Document Xzv21z504gdvRjxpwRqgwDkZd

E. !. d u Po n t d e Ne mo u r s Co mp a n y INCORPORATED PIGMENTS DEPARTMENT R. c. c. B. J. D. R. R. J. S. c. w* >-J. ( H* AKINS CLEMENTE J. KELT W. KAARH D. LOJEWSKI LOURIA M.' LUCKRING F. MiTCHELL F. MORGAN PELL F. RHEINHARDT S. SRRUVE A. ZAPP NEWARK PLANT REVIEW July 16, 1976 IS 27682 A meeting was held on July .14, 1976, for the purpose of reviewing the recently completed Epidemiclogicel Study Report and a need for further study of the Newark Plant. All addressees were in attendance. (See attachment for information on participants*} R. M, Salemi reviewed background information on employee dust exposure, particularly from lead chromate, pigments; the Riant as a participant in the Dry Color Manufacturers' Association (DCMA) Epidemiological Study; the results from that study together with the contractors conclusions (albeit somewhat inconclusive); and lastly the urgent need for an in-depth employee, study to determine, if possible, the cