I I - 0 m g /k g /d a y - BASELINE 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 420 283 70 0 0 135 908 422 342 360 381 118 5 1628 391 265 223 115 64 7 1065 383 334 245 200 231 149 1542 419 268 129 12 200 321 1349 332 83 0 36 0 0 451 397 301 274 198 135 87 1392 382 333 324 385 249 377 2050 416 377 314 309 169 0 1585 355 242 221 271 166 204 1459 F e m a le , G roup IV - 10 m g /k g /d a y - BASELINE 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 429 235 225 238 224 112 1463 386 317 246 42 263 151 1405 368 124 12 11 11 0 526 457 383 344 225 250 220 1879 362 99 11 15 32 0 519 440 365 247 229 231 24 1536 436 128 2 0 131 110 807 431 271 204 86 0 1 993 378 279 213 144 7 11 1032 364 191 77 261 147 165 1205 F e m a le , G roup V I - 100 m g /k g /d a y - 1BASELINE 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 454 360 255 285 10 0 1364 347 292 114 266 211 263 1493 377 283 223 299 274 18 1474 406 339 246 230 188 170 1579 368 162 130 257 198 178 1293 418 341 226 21 3 2 1011 421 179 4 17 17 11 649 404 254 207 50 0 5 920 465 282 251 16 3 2 1.019 384 295 302 250 113 38 1382 F e m a le , G ro u p V I I I - 1000 m g /k g /d a y - BASELINE 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 375 208 138 332 27 1 1081 351 245 216 278 1 0 1091 357 324 93 1 1 0 776 364 319 214 223 224 58 1402 267 228 225 120 190 129 1159 388 349 275 329 222 186 1749 463 370 291 235 69 21 1449 415 403 199 198 119 219 1553 415 305 318 347 250 251 1886 401 320 58 255 231 199 1464 -764Company Sanitized. Does not contain TSC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 In d iv id u a l M otor A c tiv ity : D u ra tio n o f Movement (sec! A nim al S uccessive 10-M inute In te rv a ls Number 1 2 3 4 5 6 F e m a le , G roup I I - 0 m g /k g /d a y - Week 13 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 475 357 320 362 282 277 415 374 226 290 287 308 403 279 104 155 25 33 431 392 348 221 241 237 486 409 101 131 361 99 348 272 295 186 138 237 444 313 247 166 281 108 447 352 333 332 267 239 433 423 355 351 164 421 478 363 323 272 157 155 F em ale, G roup IV - 10 m g /k g /d a y - Week 13 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 425 343 257 280 266 252 443 340 257 323 176 147 457 384 349 277 228 390 470 465 363 255 322 348 386 318 170 291 191 139 424 331 112 158 118 10 503 394 434 404 357 410 435 311 59 157 362 107 385 341 292 333 289 320 370 275 81 13 234 217 F e m a le , G roup VI - 100 m g /k g /d a y - Week 13 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 521 345 351 369 304 220 464 373 284 310 251 162 424 331 276 255 142 201 423 349 259 276 217 262 416 314 236 174 60 231 470 443 289 324 356 228 431 332 265 180 288 215 373 350 220 256 186 242 452 427 359 325 301 340 402 374 292 332 270 237 F e m ale , G roup V I I I - 1000 m g /k g /d a y - Week 13 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 445 425 289 340 227 253 444 324 194 257 189 16 464 462 419 321 322 183 413 285 203 101 88 323 353 271 113 125 279 103 417 382 286 222 353 219 487 419 273 358 172 284 493 474 448 418 397 354 436 376 323 352 310 198 388 298 193 136 304 147 T o tal 2073 1900 999 1870 1587 1476 1559 1970 2147 1748 1823 1686 2085 2223 1495 1153 2502 1431 1960 1190 2110 1844 1629 1786 1431 2110 1711 1627 2204 1907 1979 1424 2171 1413 1244 1879 1993 2584 1995 1466 -765 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 In d iv id u a l M otor A c tiv ity : D u ra tio n o f Movement (sec) Animal S u ccessiv e 10-M inute In te rv a ls Number 1 2 3 4 5 6 Fem ale, Group I I - 0 m g/kg/day - R ecovery 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 351 303 194 184 194 198 315 257 301 264 229 122 380 205 176 103 208 110 379 245 162 241 189 137 396 326 303 315 203 143 276 215 141 167 177 0 382 329 247 367 297 305 296 193 158 160 199 111 218 159 166 198 96 14 470 360 336 284 278 221 Fem ale, Group V III - 1000 m g/kg/day - R ecovery 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 422 298 259 239 178 113 305 200 172 249 47 184 377 291 236 328 225 233 362 173 249 125 127 2 315 209 120 161 183 240 434 346 284 290 154 111 355 136 191 219 192 108 411 342 311 304 301 264 230 186 125 17 78 147 333 172 182 204 157 161 T o tal 1424 1488 1182 1353 1686 976 1927 1117 851 1949 1509 1157 1690 1038 1228 1619 1201 1933 783 1209 ^t*m**\ -766Company Sanitized. Does not contain T SC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 APPENDIX J INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS -767 Company Sanitized. Does not contain T SC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 In d iv id u a l M otor A c tiv ity : Number o f M ovements Animal Number S u ccessive 10-M inute In te rv a ls 12345 M a le , G ro u p I - 0 m g /k g /d a y - BASELINE 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 138 131 10 9 24 126 161 171 16 6 139 123 70 6 4 155 126 154 113 57 146 127 59 102 2 123 147 116 0 3 133 162 34 5. 2 133 137 54 4 16 121 128 79 6 12 129 142 13 9 79 4 M a le , G ro u p I I I - 10 m g /k g /d a y - BASELINE 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 146 90 9 2 8 120 137 133 98 52 133 128 43 11 23 121 155 154 66 9 110 140 128 151 151 104 144 64 3 1 125 127 37 6 5 113 140 148 71 17 132 104 117 116 9 169 178 146 186 77 M a le , G roup V - 100 m g /k g /d a y - BASELINE 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 156 106 132 7 11 137 156 103 6 4 111 122 94 88 3 126 123 5 11 5 125 146 129 133 17 145 145 14 1 5 120 141 145 134 124 145 140 175 83 5 114 135 137 24 1 122 126 121 149 121 M a le , G ro u p V I I - 1000 m g /k g /d a y - BASELINE 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 129 146 147 94 9 137 156 150 48 3 136 154 140 101 3 124 133 143 133 83 125 180 117 5 1 137 93 1 12 5 106 145 5 3 6 125 147 142 33 11 131 131 137 149 134 112 101 92 42 4 6 T o tal 3 315 2 482 9 351 5 610 1 437 0 389 6 342 6 350 9 355 3 496 4 259 6 546 8 346 23 528 137 817 3 319 3 303 6 495 7 485 0 756 7 419 7 413 12 430 6 276 7 557 0 310 29 693 12 560 0 411 20 659 12 537 9 503 3 537 1 617 10 438 11 259 7 272 3 461 115 797 2 353 -768Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 I n d iv id u a l M otor A c tiv ity : Number o f M ovements A nim al S u ccessiv e 10-M inute In te rv a ls Number 1 2 3 4 5 M a le, G roup I - 0 m g /k g /d a y - Week 13 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 147 143 141 153 165 171 171 182 176 155 116 117 60 94 75 142 139 107 74 129 151 142 153 134 108 127 155 110 131 71 152 151 92 144 114 148 150 139 161 152 117 121 118 123 122 135 142 161 138 129 M ale, G roup I I I - 10 m g /k g /d a y - Week 13 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 126 150 136 143 75 140 148 148 126 113 128 130 93 116 92 148 152 160 153 75 126 150 130 123 131 115 143 139 130 128 115 140 123 150 118 128 143 136 136 109 112 152 148 128 133 165 158 170 145 99 M a le , G roup V - 100 m g /k g /d a y - Week 13 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 125 141 134 134 146 166 109 124 122 112 127 121 130 148 112 125 144 151 117 132 113 134 98 135 90 147 146 160 174 117 123 136 130 103 148 153 144 158 151 155 101 142 121 132 123 143 122 137 123 125 M a le, G roup V II - 1000 m g /k g /d a y - Week 13 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 149 156 153 123 111 150 166 135 149 110 142 133 149 128 118 118 130 130 141 132 146 180 171 175 175 126 138 122 139 124 122 136 136 115 101 121 142 151 126 124 138 123 116 125 134 117 138 146 121 116 6 117 155 99 28 129 14 84 54 80 28 96 69 36 75 112 130 80 133 105 151 99 152 129 110 120 120 116 59 129 79 97 126 152 118 160 147 37 110 108 99 T o tal 866 1010 561 619 817 608 737 804 681 733 726 744 595 763 772 785 726 785 778 888 779 785 767 779 690 864 756 820 748 729 789 836 822 769 1007 796 647 774 744 737 -769Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 I n d iv id u a l M otor A c tiv ity : Number o f M ovements Animal S u ccessiv e 10-M inute I n te r v a ls Number 1 2 3 4 5 M ale, Group I - 0 m g/kg/day - R ecovery 665008 665042 665043 665064 665098 665106 555121 665159 665081 665149 93 106 101 106 108 137 156 160 184 171 128 77 103 116 108 144 114 87 77 14 100 131 108 117 81 169 134 143 115 81 146 116 130 111 132 124 135 114 95 64 168 173 165 154 152 128 150 93 147 91 M ale, Group V II - 1000 m g/kg/day - R ecovery 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 131 153 116 47 107 131 150 150 161 141 145 142 121 87 31 136 117 136 133 107 131 158 125 115 159 101 119 118 112 119 159 144 116 110 6 86 106 94 95 15 122 135 111 136 126 155 148 86 104 106 6 T o tal 75 589 146 954 71 603 78 514 98 635 122 764 106 741 83 615 115 927 135 744 74 628 18 751 42 568 131 760 142 83 0 132 701 78 613 17 413 68 698 105 704 -770Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 In d iv id u a l M otor A c tiv ity : Number o f M ovements Anim al S u ccessiv e 10-M inute In te rv a ls Number 1 2 3 4 5 F e m a le , G ro u p IX - 0 m g /k g /d a y - BASELINE 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 146 157 63 0 1 104 125 119 143 81 101 121 122 82 66 150 160 132 139 137 128 156 104 13 92 160 80 0 32 1 155 197 189 139 158 116 120 114 126 127 137 144 142 163 85 155 146 126 160 142 F e m a le , G ro u p IV - 10 m g /k g /d a y - BASELINE 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 143 142 176 177 173 104 127 138 32 127 126 73 16 13 12 112 131 138 137 140 138 98 28 13 17 124 136 128 159 118 117 57 4 4 55 136 168 172 102 2 130 129 150 115 10 149 149 62 158 124 F e m a le , G ro u p V I - 100 m g /k g /d a y - BASELINE 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 112 123 121 123 101 118 139 155 138 141 155 157 115 93 72 152 140 116 106 123 5 152 167 175 128 106 113 165 173 178 F e m a le , G ro u p V I I I - 1000 m g /k g /d a y - BASELINE 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 158 149 106 164 160 159 139 135 64 135 164 138 149 149 165 130 137 160 127 143 150 118 136 93 127 123 126 113 130 58 133 121 157 122 126 36 15 64 11 199 166 136 7 149 96 144 104 101 143 132 7 111 131 133 127 6 24 2 3 111 39 4 3 146 117 138 49 66 125 92 6 T o tal 90 457 8 580 6 498 121 839 131 624 1 274 111 949 130 733 4 675 160 889 106 917 105 633 0 240 124 782 3 297 36 701 71 308 6 586 21 555 134 776 2 498 105 679 33 753 123 831 109 642 8 458 10 283 12 572 4 365 40 866 7 625 2 625 0 348 56 788 129 805 118 827 21 594 90 604 139 783 132 657 -771 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations D u P o n t-11418 In d iv id u a l M otor A c tiv ity : Number o f M ovements Animal S u ccessiv e 10-M inute In te rv a ls Number 1 2 3 4 5 F e m ale , G roup I I - 0 m g /k g /d a y - Week 13 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 112 160 135 160 158 107 . 110 138 145 134 126 126 69 89 28 157 142 154 124 148 106 121 73 55 150 142 162 163 116 121 145 155 146 165 168 113 119 111 134 112 122 138 139 119 105 135 166 161 166 156 F e m ale , G roup IV - 10 m g /k g /d a y - Week 13 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 172 186 150 162 153 126 149 122 127 121 127 132 115 117 112 128 149 160 159 188 121 142 132 162 127 137 144 76 103 66 99 122 111 132 120 144 178 52 74 132 135 147 159 150 149 150 164 70 19 125 F em ale, G roup V I - 100 m g /k g /d a y - Week 13 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 96 111 104 120 132 124 129 136 130 128 147 163 142 142 108 123 146 137 164 77 120 137 153 90 61 122 167 129 135 158 112 137 142 101 121 167 176 160 174 138 114 132 124 145 122 161 165 166 153 189 F e m ale , G roup V I I I - 1000 m g /k g /d a y - Week 13 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 148 155 171 156 184 161 152 139 159 162 118 138 143 137 137 139 161 139 84 56 150 153 105 105 132 140 153 137 144 145 102 151 164 159 135 102 122 119 125 124 114 120 129 134 134 122 144 114 93 136 6 T o tal 147 872 135 769 32 470 172 897 69 574 136 840 112 891 122 711 138 761 156 940 161 984 111 756 125 728 156 940 92 776 22 548 110 694 83 663 178 918 141 669 105 668 113 760 111 813 142 789 99 660 138 849 130 743 149 964 121 758 148 982 149 963 33 806 120 793 166 745 95 740 127 846 136 847 127 719 135 766 102 711 - 772- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 I n d iv id u a l M otor A c tiv ity : Number of M ovements Animal S u ccessiv e 10-M inute I n te r v a ls Number 1 2 3 4 5 Fem ale, Group I I - 0 m g/kg/day - R ecovery 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 164 139 128 163 126 151 165 143 152 146 133 119 109 74 113 145 148 112 141 149 152 141 176 143 125 185. 131 119 153 134 146 138 129 145 129 156 126 114 137 135 164 138 150 161 101 117 161 137 130 155 Fem ale, Group V III - 1000 m g/kg/day - R ecovery 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 135 127 147 148 109 130 113 115 141 46 150 143 151 147 160 149 120 161 87 107 184 146 111 148 143 137 162 151 135 132 157 137 124 128 122 136 148 153 156 154 137 158 79 20 69 148 113 107 143. 112 6 T o tal 74 794 124 881 74 622 108 803 99 836 0 722 143 830 101 769 27 741 121 821 85 751 118 663 131 882 12 636 162 894 80 797 109 777 126 873 119 582 115 738 - 773 Company Sanitized. Does not contain TSC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 APPENDIX K INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA -774Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES ABBREVIATIONS: General : ADEQ CLOT DECR INCR NSR NT OK QNS RNV UTD < a d e q u a te sam ple c lo tte d d e c re a se d in c re a s e d no sam ple re c e iv e d fo r te s tin g not taken o r no t perform ed s a m p le c o n d i t i o n OK f o r t e s t i n g q u a n tity not s u ffic ie n t fo r te stin g re su lt not v a lid unable to determ ine le s s than In d iv id u a l H em atology V a lu e s : COND - s a m p le c o n d i t i o n RBC _ r e d b l o o d c e l l c o u n t HGB - h e m o g lo b in HCT - h e m a t o c r i t MCV MCH -- mean c o rp u s c u la r volume mean c o rp u s c u la r hem oglobin MCHC - m ean c o r p u s c u l a r h e m o g lo b in c o n c e n t r a t i o n ROW - r e d c e l l d i s t r i b u t i o n w i d t h ARET - a b s o l u t e r e t i c u l o c y t e c o u n t PLT - p l a t e l e t c o u n t WBC - w h i t e b l o o d c e l l c o u n t ANEU - a b s o l u t e n e u t r o p h i l ( a l l fo rm s ) ALYM - a b s o l u t e ly m p h o c y te AMON - a b s o l u t e m o n o c y te AEOS - a b s o l u t e e o s i n o p h i l ABAS - a b s o l u t e b a s o p h i l ALUC - a b s o l u t e l a r g e u n s t a i n e d c e l l In d iv id u a l NORM ANIS MIC MAC POLY HYPO ECHI ACAN TARG RX HJB - Red B lood C e ll M orphology V a lu e s : - Normal - an iso cy to sis - m icrocytes - m acrocytes - polychrom as i a - hypochrom as i a - ech in o cy tes - acan th o cy tes - T arget c e lls - rouleaux - H o w ell-Jo lly body n o t o b serv ed o r n o t exam ined; se e w hole b lo o d sam ple co n d itio n In d iv id u a l W hite B lo o d C e l l t P la t e le t M orphology V a lu e s : NORM - 'N o rm a l SM TOX -- Smudge w h ite b lo o d c e l l s to x ic n e u tro p h ils DB - D h le b o d i e s VC - v a c u o l a t e d c y to p l a s m BC - b a s o p h i l i c c y to p l a s m PCE ~ p l a t e l e t c lu m p s / e s t i m a t e GP - g i a n t p l a t e l e t s BP - b i z a r r e p l a t e l e t s - - n o t o b se rv e d o r n o t exam ined; se e w hole b lo o d sam ple * co n d itio n -775 Company Sanitized. Does not contain TSC A CBI /""N . H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Getieration Reproductive Evaluations DuPont-11418 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) ABBREVIATIONS : ( C o n tin u e d ) In d iv id u a l PHEM PLIP PICT PT APTT C o ag u latio n V a lu es: - plasm a hem olysis - plasm a lip e m ia - plasm a ic te ru s - p ro th ro m b in tim e - a ctiv ated p a rtia l throm boplastin tim e In d iv id u a l C lin ic a l C h em istry V a lu e s : SHEM - s e r u m h e m o l y s i s SLIP - serum lip e m ia SICT - se ru m i c t e r u s AST - a s p a r t a t e a m i n o t r a n s f e r a s e ALT - a l a n i n e a m i n o t r a n s f e r a s e SDH ALKP - _ s o rb ito l dehydrogenase a lk a lin e phosphatase BILI - t o ta l b ili r u b i n BUN - u r e a n i t r o g e n CREA - c r e a t i n i n e CHOL - c h o l e s t e r o l TRIG ~ t r i g l y c e r i d e s GLUC - g l u c o s e TP - t o t a l p r o t e i n ALB - a lb u m in GLOB - g l o b u l i n CALC - c a l c i u m IPHS - i n o r g a n i c p h o sp h o ro u s NA - s o d iu m K - p otassium CL - c h l o r i d e PHEM - p l a s m a h e m o l y s i s fro m b l o o d s a m p le f o r f l u o r i d e d e t e r m i n a t i o n PLIP - p lasm a lip e m ia from b lo o d sam ple f o r f l u o r id e d e te r m in a tio n PICT - p la sm a i c t e r u s from b lo o d sam ple f o r f l u o r i d e d e te r m in a tio n PFLU " p l a s m a f l u o r i d e In d iv id u a l U r in a ly s is V a lu es: QUAL q u a lity (m odifies co lo r) COL c o l o r CLAR c la rity VOL v o lu m e ' UOSM u rin e o sm o lality PH t h e l o g a r i t h m o f t h e r e c i p r o c a l o f t h e h y d r o g e n i o n c o n c e n t r a t i o n UGLU u rin e glucose KET k e t o n e UBIL u rin e b iliru b in BLD b l o o d URO u r o b i l i n o g e n UFLU u rin e flu o rid e UMTP u rin e p ro tein In d iv id u a l EPIT UWBC UR8C NCRY MICR SPER SPEC U rin e M ic ro sc o p ic E xam ination - e p ith e lia l c e lls - u rin e w hite blood c e lls - u rin e re d blood c e lls - norm al c ry s ta ls - m icroorganism s - sperm - sp e c ia l observ atio n s V alu es: - 776Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) NOTES: When i n d i v i d u a l a n im a l d a t a a r e n o t r e p o r t e d , i t may b e due t o one o f t h e f o llo w in g r e a s o n s o r o th e r re a so n s , a l l o f w hich a re e x p la in e d in th e stu d y re c o rd s: t h e s a m p le w a s c l o t t e d (CLOT) t h e r e w as i n s u f f i c i e n t s a m p le f o r t e s t i n g (QNS) a v a l i d r e s u l t c o u l d n o t b e o b t a i n e d (RNV) th e sam ple was n o t s u ita b le fo r te s tin g th e anim al d ie d p r i o r to sam ple c o lle c tio n n o s a m p le w as a v a i l a b l e f o r t e s t i n g (NSR) When a n i n d i v i d u a l o b s e r v a t i o n w as r e c o r d e d a s b e in g l e s s th a n a c e r t a i n v a lu e , c a l c u l a t i o n s w e re p erfo rm ed on h a lf th e re c o rd e d v a lu e . F or exam ple, i f b i li r u b i n was re p o rte d a s < 0 .1 , 0 .0 5 was used fo r any c a lc u la tio n s perform ed w ith th a t b iliru b in d a ta . -777Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number COND RBC x 1 0 6/ ju.L HGB g/dL M ale, Group I - 0 m g/kg - Day 37 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 OK OK OK OK OK OK OK OK OK OK 7 .9 7 7 .9 0 8 .0 7 8 .0 5 7 .5 5 7 .7 3 7 .7 7 7 .5 5 7 .8 4 7 .7 9 1 5 .7 1 5 .4 1 6 .1 1 5 .8 1 5 .4 1 6 .1 1 5 .9 1 5 .4 1 6 .1 1 5 .7 M ale, G roup I I I - 10 m g/kg - Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 OK OK OK OK OK OK OK OK OK OK 8 .1 3 7 .4 8 7 .4 0 7 .5 8 8 .1 6 7 .3 6 8 .4 3 7 .2 9 7 .7 4 7 .4 1 1 5 .2 1 4 .9 1 5 .2 1 5 .0 1 6 .9 1 5 .8 1 6 .1 1 5 .0 1 5 .3 . 15.1 HCT % 4 6 .7 4 5 .8 4 6 .0 4 6 .2 4 5 .5 4 7 .0 4 6 .6 4 5 .4 4 7 .0 4 6 .6 4 6 .4 4 3 .3 4 3 .9 4 2 .8 5 0 .3 4 5 .3 4 8 .1 4 3 .3 4 6 .2 4 4 .1 In d iv id u a l H em atology MCV L MCH pg MCHC g /d n 5 8 .7 5 8 .0 5 7 .0 5 7 .4 6 0 .2 6 0 .8 6 0 .0 6 0 .2 6 0 .0 5 9 .8 1 9 .7 1 9 .5 1 9 .9 1 9 .6 2 0 .4 2 0 .9 2 0 .4 2 0 .4 2 0 .5 2 0 .1 3 3 .6 3 3 .6 3 4 .9 3 4 .2 3 3 .9 3 4 .4 3 4 .1 3 3 .9 3 4 .1 3 3 .7 5 7 .2 5 7 .9 5 9 .3 5 6 .4 6 1 .6 6 1 .5 5 7 .1 5 9 .3 5 9 .7 5 9 .6 1 8 .7 1 9 .9 2 0 .6 1 9 .7 2 0 .7 2 1 .4 1 9 .1 2 0 .6 1 9 .8 2 0 .4 3 2 .8 3 4 .3 3 4 .7 3 5 .0 3 3 .6 3 4 .9 3 3 .5 3 4 .7 3 3 .1 3 4 .2 Company Sanitized. Does not contain TSCA CBI - 778- V alues RDW % ARET PLT WBC xl03/fcL xl03/pL x 103/(IL 1 1 .1 1 1 .6 1 1 .2 1 1 .0 1 1 .2 1 1 .0 1 1 .0 1 1 .5 1 1 .2 1 1 .1 1 8 0 .8 1 7 8 .4 1 9 7 .5 1 5 6 .9 1 9 9 .4 2 0 8 .4 1 6 3 .0 1 5 0 .5 1 7 9 .8 1 5 9 .6 1201 1208 1352 1189 1201 RNV 1093 1070 1185 1363 1 5 .8 3 9 .9 3 1 4 .0 7 1 2 .6 8 1 5 .5 3 1 2 .7 9 1 2 .4 9 1 6 .1 9 1 5 .5 3 1 3 .6 4 1 1 .3 1 0 .8 1 1 .8 1 1 .6 1 0 .6 1 1 .1 1 1 .2 1 1 .4 1 1 .5 1 1 .3 1 6 0 .2 1 1 9 .6 1 8 0 .2 1 5 5 .2 1 6 6 .4 1 9 0 .6 1 6 3 .7 1 8 8 .9 1 4 4 .2 1 5 8 .6 1171 1259 1254 1335 RNV 1262 RNV 1228 1170 1213 1 6 .9 8 2 5 .4 9 1 5 .2 5 9 .1 9 1 3 .9 8 1 5 .4 6 1 3 .9 4 1 8 .7 6 1 4 .4 2 1 6 .5 8 D u P o n t-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC x l0 s/jiL HGB g/dL M ale, G roup V - 100 m g/kg - Day 37 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 OK OK OK OK OK OK OK OK OK OK 8 .1 4 8 .1 3 7 .6 0 7 .8 3 7 .3 2 7 .9 0 7 .2 3 7 .7 6 7 .7 3 6 .9 4 1 5 .3 1 5 .8 1 5 .3 1 6 .5 1 4 .9 1 5 .1 1 4 .8 1 5 .9 1 5 .0 1 4 .2 M ale, G roup V II - 1000 m g/kg - Day 37 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 OK OK OK OK OK OK OK OK OK OK 7 .2 4 7 .4 7 7 .5 7 7 .6 4 7 .5 0 7 .4 5 7 .2 4 7 .7 4 7 .3 7 7 .9 2 1 5 .4 1 5 .3 1 5 .2 1 5 .1 1 5 .8 1 4 .1 1 4 .2 1 5 .1 1 4 .9 1 5 .3 HCT % 4 5 .8 4 6 .8 4 4 .5 4 7 .8 4 3 .2 4 5 .0 4 2 .9 4 6 .8 4 3 .9 4 1 .2 4 5 .1 4 5 .3 4 4 .9 4 4 .9 4 5 .9 4 2 .9 4 1 .8 4 5 .0 4 4 .3 4 5 .8 In d iv id u a l H em atology MCV fL MCH pg MCHC g /d L 5 6 .2 5 7 .6 5 8 .5 6 1 .0 5 9 .0 5 7 .0 5 9 .3 6 0 .3 5 6 .9 5 9 .3 1 8 .8 1 9 .5 2 0 .2 2 1 .1 2 0 .4 1 9 .2 2 0 .5 2 0 .5 1 9 .4 2 0 .5 3 3 .5 3 3 .8 3 4 .5 3 4 .7 3 4 .6 3 3 .6 3 4 .6 3 3 .9 3 4 .1 3 4 .5 6 2 .3 6 0 .7 5 9 .4 5 8 .8 6 1 .2 5 7 .6 5 7 .7 5 8 .1 6 0 .0 5 7 .8 2 1 .2 2 0 .5 2 0 .1 1 9 .7 2 1 .1 1 8 .9 1 9 .6 1 9 .5 2 0 .3 1 9 .3 3 4 .1 3 3 .9 3 3 .9 3 3 .6 3 4 .4 3 2 .8 3 4 .0 3 3 .6 3 3 .7 3 3 .5 Company Sanitized. Does not contain TSCA CBI - 779- V alues RDW % ARET x l 0 3/jiL PLT WBC x1 0 3/ mL X l 0 3/ML 12.0 11.7 11.5 11.7 11.9 11.1 11.6 11.8 11.1 11.7 165.1 200.8 194.6 203.6 211.4 162.9 165.3 167 !7 139.5 178.8 1198 1138 1016 1401 1219 1026 1281 1190 1147 1272 14.37 14.61 9.47 17.15 17.97 18.57 20.63 12.68 18.04 13.33 11.1 11.0 11.2 11.6 11.3 11.1 11.3 10.9 11.2 11.1 200.7 162.5 154.1 169.0 198.0 159.0 150.1 188.5 181.9 135.6 1000 1028 1071 1058 1107 1260 1040 1121 1228 1094 13.06 16.60 14.66 16.12 12.66 22.46 11.25 14.56 23.62 15.78 D u P o n t-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ Animal Number ANEU xlOVitL ALYM x KT/mL AMON x l 0 3/ML M a l e , G r o u p I - 0 m g / k g - Day' ,377 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 1.49 1.20 1.61 1.11 1.85 1.66 1.34 1.95 1.04 1.08 13.52 8.24 11.90 10.83 12.96 10.51 10.73 13.49 13.85 11.89 0.32 0.32 0.22 0.19 0.34 0.25 0.23 0.30 0.23 0.33 a le , Group I I I - 10 mg/kg Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 1.42 3.97 2.38 1.28 1.75 1.70 1.89 1.80 1.07 2.02 14.98 20.78 12.19 7.49 11.56 13.15 11.39 15.98 12.66 13.75 0.23 0.24 0.24 0.19 0.24 0.25 0.37 0.39 0.28 0.32 In d iv id u a l Hematology Values AEOS - ABAS x 1 0 3/iL x i o V ml ALUC xlO 3/fil 0.21 0.07 0.14 0.11 0.13 0.20 0.07 0.13 0.07 0.14 0.08 0.05 0.06 0.21 0.08 0.07 0.06 0.13 0.16 0.07 0.21 0.06 0.15 0.24 0.16 0.11 0.07 0.19 0.17 0.13 0.09 0.10 0.15 0.10 0.22 0.12 0.11 0.33 0.10 0.17 0.13 0.15 0.11 0.04 0.09 0.09 0.06 0.06 0.14 0.17 0.13 0.26 0.17 0.09 0.12 0.14 0.11 0.20 0.17 0.15 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -780- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________ Animal Number ANEU ALYM AMON x I O V mL x IC T /mL x IO V iiL Male, Group V - 100 mg/kg - Day 37 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 1.73 2.07 1.37 2.64 2.02 1.87 1.78 2.22 2.47 1.94 11.79 11.70 7.43 13.65 14.80 15.94 17.61 9.90 14.50 10.61 0.45 0.41 0.39 0.44 0.66 0.36 b . 24 0.29 0.53 0.39 Male, Group V II - 1000 mg/kg - Day 37 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 1.66 1.41 1.59 2.36 1.77 1.83 0.97 2.18 4.97 2.07 10.88 14.27 12.52 13.20 10.22 19.83 9.79 11.77 17.24 13.11 0.19 0.47 0.29 0.27 0.18 0.39 0.20 0.18 0.36 0.35 AEOS xloV aL 0.13 0.16 0.13 0.10 0.16 0.12 0.10 0.08 0.09 0.17 0.13 0.14 0.05 0.14 0.16 0.06 0.10 0.09 0.18 0.10 In d iv id u a l Hematology Values ABAS xloViiL ALUC x 1 0 3/ mD 0.16 0.11 0.06 0.11 0.13 0.12 0.13 0.11 0.24 0.05 0.11 0.16 0.10 0.20 0.19 0.16 0.76 0.08 0.22 0.17 0.08 0.08 0.09 0.07 0.14 0.13 0.08 0.16 0.28 0.08 0.11 0.22 0.13 0.09 0.19 0.21 0.12 0.18 0.59 0.08 > DuPont-11418 Company Sanitized. Does not contain TSCA CBI -781 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Animal Number COND RBC x i o 6/ ml HGB g/dL M ale, Group I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 OK OK OK OK OK OK OK OK OK OK 8.65 8.54 8.88 8.84 8.12 8.45 8.43 8.09 8.99 8.84 15.3 15.5 16.4 15.7 15.3 16.3 16.0 15.1 16.7 15.9 Male, Group I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 OK OK OK OK OK OK OK CLOT OK OK 8.55 8.16 8.35 8.38 8.45 8.07 9.48 NT 8.80 8.51 14.9 15.0 15.9 15.0 16.3 15.6 16.2 NT 16.1 15.9 HCT % 46.8 46.2 48.7 47.4 46.3 47.9 47.4 44.3 51.7 48.9 45.7 44.7 46.9 45.2 49.8 46.8 52.0 NT 49.8 47.3 In d iv id u al Hematology MCV fL MCH pg MCHC g/dL 54.0 54.1 54.8 53.7 57.0 56.6 56.2 54.7 57.5 55.3 17.7 18.2 18.5 17.7 18.8 19.3 19.0 18.7 18.6 18.0 32.8 33.5 33.8 33.0 33.1 34.1 33.8 34.1 32.3 32.5 53.5 54.8 56.2 53.9 58.9 58.0 54.9 NT 56.6 55.6 17.5 18.4 19.0 17.9 19.3 19.4 17.1 NT 18.3 18.6 32.7 33.6 33.8 33.2 32.8 33.4 31.1 NT 32.3 33.5 Company Sanitized. Does not contain TSCA CBI -782- V alues RDW % ARET x 1 0 3/ mL PLT x l 0 3/iiL WBC x 1 0 3/ jiL 13.2 12.7 12.2 13.2 12.4 12.7 11.6 13.2 12.2 12.5 162.6 150.8 163.6 140.3 123.8 192.0 107.3 133.8 226.2 155.7 RNV RNV 1307 1136 797 1063 1050 RNV RNV 1024 12.69 11.83 11.59 9.04 11.46 11.17 10.21 17.56 14.10 13.15 12.4 12.4 13.7 13.3 11.8 12.4 13.9 NT 12.4 12.7 198.1 116.9 196.7 178.9 212.5 160.8 187.3 NT 154.3 157.5 RNV RNV RNV 1210 1010 RNV RNV NT RNV 1356 14.14 19.83 14.08 8.28 14.20 12.28 13.85 NT 11.36 17.87 D u P o n t-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __________ Animal Number COND RBC x l 0 6/ n h HGB g/dL M a l e , G ro u p V - 100 m g / k g - :Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 OK OK OK OK OK OK OK OK OK OK 9.11 8.69 8.62 8.22 8.34 8.56 8.28 8.64 8.49 8.12 15.8 15.5 15.7 16.1 15.3 15.4 15.3 16.3 14.9 14.9 M ale, G roup V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 OK OK OK OK OK OK OK OK OK OK 8.08 8.25 7.68 8.26 8.45 7.92 8.20 8.55 8.06 8.79 16.2 15.3 14.2 15.0 16.2 13.6 15.3 15.4 14.9 15.9 HCT % 49.0 46.4 49.6 47.6 47.7 46.4 45.0 48.9 45.7 45.4 47.3 46.5 42.1 45.5 49.7 42.5 47.8 46.1 44.7 47.9 In d iv id u al Hematology Values MCV fL MCH pg MCHC g/dL RDW % ARET x 1 0 3/ mL PLT x l 0 3/fiL WBC x 1 0 3/ mL 53.8 53.4 57.5 57.9 57.2 54.2 54.4 56.6 53.8 55.9 . 17.4 17.9 18.2 19.6 18.4 18.0 18.4 18.8 17.6 18.3 32.3 33.5 31.6 33.8 32.1 33.1 33.9 33.3 32.6 32.7 12.9 12.7 12.8 11.7 13.4 12.4 13.0 12.0 12.5 13.1 169.3 155.8 203.6 145.7 220.2 138.1 148.2 114.9 155.4 165.5 RNV 1106 1010 1214 1145 RNV 878 RNV 1169 1241 12.99 17.00 9.61 10.19 18.71 15.29 17.15 7.94 12.81 10.14 58.5 56.4 54.9 55.1 58.9 53.7 58.4 54.0 55.5 54.5 20.0 18.5 18.5 18.2 19.2 17.1 18.6 18.0 18.5 18.1 34.2 32.8 33.6 33.0 32.6 31.9 31.9 33.4 33.4 33.2 12.0 12.0 12.2 11.6 12.3 14.3 11.9 13.0 12.6 12.4 200.4 185.4 175.8 121.6 195.2 203.1 154.3 219.4 171.3 144.4 RNV RNV RNV RNV 1177 RNV RNV RNV 1123 1112 9.81 13.87 8.03 9.17 14.93 17.42 10.33 10.95 14.00 24.69 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -783 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______ Animal Number ANEU ALYM AMON x lO / piL x 1 0 3/ mL x 1 0 3/ mL M ale, Group I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 1.55 1.75 1.47 1.09 1.70 1.75 1.30 2.43 1.78 1.74 10.36 9.47 9.37 7.56 9.22 8.79 8.45 14.30 11.63 10.72 0.39 0.39 0.31 0.21 0.30 0.35 0.26 0.50 0.37 0.38 M ale, Group I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 1.94 8.73 2.53 1.08 2.42 1.95 2.19 NT 1.21 2.66 11.54 10.51 11.41 6.66 11.01 9.72 10.77 NT 9.49 14.28 0.33 0.35 0.00 0.31 0.35 0.23 0.41 NT 0.34 0.44 AEOS x 1 0 3/ L 0.19 0.05 0.16 0.09 0.11 0.15 0.08 0.08 0.10 0.16 0.15 0.07 0.14 0.11 0.20 0.11 0.17 NT 0.11 0.16 In d iv id u al Hematology Values ABAS ALUC x l O 3/;*!, x l 0 3/fiL 0.06 0.04 0.15 0.03 0.04 0.05 0.05 0.09 0.13 0.06 0.15 0.13 0.13 0.05 0.09 0.07 0.07 0.16 0.08 0.09 0.05 0.08 0.00 0.04 0.06 0.08 0.16 NT 0.04 0.11 0.13 0.09 0.00 0.08 0.15 0.19 0.15 NT 0.16 0.23 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -784- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANEU ALYM x 1 0 3/ L x l Q 3/ f i h AMON x 1 0 3/ L M ale, Group V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 1.94 2.97 2.07 2.75 2.21 1.95 1.77 1.06 1.98 1.62 10.22 12.95 6.97 6.75 15.19 12.60 14.71 6.59 10.08 8.01 0.39 0.62 0.31 0.38 0.80 0.36 0.30 0.14 0.47 0.24 M ale, Group V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 1.36 1.88 1.78 1.26 1.31 1.76 0.90 2.42 3.06 2.96 8.04 11.05 5.91 7.55 12.91 14.95 8.88 7.93 10.32 21.24 0.19 0.49 0.16 .0.15 0.36 0.30 0.22 0.28 0.28 0.49 AEOS x IO V L 0.10 0.19 0.11 0.13 0.20 0.16 0.20 0.05 0.14 0.13 0.14 0.22 0.07 0.08 0.19 0.09 0.20 0.13 0.17 0.00 In d iv id u a l Hematology Values ABAS xlOV/iL ALUC x lO 3/ iiL 0.05 0.15 0.06 0.07 0.15 0.06 0.06 0.05 0.06 0.05 0.30 0.12 0.09 0.11 0.16 0.16 0.10 0.05 0.08 0.09 0.03 0.07 0.02 0.06 0.07 0.07 0.05 0.05 0.07 0.00 0.05 0.17 0.09 0.07 0.08 0.26 0.09 0.15 0.11 0.00 D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -785- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Animal Number COND RBC x l 0 6/(iL HGB g/dL Male, Group I - 0 mg/kg - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 OK OK OK OK OK OK OK OK OK OK 9.00 8.27 8.77 8.52 8.94 8.13 7.96 8.38 8.52 9.13 15.9 14.3 14.6 14.7 16.0 14.5 14.7 15.4 15.0 16.0 M a l e , G ro u p V I I - 1 0 0 0 m g / k g - Day 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 OK OK OK OK OK OK OK OK OK CLOT 8.25 8.71 8.01 8.51 8.61 8.20 7.93 7.92 8.01 NT 14.8 15.3 13.8 14.0 14.4 14.4 14.0 13.9 14.6 NT HCT % 51.6 46.4 46.6 46.8 51.7 46.5 47.0 49.1 48.2 52.1 48.8 50.1 44.5 45.7 48.0 46.3 45.4 44.0 47.2 NT In d iv id u a l Hematology MCV fL MCH MCHC pg g/dL 57.4 56.1 53.2 55.0 57.8 57.2 59.0 58.6 56.7 57.1 17.7 17.3 16.7 17.2 17.9 17.8 18.4 18.3 17.7 17.6 30.9 30.8 31.4 31.3 30.9 31.2 31.2 31.3 31.2 30.8 59.2 57.5 55.6 53.8 55.7 56.5 57.2 55.6 58.9 NT 17.9 17.6 17.2 16.4 16.7 17.6 17.7 17.5 18.3 NT 30.2 30.6 31.0 30.5 30.0 31.2 30.9 31.5 31.0 NT Company Sanitized. Does not contain TSCA CBI -786- Values RDW % ARET PLT WBC x 1 0 3/ mL x 1 0 3/ kL x 1 0 3/ mL 12.5 14.0 14.7 13.6 12.2 13.5 12.9 11.7 13.1 12.1 179.7 147.7 218.7 173.2 176.8 210.0 202.9 150.3 218.7 165.8 1157 1010 1074 RNV 1037 RNV RNV 1343 1191 RNV 10.73 9.88 9.09 9.34 8.42 8.88 14.51 9.93 12.16 9.90 14.0 13.1 14.4 14.2 13.5 13.9 13.9 13.2 12.6 NT 229.0 218.9 224.1 210.7 204.7 157.4 158.9 148.7 164.8 NT 1056 1413 RNV 1308 1265 RNV 1344 RNV RNV NT 13.55 15.39 11.06 14.81 19.61 16.21 18.02 9.63 9.20 NT ) DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANEU x 1 0 3//(L ALYM AMON x l 0 3/fiL x l 0 3//iL Male, Group I - 0 mg/kg - Day 127 AEOS x l 0 3/iib 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 1.83 2.18 3.21 1.84 1.03 1.58 2.43 1.81 1.46 1.29 8.37 7.02 5.56 6.97 7.06 6.83 11-53 7.40 10.10 8.26 0.26 0.30 0.16 0.28 0.14 0.20 0.29 0.41 0.39 0.19 0.14 0.11 0.10 0.18 0.12 0.16 0.13 0.09 0.09 0.08 Male, Group V II - 1000 mg/k g Day 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 1.60 2.22 2.88 2.72 3.23 2.86 2.02 1.36 1.48 NT 11.20 12.33 7.71 11.33 15.48 12.51 15.23 7.74 7.32 NT 0.35 0.41 0.27 0.48 0.49 0.43 0.43 0.32 0.18 NT 0.20 0.28 0.11 0.11 0.19 0.23 0.11 0.10 0.10 NT In d iv id u al Hematology Values ABAS x i o V ml ALUC x 1 0 3/ mL 0.10 0.19 0.04 0.04 0.04 0.07 0.09 0.16 0.06 0.05 0.04 0.08 0.03 0.03 0.03 0.04 0.04 0.05 0.07 0.04 0.11 0.07 0.04 0.11 0.10 0.09 0.13 0.04 0.09 NT 0.08 0.07 0.04 0.06 0.11 0.08 0.11 0.06 0.04 NT DuPont-11418 Company Sanitized. Does not contain TSCA C8I -787- >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______ Animal Number COND Female, Group I I 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 OK OK OK OK OK OK OK OK OK OK Fem ale, Group IV 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 OK OK OK OK OK OK OK OK OK OK RBC x 1 0 6/ / i L HGB g/dL 0 mg/kg - Day 38 7.97 7.35 7.56 8.38 8.10 7.82 8.20 8.37 7.95 7.78 16.0 14.1 15.7 16.4 16.2 15.8 16.5 16.7 15.9 16.1 10 m g / k g - Dfiy 38 7.64 7.52 8.04 8.82 7.95 7.64 8.43 7.34 7.60 8.42 16.0 15.0 16.4 17.6 15.7 15.4 16.1 14.7 15.6 16.5 HCT % 45.6 41.2 42.7 46.5 45.6 44.5 47.3 47.0 44.8 45.4 45.5 42.8 46.4 50.2 46.2 44.4 46.0 41.5 43.7 47.5 In d iv id u a l Hematology Values MCV fL MCH pg MCHC g/dL RDW % ARET x 1 0 3/ mL PLT x l 0 3/,iL WBC x 1 0 3/ mL 57.3 56.0 56.5 55.5 56.3 56.9 57.6 56.1 56.4 58.4 20.1 19.2 20.8 19.6 20.0 20.2 20.1 19.9 19.9 20.7 35.1 34.2 36.8 35.3 35.5 35.6 34.9 35.5 35.4 35.4 10.8 11.2 10.9 10.3 10.3 10.6 10.4 10.3 10.2 10.7 104.6 90.8 186.6 102.1 129.2 174.1 126.4 141.2 118.5 172.7 RNV 1234 1010 1253 1369 1276 906 1201 1134 1264 12.18 13.90 13.03 13.77 19.76 12.56 14.49 12.74 13.97 11.07 59.5 56.9 57.7 56.9 58.1 58.1 54.6 56.5 57.5 56.4 20.9 20.0 20.4 19.9 19.7 20.2 19.0 20.0 20.5 19.6 35.2 35.1 35.3 35.0 34.0 34.7 34.9 35.5 35.6 34.7 11.2 11.3 10.4 10.6 10.5 10.3 11.2 10.4 11.1 10.6 201.3 144.2 163.6 113.3 155.0 159.1 107.0 151.9 182.8 168.3 RNV RNV RNV 1421 RNV 1383 1170 1362 1238 1622 13.79 12.06 13.13 15.92 11.70 10.25 12.72 12.38 7.66 13.32 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -788- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC x1 0 6/ / i L HGB g/dL HCT % Fem ale, Group VI - 100 mg/kg - Day 38 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 OK OK OK OK OK OK OK OK OK OK 8.00 7.63 8.07 8.38 7.62 7.55 7.79 7.62 8.23 7.79 15.5 15.7 16.0 16.0 15.8 15.6 16.4 15.1 16.2 15.7 45.1 44.8 44.8 46.0 44.8 43.5 45.8 43.0 46.4 44.8 Fem ale, Group V I I I - 1000 m g/kg - Day 38 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 OK OK OK OK OK OK OK OK OK OK 7.59 8.62 8.00 7.78 7.29 7.95 7.90 7.85 7.93 7.82 15.3 16.5 15.5 15.9 15.2 15.9 16.0 15.1 15.8 16.1 42.9 46.9 43.9 44.4 44.0 44.7 45.1 42.6 45.0 45.9 In d iv id u a l Hematology MCV fL MCH pg MCHC g/dL 56.4 58.7 55.6 54.9 58.8 57.7 58.8 56.5 56.4 57.5 19.4 20.6 19.8 19.1 20.7 20.7 21.0 19.9 19.7 20.2 34.4 35.0 35.7 34.8 35.2 35.8 35.8 35.2 34.9 35.1 56.6 54.4 54.8 57.1 60.4 56.2 57.2 54.3 56.7 58.7 20.2 19.2 19.4 20.4 20.9 20.0 20.3 19.2 20.0 20.5 35.6 35.3 35.4 35.8 34.5 35.5 35.5 35.4 35.2 35.0 Company Sanitized. Does not contain TSCA CBI -789- Values RDW % ARET PLT WBC x 1 0 3/ mL x 1 0 3/ mL x l 0 3/fiL 11.4 10.8 10.0 10.2 10.9 10.5 10.6 10.9 10.4 9.8 192.3 206.9 115.3 118.9 108.9 175.5 174.5 155.1 157.4 94.8 1266 1047 1260 1131 1122 RNV 1161 1229 1070 1316 19.48 15.31 15.18 9.98 10.87 10.99 19.59 14.84 14.56 13.79 11.3 10.0 10.9 10.2 11.1 10.5 10.6 10.8 11.0 10.3 203.7 172.7 135.6 142.6 189.3 191.5 157.6 129.7 196.4 163.5 1341 1489 1122 950 1427 1268 1093 1268 1330 RNV 11.32 15.91 12.94 14.70 14.63 17.88 15.70 9.38 13.96 17.15 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____________ Animal Number ANEU x 1 0 3/m L ALYM x 1 0 3/m L AMON x l O 3/ h Fem ale, Group I I - 0 mg/kg - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 0.65 0.85 1.41 0.89 1.75 1.32 1.54 0.88 1.44 0.82 10.85 12.48 10.96 12.25 16.98 10.62 12.27 11.05 11.78 9.69 0.20 0.21 0.34 0.26 0.61 0.26 0.33 0.42 0.37 0.19 Fem ale, Group IV - 10 mg/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 1.44 1.25 0.93 2.56 0.59 0.93 1.03 0.89 0.91 1.51 11.64 10.16 11.59 12.39 10.45 8.78 10.96 11.02 6.27 10.95 0.22 0.22 0.24 0.47 0.30 '0.25 0.38 0.18 0.28 0.34 AEOS x l 0 3/aL 0.12 0.07 0.10 0.10 0.15 0.13 0.15 0.10 0.10 0.09 0.13 0.14 0.09 0.21 0.05 0.14 0.17 0.08 0.07 0.20 In d iv id u al Hematology Values ABAS x 103/m L ALUC x 1 0 3/m L 0.20 0.14 0.07 0.11 0.11 0.11 0.10 0.10 0.10 0.11 0.15 0.15 0.15 0.15 0.15 0.13 0.11 0.19 0.18 0.17 0.20 0.13 0.11 0.19 0.11 0.06 0.06 0.11 0.05 0.14 0.15 0.17 0.17 0.10 0.20 0.09 0.12 0.10 0.09 0.17 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -790- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANEU x i o 3/ ml ALYM x1 0 3/ mL AMON xloVfiL smale, Group VI - 100 mg/kg - Day 38 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 1.89 1.20 1.96 0.97 0.48 0.89 1.67 1.75 0.77 1.22 16.83 13.63 12.30 8.51 10.01 9.59 16.85 12.38 13.17 11.78 0.30 0.17 0.71 0.24 0.13 0.14 .0.44 0.20 0.21 0.32 AEOS x 1 0 3/ mL 0.14 0.11 0.06 0.11 0.07 0.08 0.13 0.16 0.12 0.19 Fem ale, Group V III - 1000 mg/kg - Day 38 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 1.79 2.56 0.72 1.23 0.86 2.17 0.97 0.69 1.04 3.52 8.98 12.28 11.62 12.78 13.19 14.95 13.79 8.28 12.33 12.76 0.39 0.55 0.23 0.16 0.25 0.29 0.53 0.20 0.25 0.56 0.03 0.14 0.12 0.11 0.07 0.08 0.14 0.10 0.10 0.10 In d iv id u al Hematology Values ABAS ALUC x l 0 3/iiL x l O l / n 0.14 0.08 0.09 0.09 0.10 0.14 0.15 0.13 0.16 0.15 0.19 0.14 0.07 0.07 0.09 0.15 0.36 0.22 0.13 0.13 0.05 0.19 0.07 0.18 0.14 0.16 0.13 0.03 0.07 0.11 0.09 0.19 0.18 0.24 0.12 0.23 0.15 0.07 0.17 0.10 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -791 - ). H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Animal Number COND RBC x 1 0 6/ mL HGB g/dL Fem ale, Group I I - 0 m g/kg - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 OK OK OK OK OK OK OK OK OK OK 8.31 8.14 7.83 8.14 8.16 8.47 8.31 8.15 8.62 7.96 16.1 14.9 15.7 14.9 15.6 16.2 16.4 16.1 16.5 16.0 F e m ale , G roup IV - 10 m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 OK OK OK OK OK OK OK OK OK OK 7.87 8.24 7.85 8.47 8.26 7.59 8.80 8.16 7.96 8.67 15.9 15.6 15.3 15.9 15.8 14.7 16.3 15.9 15.4 15.9 HCT % 47.9 44.4 46.0 44.1 45.2 48.0 48.0 45.7 48.8 46.5 45.7 46.0 45.9 47.0 47.8 42.7 48.0 45.9 45.0 47.0 In d iv id u a l Hematology MCV fL MCH pg MCHC g/dL 57.7 54.6 58.8 54.2 55.4 56.7 57.7 56.1 56.6 58.4 19.3 18.3 20.1 18.3 19.1 19.1 19.7 19.7 19.1 20.1 33.5 33.6 34.2 33.8 34.5 33.7 34.1 35.1 33.7 34.4 58.1 55.9 58.5 55.5 57.8 56.2 54.5 56.2 56.5 54.2 20.2 18.9 19.5 18.8 19.2 19.4 18.5 19.5 19.4 18.3 34.8 33.8 33.4 33.8 33.1 34.4 34.0 34.7 34.2 33.8 Company Sanitized. Does not contain TSCA CBI -792- Values RDW % ARET PLT x l 0 3/ML X l0 3 / l l h WBC x l 0 3/(iL 11.0 11.8 11.1 11.3 11.0 10.9 10.8 10.4 11.0 10.8 74.9 116.5 182.4 129.6 122.1 116.6 81.4 150.3 138.4 115.0 RNV RNV 932 1272 RNV RNV 887 RNV RNV 1084 7.13 9.48 13.98 13.01 10.89 8.60 8.48 7.59 9.56 10.13 11.5 11.5 10.9 11.2 11.5 10.7 11.4 11.3 11.6 10.9 129.1 127.1 99.1 142.0 259.0 148.0 100.9 161.8 205.8 168.8 1129 RNV RNV RNV RNV RNV RNV 1201 RNV RNV 9.11 10.32 10.24 9.97 7.08 9.16 9.36 9.16 7.72 12.56 DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations > Animal Number COND RBC x 1 0 6/m L HGB g/dL HCT % F e m a l e , G roup VI - 100 m g/kg - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 OK OK OK OK OK OK OK OK OK OK 8.13 8.13 8.05 8.47 8.00 7.96 7.85 8.41 8.40 8.28 15.4 16.0 15.0 15.3 16.1 15.6 16.1 15.8 16.2 16.2 45.3 47.8 44.1 46.1 47.1 45.5 47.6 46.2 48.0 46.7 F e m ale , G roup V I I I - 1000 m g / k g D a y 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 OK OK OK OK OK OK OK OK OK OK 7.61 8.84 8.12 8.25 7.29 7.71 7.98 7.74 8.15 7.88 14.7 15.8 15.5 15.6 14.8 14.9 15.6 14.7 15.8 15.8 41.9 46.5 45.2 44.8 43.7 42.2 45.9 42.3 45.6 46.1 In d iv id u al Hematology MCV fL MCH pg MCHC g/dL 55.7 58.7 54.8 54.4 58.9 57.2 60.6 54.9 57.1 56.5 18.9 19.7 18.7 18.1 20.1 19.6 20.5 18.8 19.3 19.5 33.9 33.5 34.1 33.3 34.1 34.3 33.9 34.3 33.8 34.6 55.1 52.6 55.7 54.3 60.0 54.7 57.6 54.6 56.0 58.5 19.4 17.8 19.1 18.9 20.3 19.3 19.6 19.0 19.4 20.0 35.2 33.9 34.3 34.8 33.8 35.3 34.1 34.9 34.7 34.2 Company Sanitized. Does not contain TSCA CBI -793- Values RDW % ARET x 103/m L PLT x 1 0 3/ m L WBC x 103/ h L 11.8 10.9 10.5 10.8 10.9 10.9 11.3 11.2 11.2 10.8 155.8 166.9 126.2 106.2 108.2 159.0 203.1 117.8 179.0 141.4 1178 RNV RNV 1112 RNV RNV 1045 RNV RNV 1143 14.56 11.90 5.69 8.42 7.48 7.74 8.95 11.30 9.73 7.84 11.5 10.9 10.9 10.5 11-8 10.6 10.8 11.2 11.0 10.6 138.3 131.2 120.8 119.6 261.8 151.7 112.9 140.6 175.0 114.8 RNV RNV 787 RNV 1229 RNV RNV 1128 818 RNV 8.82 7.82 5.61 7.23 10.17 11.32 9.17 4.82 11.85 12.74 DuPont-11418 >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANEU ALYM x 1 0 3/ mL x l o V n L AMON x 1 0 3/ mL F e m ale , G roup I I - 0 m g/kg - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 0.82 1.16 1.07 2.75 1.09 0.82 1.22 0.92 0.93 0.74 5.88 7.98 12.06 9.06 9.23 7.26 6.69 6.29 8.08 8.84 0.18 0.11 0.36 0.76 0.25 0.18 0.22 0.22 0.24 0.23 Fem ale, G roup IV - 10 m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 1.64 1.08 1.37 1.65 1.44 2.14 1.59 2.29 1.65 1.25 6.91 8.58 8.16 7.84 5.31 6.24 6.95 6.41 5.72 10.53 0.25 0.23 0.37 0.18 0.10 0.48 0.39 0.18 0.19 0.34 AEOS x l 0 3/fiL 0.12 0.10 0.12 0.13 0.11 0.13 0.13 0.06 0.13 0.09 0.13 0.1 1 0.11 0.11 0.05 0.09 0.23 0.09 0.04 0.16 In d iv id u a l Hematology Values ABAS xloVfiL AUJC x 1 0 3/ mL 0.06 0.04 0.07 0.14 0.06 0.11 0.11 0.04 0.11 0.07 0.07 0.10 0.30 0.16 0.16 0.10 0.09 0.05 0.08 0.16 0.05 0.22 0.08 0.08 0.09 0.04 0.07 0.16 0.04 0.18 0.13 0.10 0.15 0.11 0.08 0.16 0.13 0.03 0.08 0.10 ' ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -794- Company Sanitized. Does not contain TSCA H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANEU x lO 3/ h ALYM x l 0 3/fiL AMON x 1 0 3/ mL F em ale, G roup VI - 100 m g/kg - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 2.53 0.92 1.15 0.83 0.77 0.84 1.62 1.63 1.35 0.95 11.30 10.36 4.31 7.02 6.26 6.53 6.99 9.09 7.71 6.50 0.31 0.38 0.13 0.28 0.15 0.16 0.12 0.20 0.25 0.16 F em ale, Group V III - 1000 mg/kg - Day 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 1.81 1.01 1.11 0.92 0.90 1.54 0.83 0.79 3.54 3.18 6.48 6.31 4.22 5.97 8.75 9.26 8.25 3.86 7.61 8.86 0.29 0.14 0.13 0.15 b.18 0.21 0.00 0.07 0.32 0.44 AEOS x l 0 3/ML 0.23 0.07 0.04 0.10 0.12 0.06 0.09 0.12 0.17 0.11 0.06 0.23 0.06 0.12 0.06 0.10 0.09 0.03 0.15 0.09 In d iv id u al Hematology Values ABAS ALUC x 1 0 3/ mL x 1 0 3/ mL 0.05 0.07 0.02 0.08 0.09 0.08 0.07 0.13 0.14 0.06 0.15 0.10 0.03 0.11 0.09 0.07 0.07 0.13 0.10 0.06 0.07 0.06 0.04 0.02 0.15 0.04 0.00 0.02 0.08 0.09 0.11 0.07 0.05 0.05 0.13 0.17 0.00 0.03 0.14 0.08 O 03 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC x l O 6/fiL HGB g/dL Female, Group I I - 0 mg/kg - Day 127 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 OK OK OK OK OK OK OK OK OK OK 7.91 8.64 8.23 8.07 7.95 7.90 8.05 8.17 8.21 8.30 14.9 16.1 15.5 14.8 15.3 15.4 14.5 15.5 15.5 15.0 F em ale, Group V III - 1000 mg/kg - Day 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 OK OK OK OK OK OK OK OK OK OK 8.61 8.57 7.76 8.41 8.44 8.00 7.55 7.99 8.01 7.88 15.8 15.5 15.2 15.9 16.2 14.7 14.3 14.5 14.6 14.7 HCT % 47.8 50.5 48.1 46.2 49.4 48.0 46.8 49.5 48.7 48.2 52.0 49.0 46.3 51.5 54.2 45.9 45.4 46.1 47.1 47.6 In d iv id u al Hematology MCV fL MCH pg MCHC g/dL 60.5 58.5 58.5 57.3 62.2 60.7 58.2 60.7 59.3 58.0 18.8 18.6 18.8 18.4 19.3 19.5 18.0 19.0 18.9 18.1 31.2 31.8 32.2 32.1 31.0 32.2 30.9 31.4 31.8 31.3 60.4 57.2 59.6 61.2 64.2 57.3 60.1 57.7 58.8 60.4 18.4 18.1 19.6 18.9 19.2 18.4 19.0 18.1 18.2 18.6 30.4 31.6 32.8 30.9 29.9 32.1 31.6 31.4 31.0 30.8 Company Sanitized. Does not contain TSCA CBI -796- V alues RDW % ARET PLT WBC x 103/ jiL x 1 0 3/ mL x 1 0 3/ hL 12.0 11.6 11.9 11.5 11.6 11.9 11.4 12.1 11.4 11.8 192.7 211.0 163.6 140.4 255.6 166.4 180.6 171.9 192.1 134.6 RNV RNV 922 RNV RNV 1192 1141 1268 1218 RNV 6.52 4.87 11.93 6.32 8.67 5.04 12.45 6.52 7.04 10.20 10.9 11.0 11.5 11.4 11.1 11.1 11.5 11.4 11.8 12.8 132.2 169.9 166.6 224.3 237.1 136.8 214.3 174.7 143.0 251.9 992 RNV 935 RNV 1097 RNV RNV RNV RNV RNV 8.97 8.35 8.87 10.91 8.26 6.57 8.84 6.10 9.09 6.34 DuPont-11418 )' H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) ___________________ Animal Number ANEU x 1 0 3/ mL ALYM x l O 3/tiL AMON xioV aL AEOS x I O V mL amale, Group I I - 0 mg/kg - Day 127 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 0.61 0.94 1.89 0.87 0.91 . 0.81 1.23 1.53 1.07 1.82 5.67 3.72 9.45 5.19 7.47 4.00 10.64 4.68 5.56 7.91 0.09 0.06 0.29 0.13 0.09 0.11 0.32 0.12 0.17 0.26 0.06 0.08 0.12 0.08 0.10 0.07 0.11 0.14 0.12 0.09 =male, Group V III - 1000 mg/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 1.33 1.78 1.21 0.96 1.06 1.08 2.19 1.09 1.91 0.71 7.17 6.07 7.31 9.51 6.83 5.13 6.20 4.76 6.67 5.36 0.34 0.18 0.16 0.18 0.22 0.16 0.27 0.15 0.09 .12 0.06 0.22 0.09 0.18 0.09 0.10 0.10 0.07 0.32 0.09 In d iv id u al Hematology Values ABAS ADUC x l 0 3/fiL X l 0 3/M 0.05 0.06 0.11 0.03 0.04 0.04 0.03 0.03 0.10 0.05 0.04 0.02 0.07 0.03 0.05 0.01 0.11 0.02 0.03 0.07 0.06 0.08 0.06 0.05 0.04 0.06 0.03 0.02 0.05 0.03 0.03 0.02 0.05 0.04 0.02 0.04 0.04 0.02 0.06 0.03 ) DuPont-11418 Company Sanitized. Does not contain TSCA C8I -797- 'X ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS MIC In d iv id u a l Red Blood C ell Morphology Values MAC POLY HYPO ECHI ACAN TARG RX HJB Male, Group I - 0 mg/kg - Day 37 665015 NO _ _ TRACE FEW 665016 NO - - - TRACE - FEW MODERATE - - - 665047 665049 NO NO - - - - TRACE - TRACE - MANY - TRACE FEW - _ - - 665068 NO - - - TRACE - FEW - - - - 665070 NO - - - TRACE - MODERATE FEW - - - 665076 NO - - - TRACE - MANY FEW - - - 665086 NO _ - - TRACE - MANY TRACE - - - 665130 665148 NO NO - - - TRACE TRACE MA_NY TRACE _ _ - - - - Male, Group I I I - 10 mg/kg - Day 37 664993 NO TRACE TRACE _ TRACE - TRACE - 664995 NO - - TRACE - MANY MODERATE - 665033 NO - - - TRACE - MANY FEW - 665053 NO - - - TRACE - TRACE MODERATE - 665060 NO - - - TRACE - TRACE - - 665074 NO - - TRACE - FEW - - 665080 NO - - - TRACE - FEW MODERATE - 665128 NO - - - TRACE - MANY MODERATE - 665131 NO - - - TRACE - MANY FEW - 665136 NO - - - TRACE - MODERATE FEW - -- -- -- -- -- -_ - -- -- -- D u P o n t-11418 Company Sanitized. Does not contain TSCA CBi -798- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS MIC M ale, G roup V - 100 m g /k g - Day 37 665035 NO - - 665054 NO TRACE TRACE 665073 NO - - 665089 NO - _ 665103 NO - - 665119 NO - - 665122 NO - - 665137 NO - - 665143 NO - 665155 NO - - a l e . Group V II - 1000 m g/kg - Day 37 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 NO NO NO NO NO NO NO NO NO NO - - - - - - In d iv id u a l Red Blood C ell Morphology V alues MAC POLY HYPO ECHI ACAN TARG - TRACE MODERATE FEW - TRACE - FEW FEW - - TRACE - MODERATE TRACE - - FEW - MANY TRACE - - TRACE - MANY MODERATE - - TRACE - MODERATE MODERATE - - TRACE - TRACE TRACE - - TRACE - MANY MODERATE - - TRACE - MODERATE MODERATE - - TRACE - MANY FEW - TRACE - MODERATE TRACE - - TRACE - TRACE TRACE - - TRACE - MANY MODERATE - TRACE - MANY TRACE - - TRACE - MODERATE - - - TRACE _ MANY MANY - - TRACE - MANY FEW - TRACE - MANY TRACE - - TRACE TRACE _ MODERATE MODERATE _ RX - - - - - _ HJB - - - - - - _ DuPont-11418 Company Sanitized. Does not contain TSCA CBI -799- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS MIC In d iv id u a l Red Blood C ell Morphology Values MAC POLY HYPO ECHI ACAN TARG RX HJB M ale, Group I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 NO NO NO NO NO NO NO NO NO NO _ - - * _ _ - M ale, Group I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 NO NO NO NO NO NO NO CLOT NO NO _ NT - - _ - NT - TRACE TRACE TRACE TRACE - TRACE FEW - - TRACE - FEW MODERATE - - TRACE - FEW MANY - - TRACE - TRACE TRACE - - TRACE - MODERATE MANY - - TRACE - FEW TRACE - - TRACE - FEW MODERATE - - TRACE - FEW FEW - - TRACE - - TRACE - TRACE - TRACE - - TRACE - FEW FEW - - TRACE - FEW MANY - - TRACE - TRACE FEW MANY - - TRACE _ MODERATE FEW _ - TRACE - FEW MANY - NT NT NT _ TRACE - NT FEW NT FEW NT - - TRACE - MODERATE MODERATE - -_ __ __ __ _- -- -_ - '- --- -- __ -_ NT NT --- DuPont-11418 Company Sanitized. Does not contain TSCA CBI -800- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS MIC M ale, Group V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 NO NO NO NO NO NO NO NO NO NO __ ----- *---- "- M ale, Group V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 NO NO NO NO NO NO NO NO NO NO _ - TRACE _ - - TRACE In d iv id u a l Red Blood C ell Morphology Values MAC POLY HYPO ECHI ACAN TARG _ TRACE _ TRACE FEW - - TRACE - FEW MODERATE - - TRACE - TRACE - - - TRACE - MODERATE MODERATE - - TRACE - FEW MODERATE - _ TRACE - FEW MODERATE - - TRACE - FEW MODERATE - - TRACE - FEW MODERATE - - TRACE - MODERATE MODERATE - - TRACE - MODERATE MODERATE - _ TRACE _ TRACE TRACE - - TRACE - TRACE TRACE - _ TRACE - TRACE FEW - - TRACE - MANY MANY - - TRACE _ - FEW - - TRACE - FEW MANY - - TRACE - MODERATE MANY - - TRACE - FEW MODERATE - - TRACE - - - - - TRACE _ TRACE MODERATE - RX - - HJB - - D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -801- )' H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) In d iv id u a l Red Blood C e ll Morphology V alues Animal Number NORM ANIS MIC MAC POLY HYPO ECHI ACAN TARG RX HJB Male, Group I - 0 m g/kg - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 NO NO NO NO NO NO NO NO NO NO _ - - - - - - _ TRACE _ TRACE _ _ - TRACE - MODERATE MODERATE - - TRACE - FEW MODERATE - - TRACE - TRACE FEW - - TRACE - MANY MODERATE - - TRACE - FEW MODERATE - - TRACE - FEW FEW - - TRACE - FEW FEW - - TRACE - FEW - ~ TRACE TRACE TRACE - - - - - - Male, Group V II - 1000 mg/kg - Day 127 665002 NO _ _ TRACE - MODERATE MANY - - - 665007 NO - - TRACE - - - -- - 665031 NO - - TRACE - FEW MANY - - - 665062 NO - - TRACE - TRACE MODERATE - - - 665067 NO - TRACE - FEW MODERATE - - - 665095 NO - - TRACE - FEW FEW - - - 665112 NO - - TRACE - FEW MODERATE - - - 665138 NO - - TRACE - TRACE FEW - - - 665146 NO - - TRACE - FEW FEW - - - 665158 CLOT NT NT NT NT NT NT NT NT NT NT ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -802- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________ _________________ Animal Number NORM ANIS MIC F e m a l e , iS r o u p I I - 0 m g / k g - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 NO NO NO NO NO NO NO NO NO NO - - _ - - - _ - - Fem ale, Group IV - 10 mg/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 NO NO NO NO NO NO NO NO NO NO _ - - - - - _ - - - - In d iv id u a l Red Blood C e ll Morphology Values MAC POLY HYPO ECHI ACAN TARG _ TRACE _ FEW _ - TRACE - TRACE FEW - - TRACE - MANY - - _ TRACE TRACE MODERATE - - TRACE - MANY FEW - - TRACE - MODERATE FEW - - TRACE - FEW TRACE - - TRACE - TRACE - - - TRACE - MANY TRACE - - TRACE - MANY MODERATE - _ TRACE - FEW - _ - TRACE - MODERATE TRACE - - TRACE - FEW - - - TRACE MODERATE TRACE - - TRACE - - - - - TRACE - FEW TRACE - - TRACE _ MANY MODERATE - - FEW - MANY - - - TRACE - MANY FEW - - TRACE - MODERATE TRACE - RX _ - - - - HJB _ - - - - ) D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -803- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u a l Red Blood C e ll Morphology Values Animal Number NORM ANIS MIC MAC POLY HYPO ECHI ACAN TARG Fem ale, Group VI - 100 mg/kg - Day 38 665170 NO - - - TRACE - MANY TRACE - 665199 NO - - - TRACE - MODERATE TRACE - 665238 NO - - - TRACE - - FEW - 665250 NO - - - TRACE - FEW - - 665251 NO - - - TRACE - TRACE FEW - 665259 NO - - - TRACE - MANY FEW - 665295 NO - - - TRACE - MODERATE - 665300 NO - - - TRACE - MANY MODERATE - 665340 NO - - - TRACE - FEW - - 665341 NO TRACE - FEW TRACE - F e m a l e , <G roup V I I I - 1 0 0 0 m g / k g - Day 38 665183 NO _ _ _ FEW - MODERATE MODERATE - 665200 NO - - _ TRACE - FEW TRACE - 665234 NO - - - TRACE - MANY MODERATE - 665242 NO - - - TRACE - MANY TRACE - 665261 NO - - - TRACE - FEW - - 665291 NO - - - TRACE - MANY FEW - 665310 NO - - - TRACE - MANY TRACE - 665326 NO - - - TRACE - MANY MODERATE - 665333 NO - - - TRACE - MANY TRACE ~ 665337 NO - - - TRACE - MANY FEW - RX - - - - - - - - HJB - - - - ~ - - - - - - DuPont-11418 Company Sanitized. Does not contain TSCA CBI -804- >. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations > Anim al Number NORM ANIS MIC F em ale, G roup I I - 0 m g/kg - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 NO NO NO NO NO NO NO NO NO NO _ - - - - _ - _ - - - - F e m a le , G roup IV - 10 m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 NO NO NO NO NO NO NO NO NO NO __ --- *- -_- ----_ In d iv id u a l Red B lood C e ll M orphology V alues MAC POLY HYPO ECHI ACAN TARG _ TRACE _ TRACE - TRACE _ TRACE _ TRACE - TRACE - TRACE - . TRACE - TRACE - TRACE _ TRACE - TRACE - TRACE - TRACE - TRACE - TRACE - TRACE - TRACE - TRACE - TRACE FEW TRACE - MODERATE FEW - MANY TRACE - TRACE FEW - MANY FEW - MODERATE FEW - FEW - - FEW TRACE - FEW TRACE - FEW - - FEW - - TRACE TRACE - TRACE - - FEW TRACE --- - MODERATE FEW - MANY FEW MANY TRACE - MODERATE TRACE - FEW TRACE - - - - _ - - RX - - - - ~ - - - - - - - HJB D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -805- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 Anim al Number NORM ANIS MIC In d iv id u a l Red B lood C e ll M orphology V alues MAC POLY HYPO ECHI ACAN TARG F e m a le , <G roup V I - 100 m g /k g - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 NO NO NO NO NO NO NO NO NO NO _ _ - - _ - _ _ - TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE _ MODERATE FEW __ _ _ FEW --_ - TRACE _ - FEW FEW - FEW - - MODERATE TRACE --- MODERATE TRACE _ - - F e m a le , G roup V I I I - 1000 m g/kg - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 NO NO NO NO NO NO NO NO NO NO _ _ - - _ _ _ _ - TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE _ - MODERATE FEW - FEW _ - FEW TRACE -- _ - MANY FEW - MANY FEW - MANY FEW - TRACE - - MANY FEW _ _ - RX _ _ - _ _ - HJB _ - - - - - _ _ ~ - - Company Sanitized. Does not contain TSCA CBI -806- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u a l Red B lood C e ll M orphology V alues Anim al Number NORM ANIS MIC MAC POLY HYPO ECHI ACAN TARG F e m a le , <G roup I I - 0 m g /k g - D ay 127 665189 NO _ _ _ TRACE _ _ _ _ 665197 NO - - - TRACE - TRACE - - 665201 NO - - - TRACE - - - - 665204 NO - - _ TRACE - FEW TRACE - 665228 NO - ~ - TRACE - - - - 665256 NO - - - TRACE - - - - 665260 NO - - TRACE - FEW TRACE _ 665276 NO - - - TRACE _ - - - 665323 NO - - - TRACE --- 665327 NO - - - TRACE - FEW MODERATE - Fem ale, G roup V III - 1000 m g/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 NO NO NO NO NO NO NO NO NO NO - - - - _ _ - - -- - _ - - - - - TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE _ - - - - - _ ~ - - - TRACE - _ - - - TRACE - _ - _ - - RX _ - - - _ - - HJB DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 Anim al Number NORM SM TOX M ale, G roup I - 0 m g/kg ~ Day 37 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 YES YES YES YES YES NO YES YES YES YES __ _--- -_ -_ --~- *- M ale, Group I I I - 10 m g/kg - Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 YES YES YES YES NO YES NO YES YES YES - - - _ _ _ _ - - - - In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues DB VC BC PCE GP BP _ - - - _ - YES/ADEQ TRACE _ - - _ _ _ - YES/ADEQ - - YES/ADEQ - _ Company Sanitized. Does not contain TSCA CBI -808- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues Anim al NORM SM TOX DB Number VC BC PCE GP BP M ale, G roup V - 100 m g/kg - D ay'37 665035 YES - - - - - - - - 665054 YES - - - - - - - - 665073 YES - - - - - - - - 665089 YES - - - - - - _- 665103 YES - - - - - - _- 665119 YES - - - - - - _- 665122 YES - - - - - - - - 665137 YES - - - - - - - - 665143 YES - - - ~- -- - - 665155 YES " - - - - - - - M ale, G roup V II - 1000 m g/kg - Day 37 664999 YES _ _ _ _ _ __ 665026 YES - - - - - - - - 665027 YES - - - - _ - - - 665082 YES - - _ _ _-- 665096 YES _ -- --- - 665107 YES - - _ _ _ - - - 665120 YES - - - - - - - - 665152 YES - _ __ --- 665160 YES - - - - - ~ - - 665162 YES - - - _ -- - DuPont-11418 Company Sanitized. Does not contain TSCA CBI -809- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number NORM SM TOX M ale, G roup I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 NO NO YES YES YES YES YES NO NO YES ~ - " - - M ale, G roup I I I - 10 m g/kg - Day 92 664993 NO _ 664995 NO - - 665033 665053 NO YES - * -_ 665060 YES - - 665074 NO - - 665080 NO - - 665128 CLOT NT NT 665131 NO - - 665136 YES - - In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues DB VC BC PCE GP BP - - - YES/ADEQ - - - - YES/ADEQ - ------ - __- - ---------------- - - YES/ADEQ - - - - YES/ADEQ - - ------ _ _ _ YES/ADEQ - - - _ - YES/ADEQ - - - - - YES/DECR - - ------ ------ - - - YES/DECR - - - - - YES/DECR - - NT NT NT NT NT NT - - - YES/ADEQ - - ------ DuPont-11418 Company Sanitized. Does not contain TSCA CBI -810- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________ Anim al Number NORM SM In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues TOX DB VC BC PCE GP BP M ale, G roup V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 NO YES YES YES YES NO YES NO YES YES _ - - _ - _ _ _ YES/DECR _ --------- _- - ----- - YES/ADEQ ----- - - YES/ADEQ ----- ----- - - M ale, G roup V II - 1000 m g/kg - Day 92 664999 NO _ _ - _ YES/DECR - - 665026 NO - - - - - YES/DECR - - 665027 NO - - - - YES/DECR - - 665082 NO - - - - - YES/DECR - - 665096 YES - - - - - - - - 665107 NO - - - - - YES/ADEQ - - 665120 NO _ - - - - YES/DECR - - 665152 NO - - - - - YES/DECR - - 665160 YES - - - - - - - - 665162 YES - - - - - - - - DuPont-11418 Company Sanitized. Does not contain TSCA CBI -811- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________ In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues Animal NORM SM TOX DB VC BC PCE GP BP Number M ale, Group I - 0 m g/kg - Day 127 665008 NO _ _ _ _ _ _ TRACE - 665042 YES - - - - - - - - 665043 YES - - - - - - - - 665064 NO - - - - YES/UTD - - 665081 YES - - - - - - - - 665098 NO - - - - - YES/DECR - - 665106 NO - - - - - YES/UTD - - 665121 YES - - - - - - - - 665149 YES - ------ 665159 NO - - - - - YES/DECR TRACE - M ale, Group V II - 1000 m g/kg - Day 127 665002 YES - __- - - - - 665007 YES - - - - - - - - 665031 NO - - _- - YES/UTD - - 665062 YES ------- 665067 YES - - - - - - - - 665095 NO - - - - - YES/UTD - - 665112 YES - - - - - - - - 665138 NO - - - - - YES/UTD - - 665146 NO - - - - - YES/ADEQ - - 665158 CLOT NT NT NT NT NT NT NT NT DuPont-11418 Company Sanitized. Does not contain TSCA CBI -812- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________________________________ Anim al Number NORM SM TOX Fem ale, Group I I - 0 m g/kg - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 NO YES YES YES YES YES YES YES YES YES - - - - - em ale, G roup IV - 10 m g/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 NO NO NO YES NO YES YES YES YES YES _ - - _ - - In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues DB VC BC PCE GP BP - - - YES/ADEQ - ------ - _- - -- -- --- ------ - --- - ------ ------ ------ - - - - -- _ _ _ YES/ADEQ - - - - - YES/DECR - - - - - YES/ADEQ - - -- - --- _- - YES/ADEQ - - - _- - - - ------ ------ ------ ------ ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -813- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues Anim al NORM SM T0X DB VC BC PCE GP BP Number Fem ale, G roup VI - 100 m g/kg - Day 38 665170 YES - - - - - - - - 665199 YES - - - - - - - - 665238 YES - - - - - - - - 665250 YES - ------ 665251 YES - - - - - - - - 665259 NO - - - - - YES/ADEQ - - 665295 YES - ------ 665300 YES - - - - - _ - - 665340 YES - - - - - - - - 665341 YES - ----- Fem ale, G roup V III - 1000 m g/kg - Day 38 665183 YES ~ _ _ _ _ _- - 665200 YES - - - - - - - - 665234 YES ~ - - - - - - - 665242 YES - - - - - - - - 665261 YES - - - - - - _ - 665291 YES - - - - - - - - 665310 YES - _ - - - - - - 665326 YES - - - - - - - - 665333 YES - - - -- - - 665337 NO - - - - - YES/ADEQ - - D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -814- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 Animal NORM SM TOX Number F e m a le , <G roup I I - 0 m g /k g - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 NO NO YES YES NO NO YES NO NO YES __ -_ - *- ---_ _--- -- F em ale, G roup IV - 10 xng/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 YES NO NO NO NO NO NO YES NO NO _ - - - - - - I n d iv id u a l W hite B lood C e ll / P l a t e l e t M orphology V alu es DB VC BC PCE GP BP _ YES/UTD _ YES/ADEQ _ - YES/INCR _ YES/UTD _ - YES/ADEQ _ YES/UTD - _ - YES/UTD - YES/UTD - YES/ADEQ - YES/UTD - YES/UTD - YES/DECR ~ - YES/ADEQ - YES/ADEQ Company Sanitized. Does not contain TSCA CBI -815- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues Anim al NORM SM TOX DB VC BC PCE GP BP Number F e m ale , G roup VI - 100 m g/kg - Day 93 6 6 5170 YES - 665199 NO 665238 NO -- 665250 YES - 665251 NO 665259 NO 665295 YES - 665300 NO - 665340 NO 665341 YES - YES/ADEQ YES/ADEQ ' YES/UTD YES/UTD YES/ADEQ YES/UTD F em ale, G roup V I I I - 1000 m g/kg - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 NO NO YES NO YES NO NO YES YES NO - `- - -- YES/ADEQ YES/UTD YES/UTD YES/ADEQ YES/UTD YES/UTD DuPont-11418 Company Sanitized. Does not contain TSCA CBI -816- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________DuPont-11418 Anim al Number NORM SM In d iv id u a l W hite B lood C e ll / P l a te l e t M orphology V alues T0X DB VC BC PCE GP BP F em ale, G roup I I - 0 m g/kg - Day 127 665189 NO _ _ _ _ _ YES/ADEQ - - 665197 NO - - - - - YES/UTD - - 665201 YES - - - - - - - - 665204 NO - - - - - YES/UTD - - 665228 NO - - - - - YES/UTD - - 665256 YES - - - - - - - - 665260 YES _ - - - - - - - 665276 YES - - - - - - - 665323 YES - - - - - - _ - 665327 NO - - - - - YES/UTD - - Fem ale, G roup V III - 1000 m g/kg - Day 127 665209 YES _ _ _ _ _ _ _ _ 665229 NO - - - - - YES/ADEQ - - 665237 YES - - - - - - - - 665275 NO - - ~ - YES/DECR - - 665282 YES - - - - - - - - 665288 NO - - - - - YES/ADEQ - - 665299 NO - - - - - YES/UTD TRACE - 665303 NO - ~ - - - YES/DECR - - 665328 NO - - - - - YES/UTD - - 665335 NO - - - - - YES/UTD Company Sanitized. Does not contain TSCA CBI -817- >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number PHEM PLIP . PICT M ale, G roup I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M ale, G roup I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PT sec 1 5 .3 1 7 .1 1 6 .7 1 5 .9 1 5 .1 1 7 .5 1 5 .1 1 5 .7 1 5 .5 1 5 .6 1 7 .5 1 5 .5 1 5 .5 1 5 .7 1 5 .0 1 6 .0 1 7 .7 1 5 .2 1 5 .3 1 5 .1 In d iv id u a l C o ag u latio n V alues APTT sec 2 0 .4 2 1 .4 2 1 .1 1 9 .9 1 9 .9 2 2 .8 1 8 .5 2 0 .0 2 2 .8 1 9 .6 2 2 .0 2 0 .1 1 8 .6 1 9 .9 1 7 .0 1 9 .1 1 9 .6 1 9 .7 2 0 .3 1 7 .5 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -818- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number PHEM PLIP PICT M ale, G roup V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M ale, G roup V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PT sec 1 5 .6 1 5 .5 1 5 .9 1 5 .9 1 5 .1 1 5 .6 1 5 .1 1 5 .2 1 4 .9 1 5 .4 1 4 .8 1 5 .4 1 5 .9 1 5 .9 1 6 .8 1 5 .1 1 6 .5 1 6 .2 1 5 .5 1 5 .2 In d iv id u a l C o ag u latio n V alues APTT sec 1 7 .4 1 9 .5 2 1 .6 2 0 .4 1 6 .9 2 0 .6 1 8 .5 1 5 .0 1 9 .0 1 9 .6 1 5 .6 1 9 .0 1 9 .5 1 9 .1 2 0 .9 2 0 .4 1 9 .9 1 7 .2 1 9 .1 1 9 .5 ' ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -819- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number PHEM PLIP PICT M ale, G roup I - 0 m g/kg - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 NONE NSR NONE NONE TRACE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE , NONE NT NONE NONE NONE NONE NONE NONE NONE NONE M a le , G ro u p V I I - 1000 m g /k g - D ay 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PT sec 1 6 .5 NT 1 8 .1 1 5 .5 1 6 .1 1 5 .7 1 5 .1 1 5 .5 1 5 .9 1 5 .9 1 5 .9 1 5 .3 1 4 .7 1 5 .5 1 5 .1 1 6 .5 1 5 .5 1 5 .3 1 5 .7 1 5 .5 In d iv id u a l C o ag u latio n V alues APTT sec 2 1 .8 NT 2 0 .5 2 0 .7 2 3 .2 2 0 .4 2 1 .7 1 9 .3 2 1 .3 1 7 .8 2 2 .6 1 8 .7 2 2 .3 1 9 .6 1 9 .8 2 1 .7 2 2 .2 1 8 .8 2 1 .3 2 3 .9 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -820- ) H-25425 Subchronic Toxicity 90-Day Cravage Study in Rats with One-Generation Reproductive Evaluations ) A nim al Number PHEM PLIP PICT F em ale, G roup I I - 0 m g /k g - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 NONE NONE NONE NONE NONE NONE NONE NONE CLOT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE F e m ale , G roup IV - 10 m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE .NONE NONE NONE NONE NONE PT sec 1 4 .3 1 5 .0 1 5 .0 1 5 .1 1 4 .8 1 4 .7 1 5 .1 1 5 .1 NT 1 5 .8 1 5 .0 1 5 .8 1 5 .1 1 5 .5 1 6 .4 1 5 .1 1 6 .0 1 5 .5 1 4 .7 1 5 .6 In d iv id u a l C o ag u latio n V alues APTT sec 1 4 .6 1 9 .0 1 9 .5 1 6 .6 1 8 .5 1 7 .8 1 9 .6 1 8 .6 NT 1 7 .9 1 9 .1 1 8 .3 1 9 .2 1 9 .1 1 9 .3 1 7 .7 1 7 .1 1 9 .6 1 8 .8 1 8 .8 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -821- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PHEM PLIP PICT PT sec F em ale, G roup VI - 100 m g/kg - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE .NONE NONE NONE NONE 1 6 .0 1 5 .8 1 5 .6 1 5 .3 1 5 .3 1 6 .3 1 5 .2 1 5 .7 1 5 .3 1 4 .9 F e m ale , G roup V I I I - 1000 m g/kg - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 CLOT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT 1 4 .9 1 4 .3 1 4 .6 1 6 .3 1 5 .6 1 4 .5 1 5 .0 1 4 .3 1 6 .1 In d iv id u a l C o ag u latio n V alues APTT sec 1 7 .6 2 1 .7 1 5 .5 1 5 .8 1 5 .8 1 6 .7 1 5 .9 1 8 .1 1 9 .0 1 9 .6 NT 1 9 .1 2 2 .2 1 9 .8 2 0 .4 1 6 .4 1 6 .6 1 8 .8 2 0 .0 1 9 .1 ) DuPont-11418 Company Sanitized. Does not contain TSCA C8I -822- Company Sanitized. Does not contain TSCA H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number PHEM PLIP PICT PT sec sm ale. G roup I I - 0 m g/kg - Day 127 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 1 5 .1 1 4 .6 1 5 .3 1 5 .1 1 4 .3 1 4 .7 1 4 .7 1 3 .5 1 5 .5 1 6 .0 F em ale, G roup V III - 1000 m g/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 1 5 .9 1 5 .0 1 5 .9 1 4 .3 1 4 .3 1 5 .1 1 6 .0 1 5 .5 1 5 .1 1 5 .5 In d iv id u a l C o ag u latio n V alues APTT sec 1 8 .5 1 6 .0 1 7 .2 1 5 .8 1 6 .0 1 5 .2 2 1 .8 1 8 .0 1 8 .3 1 7 .9 1 7 .7 1 7 .6 1 8 .5 1 6 .0 1 8 .5 2 0 .1 1 2 .7 1 7 .6 2 2 .1 1 6 .5 O 00 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations A nim ai Number SHEM SLIP SICT M ale, G roup I - 0 m g/kg - Day 37 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 NONE NONE TRACE TRACE NONE SMALL NONE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M ale, Group I I I - 10 m g/kg - Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 TRACE NONE TRACE TRACE TRACE SMALL TRACE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE In d iv id u a l C lin ic a l C hem istry V alues AST ALT SDH ALKP B IL I BUN CREA CHOL U/L U /L U/L U/L m g/dL mg/dL mg/dL mg/dL 68 29 13 .1 177 < 0.10 13 0 .3 8 63 66 31 10..9 166 0 .1 0 14 0 .3 2 47 73 29 12..0 116 < 0.10 13 0 .3 1 68 68 27 14..8 177 0 .1 0 14 0 .3 0 54 70 29 13..9 180 0 .1 0 13 0 .3 3 65 91 31 14..0 144 0 .1 1 15 0 .4 2 84 78 33 12..2 251 0 .1 1 15 0 .4 4 61 68 28 11..9 120 <0.10 14 0 .3 6 67 74 28 11..0 121 < 0.10 15 0 .3 6 76 70 28 12..6 107 0 .1 0 14 0 .3 3 58 78 30 8 .2 249 < 0.10 15 0 .3 1 44 62 29 1 1 .4 210 0 .1 1 13 0 .3 2 88 74 33 9 .9 160 0 .1 0 15 0 .3 2 86 82 34 1 2 .4 118 < 0.10 14 0 .2 9 47 82 34 9 .5 187 0 .1 0 12 0 .3 4 86 74 25 1 2 .7 142 < 0.10 13 0 .3 3 60 72 31 1 4 .5 122 < 0.10 14 0 .4 2 39 74 37 1 3 .9 190 <0.10 12 0 .3 3 67 72 27 1 2 .9 148 0 .1 0 14 0 .3 2 69 66 34 1 0 .8 112 < 0.10 14 0 .3 1 65 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -824- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number SHEM SLIP SICT M ale, G roup V - 100 m g/kg 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 NONE TRACE TRACE SMALL SMALL TRACE TRACE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M ale, G roup V II - 1000 m g/kg 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 TRACE TRACE TRACE SMALL NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE ' 37 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Day 37 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE AST U /L 72 76 69 63 82 86 82 62 86 76 72 80 77 72 63 67 67 64 65 76 In d iv id u a l C lin ic a l C hem istry V alues ALT SDH ALKP B IL I U/L U/L U/L mg/dL BUN mg/dL CREA m g/dL CHOL m g/dL 38 1 2 .2 145 < 0.10 14 0 .2 6 64 34 1 0 .7 149 < 0.10 14 0 .3 3 55 30 1 1 .6 201 <0.10 13 0 .3 1 49 30 1 1 .0 175 0 .1 2 13 0 .3 4 62 30 1 1 .3 136 < 0.10 15 0 .4 1 63 34 1 2 .7 182 <0.10 14 0 .3 2 42 41 1 1 .5 171 0 .1 1 14 0 .3 7 52 29 1 2 .0 173 <0.10 13 0 .3 4 65 34 1 2 .9 138 <0.10 14 0 .3 4 52 36 8 .8 119 <0.10 13 0 .2 8 46 25 1 0 .5 180 < 0.10 14 0 .2 8 77 32 1 1 .2 187 < 0 .1 0 16 0 .3 0 54 35 1 0 .3 167 < 0 .1 0 12 0 .3 0 53 25 1 6 .5 101 <0.10 12 0 .3 9 61 29 1 4 .5 116 <0.10 13 0 .3 8 58 33 1 4 .8 162 <0.10 15 0 .2 5 47 29 9 .7 152 < 0.10 14 0 .2 6 48 27 1 0 .7 139 < 0.10 16 0 .2 5 40 30 1 3 .8 180 0 .1 0 14 0 .3 6 46 40 1 3 .2 113 <0.10 15 0 .3 2 42 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -825- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations A nim al Number TRIG mg/dL GLUC mg/dL TP g /d L a le , G roup I - 0 m g/kg - Day 37 665015 104 100 7 .3 665016 42 91 7 .0 665047 57 88 6 .6 665049 38 95 7 .0 665068 39 114 6 .9 665070 29 83 6 .4 665076 37 95 6 .5 665086 58 111 6 .6 665130 50 106 6 .7 665148 30 103 7 .2 a l e , G ro u p I I I - 10 m g /k g - ;Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 51 51 32 22 18 45 28 40 46 39 100 6 .8 108 6 .6 112 7 .2 109 6 .5 97 7 .2 100 >6.5 104 7 .1 117 6 .6 96 6 .2 109 6 .6 ALB g /d L In d iv id u a l C lin ic a l c h em istry V alues GLOB g /d L CALC m g/dL IPHS mg/dL NA m m ol/L K m m ol/L CL m m ol/L 4 .6 2 .7 1 1 .1 8 .0 1 5 1 .8 6 .0 0 1 0 2 .5 4 .5 2 .5 1 1 .1 9 .0 1 5 4 .8 6 .3 5 1 0 7 .0 4 .3 2 .3 1 0 .4 7 .6 1 4 6 .9 5 .9 4 9 8 .3 4 .4 2 .6 1 0 .7 8 .0 1 4 8 .4 6 .1 1 9 8 .9 4 .5 2 .4 1 1 .0 8 .7 1 5 2 .4 5 .6 5 1 0 3 .5 4 .1 2 .3 1 0 .5 9 .1 1 5 0 .2 6 .1 5 1 0 2 .1 4 .2 2 .3 1 1 .0 8 .6 1 5 0 .8 5 .7 7 1 0 2 .4 4 .2 2 .4 1 1 .2 9 .0 1 5 7 .7 6 .0 7 1 0 7 .2 4 .2 2 .5 1 1 .0 8 .2 1 4 9 .3 6 .5 7 9 9 .9 4 .6 2 .6 1 0 .9 8 .2 1 5 3 .4 5 .7 9 1 0 3 ,9 4 .2 2 .6 1 1 .5 8 .1 1 4 9 .9 6 .1 3 1 0 2 .3 4 .3 2 .3 1 1 .3 8 .4 1 5 3 .9 5 .5 0 1 0 5 .4 4 .5 2 .7 1 1 .3 8 .0 1 5 2 .9 6 .1 9 1 0 3 .6 4 .1 2 .4 1 0 .1 8 .2 1 4 5 .8 5 .5 3 1 0 0 .3 4 .6 2 .6 1 1 .0 8 .2 1 5 3 .6 6 .2 7 1 0 3 .5 4 .3 2 .2 1 0 .6 8 .0 1 4 7 .8 6 .0 6 9 9 .7 4 .5 2 .6 1 1 .9 9 .9 1 5 1 .5 7 .7 3 1 0 3 .2 4 .4 2 .2 1 0 .8 7 .6 1 4 6 .2 5 .4 0 1 0 1 .3 4 .4 1 .8 1 0 .8 9 .1 1 5 2 .1 6 .3 9 1 0 5 .4 4 .0 2 .6 1 1 .3 9 .2 1 5 4 .2 5 .7 3 1 0 4 .6 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -826- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number TRIG mg/dL GLUC mg/dL TP g/dL M ale, Group V - 100 m g/kg - Day 37 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 47 69 128 44 74 39 57 46 43 43 102 6 .7 97 7 .0 101 7 .0 98 7 .3 97 6 .9 94 6 .2 99 .6 .6 97 7 .0 110 6 .6 80 6 .1 M ale, Group V II - 1000 m g/kg - Day 37 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 42 49 32 15 29 36 16 93 48 89 98 6 .0 98 6 .6 110 7 .0 91 7 .2 90 6 .8 92 6 .3 106 6 .1 104 6 .3 97 7 .0 107 6 .6 ALB g /d L 4 .2 4 .4 4 .3 4 .9 4 .4 3 .9 4 .5 4 .2 4 .3 4 .0 4 .4 4 .4 4 .5 4 .5 4 .5 4 .1 4 .1 4 .2 4 .6 4 .3 In d iv id u a l C lin ic a l C hem istry V alues GLOB g/dL CALC m g/dL IPHS m g/dL NA m m ol/L K m m ol/L CL m m ol/L 2 .5 1 1 .1 8 .8 1 5 4 .2 6 .1 2 1 0 4 .4 2 .6 1 1 .1 8 .6 1 5 3 .1 6 .2 9 1 0 4 .5 2 .7 1 0 .7 9 .2 1 4 8 .5 5 .8 1 9 9 .3 2 .4 1 1 .6 8 .6 1 4 8 .9 5 .8 8 9 9 .0 2 .5 1 1 .1 8 .7 1 5 4 .2 6 .4 2 1 0 5 .3 2 .3 1 0 .4 8 .9 1 5 1 .5 6 .1 8 1 0 4 .0 2 .1 1 0 .8 8 .5 1 4 7 .0 6 .0 5 9 7 .3 2 .8 1 0 .9 8 .2 1 5 3 .8 5 .9 9 1 0 4 .6 2 .3 1 1 .1 9 .3 1 5 1 .7 5 .5 1 1 0 1 .9 2 .1 1 0 .6 8 .7 1 4 9 .4 5 .9 8 1 0 2 .1 1.6 10.6 2 .2 .11.3 2 .5 11.3 2 .7 11.1 2.3 10.9 2 .2 11.2 2.0 10.6 2.1 11.1 2 .4 11.2 2.3 11.7 8 .8 1 5 2 .0 6 .1 2 1 0 6 .7 9 .5 1 5 4 .8 6 .3 8 1 0 6 .0 8 .6 1 5 4 .7 6 .4 0 1 0 6 .1 8 .1 1 4 9 .0 6 .3 0 1 0 1 .7 8 .6 1 4 8 .6 5 .9 2 1 0 0 .3 9 .2 1 4 8 .4 6 .1 7 1 0 2 .1 8 .8 1 5 3 .1 5 .5 5 1 0 3 .9 8 .7 1 5 0 .9 6 .1 5 1 0 3 .2 8 .6 1 4 9 .1 5 .5 7 9 8 .9 9 .8 155.3 6 .8 2 1 0 5 .6 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -827- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP SICT M ale, G roup I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 NONE NONE TRACE TRACE NONE TRACE NONE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M a le , G ro u p I I I - 10 m g /k g - :Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 TRACE NONE NONE TRACE TRACE TRACE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE In d iv id u a l C lin ic a l C hem istry V alues AST ALT SDH ALKP B IL I BUN CREA CHOL U /L U/L U/L U /L mg/dL mg/dL m g/dL m g/dL 89 38 1 9 .0 102 < 0.10 13 0 .4 4 66 75 33 1 8 .5 92 0 .1 1 13 0 .3 6 53 85 33 1 9 .8 71 0 .1 3 16 0 .3 9 67 65 29 1 8 .6 95 0 .1 2 16 0 .5 0 59 68 39 1 9 .5 133 0 .1 2 16 0 .4 4 69 103 33 2 0 .1 81 0 .1 3 15 0 .5 6 93 84 37 2 0 .6 147 0 .1 2 18 0 .5 4 46 75 30 2 1 .1 70 < 0 .1 0 13 0 .4 2 65 79 30 1 4 .5 74 0 .1 2 15 0 .5 1 80 72 32 2 0 .4 94 0 .1 2 15 0 .5 0 77 79 31 1 1 .9 136 < 0.10 17 0 .4 6 37 64 31 1 2 .6 122 < 0.10 12 0 .3 6 97 74 30 1 6 .7 96 0 .1 2 14 0 .4 6 90 107 64 2 9 .5 82 0 .1 0 14 0 .4 7 46 95 49 1 2 .5 146 0 .1 2 16 0 .3 9 96 79 33 2 3 .4 91 0 .1 1 15 0 .4 3 73 92 40 2 0 .8 80 0 .1 0 16 0 .6 2 35 159 129 4 6 .5 131 0 .1 3 17 0 .4 5 71 81 34 1 9 .0 82 0 .1 4 16 0 .4 2 72 86 36 1 5 .2 68 0 .1 1 15 0 .4 4 74 DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 828- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP SICT M ale, Group V - 100 m g/kg - Day 92 665035 665054 665073 665089 66510.3 665119 665122 665137 665143 665155 NONE NONE NONE TRACE TRACE TRACE TRACE TRACE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M ale, G roup V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 TRACE TRACE TRACE TRACE TRACE NONE TRACE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE AST U/L 75 75 70 75 82 81 87 66 92 75 68 87 71 63 81 72 77 78 67 92 In d iv id u a l C lin ic a l C hem istry V alues ALT SDH ALKP B IL I U/L U/L U/L mg/dL BUN m g/dL CREA mg/dL CHOL m g/dL 50 1 3 .7 102 0 .1 0 16 0 .4 9 63 35 1 2 .9 83 0 .1 1 12 0 .4 2 59 38 1 5 .9 122 < 0.10 15 0 .3 6 50 40 1 3 .9 86 0 .1 4 16 0 .4 7 50 32 2 1 .6 84 0 .1 1 14 0 .3 9 55 37 1 7 .3 119 <0.10 15 0 .3 8 40 42 1 3 .6 109 0 .1 2 19 0 .4 2 55 35 1 4 .4 101 < 0.10 18 0 .4 0 55 45 2 2 .8 82 0 .1 1 16 0 .3 2 39 29 1 6 .6 86 < 0 .1 0 16 0 .4 0 51 31 1 1 .4 116 0 .1 2 19 0 .4 5 85 34 1 7 .3 117 0 .1 0 15 0 .3 7 56 34 9 .8 143 < 0.10 13 0 .3 9 54 28 1 3 .5 83 0 .1 0 16 0 .4 3 51 34 2 2 .4 107 < 0.10 17 0 .5 2 49 33 1 8 .5 112 < 0.10 16 0 .4 0 40 36 2 0 .9 121 < 0.10 15 0 .5 0 47 37 2 0 .4 120 < 0.10 16 0 .3 9 42 34 1 7 .2 106 <0.10 17 0 .4 0 45 53 2 3 .7 86 0 .1 1 16 0 .5 4 41 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -829- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________ Anim al Number TRIG mg/dL GLUC m g/dL TP g /d L M ale, G roup I - 0 m g/kg - Day 92 665015 123 112 7 .5 665016 93 92 7 .6 665047 62 97 7 .1 665049 78 99 7 .6 665068 78 109 7 .3 665070 48 93 6 .9 665076 68 86 7 .2 665086 88 107 7 .2 665130 69 174 7 .5 665148 78 96 8 .1 l e . G roup I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 36 60 76 31 41 88 31 71 33 79 115 7 .0 98 7 .1 161 7 .7 139 7 .3 148 7 .4 97 7 .2 156 7 .8 202 6 .9 134 6 .9 100 7 .5 ALB g /d L In d iv id u a l C lin ic a l C hem istry V alues GLOB g/dL CALC m g/dL IPHS m g/dL NA m m ol/L K m m ol/L CL m m ol/L 4 .4 3 .1 1 1 .2 1 0 .0 1 4 9 .8 7 .3 0 1 0 8 .9 4 .7 2 .9 1 1 .5 9 .9 1 5 2 .4 6 .8 3 1 1 0 .1 4 .3 2 .8 1 0 .4 7 .3 1 4 4 .9 5 .4 7 9 8 .8 4 .5 3 .1 1 1 .1 9 .1 1 4 7 .9 6 .2 8 1 0 2 .6 4 .7 2 .6 1 2 .0 9 .8 1 5 1 .9 6 .4 4 108-2 4 .3 2 .6 1 0 .3 1 0 .0 1 4 9 .4 6 .1 1 1 0 6 .6 4 .4 2 .8 1 1 .1 9 .1 1 5 0 .9 6 .8 7 1 0 7 .8 4 .4 2 .8 1 1 .4 9 .4 1 5 4 .5 6 .3 4 1 1 1 .5 4 .5 3 .0 1 1 .6 1 0 .8 1 4 9 .4 6 .1 7 1 0 5 .0 5 .0 3 .1 1 2 .1 1 0 .1 1 5 4 .3 6 .8 4 1 0 9 .7 4 .1 2 .9 1 1 .0 9 .9 1 4 8 .9 7 .7 1 1 0 9 .2 4 .1 3 .0 . 11.6 9 .5 1 5 2 .9 6 .1 8 1 0 9 .2 4 .7 3 .0 1 2 .4 9 .8 1 5 5 .7 6 .4 6 1 1 1 .3 4 .6 2 .7 1 1 .4 8 .9 1 4 9 .0 6 .2 9 9 9 .1 4 .4 3 .0 1 2 .0 1 0 .3 1 5 2 .1 7 .0 0 1 0 7 .0 4 .5 2 .7 1 0 .9 8 .4 1 4 8 .6 6 .2 3 1 0 4 .6 4 .7 3 .1 1 2 .5 1 2 .3 1 5 4 .3 7 .1 7 1 0 6 .1 4 .4 2 .5 1 1 .8 9 .9 147.3 5 .2 1 1 0 5 .8 4 .5 2 .4 1 1 .7 1 0 .7 1 5 1 .7 7 .7 5 1 0 9 .6 4 .4 3 .1 1 1 .6 8 .9 1 5 5 .2 6 .8 8 1 0 9 .6 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -830- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations A nim al Number TRIG mg/dL GLUC m g/dL TP g /d L a l e , G roup V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 47 90 92 25 55 57 45 44 51 90 209 7 .4 97 7 .6 201 7.3 120 7 .5 177 7.3 85 6 .8 104 6 .7 91 6 .9 104 7 .1 91 7 .2 a l e , G roup V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 48 47 32 27 43 59 16 61 47 81 103 6 .8 97 7 .0 113 7 .0 104 7 .4 157 7 .1 93 7 .0 175 7 .0 112 7 .0 102 7 .0 216 7 .3 ALB g/dL 4 .6 4 .7 4 .3 4 .6 4 .7 4 .1 4 .5 4 .4 4 .4 4 .6 4 .9 4 .7 4 .4 4 .7 4 .8 4 .6 4 .7 4 .6 4 .5 4 .7 In d iv id u a l C lin ic a l C hem istry V alues GLOB g/dL CALC mg/dL IPHS mg/dL NA m m ol/L K m m ol/L CL m m ol/L 2 .8 1 2 .1 1 1 .3 1 5 5 .7 5 .8 6 1 1 0 .3 2 .9 1 1 .6 8 .5 156.3 5 .9 0 1 0 9 .6 3 .0 1 2 .0 9 .8 1 4 9 .8 6 .0 0 1 0 5 .0 2 .9 1 1 .9 1 0 .1 1 4 7 .2 7 .7 8 1 0 3 .8 2 .6 1 2 .1 1 3 .0 1 5 2 .9 5 .9 9 1 0 8 .5 2 .7 1 0 .4 1 0 .1 1 4 9 .5 7 .2 6 1 0 8 .7 2 .2 1 0 .1 8 .9 145.3 6 .5 6 1 0 2 .5 2 .5 1 1 .4 9 .7 1 5 2 .0 6 .4 8 1 0 9 .1 2 .7 1 1 .2 9 .0 1 5 3 .5 6 .6 3 1 1 0 .3 2 .6 1 0 .9 7 .7 1 5 0 .6 6 .1 7 1 0 5 .0 1 .9 1 1 .0 9 .2 1 5 2 .2 6 .9 9 1 1 1 .5 2 .3 1 1 .3 9 .8 1 5 2 .1 6 .9 9 1 1 1 .9 2 .6 1 0 .2 9 .3 1 5 4 .1 7 .6 3 1 1 4 .1 2 .7 1 1 .0 8 .0 1 4 9 .4 7 .5 0 1 0 6 .5 2 .3 1 0 .2 1 3 .1 1 4 8 .5 5 .6 4 1 0 6 .2 2 .4 1 1 .4 1 1 .3 1 4 8 .7 8 .2 2 1 0 6 .6 2 .3 1 1 .3 1 2 .6 1 5 4 .2 5 .3 1 1 1 0 .7 2 .4 1 1 .5 1 0 .6 1 4 9 .1 7 .7 7 1 0 8 .4 2 .5 1 0 .5 9 .0 1 4 7 .4 6 .4 1 1 0 2 .9 2 .6 1 1 .7 1 1 .0 1 5 3 .2 5 .0 9 1 1 0 .8 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -831 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________ Anim al Number PHEM PLIP PICT CO M ale, Group I - 0 m g/kg - Day 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE ONE NONE NONE NONE NONE M ale, G roup I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PFLU Mg/mL In d iv id u a l C lin ic a l C hem istry V alues 0 .1 0 .1 0 .2 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -832- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations A nim al Number PHEM PLIP PICT M ale, G roup V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M a le , G ro u p V I I - 1 0 0 0 m g /k g -- D ay 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PFLU ng/m L 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 In d iv id u a l C lin ic a l C hem istry V alues DuPont-11418 Company Sanitized. Does not contain TSCA CBI 833 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number SHEM SLIP SICT M ale, Group H i O m g/kg - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 TRACE NONE NONE NONE TRACE NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M ale, G roup V II - 1000 m g/kg - Day 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 TRACE TRACE TRACE NONE TRACE TRACE NONE NONE TRACE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE AST U/L 91 76 75 71 111 73 80 68 68 79 91 151 85 92 100 77 73 91 92 82 In d iv id u a l C lin ic a l C hem istry V alues ALT SDH ALKP B IL I U/L U/L U/L mg/dL BUN mg/dL 49 2 1 .1 76 0 .1 5 14 31 2 3 .6 67 0 .1 1 15 38 1 8 .1 94 0 .1 0 11 37 1 5 .9 86 < 0 .1 0 13 53 1 4 .1 84 0 .1 5 17 27 1 4 .8 115 0 .1 8 14 34 7 .2 65 0 .1 2 15 31 1 4 .2 80 0 .1 5 11 28 1 7 .2 64 0 .1 0 13 38 2 5 .9 87 0 .1 3 18 60 3 7 .7 78 0 .1 0 13 65 2 1 .3 73 0 .1 1 18 36 1 5 .9 74 0 .1 2 16 41 2 3 .9 82 < 0 .1 0 18 56 2 0 .1 78 0 .1 2 11 40 1 8 .4 64 < 0 .1 0 15 34 1 8 .8 85 0 .1 3 14 42 1 9 .9 98 0 .1 0 16 41 3 .2 76 0 .1 0 16 38 6 .6 78 0 .1 1 17 CREA mg/dL CHOL mg/dL 0 .3 4 0 .3 7 0 .3 0 0 .2 8 0 .3 9 0 .3 2 0 .3 9 0 .2 9 0 .3 2 0 .4 5 47 63 68 77 57 76 73 104 61 73 0 .3 4 0 .4 1 0 .2 7 0 .3 5 0 .3 2 0 .3 6 0 .3 2 0 .3 3 0 .3 3 0 .3 9 53 44 58 67 67 69 81 53 62 42 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -834- >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations A nim al Number TRIG m g/dL GLUC m g/dL TP g/dL M ale, G roup I - 0 m g/kg - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 34 73 89 98 23 50 68 117 77 76 111 ' 7 .3 90 6 .7 117 7 .5 106 7 .2 153 7 .0 94 6 .7 141 6 .9 100 7.3 99 7 .1 117 7 .4 M ale, Group V II - 1000 m g/kg - Day 127 665002 85 231 6 .8 665007 45 181 7.1 665031 117 109 7 .5 665062 84 104 7 .7 665067 64 180 6 .8 665095 20 124 7.3 665112 89 92 7 .5 665138 104 134 6 .6 665146 35 108 7 .0 665158 42 174 7 .2 ALB g/dL 4 .5 4 .6 4 .6 4 .3 4 .4 4 .3 4 .2 4 .5 4 .4 4 .8 4 .5 4 .3 4 .8 4 .9 4 .5 4 .7 4 .9 4 .6 4 .6 4 .8 In d iv id u a l C lin ic a l C hem istry V alues GLOB g/dL CALC m g/dL IPHS mg/dL NA m m ol/L K m m ol/L CL m m ol/L 2 .8 1 1 .0 8 .3 1 5 2 .7 6 .3 3 1 0 7 .6 2 .1 1 0 .9 7 .5 1 5 0 .0 6 .3 8 1 0 0 .5 2 .9 1 0 .9 7 .0 1 4 7 .9 6 .3 2 1 0 3 .9 2 .9 1 1 .4 7 .5 1 5 0 .0 6 .1 6 1 0 3 .5 2 .6 1 0 .8 9.3 1 4 7 .7 6 .6 3 1 0 4 .5 2 .4 1 0 .4 7 .5 1 4 6 .5 6 .3 4 1 0 3 .0 2 .7 1 1 .4 9 .1 1 5 1 .4 6 .7 8 1 0 4 .8 2 .8 1 1 .5 7 .5 1 5 1 .7 6 .1 9 1 0 3 .1 2 .7 1 0 .9 7 .4 148.3 6 .0 1 1 0 2 .7 2 .6 1 1 .6 8 .7 1 4 8 .9 6 .3 6 1 0 2 .8 2 .3 1 1 .7 1 0 .7 1 4 8 .9 6 .0 1 1 0 3 .8 2 .8 1 1 .3 8 .3 1 4 9 .7 5 .2 7 1 0 5 .8 2 .7 1 1 .2 9 .0 1 4 8 .7 6187 1 0 4 .5 2 .8 1 1 .3 8 .4 1 5 0 .4 6 .5 6 1 0 3 .3 2 .3 1 1 .5 9 .2 1 4 6 .7 6 .1 1 1 0 6 .1 2 .6 1 0 .8 8 .7 1 5 0 .7 6 .3 1 1 0 4 .8 2 .6 1 1 .6 8 .1 1 5 3 .0 6 .0 4 1 0 2 .6 2 .0 1 1 .5 8 .8 1 5 1 .6 6 .2 2 1 0 5 .8 2 .4 1 1 .0 8 .5 1 4 8 .8 6 .9 0 1 0 3 .8 2 .4 1 2 .1 1 0 .6 1 5 0 .6 7 .5 6 1 0 2 .5 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI 835 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PHEM PLIP PICT M ale, Group I - 0 m g/kg - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 NONE NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE M ale, Group V II - 1000 m g/kg - Day 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PFLU MS/mL 0 .1 NSR 0 .0 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .0 0 .1 0 .0 0 .0 0 .1 0 .1 0 .1 0 .1 0 .0 0 .1 0 .1 In d iv id u a l C lin ic a l C hem istry V alues DuPont-11418 Company Sanitized, Does not contain TSCA CBI 836 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Anim al Number SHEM SLIP SICT Fem ale, G roup I I - 0 m g/kg - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 TRACE NONE TRACE NONE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Fem ale, G roup IV - 10 m g/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 NONE TRACE NONE TRACE NONE NONE NONE TRACE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE In d iv id u a l C lin ic a l C hem istry V alues AST ALT SDH ALKP B IL I BUN CREA CHOL U/L U/L U/L U/L m g/dL m g/dL mg/dL mg/dL 87 33 1 5 .1 106 0 .1 2 18 0 .4 5 49 56 25 1 1 .3 74 0 .1 0 17 0 .4 6 66 88 34 1 8 .6 151 0 .1 0 15 0 .4 5 72 88 36 1 6 .4 162 < 0.10 24 0 .5 9 60 70 31 1 1 .4 113 0 .1 1 17 0 .4 5 72 72 39 1 4 .8 115 0 .1 4 15 0 .5 3 65 82 45 1 6 .5 103 0 .1 2 16 0 .4 6 86 72 29 1 6 .2 126 < 0.10 15 0 .3 7 62 71 32 1 2 .9 98 0 .1 1 18 0 .4 9 93 66 35 1 1 .0 153 0 .1 4 18 0 .4 4 66 67 32 1 3 .8 72 0..10 16 0..52 65 85 30 1 4 .6 109 0..13 15 0..39 44 81 27 1 9 .7 132 0..13 13 0..49 84 61 24 7 . 0 181 0..11 15 0..45 83 93 41 1 8 .4 105 0..13 15 0..38 45 73 40 1 3 .0 103 0..12 18 0..47 67 77 35 1 5 .3 105 0..12 15 0..45 65 78 30 1 4 .0 130 0..12 13 0..44 68 70 29 65 0..11 18 0,.41 67 66 27 1 4 .4 109 0..10 17 0..52 64 ) DuPont-11418 1" CO Company Sanitized. Does not contain TSCA CBI - 837- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________ Anim al NuirDer SHEM SLIP SICT Fem ale, G roup VI - 100 m g/kg - Day 38 AST U/L 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 TRACE NONE NONE NONE TRACE NONE NONE TRACE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 61 75 72 75 79 80 80 76 62 52 Fem ale, G roup V III - 1000 m g/kg - Day 38 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 TRACE TRACE TRACE TRACE NONE TRACE TRACE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE {TONE NONE 85 80 61 101 75 82 72 76 65 75 In d iv id u a l C lin ic a l C hem istry V alues ALT SDH ALKP B IL I U/L U/L U/L mg/dL BUN m g/dL CREA mg/dL CHOL m g/dL 27 1 0 .1 98 0 .1 1 15 0 .4 9 84 32 1 4 .9 122 0 .1 2 15 0 .4 4 65 29 1 2 .9 125 < 0.10 20 0 .5 0 59 27 1 6 .2 130 0 .1 2 15 0 .4 8 56 28 1 4 .8 140 0.13 16 0 .4 4 62 35 1 9 .8 127 0 .1 1 16 0 .4 5 73 25 1 6 .7 155 0 .1 0 15 0 .3 8 66 28 1 0 .5 146 <0.10 17 0 .5 1 80 26 1 0 .6 88 0 .1 1 17 0 .4 6 56 22 1 1 .2 87 0 .1 1 13 0 .3 8 73 31 2 1 .2 74 0 .1 5 15 0 .4 6 61 26 1 2 .6 153 0 .1 2 16 0 .4 9 89 27 1 4 .1 88 0 .1 1 16 0 .4 2 91 39 1 6 .0 126 < 0.10 13 0 .4 7 70 30 1 8 .3 109 <0.10 19 0 .4 5 51 42 1 2 .1 185 < 0.10 15 0 .4 6 64 37 1 5 .6 104 0 .1 2 17 0 .4 3 57 39 1 3 .8 93 0 .1 1 19 0 .4 6 68 29 1 4 .2 118 0 .1 1 15 0 .4 1 88 32 1 0 .2 133 0 .1 1 17 0 .3 6 63 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -838- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________ Animal Number TRIG m g/dL GLUC mg/dL TP g/dL Fem ale, G roup I I - 0 m g/kg - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 28 40 38 30 33 33 61 51 53 37 96 7 .2 93 6 .9 104 6 .8 93 7 .7 93 7 .3 105 7 .5 105 7 .8 94 7 .0 98 6 .8 117 .7 .4 Fem ale, G roup IV - 10 m g/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 26 32 31 23 26 38 68 51 24 22 110 7 .4 94 7 .2 91 7 .7 97 7 .2 88 7 .0 104 7.8 101 7.3 98 7 .0 97 7 .3 116 7.7 ALB g /d L In d iv id u a l C lin ic a l C hem istry V alues GLOB g/dL CALC mg/dL IPHS mg/dL NA m m ol/L K m m ol/L CL m m ol/L 4 .8 2 .4 1 1 .1 7 .5 1 4 5 .0 5 .8 9 9 9 .0 4 .7 2 .2 1 0 .9 8 .5 1 4 5 .0 6 .1 0 9 9 .7 4 .7 2 .1 1 0 .6 7 .0 1 4 1 .5 4 .9 6 9 7 .7 5 .0 2 .7 1 1 .4 7 .5 1 4 5 .5 6 .1 5 1 0 0 .9 4 .8 2 .5 1 1 .1 7 .7 144.3 6 .0 0 1 0 0 .0 5 .3 2 .2 1 1 .5 7 .1 1 4 8 .9 5 .6 1 1 0 2 .5 5 .5 2 .3 1 1 .8 6 .4 1 4 6 .7 5 .8 7 1 0 0 .3 4 .7 2 .3 1 1 .2 7 .5 1 4 6 .7 5 .3 9 1 0 2 .5 4 .8 2 .0 1 1 .2 6 .7 1 4 6 .2 5 .8 2 1 0 3 .0 5 .1 2 .3 1 1 .0 6 .9 1 4 6 .9 5 .7 0 1 0 0 .7 5 .2 2 .2 1 1 .7 7 .5 1 4 9 .8 5 .8 7 1 0 3 .8 4 .8 2 .4 1 1 .1 7 .7 1 4 5 .8 5 .7 0 1 0 1 .3 5 .3 2 .4 1 1 .8 8 .4 152.2 5 .8 5 1 0 5 .6 4 .6 2 .6 1 1 .6 8 .5 1 4 6 .0 6 .9 2 1 0 0 .3 4 .9 2 .1 1 1 .4 8 .4 1 4 6 .5 5 .8 5 1 0 2 .3 5 .4 2 .4 1 1 .8 8 .2 1 4 7 .8 6 .0 9 1 0 0 .5 4 .8 2 .5 1 1 .5 8 .2 1 4 7 .4 6 .0 4 1 0 0 .7 4 .8 2 .2 1 1 .0 7 .3 144.3 5 .6 4 1 0 0 .8 4 .8 2 .5 1 1 .2 7 .8 1 4 4 .9 5 .9 6 1 0 0 .1 5 .0 2 .7 1 2 .0 7 .4 1 4 7 .5 6 .4 9 1 0 2 .5 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 839- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number TRIG mg/dL GLUC mg/dL TP g/dL ALB g/dL am ale, G roup VI - 100 m g/kg - Day 38 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 38 38 28 37 28 30 58 27 36 68 109 7 .5 4 .9 95 7 .2 5 .0 101 7 .6 4.9 91 7 .8 5 .4 103 6 .9 5 .0 109 7 .6 5.1 100 7 .1 5.0 89 7 .3 4 .5 102 7 .4 5.1 98 7 .6 5 .4 sm ale, G roup V I I I - 1000 m g/kg - Day 38 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 22 28 95 21 27 28 40 35 46 30 111 7 .4 98 7 .7 78 7 .3 97 7 .6 98 7 .2 96 7 .5 105 7 .8 110 7 .5 112 8 .0 96 7 .5 5 .1 5 .0 5 .5 5 .0 5 .0 5 .0 5 .2 5 .2 5 .6 5 .0 In d iv id u a l C lin ic a l C hem istry V alues GLOB g/dL CALC mg/dL IPHS mg/dL NA m m ol/L K m m ol/L CL mmol/L 2 .6 1 1 .8 7 .7 148.3 5 .9 3 1 0 2 .1 2 .2 1 1 .3 7 .3 1 4 5 .5 5 .6 9 1 0 1 .0 2 .7 1 1 .6 8 .0 1 4 5 .6 5 .6 1 9 9 .0 2 .4 1 1 .9 7 .8 1 4 8 .0 6 .0 0 1 0 2 .3 1 .9 1 1 .1 7 .9 1 4 5 .4 5 .6 8 1 0 0 .7 2 .5 1 1 .6 7 .2 1 5 0 .0 5 .9 2 1 0 3 .5 2 .1 1 1 .2 8 .1 1 4 5 .7 5 .7 1 1 0 0 .2 2 .8 1 1 .1 8 .1 1 4 5 .9 6 .0 0 1 0 0 .7 2 .3 1 1 .7 7 .8 1 4 8 .2 6 .0 2 1 0 2 .4 2 .2 1 1 .8 7 .9 145.3 6 .3 6 1 0 1 .4 2 .3 1 1 .5 9 .6 146.2 5 .3 8 1 0 4 .0 2 .7 1 2 .0 8 .8 1 4 5 .7 6 .4 7 1 0 1 .5 1 .8 1 1 .4 7 .9 1 4 3 .8 5 .7 0 9 7 .8 2 .6 1 1 .6 8 .5 1 4 7 .8 6 .2 3 1 0 1 .3 2 .2 1 1 .8 8 .5 1 4 8 .8 6 .0 9 1 0 2 .8 2 .5 1 0 .8 7 .5 1 4 7 .7 5 .9 4 1 0 2 .5 2 .6 1 2 .0 8 .1 145.3 6 .1 4 1 0 0 .2 2 .3 1 1 .4 8 .4 1 4 6 .2 5 .8 5 1 0 2 .9 2 .4 1 1 .6 7 .6 1 4 6 .4 5 .6 0 1 0 0 .0 2 .5 1 1 .9 8 .1 1 4 5 .7 6 .2 5 1 0 0 .6 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -840- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim ai Number SHEM SLIP SICT F e m ale , G roup XI - 0 m g /k g - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 TRACE NONE NONE NONE NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Fem ale, G roup IV - 10 m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 TRACE TRACE NONE NONE NONE NONE TRACE TRACE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE In d iv id u a l C lin ic a l C hem istry V alues AST ALT SDH ALKP B IL I BUN CREA CHOL U /L U/L U/L U/L m g/dL mg/dL mg/dL m g/dL 112 51 1 9 .0 49 < 0 .1 0 16 0 .5 6 60 77 44 2 1 .1 43 < 0 .1 0 14 0 .4 4 83 97 51 2 9 .3 70 0 .1 1 15 0 .6 0 72 280 223 5 9 .9 57 0 .1 2 21 0 .5 6 95 69 28 1 3 .2 59 < 0 .1 0 19 0 .5 4 76 73 46 2 1 .1 56 0 .1 2 15 0 .5 8 73 89 45 2 1 .8 58 0 .1 2 18 0 .5 7 80 78 43 1 8 .2 69 < 0 .1 0 15 0 .4 5 76 79 32 1 7 .0 51 0 .1 1 15 0 .5 2 80 69 40 1 1 .1 65 0 .1 3 17 0 .5 4 63 68 34 1 2 .7 33 0 .1 8 15 0 .5 4 107 92 45 2 1 .5 67 0 .1 2 17 0 .4 7 46 102 69 2 8 .5 62 0 .1 5 15 0 .5 1 85 74 32 1 3 .1 95 < 0 .1 0 16 0 .4 4 72 108 52 2 0 .5 74 0 .1 0 16 0 .4 0 45 107 64 2 3 .3 44 < 0 .1 0 16 0 .5 3 73 92 39 1 6 .5 66 0 .1 3 16 0 .4 4 82 72 29 1 4 .5 54 0 .1 0 13 0 .5 0 81 86 42 1 8 .4 38 0 .1 1 18 0 .5 8 62 207 165 5 3 .6 65 0.1 2 18 0 .4 6 72 > DuPont-11418 Company Sanitized. Does not contain TSCA CBI -841- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number SHEM SLIP SICT e m a le , G roup VI - 100 m g/kg - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 TRACE NONE NONE NONE TRACE NONE TRACE TRACE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE AST U/L 120 80 76 63 94 86 107 78 75 62 F e m ale , G roup V I I I - 1000 m g/kg - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 TRACE TRACE NONE NONE NONE TRACE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 85 69 71 132 76 94 71 84 84 72 In d iv id u a l C lin ic a l C hem istry V alues ALT SDH ALKP B IL I U/L U/L U/L mg/dL BUN mg/dL CREA m g/dL CHOL m g/dL 94 3 4 .7 62 < 0 .1 0 15 0 .5 0 103 33 2 4 .4 51 < 0 .1 0 14 0 .4 8 62 28 14 .1 68 < 0.10 20 0 .5 2 64 34 1 5 .4 63 0 .1 3 17 0 .4 7 54 50 2 3 .0 61 0 .1 4 18 0 .5 6 61 39 1 8 .3 61 0 .1 3 17 0 .5 6 68 43 2 1 .9 72 0 .1 3 16 0 .5 5 57 34 1 4 .2 66 0 .1 0 16 0 .5 2 77 29 1 5 .2 48 < 0 .1 0 16 0 .5 5 83 23 1 6 .6 48 0 .1 1 16 0 .5 2 79 32 1 6 .4 42 < 0 .1 0 21 0 .5 2 59 28 1 4 .6 67 < 0.10 19 0 .5 5 77 32 2 0 .5 48 < 0.10 19 0 .5 1 80 56 8 .0 76 < 0 .1 0 17 0 .5 2 77 31 1 8 .2 71 < 0 .1 0 19 0 .5 0 64 49 1 2 .6 109 < 0.10 15 0 .4 3 64 38 1 4 .6 59 < 0 .1 0 18 0 .5 4 75 45 1 5 .4 53 < 0 .1 0 20 0 .4 8 69 27 9 .3 69 < 0 .1 0 14 0 .4 5 82 35 1 1 .8 71 < 0 .1 0 18 0 .4 9 59 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI 842 j H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations > Animal Number TRIG m g/dL GLUC mg/dL TP g/dL F e m a le , G roup I I - 0 m g /k g Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 51 47 59 75 48 46 68 50 50 33 136 7 .6 99 7 .9 159 7 .4 72 8 .6 93 7 .4 87 ,7 .4 90 8 .4 87 7 .2 92 7 .1 100 7 .5 F em ale, G roup IV - 10 m g/kg Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 37 36 36 19 15 34 52 35 42 32 96 8 .6 79 7 .6 98 7 .8 96 7..1 97 7 .5 87 8 .0 88 7 .9 91 7 .7 104 7 .6 105 8.0 ALB g/dL 5 .1 5 .4 5 .3 5 .8 5 .0 5 .0 5 .8 4 .8 5 .0 5 .0 6 .1 5 .1 5 .5 4 .6 5 .2 5 .5 5 .1 5 .2 5 .0 5 .1 In d iv id u a l C lini GLOB g/dL CALC m g/dL C hem istry V alues IPHS mg/dL NA m m ol/L K m m ol/L CL m m ol/L 2 .5 1 2 .0 8 .4 1 4 7 .1 6 .0 2 9 8 .0 2 .5 1 1 .1 6 .3 1 4 4 .5 5 .2 8 1 0 0 .0 2 .1 1 1 .1 9 .7 143.3 4 .3 9 9 5 .5 2 .8 1 1 .8 6 .0 1 4 4 .2 5 .1 3 9 6 .5 2 .4 1 0 .9 6 .2 1 4 5 .3 5 .3 0 1 0 0 .8 2 .4 1 1 .2 6 .2 1 4 5 .2 5 .2 1 9 8 .4 2 .6 1 1 .4 4 .8 1 4 5 .7 5 .2 8 9 8 .4 2 .4 1 0 .6 7 .0 1 4 3 .7 4 .8 2 9 9 .2 2 .1 1 0 .8 5 .2 1 4 6 .1 5 .7 3 9 9 .8 2 .5 1 1 .1 6 .5 1 4 4 .1 5 .8 1 9 8 .4 2 .5 1 1 .5 5 .7 1 4 4 .5 4 .6 6 9 8 .1 2 .5 1 0 .8 5 .9 1 4 4 .9 4 .8 5 9 8 .2 2 .3 1 1 .3 7 .4 1 4 6 .2 5 .3 3 1 0 0 .5 2 .5 1 1 .0 6 .8 1 4 4 .6 5 .9 2 9 8 .4 2.3 10.9 146.3 5 .5 0 1 0 1 .6 2 .5 1 1 .3 8 .1 1 4 2 .9 6 .0 4 9 7 .4 2 .8 1 1 .4 7 .5 1 4 5 .8 6 .0 6 9 9 .3 2 .5 1 0 .9 5 .7 1 4 5 .6 5 .7 8 9 8 .4 2 .6 1 0 .8 5 .0 147.3 5 .2 2 1 0 1 .9 2 .9 1 1 .4 7 .0 1 4 8 .0 6 .0 7 1 0 2 .7 ) D u P o n t-11418 CO in Company Sanitized. Does not contain TSCA O CD H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number TRIG m g/dL GLUC m g/dL TP g/dL ALB g/dL F e m ale , G roup VI - 100 m g/kg - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 36 47 51 39 35 34 41 33 34 67 100 7 .2 4 .8 97 7 .3 4 .9 96 7 .3 4 .7 88 7 .8 5 .6 98 7 .7 5 .5 95 7 .5 4 .9 99 7 .8 5 .6 93 7 .2 4 .4 93 7 .7 5 .2 94 8 .7 6 .1 F e m ale , G roup V I I I - 1000 m g/kg - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 24 23 70 34 37 31 34 30 75 61 94 7 .3 5 .0 124 7 .5 4 .9 89 7 .7 5 .7 94 7 .4 5 .0 86 7 .0 4 .9 89 7 .3 5 .0 145 7 .6 5.2 112 7 .7 5 .6 123 7 .8 5 .4 102 7 .6 5 .0 In d iv id u a l C lin ic a l C hem istry V alues GLOB g /d L CALC m g/dL IPHS mg/dL NA m m ol/L K m m ol/L CL m m ol/L 2 .4 1 1 .0 7 .4 1 4 3 .8 6 .0 8 1 0 0 .1 2 .4 1 1 .5 7 .6 1 4 8 .8 6 .4 1 1 0 2 .8 2 .6 1 1 .0 7 .2 1 4 1 .5 5 .9 2 9 7 .3 2 .2 1 1 .4 7 .0 1 4 6 .8 5 .2 3 1 0 0 .0 2 .2 1 1 .2 5 .9 1 4 5 .9 5 .5 2 9 9 .5 2 .6 1 0 .6 5 .0 1 4 6 .5 5 .3 7 9 9 .3 2 .2 1 0 .4 5 .7 1 4 4 .8 5 .4 9 9 8 .7 2 .8 1 0 .9 6 .0 1 4 7 .0 5 .2 8 1 0 1 .4 2 .5 1 1 .1 5 .8 1 4 5 .9 5 .5 0 9 8 .5 2 .6 1 1 .5 5 .4 1 4 6 .6 5 .7 1 1 0 1 .7 2 .3 1 0 .9 6 .7 1 4 5 .3 5 .4 0 1 0 0 .4 2 .6 1 1 .0 7 .8 1 4 4 .2 5 .4 7 1 0 0 .6 2 .0 1 1 .1 4 .9 1 4 5 .0 5 .0 7 9 8 .2 2 .4 1 0 .4 7 .6 1 4 4 .5 6 .0 2 1 0 2 .2 2 .1 1 1 .2 6 .7 1 4 3 .8 5 .6 5 9 8 .7 2 .3 1 0 .3 6 .0 1 4 2 .7 5 .9 3 9 9 .8 2 .4 1 1 .7 8 .4 1 4 2 .1 5 .6 6 9 7 .9 2 .1 1 0 .6 7 .5 1 4 4 .9 6 .0 3 1 0 2 .7 2 .4 1 1 .0 7 .2 1 4 5 .2 6 .0 2 1 0 3 .4 2 .6 1 1 .3 6 .8 1 4 7 .5 6 .2 7 1 0 0 .7 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -844- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number PHEM PLIP PICT F e m ale , G roup I I - 0 m g/kg - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 NONE NONE NONE NONE NONE NONE NONE NONE CLOT NONE ornale, G roup IV NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PFLU Mg/mL In d iv id u a l C lin ic a l C hem istry V alues 0 .1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 NT 0.1 0.1 0.1 0 .1 0 .1 0.1 0.1 0.1 0.1 0.1 0.1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -845- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Animal Number PHEM PLIP PICT PFLU u g/m L F em ale, G roup VI - 100 m g/kg - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE `NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 F em ale, G roup V I I I - 1000 m g /k g - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 In d iv id u a l C lin ic a l C hem istry V alues ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -846- ) ') . H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________________ Animal Number SHEM SLIP SICT Fem ale, G roup I I - 0 m g/kg - Day 127 AST U/L 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 NONE NONE NONE NONE NONE TRACE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 90 93 104 80 106 106 138 109 95 93 Fem ale, G roup V III - 1000 m g/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 NONE TRACE NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 'NONE NONE NONE NONE NONE NONE 174 90 106 93 81 78 105 95 83 143 In d iv id u a l C lin ic a l C hem istry V alues ALT SDH ALKP B IL I U/L U/L U/L m g/dL BUN m g/dL CREA mg/dL CHOL m g/dL 50 2 0 .9 49 0 .1 2 17 0 .4 7 61 48 2 1 .2 57 0 .1 5 16 0 .4 7 61 72 2 7 .7 43 0 .1 5 16 0 .4 7 78 68 1 3 .7 35 0 .1 1 15 0 .4 0 99 54 2 1 .4 73 0 .1 3 17 0 .4 5 58 54 2 0 .3 42 0 .1 6 18 0 .5 1 87 76 34 .6 21 0.13 14 0 .4 8 96 71 2 5 .8 40 0 .1 6 13 0 .5 5 103 38 2 3 .8 110 0 .2 0 18 0 .5 9 78 53 1 0 .8 43 0 .1 4 17 0 .5 5 82 131 3 7 .6 66 0 .1 3 18 0 .5 6 63 43 1 1 .7 57 0 .1 1 18 0 .4 1 69 68 2 2 .5 57 0 .1 2 20 0 .4 1 73 49 1 6 .2 62 0 .1 4 18 0 .4 3 83 37 2 2 .1 47 0 .1 6 17 0 .5 4 82 40 1 7 .4 23 0 .1 2 15 0 .4 3 85 28 4 .2 57 0 .1 2 20 0 .4 3 76 40 1 7 .7 53 0 .1 5 16 0 .4 4 95 29 1 4 .2 40 0 .1 2 17 0 .4 8 69 109 4 5 .5 32 0 .1 5 17 0 .4 3 81 ') DuPont-11418 Company Sanitized. Does not contain TSCA CBI -847- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________________ Animal Number TRIG mg/dL GLUC m g/dL TP g/dL ALB g/dL F e m a le , G ro u p I I - 0 m g /k g - D ay 127 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 31 49 42 45 31 47 85 44 35 36 114 8.3 111 8 .0 101 7 .8 104 9 .0 160 7 .8 112 ` 7 .5 115 9 .1 119 8.4 105 8 .7 110 8 .1 5 .6 5 .4 5 .6 5 .7 5 .3 5 .3 6 .2 6 .0 5 .7 5 .6 Fem ale, G roup V III - 1000 m g/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 23 35 31 56 55 33 48 33 41 36 97 8 .2 95 8 .1 125 8 .5 121 7 .8 178 8.2 110 9 .0 105 8.1 104 8.4 93 7 .7 108 8.7 5 .5 5 .0 5 .8 5 .2 5 .4 6 .4 5 .4 5 .9 5 .3 6 .2 In d iv id u a l C lin ic a l C hem istry V alues GLOB g/dL CALC m g/dL IPHS mg/dL NA m m ol/L K m m ol/L CL m m ol/L 2 .7 1 1 .4 6 .6 1 5 2 .8 6 .1 8 1 0 7 .7 2 .6 1 0 .9 5 .8 1 5 0 .8 6 .6 5 1 0 6 .9 2 .2 1 1 .4 4 .9 1 4 9 .8 5 .1 4 1 0 2 .2 3 .3 1 2 .2 6 .8 1 5 3 .7 5 .4 3 1 0 5 .2 2 .5 1 2 .0 7 .4 1 5 0 .2 6 .1 8 1 1 0 .3 2 .2 1 1 .4 6 .1 151.3 5 .4 2 1 0 4 .0 2 .9 1 2 .2 7 .6 1 5 3 .4 5 .3 8 1 0 2 .5 2 .4 1 1 .7 5 .1 1 5 1 .8 5 .3 1 1 0 6 .7 3 .0 1 1 .8 5 .4 1 5 1 .8 5 .6 3 1 0 3 .2 2 .5 1 2 .1 6 .6 1 5 3 .7 6 .0 3 1 0 7 .3 2 .7 1 2 .7 1 1 .2 153.2 5 .7 3 1 0 9 .0 3 .1 1 1 .3 5 .8 1 5 3 .5 6 .2 9 1 0 6 .6 2 .7 1 1 .6 6 .0 1 5 1 .6 6 .2 3 1 0 5 .0 2 .6 1 1 .6 7 .7 1 5 0 .2 6 .4 5 1 0 6 .1 2 .8 1 1 .8 1 0 .3 1 5 1 .5 5 .9 7 1 0 5 .3 2 .6 1 1 .8 5 .2 1 5 0 .6 5 .1 6 1 0 5 .5 2 .7 1 1 .2 7 .7 1 5 2 .9 6 .3 2 1 1 0 .9 2 .5 1 1 .7 6 .6 149.3 5 .6 5 1 0 7 .7 2 .4 1 1 .5 6 .8 152.3 5 .9 0 1 0 7 .1 2 .5 1 2 .2 6 .6 1 5 6 .5 5 .7 6 1 0 5 .8 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -848- o o Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number PHEM PLIP PICT PFLU lig/m L Fem ale, Group I I - 0 m g/kg - Day 127 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 0 .1 Fem ale, G roup V III - 1000 m g/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0 .0 0 .0 0 .0 0 .1 0 .1 0 .1 0 .1 0 .0 0 .1 0 .1 In d iv id u a l C lin ic a l C hem istry V alues ) DuPont-11418 -849- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 A nim al QUAL COL CLAR Number M ale, G roup I - 0 m g/kg - Day 37 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLEAR CLEAR CLEAR HAZY HAZY HAZY HAZY CLEAR M ale, G roup I I I - 10 m g/kg - Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 MEDIUM LIGHT MEDIUM MEDIUM ' MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR HAZY CLEAR CLEAR HAZY CLEAR CLEAR CLEAR In d iv id u a l U rin a ly s is V alues VOL UOSM mL mOsm/kg pH UGLU m g/dL KET m g/dL UBIL BLD URO EU/dL 7 .0 7 .0 6 .6 6 .2 6 .8 6 .0 7 .2 1 9 .2 1 1 .8 8 .6 1029 756 1106 1083 778 1394 920 891 734 1738 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 5 .4 4 3 .2 5 .4 1 4 .8 3 .0 8 .6 1 8 .0 8 .4 2 .6 7 .0 1153 451 449 703 1160 1087 481 QNS 866 1710 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 - NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE SMALL 0 .2 QNS NT NT NT NT NT 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 Company Sanitized. Does not contain TSCA CBI -850- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations )) ________________________________________________________ DuPont-11418 Animal QUAL COL CLAR Number M ale, G roup V - 100 m g/kg - Day 37 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 DARK MEDIUM MEDIUM LIGHT LIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLOUDY CLOUDY HAZY HAZY CLEAR HAZY CLOUDY HAZY CLEAR M ale, G roup V II - 1000 m g/kg - Day 37 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 LIGHT MEDIUM LIGHT MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLEAR CLOUDY CLEAR HAZY CLEAR HAZY CLEAR HAZY VOL mL 3 .8 1 1 .4 6 .0 1 6 .0 1 0 .0 9 .4 1 2 .8 9 .8 9 .4 6 .6 1 9 .0 1 3 .0 1 7 .2 3 .6 9 .8 6 .8 3 .2 1 5 .4 5 .8 8 .4 In d iv id u a l U rin a ly s is V alues UOSM mOsm/kg pH UGLU m g/dL KET m g/dL UBIL BLD URO EU/dL 1264 1251 1315 615 414 760 749 1112 1176 1485 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 5 NEGATIVE TRACE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE TRACE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 5 NEGATIVE TRACE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 1442 1373 231 1715 851 1246 1499 714 1710 2012 7 . 5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 . 5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 Company Sanitized. Does not contain TSCA CBI -851- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________ _______________________ ____________ DuPont-11418 Anim al Number UMTP m g/dL M ale, G roup I - 0 m g/kg - Day 37 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 100 108 65 70 132 79 82 18 28 76 M ale, G roup I I I - 10 m g/kg - Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 98 9 77 44 176 96 25 QNS 65 70 In d iv id u a l U rin a ly s is V alues Company Sanitized. Does not contain TSCA CBI - 852 - 5 )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________ _____________ DuPont-11418 Anim al Number UMTP mg/dL M ale, G roup V - 100 m g/kg - Day 37 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 114 39 145 23 29 36 42 27 58 67 M ale, G roup V II 1000 m g/kg - Day 37 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 12 33 13 72 29 54 77 33 128 60 In d iv id u a l U rin a ly s is V alues Company Sanitized. Does not contain TSCA CBI - 853 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al QUAL COL CLAR Number M ale, G roup I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR HAZY CLOUDY HAZY HAZY CLEAR HAZY CLOUDY M ale, G roup I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY CLEAR HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR In d iv id u a l U rin a ly s is V alues VOL UOSM mL mOsm /kg pH UGLU m g/dL KET mg/dL UBIL BLD URO EU/dL 1 2 .0 8 .0 6 .8 3 .9 7 .4 8 .5 2 .9 2 4 .6 4 .9 7 .8 890 1144 1109 1829 1344 1230 1519 370 1236 1265 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 .5 NEGATIVE 15 NEGATIVE SMALL 0 .2 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE TRACE 0 .2 3 .4 1 9 .0 5 .0 1 5 .6 6 .4 9 .0 9 .0 6 .0 7 .0 4 .3 1385 519 1260 622 1273 1111 809 1322 879 1521 6 .0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -854- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al QUAL C0L CLAR Number M ale, G roup V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY HAZY CLEAR CLEAR HAZY HAZY CLOUDY HAZY M ale, G roup V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW BROWN YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLOUDY HAZY CLEAR HAZY In d iv id u a l U rin a ly s is V alues VOL UOSM mL mOsm/kg pH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 2 .7 8 .2 5 .0 9 .0 8 .3 7 .9 4 .5 5 .8 1 1 .0 4 .8 2731 1166 2020 914 905 975 2241 1735 915 1737 6 .5 NEGATIVE 15 SMALL NEGATIVE 1 .0 7 .5 NEGATIVE 5 NEGATIVE TRACE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 1 .0 6 .0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 . 5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 1 .0 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 ,2 7 .0 NEGATIVE 5 NEGATIVE LARGE 0 .2 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 8 .0 6 .5 9 .4 5 .9 1 1 .0 7 .3 4 .8 1 6 .0 6 .4 1 4 .6 940 1486 993 1225 836 1232 1943 671 1526 701 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 . 5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0 .2 6 . 5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 . 5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 15 MODERATE LARGE 1 .0 7 . 0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 D u P o n t-11418 Company Sanitized. Does not contain TSCA C8I - 855 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number UFLU ig UMTP mg/dL M ale, G roup I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 1 5 .7 7 .4 4 .8 7 .0 1 1 .3 1 0 .7 5 .4 1 5 .5 7 .1 9 .9 82 108 135 177 119 78 190 24 67 126 M ale, G roup I I I - 10 m g/kg 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 5 .1 1 4 .5 7 .1 9 .7 1 0 .2 1 1 .6 8 .9 9.3 6 .9 9 .1 146 26 69 44 91 102 38 81 34 116 In d iv id u a l U rin a ly s is V alues D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -856- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________ Anim al Number UFLU /g UMTP m g/dL M ale, G roup V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 1 1 .6 2 2 .7 2 2 .2 1 8 .3 1 3 .8 1 7 .5 1 5 .1 1 6 .5 1 9 .8 1 7 .5 159 87 197 55 45 53 145 52 43 87 M ale, Group V II - 1000 m g/kg 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 3 9 .5 4 7 .7 5 3 .8 4 4 .4 5 4 .8 4 6 .3 5 7 .1 6 9 .1 5 8 .6 6 2 .8 29 92 40 47 31 54 157 34 92 29 In d iv id u a l U rin a ly s is V alues ) DuPont-11418 Company Sanitized. Does not contain TSCA O 00 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Anim al QUAL COL CLAR Number M a le , G roupi I - 0 mg / k g - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLEAR HAZY qLEAR HAZY CLEAR CLEAR CLEAR CLEAR M a le , G ro u p V I I - 1000 m g /k g -- D ay 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 MEDIUM RNV MEDIUM LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW RNV YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR RNV CLEAR HAZY CLEAR CLEAR CLEAR CLEAR HAZY CLEAR VOL mL 6 .2 2 .6 5 .8 5 .2 2 .4 2 .6 7 .0 5 .4 4 .2 6 .4 RNV 4 .0 1 1 .6 5 .5 8 .0 1 3 .8 1 2 .8 5 .4 1 0 .8 In d iv id u a l U rin a ly s is V alues UOSM mOsm/kg pH UGLU m g/dL KET mg/dL UBIL BLD URO EU/dL 1802 2970 1628 1597 2508 3459 1888 1813 1866 1388 6 .5 NEGATIVE TRACE NEGATIVE NEGATIVE 0.2 6 . 0 NEGATIVE 15 NEGATIVE NEGATIVE 1 .0 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6 . 0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 5 .5 NEGATIVE TRACE NEGATIVE NEGATIVE 1 .0 6 .0 NEGATIVE TRACE NEGATIVE NEGATIVE 1 .0 6 . 5 NEGATIVE TRACE NEGATIVE NEGATIVE 0.2 6 .5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6 .5 NEGATIVE TRACE NEGATIVE NEGATIVE 1 .0 7 . 0 NEGATIVE TRACE NEGATIVE SMALL 0.2 1399 RNV 2076 962 1665 1229 649 825 1431 816 7 .0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 RNV RNV RNV RNV RNV RNV 6 .0 NEGATIVE TRACE NEGATIVE NEGATIVE 1 .0 7 . 5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 . 0 NEGATIVE TRACE NEGATIVE NEGATIVE 0.2 6 .0 6 .0 NEGATIVE TRACE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE NEGATIVE 00.. 22 6 .5 NEGATIVE TRACE NEGATIVE NEGATIVE 0.2 7 . 0 NEGATIVE TRACE NEGATIVE NEGATIVE 0. 2 7 . 0 NEGATIVE TRACE NEGATIVE NEGATIVE 0 . 2 ) DuPont-11418 CO C- Company Sanitized. Does not contain TSCA CBI - 858- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number UFLU ig UMTP mg/dL M ale, Group I - 0 m g/kg - 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 9 .3 6 .5 8 .0 7 .7 4 .8 8 .1 1 1 .6 7 .9 6 .6 6 .6 132 212 146 117 140 162 117 130 184 88 M ale, Group V II - 1000 m g/kg - Day 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 1 1 .6 RNV 8 .9 1 0 .9 1 2 .0 9 .5 1 1 .0 1 3 .5 8 .8 1 1 .2 75 RNV 220 41 79 74 21 33 78 51 In d iv id u a l U rin a ly s is V alues DuPont-11418 Company Sanitized. Does not contain TSCA CBI -859- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al QUAL COL CLAR Number Fem ale, G roup I I - 0 m g/kg - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 LIGHT LIGHT MEDIUM MEDIUM MEDIUM LIGHT MEDIUM LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLOUDY HAZY HAZY HAZY HAZY CLEAR CLOUDY CLOUDY CLOUDY Fem ale, G roup IV - 10 m g/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 MEDIUM LIGHT LIGHT LIGHT LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLOUDY HAZY CLOUDY HAZY HAZY HAZY CLEAR HAZY CLOUDY V> CO VOL mL 1 1 .4 3 .8 4 .8 5 .6 2 5 .0 3 .2 1 5 .6 1 2 .2 1 2 .2 2 .6 1 2 .1 1 1 .1 1 0 .4 9 .2 5 .8 5 .8 1 0 .4 1 .8 7 .8 In d iv id u a l U rin a ly s is V alues UOSM mOsm/kg pH UGLU m g/dL KET mg/dL UBIL BLD URO EU/dL 592 533 1650 1311 923 308 1526 411 516 624 7 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 8 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 8 . 0 NEGATIVE NEGATIVE NEGATIVE SMALL 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 1220 440 681 723 686 959 1152 637 2193 832 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 . 5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 8 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -860- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al QUAL COL CLAR VOL Number mL F e m a le , i3 ro u p V I - 100 m g /k g - Day 38 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 LIGHT LIGHT LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY HAZY HAZY HAZY CLEAR HAZY HAZY HAZY CLEAR CLOUDY 1 1 .6 9 .6 8 .8 3 .8 3 .6 1 0 .8 5 .0 9 .0 3 .4 9 .0 Fem ale, G roup V III - 1000 m g/kg - Day 38 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 LIGHT MEDIUM LIGHT MEDIUM MEDIUM MEDIUM LIGHT MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY HAZY HAZY HAZY HAZY HAZY HAZY HAZY HAZY HAZY 1 1 .0 7 .0 5 .0 2 .6 2 .8 3 .4 2 9 .0 3 .8 4 .4 2 .2 In d iv id u a l U rin a ly s is V alues UOSM mOsm/kg pH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 562 631 724 1343 1355 602 1307 715 921 523 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 . 5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 484 1025 763 1524 2092 1738 281 1941 968 1977 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 861- ) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________DuPont-11418 Anim al Number UMTP mg/dL F em ale, G roup I I - 0 m g/kg - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 17 17 48 32 26 5 30 9 21 13 Fem ale, G roup IV - 10 m g/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 30 15 15 21 17 21 35 17 85 20 In d iv id u a l U rin a ly s is V alues ) Company Sanitized. Does not contain TSCA CBI - 862- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________ A nim al Number UMTP mg/dL F em ale, G roup VI - 100 m g/kg - Day 38 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 16 16 15 27 29 13 31 11 18 16 Fem ale, G roup V III - 1000 m g/kg - Day 38 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 12 24 20 39 60 48 5 36 20 57 In d iv id u a l U rin a ly s is V alues DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 863- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 Anim al QUAL COL CLAR Number F e m a le , <G roup I I - 0 m g /k g - D ay 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR HAZY CLEAR HAZY F e m ale , G roup IV - 10 m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY CLEAR HAZY HAZY CLEAR CLEAR CLEAR CLEAR HAZY In d iv id u a l U rin a ly s is V alues VOL UOSM mL mOsm/kg pH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 2 .4 1 .8 7 .0 5 .0 2 .0 1 9 .8 3 .5 1 0 .0 7 .8 1 .5 2071 1174 771 1234 1860 348 1250 628 725 1136 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .0 NEGATVIE NEGATIVE NEGATIVE NEGATIVE 0 .2 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 1 . 0 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 2 .2 1402 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 2 .3 2006 6 .0 NEGATIVE NEGATIVE SMALL TRACE 1 .0 4 .9 1198 6 .0 NEGATIVE 5 NEGATIVE NEGATIVE 0 .2 6 .0 921 6 .0 NEGATIVE NEGATIVE NEGATIVE TRACE 0 .2 7 . 0 804 7 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 4 . 0 910 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 1 . 5 2016 5 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 8 .5 530 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 1 .3 1964 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 3 .0 1641 6 .5 NEGATIVE NEGATIVE NEGATIVE MODERATE 0 .2 Company Sanitized. Does not contain TSCA CBI - 864- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al QUAL COL CLAR VOL Number mL F e m ale , G roup VI - 100 m g/kg - Day 93 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLEAR HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR 1 2 .0 3 .4 4 .8 4 .6 1 .4 6 .2 3 .7 7 .5 0 .6 1 .0 F em ale, G roup V I I I - 1000 m g/kg - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 LIGHT LIGHT MEDIUM MEDIUM LIGHT LIGHT LIGHT NT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW CLEAR HAZY CLEAR CLEAR HAZY CLEAR HAZY NT CLEAR CLEAR . 4 .9 4 .2 0 .8 0 .8 6 .8 1 3 .4 8 .7 QNS 1 1 .6 1 .2 In d iv id u a l U rin a ly s is V alues UOSM mOsm/kg pH UGLU m g/dL KET m g/dL UBIL BLD URO EU/dL 576 1198 1086 1006 2158 916 1612 806 1812 2074 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE TRACE 0 .2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 5 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 1188 1429 3918 3774 1007 531 747 QNS 542 2564 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 QNS NT NT NT NT NT 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 DuPont-11418 Company Sanitized. Does not contain TSCA CBI -865 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number UFLU ag Fem ale, Group I I 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 5 .9 3 .0 8.8 6 .6 3 .8 1 3 .3 4 .0 9 .3 6 .5 3.4 F em ale, G roup IV 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 3 .1 6.3 6 .4 6 .2 6 .8 4 .7 QNS 8 .2 2 .7 5 .1 UMTP m g/dL 0 m g/kg - Day 93 57 35 19 28 62 5 32 12 12 56 10 m g/kg - Day 93 36 73 25 18 14 24 70 13 59 45 In d iv id u a l U rin a ly s is V alues DuPont-11418 Company Sanitized. Does not contain TSCA CBJ -866- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number UFLU m UMTP m g/dL F em ale, Group VI - 100 m g/kg - ] 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 1 6 .5 8 .0 1 0 .5 7 .0 5 .8 9 .9 1 0 .6 9 .8 QNS QNS 8 27 25 18 51 16 35 14 45 82 F em ale, G roup V III - 1000 m g/kg 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 2 1 .7 2 9 .5 QNS QNS 3 6 .5 2 2 .2 3 7 .9 QNS 3 7 .5 1 5 .2 23 30 100 129 21 9 15 QNS 10 63 In d iv id u a l U rin a ly s is V alues DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 867- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al QUAL COL CLAR VOL Number mL Fem ale, Group I I - 0 m g/kg - Day 127 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 MEDIUM LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR HAZY HAZY CLEAR CLEAR CLEAR CLEAR 6 .0 5 .0 8 .2 8 .2 5 .8 6 .2 1 7 .6 4 .0 1 6 .8 8 .6 Fem ale, G roup V III - 1000 m g/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM MEDIUM MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR HAZY 1 .5 4 .6 2 .8 6 .5 4 .8 1 .6 2 .0 1 .6 5 .8 3 .0 In d iv id u a l U rin a ly s is V alues UOSM mOsm/kg pH UGLU mg/dL KET m g/dL UBIL BLD URO EU/dL 1514 1352 947 956 1234 1048 605 1428 569 701 6 .5 NEGATIVE NEGATIVE NEGATIVE TRACE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE TRACE 0 .2 6 .5 NEGATIVE NEGATIVE NEGATIVE SMALL 0 .2 6 . 5 NEGATIVE NEGATIVE NEGATIVE TRACE 0 .2 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 6 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 QNS 1497 1725 1030 911 QNS QNS QNS 1121 2043 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 1 . 0 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 5 . 0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 . 2 6 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 5 . 5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 1 . 0 5 .5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 1 . 0 5 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 1 .0 6 .0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0 .2 5 .5 NEGATIVE NEGATIVE NEGATIVE TRACE 0 .2 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -868- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number UFLU H<3 UMTP mg/dL Fem ale, Group I I - 0 m g/kg - Day 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 6 .0 4 .9 6 .2 5.9 5 .1 4 .1 1 2 .2 4 .3 9.3 5 .1 16 18 16 18 31 19 34 25 7 8 Fem ale, G roup V III - 1000 m g/kg 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 4 .3 6 .8 4 .7 5 .6 3 .6 QNS 3 .8 3.3 5 .6 5 .8 62 21 27 16 14 60 46 55 16 35 In d iv id u a l U rin a ly s is V alues DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 869- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Anim al Number EPIT UWBC URBC M ale, Group I - 0 m g/kg - Day 37 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 NONE NONE FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE {TONE NONE M ale, Group I I I - 10 m g/kg Day 37 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 NONE NONE NONE NONE NONE NONE NONE QNS NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NCRY In d iv id u a l U rine M icroscopic V alues MICR SPER FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE FEW FEW FEW MODERATE FEW MANY FEW MODERATE FEW FEW MODERATE FEW MODERATE MANY MODERATE FEW FEW FEW FEW FEW FEW FEW FEW FEW NT FEW FEW FEW FEW FEW MODERATE FEW FEW MODERATE NT FEW FEW FEW FEW FEW MODERATE FEW FEW FEW NT FEW FEW ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -870- )' H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) Anim al Number EPIT UWBC URBC NCRY In d iv id u a l U rine M icroscopic V alues MICR SPER M ale, G roup V - 100 m g/kg - Day 37 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE MODERATE MODERATE FEW FEW MODERATE FEW FEW FEW FEW MODERATE MANY MODERATE FEW MODERATE MODERATE FEW MODERATE MODERATE M ale, G roup V II - 1000 m g/kg - Day 37 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 'NONE FEW NONE NONE FEW NONE NONE NONE FEW FEW FEW MODERATE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE FEW FEW FEW FEW FEW FEW FEW MANY FEW FEW MODERATE MODERATE FEW MODERATE ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -871 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPIT UWBC URBC M ale, G roup I - 0 m g/kg - Day 92 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 FEW NONE FEW FEW NONE NONE FEW NONE NONE FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE M ale, Group I I I - 10 m g/kg - Day 92 664993 664995 665033 665053 665060 665074 665080 665128 665131 665136 NONE NONE NONE FEW FEW FEW FEW FEW NONE FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NCRY In d iv id u a l U rine M icroscopic V alues MICR SPER SPEC MODERATE MODERATE FEW FEW FEW FEW FEW FEW FEW FEW MODERATE FEW , FEW FEW MANY FEW FEW FEW FEW MANY MANY MODERATE FEW FEW MUCUS STRANDS MANY FEW MANY MANY MODERATE MANY FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE FEW MANY MANY MODERATE MODERATE MODERATE FEW MODERATE DuPont-11418 Company Sanitized. Does not contain TSCA CBI -872- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number EPIT UWBC URBC NCRY In d iv id u a l U rine M icroscopic V alues MICR SPER SPEC M ale, G roup V - 100 m g/kg - Day 92 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 NONE NONE NONE NONE NONE FEW FEW FEW FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE MODERATE FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE MODERATE FEW FEW FEW FEW FEW FEW MANY FEW MANY MODERATE MANY MODERATE FEW MANY MANY MODERATE MANY MODERATE M ale, G roup V II - 1000 m g/kg - Day 92 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 NONE FEW NONE NONE FEW FEW NONE FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE MANY .NONE NONE NONE FEW FEW MODERATE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE FEW MODERATE MODERATE FEW MUCUS STRANDS NONE MODERATE FEW MUCUS STRANDS FEW MANY FEW FEW MUCUS STRANDS MANY D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI - 873 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPIT UWBC URBC NCRY M ale, Group I - 0 m g/kg - Day 127 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 NONE FEW NONE NONE QNS QNS FEW NONE NONE NONE NONE FEW NONE FEW NT NT NONE NONE NONE NONE NONE NONE NONE NONE NT NT NONE NONE , FEW FEW FEW NONE FEW NONE NT NT FEW NONE FEW NONE M ale, Group V II - 1000 m g/kg - Day 127 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 FEW RNV NONE NONE NONE NONE NONE NONE QNS NONE NONE RNV NONE NONE NONE NONE NONE NONE NT NONE NONE RNV NONE NONE NONE NONE NONE NONE NT NONE FEW RNV NONE FEW FEW NONE NONE NONE NT FEW In d iv id u a l U rine M icroscopic V alues MICR SPER SPEC FEW FEW FEW FEW NT NT NONE NONE FEW FEW MANY MANY MANY MANY NT NT FEW FEW MODERATE FEW FEW FINELY GRANULAR CASTS FEW RNV NONE FEW FEW FEW FEW FEW NT FEW FEW RNV FEW FEW FEW MANY FEW MANY NT FEW DuPont-11418 Company Sanitized. Does not contain TSCA CBI -874- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number EPIT UWBC URBC , Fem ale, Group I I - 0 m g/kg - Day 38 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE F em ale, G roup IV - 10 m g/kg - Day 38 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 NONE NONE NONE NONE NONE FEW NONE NONE QNS NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NCRY In d iv id u a l U rine M icroscopic V alues MICR SPER FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE MODERATE FEW FEW FEW FEW FEW FEW MODERATE MODERATE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW FEW FEW MODERATE FEW FEW MODERATE FEW NT FEW FEW MODERATE FEW MODERATE MODERATE FEW FEW FEW NT MODERATE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE DuPont-11418 Company Sanitized. Does not contain TSCA CBI -875- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number EPIT UWBC URBC NCRY Fem ale, G roup VI - 100 m g/kg - Day 38 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW Fem ale, G roup V III - 1000 m g/kg - Day 38 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE `n o n e NONE NONE NONE NONE NONE NONE NONE NONE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW In d iv id u a l U rine M icroscopic V alues MICR SPER MODERATE MODERATE FEW FEW FEW FEW FEW FEW FEW MODERATE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW MODERATE FEW FEW FEW FEW FEW FEW FEW FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE DuPont-11418 Company Sanitized. Does not contain TSCA CBI -876- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations A nim al Number EPIT UWBC URBC F e m ale , G roup I I - 0 m g/kg - Day 93 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 FEW QNS FEW NONE QNS NONE NONE NONE FEW QNS NONE NT NONE NONE NT NONE NONE NONE NONE NT NONE NT NONE NONE NT NONE NONE NONE NONE NT F e m ale , G roup IV - 10 m g/kg - Day 93 665182 665215 665236 665239 665241 665268 665277 665308 665324 665332 FEW FEW NONE NONE FEW NONE NONE FEW QNS FEW NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NCRY In d iv id u a l U rine M icroscopic V alues MICR SPER SPEC FEW NT MODERATE FEW NT FEW FEW FEW FEW NT FEW NT FEW FEW NT FEW FEW FEW FEW NT NONE NT NONE NONE NT NONE NONE NONE NONE NT FEW MUCUS STRANDS FEW FEW FEW MODERATE FEW FEW MODERATE FEW NT FEW FEW MODERATE FEW MODERATE FEW FEW MODERATE FEW NT MODERATE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE FEW MUCUS STRANDS FEW MUCUS STRANDS D u P o n t-11418 Company Sanitized. Does not contain TSCA CBI -877- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) ______________ Anim al Number EPIT UWBC URBC NCRY In d iv id u a l U rine M icroscopic V alues MICR SPER SPEC F e m a le , G ro u p V I - 100 m g /k g - Day 93 665170 665199 665238 665250 665251 665259 66529.5 665300 665340 665341 NONE NONE NONE NONE QNS NONE FEW NONE QNS NONE NONE NONE NONE NONE NT NONE NONE NONE NT NONE NONE NONE NONE NONE NT NONE NONE NONE NT NONE FEW FEW MODERATE FEW NT FEW FEW FEW NT FEW FEW FEW MODERATE MODERATE NT FEW FEW FEW NT FEW F e m ale , G roup V I I I - 1000 m g/kg - Day 93 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 NONE NONE QNS QNS NONE NONE NONE QNS NONE QNS NONE NONE NT NT NONE NONE NONE NT NONE NT NONE NONE NT NT NONE NONE NONE NT NONE NT FEW FEW NT NT FEW FEW FEW NT FEW NT FEW MODERATE NT NT FEW FEW FEW NT FEW NT NONE NONE NONE NONE NT NONE NONE NONE NT NONE FEW MUCUS STRANDS NONE NONE NT NT NONE NONE NONE NT NONE NT ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -878- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anim al Number EPIT UWBC URBC NCRY Fem ale, Group I I - 0 m g/kg - Day 127 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 FEW QNS FEW FEW NONE FEW NONE FEW NONE NONE NONE NT FEW FEW FEW FEW FEW NONE NONE NONE NONE NT NONE NONE NONE NONE NONE .NONE NONE NONE NONE NT NONE NONE NONE FEW NONE NONE NONE NONE Fem ale, G roup V III - 1000 m g/kg - Day 127 665209 665229 665237 665275 665282 665288 665299 665303 665328 665335 QNS NONE QNS NONE QNS QNS QNS QNS FEW QNS NT NONE NT NONE NT NT NT NT NONE NT NT NONE NT NONE NT NT NT NT NONE NT NT NONE NT NONE NT NT NT NT NONE NT In d iv id u a l U rine M icroscopic V alues MICR SPER FEW NT FEW FEW FEW FEW NONE NONE FEW NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NT NONE NT NT NT NT NONE NT NT NONE NT NONE NT NT NT NT NONE NT ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI 879 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX L INDIVIDUAL ANIMAL BIOCHEMICAL DATA -880Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________ DuPont-11418 Individual Animal Biochemical Data In Male Rats At The 10-Day Time Point Group Animal Number Beta-Oxidation Rate (nmol/min/mg protein) I 668965 668966 668967 668968 668969 17.78 17.81 17.19 15.39 19.00 III 668970 668971 668972 668973 668974 20.62 15.69 19.62 18.53 18.39 V 668975 668976 668977 668978 668979 14.18 15.28 14.86 14.24 16.38 VII 668980 668981 668982 668983 668984 18.30 15.30* 14.41 17.11 13.82 * Due to pipetting error this sample is not included in the calculations. -881Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Animal Biochemical Data In Male Rats At The 92-Day Time Point Group I III V VII Animal Number 665047 665049 665070 665130 665076 665053 665074 665128 665080 664993 665122 665155 665073 665089 665119 665160 665096 665082 665107 665152 Beta-Oxidation Rate (nmol/min/mg protein) 19.32 18.05 17.59 18.44 20.18 18.77 17.74 21.07 16.83 15.97 21.06 22.35 21.07 18.49 17.64 32.74 30.85 28.87 27.81 28.40 D u P o n t-11418 - 882 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Animal Biochemical Data In Male Rats At The One-Month Recovery Time Point Group I VII Animal Number 665043 665098 665149 665081 665159 665007 665112 665138 665062 665146 Beta-Oxidation Rate (nmol/min/mg protein) 17.79 15.79 17.56 14.53 17.41 26.44 28.64 30.98 20.18 17.80 DuPont-11418 - 883 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________ Individual Animal Biochemical Data In Female Rats At The 10-Day Time Point Group II IV VI VIII Animal Number 668987 668988 668989 668990 668991 668992 668993 668994 668995 668996 668997 668998 668999 669000 669001 669002 669003 669004 669005 669006 Beta-Oxidation Rate (nmol/min/mg protein) 12.37 17.44 19.76 13.24 16.80 20.01 13.66 13.85 19.66 17.71 19.18 22.16 20.61 16.39 17.63 14.02 21.49 20.84 20.71 18.53 DuPont-11418 - 884Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Animal Biochemical Data In Female Rats At The 93-Day Time Point Group II IV VI VIII Animal Number 665211 665271 665178 665317 665230 665308 665215 665277 665241 665236 665295 665251 665300 665340 665259 665234 665242 665183 665261 665291 Beta-Oxidation Rate (nmol/min/mg protein) 19.05 19.63 16.60 20.26 20.22 22.73 19.19 22.02 17.21 15.88 17.32 23.19 20.93 21.96 21.46 28.23 21.94 25.29 22.95 21.70 DuPont-11418 - 885 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations individual Animal Biochemical Data In Female Rats At The One-Month Recovery Time Point Group II VIII Animal Number 665276 665201 665197 665256 665323 665275 665229 665237 665209 665335 Beta-Oxidation Rate (nmol/min/mg protein) 20.71 21.2,1 18.92 23.82 21.45 22.09 26.21 22.73 20.23 25.64 DuPont-11418 - 886Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D u P o n t-11418 APPENDIX M INDIVIDUAL ANIMAL BODY AND ORGAN WEIGHTS -887 Company Sanitized. Does not contain TSC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION Orgat^W ei L i s t i n g S tudy| 5425/m ale I n d i v id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : I 0 m g /k g T r e a tm e n t : 0 m g /k g I S e x :MALES I ANIMAL I FBW I BRAIN 1 ADRENAL GLANDS 1 EPIDIDYMIDES 1 1 1 (Gms) ] (Gms) %FBW 1 (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) HEART 1 KIDNEYS I %FBW %BRAIN (Gms) %FBW %BRAIN | 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 6 3 5 .5 0 5 3 1 .9 0 5 2 8 .6 0 5 4 2 .8 0 5 8 5 .3 0 6 7 5 .4 0 5 1 0 .4 0 4 7 8 .8 0 5 9 6 .1 0 6 1 9 .0 0 2 .171 0.3416 2 .1 0 3 0.3954 2.140 0.4048 2 .1 9 8 0.4049 2 .2 4 1 0.3829 2 .1 6 5 0.32C6 2 .0 7 3 0.4062 2.007 0.4192 2 .407 0.4038 2.243 0.3624 0.039 0.0061 1.7964 0.049 0.0092 2.3300 0.052 0.0098 2.4299 0.056 0.0103 2.5478 0 .0 3 8 0.0065 1.6957 0.061 0.0090 2.8176 0.044 0.0086 2.1225 0.053 0.0111 2.6408 0.053 0.0089 2.2019 0.063 0.0102 2.8087 1.261 0.1984 58.084 1.381 0.2596 65.668 1.540 0.2913 71.963 1.672 0.3080 76.069 1.465 0.2503 65.373 1.732 0.2564 80.000 1.253 0.2455 60.444 1 .285 0.2684 64.026 1.539 0.2582 63.939 1.559 0.2519 69.505 1.695 0.2667 78.075 1.678 0.3155 79.791 1 .731 0.3275 80.888 1 .680 0.3095 76.433 1.872 0.3198 83.534 1.831 0.2711 84.573 1.591 0.3117 76.749 1.349 0.2817 67.215 1.918 0.3218 79.684 1.707 0.2758 76.103 4.311 0.6784 198.57 4.385 0.8244 208.51 3.857 0.7297 180.23 3.378 0.6223 153.69 3.822 0.6530 170.55 4.371 0.6472 201.89 3.174 0.6219 153.11 3.254 0.6796 162.13 4 .265 0.7155 177.19 4.399 0.7107 196.12 Mean S . D. 5 7 0 .3 8 6 1 .9 0 4 2 .1 7 5 0.3842 0 .110 0.0323 0.051 0.0090 2.3391 0 .0 0 8 0 .0016 0.3897 1 .469 0.2588 67.507 0 .170 0.0289 6.8695 1.705 0.3001 78.304 0.160 0.0235 4.8446 3.922 0.6883 180.20 0.498 0.0609 20.354 G ro u p : I I I 10 m g /k g T r e a tm e n t : 10 m g /k g I I I S e x : MALES i ANIMAL 1 FBW BRAIN ADRENAL GLANDS (Gms) (Gms) %FBW , (Gms) %FBW %BRAIN EPIDIDYMIDES (Gms) %FBW %BRAIN 664993 664995 665033 665053 665060 665074 665080 665128 4 8 4 .6 0 5 0 6 .1 0 5 0 8 .8 0 5 9 6 .1 0 5 7 8 .6 0 6 0 8 .3 0 5 3 1 .7 0 6 1 9 .8 0 2 .176 0.4490 2 .0 2 8 0.4007 2.143 0.4212 2 .088 0.3503 2 .306 0.3985 2 .282 0.3751 2 .177 0.4094 2.270 0.3662 0 .0 6 6 0 .0 6 1 0 .0 6 7 0 .0 4 8 0 .0 6 4 0 .0 4 5 0 .0 6 1 0 .0 6 5 0 .0 1 3 6 0 .0 1 2 1 0 .0 1 3 2 0 .0 0 8 1 0 .0 1 1 1 0.0074 0 .0 1 1 5 0.0105 3 .0 3 3 1 3 .0 0 7 9 3 .1 2 6 5 2 .2 9 8 9 2 .7 7 5 4 1.9720 2 .8 0 2 0 2 .8 6 3 4 1.525 0.3147 70.083 1.618 0.3197 79.783 1.455 0.2860 67.895 1.546 0.2594 74.042 1.722 0.2976 74.675 1.381 0.2270 60.517 1 .628 0.3062 74.782 1.658 0.2675 73.040 (Gms) HEART %FBW %BRAIN 1.513 0.3122 69.531 1.661 0.3282 81.903 1.598 0.3141 74.568 1.715 0.2877 82.136 1.831 0.3165 79.402 1.937 0.3184 84.882 1.552 0.2919 71.291 2.150 0.3469 94.714 KIDNEYS 1 (Gms) %FBW %BRAIN j 3 .5 1 6 4 .0 0 6 3 .4 7 2 4 .3 5 0 4 .4 4 9 4 .2 9 0 3 .8 3 2 4 .2 3 1 0 .7 2 5 5 0 .7 9 1 5 0 .6 8 2 4 0 .7 2 9 7 0 .7 6 8 9 0 .7 0 5 2 0 .7 2 0 7 0 .6 8 2 6 1 6 1 .5 8 1 9 7 .5 3 1 6 2 .0 2 2 0 8 .3 3 1 9 2 .9 3 1 8 7 .9 9 1 7 6 .0 2 1 8 6 .3 9 FBW - F i n a l B ody W e ig h t Company Sanitized. Does not contain TSCA CBI -888- ) H-25^25: Subchronic Toxicity 90-Bay Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 HATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION O rg stu d ft L i s t i n g 25425/m ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : I I I 10 m g /k g T r e a tm e n t : 10 m g /k g I I I S e x MALES I ANIMAL j FBW 1 BRAIN 1 ADRENAL GLANDS I EPIDIDYMIDES 1 I i (Gms) j (Gms) %FBW j (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) HEART I KIDNEYS I %FBW %BRAIN | (Gms) %FBW %BRAIN | 665131 505.60 665136 589.10 2.000 0.3956 2 .2 3 4 0.3792 0.041 0.0081 2.0500 0.078 0.0132 3.4915 1.533 0.3032 76.650 1.577 0.2677 70.591 1 .700 0.3362 85.000 1.629 0.2765 72.919 4 .243 0.8392 2 12.15 4 .061 0.6894 181.78 Mean S.D . 5 5 2 .8 7 5 0 .4 0 8 2 .1 7 0 0.3945 0 .106 0.0285 0 .0 6 0 0.0109 2.7421 0 .011 0.0023 0.4891 1.564 0.2849 72.206 0.100 0.0292 5.3363 1.729 0.3129 79.635 0.195 0.0221 7.7289 4 .045 0.7335 186.67 0.341 0.0516 17.166 G ro u p : V 100 m g /k g T r e a tm e n t : 100 m g /k g V S e x MALES I ANIMAL 1 FBW (Gms) 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 4 3 7 .4 0 5 4 5 .6 0 6 2 1 .2 0 5 5 8 .2 0 5 5 5 .7 0 4 9 6 .6 0 5 8 8 .9 0 4 8 8 .2 0 5 7 3 .0 0 5 7 5 .6 0 BRAIN (Gms) %FBW 1 .962 0.4486 2 .0 6 9 0.3792 2 .096 0.3374 2 .1 9 9 0.3939 2 .256 0.4060 2 .102 0.4233 2.188 0.3715 2 .1 6 0 0.4424 2 .1 1 0 0.3682 2.139 0.3716 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.052 0.0119 2.6504 0.054 0.0099 2.6100 0.065 0.0105 3.1011 0.077 0.0138 3.5016 0.071 0.0128 3.1472 0.048 0.0097 2.2835 0 .037 0.0063 1.6910 0 .047 0.0096 2.1759 0.063 0.0110 2.9858 0 .059 0.0103 2.7583 EPIDIDYMIDES (Gms) %FBW %BRAIN 1 .4 2 0 0 .3 2 4 6 72..375 1.555 0.2850 75.157 1.894 0.3049 90.363 1.297 0.2324 58.981 1.505 0.2708 66.711 1.350 0.2718 64.225 1.529 0.2596 69.881 1.209 0.2476 55.972 1.447 0.2525 68.578 1.593 0.2768 74.474 Mean S.D . 5 4 4 .0 4 5 4 .6 5 1 2.128 0.3942 0.081 0.0356 0.057 0.0106 2.6905 0.012 0.0021 0.5338 1.480 0.2726 69.672 0.189 0.0274 9.6045 (Gms) HEART %FBW %BRAIN 1.321 0.3020 67.329 1.701 0.3118 82.214 1.786 0.2875 85.210 1.960 0.3511 89.131 1.724 0.3102 76.418 1.679 0.3381 79.876 1.648 0.2798 75.320 1.599 0.3275 7 4.028 1 .797 0.3136 85.166 1 .730 0.3006 80.879 1.695 0.3122 79.557 0.164 0.0219 6.4281 KIDNEYS (Gms) %FBW %BRAIN 3 .310 0.7567 168.71 3.708 0.6796 179.22 4.697 0.7561 224.09 4.549 0.8149 206.87 3.907 0.7031 173.18 4.001 0.8057 190.34 4.015 0.6818 183.50 3.522 0.7214 163.06 3.887 0.6784 184.22 4.351 0.7559 203.41 3.995 0.7354 187.66 0 .437 0.0506 18.934 FBW - F i n a l Body W e ig h t Company Sanitized. Does not contain TSCA CBi -889- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________ DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION L istin g 5425/m ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : V I I 1000 m g /k g T r e a t m e n t : 1 0 0 0 m g /k g V I I S e x : MALES ] ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES 1 (Gins) (Gms) %FBW (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN | (Gms) HEART 1 KIDNEYS j %FBW; %BRAIN 1 (Gms) %FBW %BRAIN j 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 5 4 1 .9 0 5 3 2 .9 0 5 2 6 .5 0 5 2 1 .9 0 5 6 5 .6 0 5 6 4 .5 0 4 8 3 .5 0 5 9 2 .9 0 5 7 0 .1 0 6 1 0 .9 0 2 .2 2 4 0.41C 4 2.223 0.4172 2 .0 5 4 0.39C1 2 .004 0.3840 2.044 0.3614 2.234 0.3957 2.114 0.4372 2 .3 0 3 0.3864 1.994 0.34S8 2 .1 5 7 0.-3531 0.041 0.0076 1.8435 0.040 0.0075 1.7994 0.047 0.0089 2.2882 0.049 0.0094 2.4451 0.049 0.0087 2.3973 0.055 0.0097 2.4620 0 .0 6 5 0.0134 3.0747 0.061 0.0103 2.6487 0.059 0.0103 2.9589 0.046 0.0075 2.1326 1.559 0.2877 70.099 1.598 0.2999 71.885 1.501 0.2851 73.077 1.349 0.2585 67.315 1.493 0.2640 73.043 1 .588 0.2813 71.083 1.591 0.3291 75.260 1.434 0.2419 62.267 1.491 0.2615 74.774 1.396 0.2285 64.720 1 .759 0.3246 79.092 1.720 0.3228 77.373 1.676 0.3183 81.597 1.687 0.3232 84.182 2.024 0.3579 99.022 1 .865 0.3304 83.483 1 .6 8 8 0.3491 79.849 1 .8 2 8 0.3083 79.375 1 .778 0.3119 89.168 1.777 0.2909 82.383 3 .728 0.6879 167.63 4.237 0.7951 190.60 4 .3 2 1 0.8207 210.37 4 .564 0.8745 227.74 4.528 0.8006 221.53 4.518 0.8004 202.24 4.508 0.9324 213.25 4.707 0.7939 204.39 4 .494 0.7883 225.38 4 .281 0.7008 198.47 Mean S.D . 551.07 2 .1 3 5 0.3867 0 .0 5 1 0.0093 2.4050 37.294 1 0 .109 0.0264 | 0 .008 0.0018 0.4203 1 .500 0.2737 70.352 0.086 0.0292 4.3151 1.780 0.3237 83.552 0 .1 0 6 0.0193 6.3742 4.389 0.7994 206.16 0.273 0.0716 18.086 Company Sanitized. Does not contain TSCA CBI FBW - F i n a l B ody W e ig h t -890- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION Org.aiwW eiokl,t L i s t i n g Study, 125425/m ale f I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : I 0 m g /k g T r e a tm e n t : 0 m g /k g I S e x : MALES 1 ANIMAL 1 1 i (Gms) LIVER [ SPLEEN 1 TESTES j THYMUS : ! THYROID GLAND j %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 16.194 2.5482 745.92 15.893 2.9880 755.73 12.908 2.4419 603.18 14.861 2.7378 676.11 15.592 2.6639 695.76 16.570 2.4534 765.36 12.669 2.4822 611.14 12.761 2.6652 635.82 16.861 2.8286 70P.50 17.579 2.8399 783.73. 0.849 0.1336 39.106 0.693 0.1303 32.953 0.698 0.1320 32.617 0.827 0.1524 37.625 0.833 0.1423 37.171 1.026 0.1519 47.390 0 .715 0.1401 34.491 0.789 0.1648 39.312 0.826 0.1386 34.317 0.774 0.1250 34.507 3.376 0.5312 155.50 3.281 0.6168 156.02 3.645 0.6896 170.33 3.666 0.6754 166.79 3.709 0.6337 165.51 4.101 0.6072 189.42 2.840 0.5564 137.00 2.825 0.5900 140.76 3.956 0.6636 164.35 3 .730 0.6026 166.30 0.513 0.0807 23.630 0 .386 0.0726 18.355 0.407 0.0770 19.019 0.404 0.0744 18.380 0.415 0.0709 18.519 0.472 0.0699 21.801 0.253 0.0496 12.205 0.431 0.0900 21.475 0 .388 0.0651 16.120 0 .541 0.0874 24.119 0 .0 2 2 0 .0 2 9 0 .0 3 6 0 .0 2 5 0 .0 2 5 0 .0 0 3 5 0 .0 0 5 5 0 .0 0 6 8 0 .0 0 4 6 0 .0 0 4 3 1 .0 1 3 4 1 .3 7 9 0 1 .6 8 2 2 1 .1 3 7 4 1 .1 1 5 6 0.017 0.0033 0.8201 0 .018 0.0038 0.8969 0.024 0.0040 0.9971 0.029 0.0047 1.2929 Mean S.D . 15.189 2.6649 697.33 1.815 0.1852 65.322 0.803 0.1411 36.949 0.098 0.0121 4.3898 3.513 0.6167 161.20 0.430 0.0508 15.013 0.421 0.0738 19.362 0.079 0.0115 3.5872 0.025 0.0045 1.1483 0.006 0.0011 0.2675 G ro u p ; I I I 10 m g /k g T r e a t m e n t : 10 m g /k g I I I S e x :MALES 1 ANIMAL 1 664993 664995 665033 665053 665060 665074 665080 665128 (Gms) LIVER %FBW %BRAIN 13.921 2.8727 639.75 14.010 2.7682 690.83 13.359 2.6256 623.38 17.386 2.9166 832.66 15.864 2.7418 687.94 16.681 2.7422 730.98 14.933 2.8085 685.94 15.354 2.4773 676.39 SPLEEN (Gms) %FBW %BRAIN 0.765 0.1579 35.156 1.023 0.2021 50.444 0.881 0.1732 41.111 0.811 0.1361 38.841 0.863 0.1492 37.424 1.067 0.1754 46.757 0.708 0.1332 32.522 1.055 0.1702 46.476 TESTES (Gms) %FBW %BRAIN 3.968 0.8188 182.35 3.729 0.7368 183.88 3.177 0.6244 148.25 3.590 0.6022 171.93 3.980 0.6879 172.59 3.453 0.5676 151.31 3.708 0.6974 170.33 3.944 0.6363 173.74 THYMUS (Gms) %FBW ' %BRAIN 0 .418 0.0863 19.210 0.583 0.1152 28.748 0.524 0.1030 24.452 0.417 0.0700 19.971 0.397 0.0686 17.216 0.607 0.0998 26.599 0.394 0.0741 18.098 0.540 0.0871 23.789 THYROID GLAND j (Gms) %FBW %BRAIN | 0.027 0.0056 1.2408 0.031 0.0061 1.5286 0.019 0.0037 0.8866 0.021 0.0035 1.0057 0.019 0.0033 0.8239 0.029 0.0048 1.2708 0 .016 0.0030 0.7350 0.017 0.0027 0.7489 FBW - F i n a l Body W e ig h t Company Sanitized. Does not contain TSCA CBI -891 - ) )7 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION O rgaj S tu d y it L is tin g 25425/m ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : I I I 10 m g /k g T r e a t m e n t : 10 m g /k g I I I S e x MALES I ANIMAL 1 1 1 (Gms) LIVER ' I SPLEEN 1 TESTES 1 THYMUS 1 THYROID GLAND | %FBW %BRAIN j (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | 665131 665136 12.936 2.5585 646.80 16.471 2.7960 737.29 0.710 0.1404 35.500 0.982 0.1667 43.957 3 .408 0.6741 170.40 3.410 0.5788 152.64 0.320 0.0633 16.000 0 .3 7 9 0.0643 16.965 0.016 0.0032 0.8000 0.017 0.0029 0.7610 Mean S.D . 15.092 2.7307 695.20 1.512 0.1381 60.585 0.887 0.1604 40.819 0.139 0.0214 5.9111 3.637 0.6624 167.74 0.276 0.0773 12.660 0 .458 0.0832 21.105 0 .0 9 7 0 .0181 4.4627 0.021 0.0039 0.9801 0 .006 0.0012 0.2751 G ro u p : V 100 m g /k g T r e a t m e n t : 100 m g /k g V S e x MALES | ANIMAL 1 665035 665054 665073 665089 665103 665119 665122 665137 665143 665155 (Gms) LIVER %FBW %BRAIN 12.066 2.7586 614.98 14.927 2.7359 721.46 18.317 2.9486 873.90 14.618 2.6188 664.76 16.354 2.9430 724.91 13.167 2.6514 626.40 16.279 2.7643 744.01 12.144 2.4875 562.22 15.295 2.6693 724.88 16.468 2.8610 769.89 SPLEEN (Gms) %FBW %BRAIN 0.634 0.1449 32.314 0.914 0.1675 44.176 0.908 0.1462 43.321 0.835 0.1496 37.972 1 .105 0.1988 48.980 0 .785 0.1581 37.345 0 .866 0.1471 39.580 0.777 0.1592 35.972 0 .552 0.0963 26.161 0.749 0.1301 35.016 TESTES (Gms) %FBW %BRAIN 3.074 0.7028 156.68 3 .520 0.6452 170.13 4.258 0.6854 203.15 3.482 0.6238 158.34 3.533 0.6358 156.60 3.418 0.6883 162.61 3.565 0.6054 162.93 3.394 0.6952 157.13 3 .2 4 0 0.5654 153.55 3.742 0.6501 174.94 THYMUS (Gms) %FBW' %BRAIN 0.302 0.0690 15.392 0.415 0.0761 20.058 0 .454 0.0731 21.660 0 .515 0.0923 23.420 0.585 0.1053 25.931 0 .408 0.0822 19.410 0.434 0.0737 19.835 0.261 0.0535 12.083 0.450 0.0785 21.327 0 .460 0.0799 21.505 THYROID GLAND 1 (Gms) %FBW %BRAIN | 0.019 0.0043 0.9684 0.026 0.0048 1.2566 0.028 0.0045 1.3359 0.026 0.0047 1.1824 0.030 0.0054 1.3298 0.015 0.0030 0.7136 0.016 0.0027 0.7313 0.022 0.0045 1.0185 0.018 0.0031 0.8531 0.028 0.0049 1.3090 Mean S.D . 14.964 2.7438 702.74 2.027 0.1459 89.168 0.813 0.1498 38.084 0 .154 0.0262 6.4582 3.523 0.6497 165.61 0.316 0.0442 14.772 0 .4 2 8 0.0783 20.062 0.094 0.0137 3.9143 0.023 0.0042 1.0699 0.005 0.0009 0.2460 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -892- ) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________ _______________________ ) DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION: O rgaj^W eis L is tin g S tudy| 25425/m ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : V I I 1000 m g /k g T r e a tm e n t : 1000 m g /k g V I I S e x : MALES 1 ANIMAL 1 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 (Gms) LIVER | SPLEEN I TESTES ] THYMUS %FBW %BRAIN 1 (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 16.662 3.0747 749.19 17.238 3.2348 775.44 16.725 3.1766 814.26 17.352 3.3248 865.87 19.291 3.4107 943.79 19.447 3.4450 870.50 15.664 3.2397 740.96 20.956 3.5345 909.94 19.290 3.3836 967.40 18.720 3.0643 867.87 0.796 0.1469 35.791 0.744 0.1396 33.468 0.701 0.1331 34.129 0 .810 0.1552 40.419 0.731 0.1292 35.763 0 .9 2 7 0.1642. 4 1 .4 9 5 0.692 0.1431 32.734 0.927 0.1564 40.252 0.866 0.1519 43.430 0.899 0.1472 41.678 3.481 0.6424 156.52 3.947 0.7407 177.55 3.741 0.7105 182.13 3.265 0.6256 162.92 3.879 0.6858 189.77 3.751 0.6645 167.91 4.204 0.8695 198.86 3.207 0.5409 139.25 3 .964 0.6953 198.80 3.582 0.5863 166.06 0.501 0.0925 22.527 0.375 0.0704 16.869 0.367 0.0697 17.868 0.378 0.0724 18.862 0.490 0.0866 23.973 0.437 0.0774 19.561 0.312 0.0645 14.759 0.606 0.1022 26.314 0.508 0 .0 8 9 25.476 0.392 0.0642 18.173 THYROID GLAND I (Gms) %FBW %BRAIN | 0.026 0.0048 1.1691 0.019 0.0036 0.8547 0.025 0.0047 1.2171 0.026 0.0050 1.2974 0.014 0.0025 0.6849 0 .030 0.0053 1 .3429 0 .020 0.0041 0.9461 0.026 0.0044 1.1290 0.018 0.0032 0.9027 0.027 0.0044 1.2517 Mean S.D . 18.135 3.2889 850.52 1.646 0.1578 78.915 0.809 0.1467 37.916 0.091 0.0108 3.9331 3.702 0.6762 173.98 0.319 0.0903 19.138 0.437 0.0789 20.438 0.088 0.0130 3.8979 0.023 0.0042 1.0796 0.005 0.0009 0.2189 Company Sanitized. Does not contain TSCA FBW - Final Body Weight O CD H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________ _______ DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION; O rgaa,W eigfafc L i s t i n g S tu d y p B B B 5 4 2 5 /fem ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : I I 0 m g /k g T r e a tm e n t : 0 m g /k g I I S ex : FEMALES 1 ANIMAL 1 FBW 1 BRAIN j ADRENAL GLANDS I 1 1 (Gms) 1 !Gms) %FBW 1 (Gms) %FBW %BRAIN | (Gms) HEART j KIDNEYS | %FBW %BRAIN | (Gms) %FBW; %BRAIN | (Gms) LIVER I %FBW %BRAIN j 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 3 1 5 .5 0 3 1 5 .9 0 3 6 4 .9 0 3 0 6 .2 0 2 9 5 .6 0 3 1 7 .3 0 2 5 8 .9 0 2 7 2 .7 0 2 8 6 .3 0 2 9 7 .2 0 1.763 0.5588 1.965 0.6220 1 .9 3 6 0.5306" 2 .0 1 9 0.6594 1.968 0.6658 1 .9 5 0 0.6146 1.815 0.7010 1.893 0.6942 1.785 0.6235 1.865 0.6275 0.069 0.0219 3.9138 0.075 0.0237 3.8168 0.077 0.0211 3.9773 0.091 0.0297 4.5072 0.063 0.0213 3.2012 0 .064 0.0202 3.2821 0.052 0.0201 2.8650 0.054 0.0198 2.8526 0.067 0.0234 3.7535 0.066 0.0222 3.5389 1.077 0.3414 61.089 1.218 0.3856 61.985 1.294 0.3546 66.839 1.193 0.3896 59.089 1.076 0.3640 54.675 1.097 0.3457 56.256 0.952 0.3677 52.452 1.083 0.3971 57.211 1.040 0.3633 58.263 0.954 0.3210 51.153 2.280 0.7227 129.33 2 .436 0.7711 123.97 2 .651 0.7265 136.93 2 .106 0.6878 104.31 2 .128 0.7199 108.13 2 .4 4 1 0.769(3 1 2 5 .1 8 1.938 0.7486 106.78 2.266 0.8309 119.70 1.826 0.6378 102.30 2 .128 0.7160 114.10 8.291 2.6279 470.28 9.677 3.0633 492.47 9.420 2.5815 486.57 9.122 2.9791 451.81 7.943 2.6871 403.61 8.469 2.6691 434.31 6.736 2.6018 371.13 7.288 2.6725 385.00 6.641 2.3196 372.04 6.940 2.3351 372.12 Mean S.D . 3 0 3 .0 5 2 9 .0 5 8 1.896 0.6297 0.086 0.0544 0.068 0.0223 3.5708 0.011 0.0029 0.5258 1 .098 0.3630 57.901 0.110 0.0236 4.6796 2 .220 0.7331 117.07 0 .248 0.0520 11.741 8.053 2.6537 423.93 1 .128 0.2350 49.157 G ro u p : IV 10 m g /k g T r e a tm e n t : 10 m g /k g IV S e x -.FEMALES 1 ANIMAL 1 FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN (Gms) HEART %FBW %BRAIN 665182 665215 665236 665239 665241 665268 665277 665308 2 8 5 .7 0 2 4 5 .8 0 3 3 4 .4 0 2 7 4 .3 0 2 5 9 .6 0 3 0 1 .4 0 2 8 3 .2 0 3 0 6 .3 0 1.851 0.6479 1.734 0.7055 1.822 0.5449 2.058 0.7503 1.772 0.6826 1.961 0.6506 1.966 0.6942 1 .8 9 6 0.6190 0.073 0.0256 3.9438 0 .061 0.0248 3.5179 0 .0 7 5 0.0224 4.1164 0.082 0.0299 3.9845 0 .061 0.0235 3.4424 0.081 0.0269 4.1305 0.059 0.0208 3.0010 0.072 0.0235 3.7975 1.185 0.4148 64.019 0.849 0.3454 48.962 1.088 0.3254 59.715 1.049 0.3824 50.972 0.886 0.3413 50.000 1.202 0.3988 61.295 1.062 0.3750 54.018 1.146 0.3741 60.443 KIDNEYS (Gms) %FBW . %BRAIN 2 .3 5 8 1 .9 3 2 2 .4 4 6 2 .1 9 7 2 .0 2 1 2 .4 9 7 2 .3 2 5 2 .5 7 5 0 .8 2 5 3 0.786q 0 .7 3 1 5 0.8009 0 .7 7 8 5 0 .8 2 8 5 0 .8 2 1 0 0 .8 4 0 7 1 2 7 .3 9 1 1 1 .4 2 1 3 4 .2 5 1 0 6 .7 5 1 1 4 .0 5 127.33 1 1 8 .2 6 1 3 5 .8 1 (Gms) LIVER I %FBW %BRAIN | 8.526 2.9842 460.62 6.762 2.7510 389.97 9.600 2.8708 526.89 7.620 2.7780 370.26 6.365 2.4518 359.20 9.095 3.0176 463.79 7 .942 2.8044 403.97 7.943 2.5932 418.93 FBW - F i n a l B ody W e ig h t Company Sanitized. Does not contain TSCA CBI -894- )> H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________________DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION Orgi S tu d y L istin g 5425/fem ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 Group : IV 10 m g/kg T rea tm e n t 10 m g /k g IV S e x : FEMALES 1 ANIMAL I FBW I BRAIN i ADRENAL GLANDS I 1 1 (Gms) I (Gms) %FBW 1 (Gms) %FBW %BRAIN | (Gms) HEART I KIDNEYS I %FBVJ %BRAIN | (Gms) %FBW %BRAIN | (Gms) LIVER I %FBW %BRAIN ] 665324 275.90 665332 316.80 1 .934 0.7010 2 .0 8 2 0.6572 0.075 0.0272 3.8780 0.082 0.0259 3.9385 1.072 0.3885 55.429 1.135 0.3583 54.515 2 .130 0.7720 110.13 2.173 0.6859 104.37 7.553 2.7376 390.54 8.516 2.6881 409.03 Mean S.D . 2 8 8 .3 4 2 6 .7 6 1 1 .9 0 8 0.6653 0.115 0.0562 0.072 0.0250 3.7750 0.009 0.0026 0.3542 1.067 0.3704 55.937 0.117 0.0278 5.1975 2.265 0.7870 118.98 0.210 0.0483 11.451 7.992 2.7677 419.32 0.992 0.1697 50.890 G ro u p : V I 100 m g /k g T r e a t m e n t : 100 m g /k g V I S e x : FEMALES 1 ANIMAL 1 FBW (Gms) 665170 665X99 665238 665250 665251 665259 665295 665300 665340 665341 2 7 8 .0 0 2 8 8 .3 0 2 9 1 .9 0 2 7 8 .1 0 2 8 3 .1 0 2 9 2 .2 0 3 2 6 .5 0 3 0 5 .5 0 2 6 7 .9 0 2 8 9 .3 0 BRAIN (Gms) %FBW 1 .918 0.6899 1 .959 0.6795 1.993 0.6828 2 .069 0.7440 1.916 0.6768 1.907 0.6526 2 .1 3 0 0.6524 1.911 0.6255 1 .9 4 5 0.7260 1.848 0 .63 ADRENAL GLANDS (Gms) %FBW %BRAIN 0 .067 0.0241 3.4932 0.064 0.0222 3.2670 0.094 0.0322 4.7165 0.057 0.0205 2.7550 0.058 0.0205 3.0271 0.064 0.0219 3.3561 0.092 0.0282 4.3192 0.070 0.0229 3.6630 0.059 0.0220 3.0334 0.075 0.0259 4.0584 (Gms) HEART %FBW %BRAIN 1.030 0.3705 53.702 1.040 0.3607 53.088 1.097 0.3758 55.043 1 .010 0.3632 48.816 1.058 0.3737 55.219 1.059 0.3624 55.532 1.133 0.3470 53.192 0.988 0.3234 51.701 1.154 0.4308 59.332 1.220 0.4217 66.017 Mean S.D . 2 9 0 .0 8 1 6 .3 5 0 1 .960 0.6768 0 .084 0.0371 0 .070 0.0240 3.5689 0.013 0.0037 0.6248 1.079 0.3729 55.164 0.072 0.0320 4.6898 KIDNEYS (Gms) %FBW %BRAIN 1 .849 0.6651 96.403 2 .138 0.7415 109.14 2 .428 0.8318 121.83 2 .2 0 9 0.7943 106.77 2 .156 0.7616 112.53 2 .230 0.7632 116.94 2.594 0.7945 121.78 2 .058 0.6736 107.69 1.993 0.7439 102.47 2.424 0.8379 131.17 2 .2 0 8 0.7608 112.67 0.224 0.0584 10.372 (Gms) LIVER I %FBW %BRAIN | 7.529 2.7083 392.54 7.973 2.7655 406.99 9.055 3.1021 454.34 6.981 2.5102 337.41 7.054 2.4917 368.16 7 .858 2,6893 412.06 8.784 2.6904 412.39 7.768 2.5427 406.49 7.873 2.9388 404.78 9.020 3.1179 488.10 7.990 2.7557 408.33 0.746 0.2288 41.392 FBW - F i n a l Body W e ig h t Company Sanitized. Does not contain TSCA CBI -895- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________________ DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TO XICITY EVALUATION Organ W eiit L is tin g S tu d i B M 5 4 2 5 /fem a le I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : V i l i 1000 m g /k g T r e a tm e n t : 1000 m g /k g V I I I S e x : FEMALES 1 ANIMAL I FBW 1 BRAIN 1 ADRENAL GLANDS | 1 1 (Gms) (Gms) %FBN (Gms) %FBW %BRAIN j (Gms) HEART %FBW %BRAIN 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 2 7 6 .5 0 3 1 1 .5 0 3 0 4 .8 0 2 8 0 .9 0 3 1 2 .9 0 3 1 3 .7 0 3 3 3 .4 0 2 5 7 .1 0 2 8 5 .7 0 2 7 3 .4 0 1.874 0.6778 2 .1 4 8 0.6896 2 .1 7 5 0.7136 1 .925 0.6853 1.836 0.5868 2.083 0.6640 2.019 0.6056 1 .8 9 8 0.7382 1.937 0.6780 1 .9 1 3 0..6997- 0.075 0.0271 4.0021 0.076 0.0244 3.5382 0.089 0.0292 4.0920 0.072 0.0256 3.7403 0.056 0.0179 3.0501 0.071 0.0226 3.4085 0.064 0.0192 3.1699 0 .078 0.0303 4.1096 0.062 0.0217 3.2008 0.067 0.0245 3.5024 0.900 0.3255 48.026 1 .171 0.3759 54.516 1.208 0.3963 55.540 0.938 0.3339 48.727 1.090 0.3484 59.368 1.143 0.3644 54.873 1.150 0.3449 56.959 1 .0 1 9 0.3963 53.688 1.269 0.4442 65.514 1.028 0.3760 53.738 Mean S.D . 2 9 4 .9 9 2 3 .6 7 2 1 .981 0.6738 0.119 0.0461 0.071 0.0243 3.5814 0.009 0.0040 0.3911 1.092 0.3706 55.095 0 .119 0.0355 5.0024 KIDNEYS (Gms) %FBW %BRAIN i (Gms) LIVER I %FBW %BRAIN j 2 .224 0.8043 118.68 2 .4 6 0 0.7897 114.53 2.100 0.6890 96.552 1.926 0.6857 100.05 2 .414 0.7715 131.48 2.687 0.8566 129.00 2.357 0.7070 116.74 2.202 0.8565 116.02 2 .348 0.8218 121.22 2 .102 0.7688 109.88 8.109 2.9327 432.71 8.888 2.8533 413.78 9.034 2.9639 415.36 7.835 2.7892 407.01 8.121 2.5954 442.32 8.924 2.8448 428.42 9.517 2.8545 471.37 7.777 3.0249 409.75 8.711 3.0490 449.72 8.207 3.0018 429.01 2 .282 0.7751 115.41 0.217 0.0638 11.117 8.512 2.8910 429.94 0.581 0.1353 20.218 Company Sanitized. Does not contain TSCA CBI FBW - F i n a l B ody W e ig h t -896- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION O rg S tu d . L istin g 5425/fem ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : I I 0 m g /k g T r e a tm e n t : 0 m g /k g I I S e x : FEMALES 1 ANIMAL j OVARIES 1 SPLEEN 1 THYMUS I THYROID GLAND 1 UTERUS 1 1 1 (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN ] (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 0.140 0.0444 7.9410 0.099 0.0313 5.0382 0.122 0.0334 6.3017 0.101 0.0330 5.0025 0.148 0.0501 7.5203 0.114 0.0359 5.8462 0.086 0.0332 4.7383 0.123 0.0451 6.4976 0.121 0.0423 6.7787 0 .118 0.0397 6.3271 0.481 0.1525 27.283 0.566 0.1792 28.804 0.568 0.1557 29.339 0.468 0.1528 23.180 0.519 0.1756 26.372 0.549 0.1730 28.154 0.363 0.1402 20.000 0.539 0.1977 28.473 0.503 0.1757 28.179 0.422 0.1420 22.627 0.312 0.0989 17.697 0.315 0.0997 16.031 0.270 0.0740 13.946 0.167 0.0545 8.2714 0.243 0.0822 12.348 0.285 0.0898 14.615 0.251 0.0969 13.829 0.213 0.0781 11.252 0.463 0.1617 25.938 0.241 0.0811 12.922 0 .0 1 2 0.0038 0.6807 0 .018 0.0057 0.9160 0.022 0.0060 1.1364 0.014 0.0046 0.6934 0.011 0.0037 0.5589 0 .016 0.0050 0.8205 0.010 0.0039 0.5510 0.015 0.0055 0.7924 0.016 0.0056 0.8964 0.018 0.0061 0.9651 0.461 0.1461 26.149 0.632 0.2001 32.163 0.887 0.2431 45.816 0.649 0.2120 32.145 0 .670 0.2267 34.045 1.041 0.3281 53.385 0 .579 0.2236 31.901 1.125 0.4125 59.429 0.727 0.2539 40.728 0.579 0.1948 31.046 Mean S .D . 0.117 0.0388 6.1992 0.019 0.0064 1.0682 0.498 0.1644 26.241 0.066 0.0185 3.1806 0.276 0.0917 14.685 0.079 0.0281 4.7175 0.015 0.0050 0.8011 0.004 0.0009 0.1854 0.735 0.2441 38.681 0.215 0.0755 10.903 G ro u p : IV 10 m g /k g T r e a t m e n t : 10 m g /k g IV S e x :FEMALES 1 ANIMAL OVARIES (Gms) %FBW %BRAIK SPLEEN (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN 665182 665215 665236 665239 665241 665268 665277 665308 0.157 0.0550 8.4819 0.114 0.0464 6.5744 0 .137 0.0410 7.5192 0.134 0.0489 6.5112 0 .146 0.0562 8.2393 0 .1 5 7 0 .0 5 2 1 8.0061 0.092 0.0325 4.6796 0.147 0.0480 7 .7532 0.525 0.1838 28.363 0 .480 0.1953 27.682 0 .670 0.2004 36.773 0.577 0.2104 28.037 0.512 0.1972 28.894 0 .596 0.1977 30.393 0.464 0.1638 23.601 0 .6 3 2 0.2063 33.333 0.296 0.1036 15.991 0.294 0.1196 16.955 0.373 0.1115 20.472 0.303 0.1105 14.723 0.345 0.1329 19.470 0.303 0.1005 15.451 0 .240 0.0847 12.208 0 .346 0.1130 18.249 THYROID GLAND (Gms) %FBW %BRAIN 0.022 0.007? 1.1885 0.019 0.0077 1.0957 0.017 0 .0 0 5 0.9330 0.018 0 .0 0 6 0.8746 0.016 0.0062 0.9029 0.021 0.0070 1.0709 0 .0 1 4 0.0049 0.7121 0.020 0.0065 1.0549 UTERUS (Gms) %FBW %BRAIN 0.738 0.2583 39.870 0.462 0.1880 26.644 0.796 0.2380 43.688 0.921 0.3358 44.752 0.567 0.2184 31.998 0.687 0.2279 35.033 0.453 0.1600 23.042 1.291 0.4215 68.091 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -897- ) ') ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _____________________________________________________ DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION O rgaafW ei^. L is tin g S tud} H B W 25425/fem ale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G ro u p : IV 10 m g /k g T r e a tm e n t : 10 m g /k g IV S e x : FEMALES 1 ANIMAL I OVARIES 1 SPLEEN 1 THYMUS ! THYROID GLAND | UTERUS | 1 1 (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN j 665324 665332 0.154 0.0558 7.9628 0.159 0.0502 7.6369 0 .502 0.1819 25.957 0.698 0.2203 33.525 0 .238 0.0863 12.306 0 .1 8 4 0.0581 8.8377 0.019 0.0069 0.9824 0.013 0.0041 0.6244 0.597 0.2164 30.869 1.102 0.3479 52.930 Mean S.D . 0.140 0.0486 7.3364 0.022 0.0074 1.1346 0.566 0.1957 29.656 0.082 0.0160 3.9272 0.292 0.1021 15.466 0.058 0.0212 3.5965 0 .018 0.0063 0.9440 0.003 0.0012 0.1749 0.761 0.2612 39.692 0.275 0.0816 13.456 G ro u p : V I 100 m g /k g T r e a t m e n t : 100 m g /k g V I S e x .-FEMALES 1 ANIMAL 1 665170 665199 665238 665250 665251 665259 665295 665300 665340 665341 OVARIES (Gms) %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN 0 .125 0.0450 6.5172 0.143 0.0496 7.2996 0.177 0 .0606 8.8811' 0.152 0.0547 7.3465 0.120 0.0424 6.2630 0 .140 0.0479 7.3414 0.132 0.0404 6.1972 0.160 0.0524 8.3726 0.124 0.0463 6.3753 0 .098 0 .0339 5.3030 0.549 0.1975 28.624 0.575 0.1994 29.352 0 .462 0.1583 23.181 0.502 0.1805 24.263 0.399 0.1409 20.825 0.552 0.1889 28.946 0.628 0.1923 29.484 0.612 0.2003 32.025 0.529 0.1975 27.198 0 .505 0.1746 27.327 THYMUS (Gms) %FBW %BRAIN 0.375 0.1349 19.552 0.241 0.0836 12.302 0 .308 0.1055 15.454 0 .364 0.1309 17.593 0 .288 0.1017 15.031 0 .341 0.1167 17.881 0.503 0.1541 23.615 0 .407 0.1332 21.298 0.318 0.1187 16.350 0.304 0.1051 16.450 THYROID GLAND (Gms) %FBW %BRAIN 0.014 0.0050 0.7299 0.015 0.0052 0.7657 0.018 0.0062 0.9032 0 .0 2 0 0.0072 0.9667 0.017 0.0060 0.8873 0.015 0 .0 0 5 i 0.7866 0.019 0.0058 0.8920 0.017 0.0056 0.8896 0.021 0.0078 1.0797 0.023 0.0080 1.2446 UTERUS I (Gms) %FBW %BRAIN | 0.577 0.2076 30.083 0.782 0.2712 39.918 0.711 0.2436 35.675 0.829 0.2981 40.068 0.886 0.3130 46.242 0.817 0.2796 42.842 1.645 0.5038 77.230 1.044 0.3417 54.631 0.430 0.1605 22.108 0.790 0.2731 4 2.749 Mean S.D . 0.137 0.0473 6.9897 0.022 0.0076 1.0770 0 .531 0.1830 27.122 0.069 0.0199 3.3925 0.345 0.1184 17.553 0.073 0.0204 3.2639 0.018 0.0062 0.9145 0 .0 0 3 O.OOli 0.1540 0.851 0.2892 43.155 0.325 0 .09i6 14.879 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -89S- ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 RATS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION Orgem W gicjto L is tin g S tu d K fK m 5 4 2 5 / fem ale I n d i v id u a l A nim al & Summary S t a t s R e p o rt PLACES 2000 v l . 4 0 0 Group : V III 1000 m g/kg T rea tm e n t 1000 m g /k g V I I I S e x : FEMALES | ANIMAL | OVARIES I SPLEEN I THYMUS I THYROID GLAND i UTERUS I I(Gm s) %FBW %BRAIN |(G m s) %FBW %BRAIN |(G m s) %FBW %BRAIN |(G m s) %FBW %BRAIN |(G m s) %FBW %BRAIN 1 665183 1 665200 665234 665242 665261 665291 665310 665326 665333 665337 0.133 0.0481 7.0971 0.118 0.0379 5.4935 0.186 0 .0610 8.5517, 0.102 0.0363 5.2987 0.116 0.0371 6.3181 0 .141 0.0449 6.7691 0.136 0.0408 6.7360 0 .141 0 .0548 7.4289 0.153 0.0536 7.8988 0 .141 0.0516 7.3706 0.517 0.1870 27.588 0.659 0.2116 30.680 0.544 0.1785 25.011 0.555 0.1976 28.831 0.642 0.2052 34.967 0.652 0.2078 31.301 0.590 0.1770 29.222 0 .360 0.1400 18.967 0.480 0.1680 24.781 0.467 0.1708 24.412 0.225 0.0814 12.006 0.273 0.0876 12.709 0.360 0.1181 16.552 0 .2 8 4 0.1011 14.753 0.403 0.1288 21.950 0.369 0.1176 17.715 0.312 0.0936 15.453 0.219 0.0852 11.538 0.359 0.1257 18.534 0.332 0.1214 17.355 0.019 0.0069 1.0139 0.016 0.0051 0.7449 0.020 0.0066 0.9195 0 .0 2 2 0.0078 1.1429 0.015 0.0048 0.8170 0.021 0.0067 1.0082 0.023 0.0069 1.1392 0.021 0.008^ 1.1064 0.008 0.0028 0.4130 0.020 0.0073 1.0455 0.597 0.2159 31.857 0.986 0.3165 45.903 0.723 0.2372 33.241 0.807 0.2873 41.922 0.478 0.1528 26.035 1.811 0.5773 86.942 0.589 0.1767 29.173 0.524 0.2038 27.608 0.933 0.3266 48.167 0 .930 0.3402 48.615 Mean S.D . 0.137 0.0466 6.8963 0.023 0 .0086 1.0105 0.547 0.1843 27.576 0.095 0.0221 4.4838 0.314 0.1061 15.857 0.062 0.0182 3.2529 0 .019 0.0063 0.9350 0.004 0.0016 0.2263 0.838 0.2834 41.946 0.387 0.1220 18.021 Company Sanitized. Does not contain TSCA FBW - Final Body Weight o CD H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________ _______ DuPont-11418 RATS DESIGNATED FOR RECOVERY EVALUATION O rq au JW eiak t L is ti n g S tU di B p 25425/inale I n d iv id u a l A nim al & Summary S t a t s R e p o rt PLACES 2000 v l . 4 0 0 G ro u p : I 0 m g /k g T r e a t m e n t : 0 m g /k g I S e x : MALES 1 ANIMAL 1 FBW I BRAIN I ADRENAL GLANDS 1 EPIDIDYMIDES 1 1 1 (Gms) 1 (Gms) %FBW | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN | (Gms) %FBW %BRAIN j 665008 665043 665064 665081 665098 665106 665121 665149 665159 6 2 8 .6 0 6 0 7 .6 0 5 2 1 .3 0 5 3 3 .2 0 5 2 9 .5 0 6 5 7 .6 0 6 1 2 .0 0 6 2 8 .7 0 5 8 5 .6 0 2.325 0.3699 1.881 0.3096 1 .9 7 2 0.3783 2.290 0.4295 2 .0 9 9 0.3964 2 .3 0 4 0.3504 2 .2 0 6 0.3605 2.272 0.3614 2 .197 0.3752 0.052 0.0083 2.2366 0.065 0.0107 3.4556 0.045 0.0086 2.2819 0.039 0.0073 1.7031 0.044 0.0083 2.0962 0.050 0.0076 2.1701 0.053 0.0087 2.4025 0.062 0.0099 2.7289 0.049 0.0084 2.2303 1.633 0.2598 70.237 1.737 0.2859 92.344 1 .521 0.2918 77.130 1.189 0.2230 51.921 1.583 0.2990 75.417 1.740 0.2646 75.521 1.518 0.2480 68.812 1.858 0.2955 81.778 1.468 0.2507 66.818 1.932 0.3073 83.097 1.726 0.2841 91.760 1.607 0.3083 81.491 1.592 0.2986 69.520 1 .6 9 6 0.3203 80.800 1.966 0.2990 85.330 1 .7 0 5 0.2786 77.289 2 .1 0 4 0.3347 92.606 1 .796 0.3067 81.748 4.095 0.6514 176.13 4.193 0.6901 222.91 3.931 0.7541 199.34 4 .351 0.8160 190.00 3.935 0.7432 187.47 4.010 0.6098 174.05 3.829 0.6257 173.57 4.424 0.7037 194.72 4 .175 0.7129 190.03 Mean S.D . 5 8 9 .3 4 4 9 .9 6 6 2 .172 0.3701 0.157 0.0327 0.051 0.0086 2.3673 0.008 0.0011 0.4890 1.583 0.2687 73.331 0 .195 0.0260 11.109 1.792 0.3042 82.627 0.174 0.0171 7.0374 4.105 0.7008 189.80 0.200 0.0657 15.475 G ro u p : V I I 1000 m g /k g T r e a tm e n t : 1000 m g /k g V I I S e x : MALES [ ANIMAL 1 FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN EPIDIDYMIDES (Gms) %FBW %BRAIN 665002 665007 665031 665062 665067 665095 665112 665138 665146 6 3 3 .9 0 6 3 9 .2 0 6 0 5 .4 0 6 4 8 .8 0 5 9 1 .0 0 5 3 2 .1 0 5 7 1 .1 0 5 0 6 .9 0 5 9 4 .9 0 2 .044 0.3224 2.087 0-3265. 2.057 0.3398 2.147 0.3309 2.185 0.3697 2.139 0.4020 2 .2 7 0 0.3975 2 .1 0 0 0.4143 2 .1 6 7 0.3643 0.051 0.0080 2.4951 0.059 0.0092 2.8270 0.057 0.0094 2.7710 0.048 0.0074 2.2357 0.048 0.0081 2.1968 0.048 0.0090 2.2440 0.050 0.0088 2.2026 0.054 0.0107 2.5714 0.054 0.0091 2.4919 1.715 0.2705 83.904 1.607 0.2514 77.000 1.630 0.2692 79.242 1.496 0.2306 69.679 1.384 0.2342 63.341 1 .6 8 8 0.3172 78.915 1.657 0.2901 72.996 1 .432 0.2825 68.190 1.352 0.2273 62.390 (Gms! HEART %FBW %BRAIN 1 .976 0.3117 96.673 1 .894 0.2963 90.752 1 .6 4 8 0.2722 80.117 1.631 0.2514 75.966 1.776 0.3005 81.281 1.753 0.3294 81.954 1.643 0.2873 72.379 1.762 0.3476 83.905 1.777 0.2987 82.003 KIDNEYS j (Gms) %FBW %BRAIN | 5.026 0.7929 245.89 4.145 0.6485 198.61 3.694 0.6102 179.58 4.133 0.6370 192.50 3 .697 0.6255 169.20 4 .260 0.8006 199.16 4.094 0.7169 180.35 3 .701 0.7301 176.24 4.351 0.7314 200.78 FEW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -900- > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations RATS DESIGNATED FOR RECOVERY EVALUATION . L isting 5425/male ) DuPont-11418 I n d i v id u a l Animal & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G r o u p : V I I 1000 m g / k g T r e a t m e n t : 1 0 0 0 m g /k g V I I S e x : MALES 1 ANIMAL 1 FBW (Gms) 665158 509.70 Mean S.D. 583.30 52.368 BRAIN (Gms) %FBK 2.098 0.4116 2.129 0.3679 0.067 0.0366 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.040 0.0078 1.9066 0.051 0.0088 2.3942 0.005 0.0009 0.2871 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.487 0.2917 70.877 1.545 0.2665 72.653 0.131 0.0301 7.0882 (Gms) HEART %FBW %BRAIN 1.670 0.3276 79.600 1.753 0.3023 82.463 0.113 0.0284 6.9297 KIDNEYS (Gms) %FBW %BRAIN 3.706 0.7271 176.64 4.081 0.7020 191.90 0.420 0.0682 22.036 Company Sanitized. Does not contain TSCA CBI FBW - F i n a l Body W e i g h t -901- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations RATS DESIGNATED FOR RECOVERY EVALUATION Ore Stud !|t L i s t i n g 25425/male ) DuPont-11418 I n d i v id u a l Animal & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 G r o u p : I 0 m g / k g T r e a t m e n t : 0 m g / k g I S e x : MALES 1 ANIMAL 1 1 1 (Gms) LIVER 1 SPLEEN I TESTES I THYMUS; j THYROID GLAND I %FBW %BRAIK j (Gms) %FBW %BRAIN j (Gits) %FBW %BRAIN | (Gms) %FBW %BRAIN ] (Gms) %FBW %BRAIN | 665008 665043 665064 665081 665098 665106 665121 665149 665159 16.807 2.6737 722.88 19.073 3.1391 1014.0 14.934 2.8648 757.30 13.360 2.5056 583.41 13.119 2.4776 625.01 16.770 2.5502 727.86 14.813 2.4204 671.49 18.621 2.9618 819.59 14.289 2.4401 650.39 0.966 0.1537 41.548 0.677 0.1114 35.991 0.911 0.1748 46.197 0.647 0.1213 28.253 0.551 0.1041 26.251 1.102 0.1676 47.830 0.713 0.1165 32.321 0.852 0.1355 37.500 0.752 0.1284 34.228 3.400 0.5409 146.24 3.874 0.6376 205.95 3.899 0.7479 197.72 3.127 0.5865 136.55 3.404 0.6429 162.17 4.018 0.6110 174.39 3.687 0.6025 167.14 3.980 0.6331 175.18 3.620 0.6182 164.77 0.287 0.0457 12.344 0.450 0.0741 23.923 0.371 0.0712 18.813 0.358 0.067 15.633 0.191 0.0361 9.0996 0.317 0.0482 13.759 0.542 0.0886 24.569 0.528 0.0840 23.239 0.354 0.0605 16.113 0.035 0.0056 1.5054 0.027 0.0044 1.4354 0.033 0.0063 1.6734 0.025 0.0047 1.0917 0.020 0.0038 0.9528 0.040 0.0061 1.7361 0.029 0.0047 1.3146 0.026 0.0041 1.1444 0.028 0.0048 1.2745 Mean S.D. 15.754 2.6704 730.21 2.172 0.2590 128.33 0.797 0.1348 36.680 0.175 0.0252 7.4543 3.668 0.6245 170.01 0.307 0.0559 22.044 0.378 0.0639 17.499 0.113 0.0178 5.5052 0.029 0.0049 1.3476 0.006 0.0009 0.2643 G ro u p : V I I 1000 m g / k g T r e a t m e r t t : 1000 m g / k g V I I S e x : MALES I ANIMAL 1 665002 665007 665031 665062 665067 665095 665112 665138 665146 (Gms) LIVER %FBW %BRAIN 18.355 2.8956 897.99 20.475 3.2032 981.07 17.740 2.9303 862.42 20.259 3.1225 943.60 16.196 2.7404 741.24 16.972 3.1896 793.45 16.086 2.8167 708.63 13.785 2.7195 656.43 17.389 2.9230 802.45 SPLEEN (Gms) %FBW %BRAIN 0.801 0.1264 39.188 0.947 0.1482 45.376 0.792 0.1308 38.503 0.955 0.1472 44.481 0.805 0.1362 36.842 0.802 0.1507 37.494 0.813 0.1424 35.815 0.828 0.1633 39.429 0.909 0.1528 41.947 TESTES (Girs) %FBW %BRAIN 3.887 0.6132 190.17 3.194 0.4997 153.04 3.390 0.5600 164.80 3.940 0.6073 183.51 3.455 0.5846 158.12 3.779 0.7102 176.67 3.894 0.6818 171.54 3.749 0.7396 178.52 3.310 0.5564 152.75 THYMUS: (Gms) %FBW %BRAIN 0.417 0.0658 20.401 0.491 0.0768 23.527 0.395 0.0652 19.203 0.479 0.0738 22.310 0.431 0.0729 19.725 0.243 0.0457 11.360 0.400 0.0700 17.621 0.184 0.0363 8.7619 0.469 0.0788 21.643 THYROID GLAND (Gms) %FBW %BRAIN 0.023 0.0036 1.1252 0.026 0.0041 1.2458 0.032 0.0053 1.5557 0.023 0.0035 1.0713 0.022 0.0037 1.0069 0.035 0-0066 1.6363 0.030 0.0053 1.3216 0.034 0.0067 1.6190 0.033 0.0055 1.5228 FBW - F i n a l Body W e i g h t Company Sanitized. Does not contain TSCA C8I -902- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 RATS DESIGNATED FOR RECOVERY EVALUATION O rga^W e^l: L is tin g S tu d v p p lK 5425/male I n d i v id u a l Animal & Summary S t a t s R e p o rt PLACES 2 0 0 0 v l . 4 0 0 Group : V II 1000 mg/kg Treatm ent 1000 m g /k g V I I S e x : MALES 1 ANIMAL 1 665158 Mean S.D. (Gms) LIVER %FBW %BRAIK 15.706 3.0814 748.62 17.296 2.9622 813.59 2.051 0.1783 105.49 SPLEEN (Gms) %FBW %BRAIN 0.744 0.1460 35.462 0.840 0.1444 39.454 0.072 0.0109 3.4540 TESTES (Gms) %FBW %BRAIN 3.152 0.6184 150.24 3.575 0.6171 167.94 0.307 0.0744 14.182 THYMUS (Gms) %FBW %BRAIN 0.308 0.0604 14.681 0.382 0.0646 17.923 0.104 0.0138 4.8661 THYROID GLAND 1 (Gms) %FBW %BRAIN | 0.028 0.0055 1.3346 0.029 0.0050 1.3439 0.005 0.0012 0.2319 Company Sanitized. Does not contain TSCA FBW - F i n a l Body W e i g h t O CD H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ DuPont-11418 RATS DESIGNATED FOR RECOVERY EVALUATION O raaix Wm cte t L i s t i n g Studs^BH B25425/fem ale I n d i v id u a l Animal & Summary S t a t s R e p o rt PLACES 2000 v l . 4 0 0 G r o u p : I I 0 m g /k g T r e a t m e n t : 0 m g / k g I I S e x : FEMALES 1 ANIMAL 1 FBW BRAIN j ADRENAL GLANDS j !Gms) (Gms) %FBW j (Gms) %FBW %BRAIN (Gms ) HEART j KIDNEYS %FBW %BRAIN (Gms) %FBW %BRAIN 1 (Gms) LIVER I %FBW %BRAIN ] 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 326.60 297.80 328.10 288.90 365.70 299.50 394.50 336.90 330.30 284.30 1.949 0.5968 1.953 0.6558 1.813 0.5526 1.959 0.6781 1.888 0.5163 1.770 0.5910 1.991 0.5047 1.907 0.5660 1.929 0.5840 1.875 0.6595 0.055 0.0168 2.8220 0.068 0.0228 3.4818 0.062 0.0189 3.4197 0.066 0.0228 3.3691 0.078 0.0213 4.1314 0.075 0.0250 4.2373 0.072 0.0183 3.6163 0.063 0.0187 3.3036 0.065 0.0197 3.3696 0.054 0.0190 2.8800 1.078 0.3301 55.310 1.101 0.3697 56.375 1.226 0.3737 67.623 1.038 0.3593 52.986 1.234 0.3374 65.360 1.118 0.3733 63.164 1.178 0.2986 59.166 1.145 0.3399 60.042 1.168 0.3536 60.550 1.063 0.3739 56.693 2.245 0.6874 115.19 2.067 0.6941 105.84 2.308 0.7034 127.30 2.367 0.8193 120.83 2.468 0.6749 130.72 2.250 0.7513 127.12 2.907 0.7369 146.01 2.297 0.6818 120.45 2.216 0.6709 114.88 1.961 0.6898 104.59 7.880 2.4127 404.31 8.311 2.7908 425.55 7.757 2.3642 427.85 8.806 3.0481 449.52 9.690 2.6497 513.24 7.857 2.6234 443.90 12.596 3.1929 632.65 8.973 2.6634 470.53 8.085 2.4478 419.13 7.096 2.4960 378.45 Mean S.D.* 325.26 34.988 1.903 0.5905 0.069 0.0593 0.066 0.0203 3.4631 0.008 0.0026 0.4553 1.135 0.3509 59.727 0.067 0.0246 4.6232 2.309 0.7110 121.29 0.254 0.0461 12.325 8.705 2.6689 456.51 1.550 0.2734 71.989 G r o u p : V I I I 1000 m g / k g T r e a t m e n t : 1 0 0 0 m g / k g V I I I S e x : FEMALES 1 ANIMAL 1 FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN (Gms) HEART %FBW %BRAIN 665209 665229 665237 665275 665282 665288 665299 665303 288.30 285.70 276.60 291.50 343.60 327.60 281.00 277.20 1.938 0.6722' 1.870 0.6545 1.963 0.7097 1.892 0.6491 1.894 0.5512 1.878 0.5733 1.876 0.6676 1.883 0.6793 0.066 0.0229 3.4056 0.069 0.0242 3.6898 0.069 0.0249 3.5150 0.064 0.0220 3.3827 0.094 0.0274 4.9630 0.073 0.0223 3.8871 0.065 0.0231 3.4648 0.069 0.0249 3.6644 1.061 0.3680 54.747 0.944 0.3304 50.481 1.009 0.3648 51.401 1.166 0.4000 61.628 1.281 0.3728 67.635 1.403 0.4283 74.707 1.133 0.4032 60.394 1.058 0.3817 56.187 KIDNEYS (Gms) %FBW %BRAIN 2.233 0.7745 115.22 2.161 0.7564 115.56 2.254 0.8149 114.82 2.398 0.8226 126.74 2.705 0.7873 142.82 2.861 0.8733 152.34 2.225 0.7918 118.60 2.271 0.8193 120.61 (Gms) LIVER j %FBW %BRAIN | 7.448 2.5834 384.31 7.787 2.7256 416.42 8.117 2.9346 413.50 9.237 3.1688 488.21 10.610 3.0879 560.19 10.484 3.2002 558.25 8.535 3.0374 454.96 7.805 2.8157 414.50 FBW - F i n a l Body W e i g h t Company Sanitized. Does not contain TSCA CBI - 904- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations RATS DESIGNATED FOR RECOVERY EVALUATION Orqan_Weifl L i s t i n g Study! 5425/fem ale DuPont-11418 I n d i v id u a l Animal & Summary S t a t s R e p o rt PLACES 2000 v l .4 0 0 G r o u p : V I I I 1000 m g / k g T r e a t m e n t : 1000 m g /k g V I I I S e x : FEMALES 1 ANIMAL 1 FBW (Gms) 665328 314.80 665335 299.90 Mean S.D. 298.62 22.864 BRAIN (Gms) %FBW 1.922 0.6105 1.793 0.5979 1.891 0.6365 0.046 0.0509 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.053 0.0168 2.7575 0.068 0.0227 3.7925 0.069 0.0231 3.6523 0.010 0.0027 0.5560 (Gms) HEART %FBW %BRAIN 1.009 0.3205 52.497 1.080 0.3601 60.234 1.114 0.3730 58.991 0.138 0.0327 7.6757 KIDNEYS (Gms) %FBW %BRAIN 2.260 0.7179 117.59 2.303 0.7679 128.44 2.367 0.7926 125.28 0.230 0.0428 12.836 (Gms) LIVER 1 %FBW %BRAIN | 8.768 2.7853 456.19 8.429 2.8106 470.11 8.722 2.9149 461.66 1.093 0.2040 60.058 Company Sanitized. Does not contain TSCA C8I FBW - F i n a l B ody W e i g h t -905- ) .)') H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________ ______________________________________________DuPont-11418 RATS DESIGNATED FOR RECOVERY EVALUATION Orgai^Weight L is tin g StudyH flpH 5425/fem ale I n d i v id u a l Animal & Summary S t a t s R ep o rt PLACES 2 0 0 0 v l . 4 0 0 G r o u p : I I 0 m g /k g T r e a t m e n t : 0 m g / k g I I S e x : FEMALES J ANIMAL OVARIES 1 SPLEEN ! THYMUS (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN UTERUS | (Gms) %FBW %BRAIN j 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 0.136 0.0416 6.9779 0.120 0.0403 6.1444 0.132 0.0402 7.2808 0.118 0.0408 6.0235 0.132 0.0361 6.9915 0.122 0.0407 6.8927 0.116 0.0294 5.8262 0.102 0.0303 5.3487 0.096 0.0291 4.9767 0.120 0.0422 6.4000 0.514 0.1574 26.372 0.549 0.1844 28.111 0.558 0.1701 30.778 0.487 0.1686 24.860 0.676 0.1849 35.805 0.627 0.2093 35.424 0.652 0.1653 32.747 0.541 0.1606 28.369 0.591 0.1789 30.638 0.447 0.1572 23.840 0.331 0.1013 16.983 0.242 0.0813 12.391 0.208 0.0634 11.473 0.203 0.0703 10.362 0.261 0.0714 13.824 0.275 0.0918 15.537 0.433 0.1098 21.748 0.363 0.1077 19.035 0.217 0.0657 11.249 0.241 0.0848 12.853 0.020 0.0061 1.0262 0.020 0.0067 1.0241 0.019 0.0058 1.0480 0.018 0.0062 0.9188 0.022 0.0060 1.1653 0.021 0.0070 1.1864 0.023 0.0058 1.1552 0.026 0.0077 1.3634 0.018 0.0054 0.9331 0.022 0.0077 1.1733 1.081 0.3310 55.464 0.590 0.1981 30.210 0.580 0.1768 31.991 0.634 0.2195 32.363 1.152 0.3150 61.017 1.086 0.3626 61.356 0.923 0.2340 46.359 0.741 0.2199 38.857 1.073 0.3249 55.625 0.577 0.2030 30.773 Mean S.D. 0.119 0.0371 6.2862 0.013 0.0054 0.7631 0.564 0.1737 29.694 0.073 0.0162 4.1432 0.277 0.0847 14.546 0.075 0.0173 3.7236 0.021 0.0065 1.0994 0.002 0.0008 0.1350 0.844 0.2585 44.402 0.242 0.0673 13.049 G r o u p : v i l i 1000 m g / k g T r e a t m e n t : 1000 m g /k g v i l i S e x : FEMALES 1 ANIMAL OVARIES i (Gms) %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN 665209 665229 665237 665275 665282 665288 665299 665303 0.166 0.0576 8.5655 0.143 0.0501 7.6471 0.118 0.0427 6.0112 0.111 0.0381 5.8668 0.133 0.0387 7.0222 0.124 0.0379 6.6028 0.121 0.0431 6.4499' 0.071 0.0256 3.7706 0.451 0.1564 23.271 0.496 0.1736 26.524 0.637 0.2303 32.450 0.673 0.2309 35.571 0.585 0.1703 30.887 0.496 0.1514 26.411 0.487 0.1733 25.959 0.415 0.1497 22.039 0.213 0.0739 10.991 0.243 0.0851 12.995 0.295 0.1067 15.028 0.431 0.1479 22.780 0.266 0.0774 14.044 0.366 0.1117 19.489 0.340 0.1210 18.124 0.212 0.0765 11.259 THYROID GLAND (Gms) %FBW %BRAIN 0.021 0.0073 1.0836 0.027 0.0095 1.4439 0.023 0.0083 1.1717 0.034 0.0117 1.7970 0.026 0.0076 1.3728 0.034 0.0104 1.8104 0.030 0.0107 1.5991 0.023 0.0083 1.2215 UTERUS I (Gms) %FBW %BRAIN | 0.513 0.1779 26.471 0.457 0.1600 24.439 1.230 0.4447 62.659 0.758 0.2600 40.063 0.674 0.1962 35.586 0.728 0.2222 38.765 0.585 0.2082 31.183 0.641 0.2312 34.041 FBW - F i n a l Body W e i g h t Company Sanitized. Does not contain TSCA CBI - 906- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________ RATS DESIGNATED FOR RECOVERY EVALUATION L isting 5425/fem ale DuPont-11418 I n d i v id u a l Animal & Summary S t a t s R ep o rt PLACES 2 0 0 0 v l . 4 0 0 G r o u p : V I I I 1 0 0 0 m g / k g T r e a t m e n t : 1000 m g / k g V I I I S e x : FEMALES 1 ANIMAL OVARIES 1 (Gms) %FBW %BRAIN 665328 665335 0.151 0.0480 7.8564 0.085 0.0283 4.7407 Mean S.D. 0.122 0.0410 6.4533 0.029 0.0096 1.4480 SPLEEN (Gms) %FBW %BRAIN 0.652 0.2071 33.923 0.365 0.1217 20.357 0.526 0.1765 27.739 0.106 0.0359 5.2178 THYMUS (Gms) %FBW %BRAIN 0.286 0.0909 14.880 0.348 0.1160 19.409 0.300 0.1007 15.900 0.071 0.0241 3.8987 THYROID GLAND (Gms) %FBW %BRAIN 0.025 0.0079 1.3007 0.016 0.0053 0.8924 0.026 0.0087 1.3693 0.006 0.0019 0.3001 UTERUS I (Gms) %FBW %BRAIN | 0.628 0.1995 32.674 1.508 0.5028 84.105 0.772 0.2603 40.999 0.334 0.1167 18.445 Company Sanitized. Does not contain TSCA FEW - F i n a l Body W e i g h t O 03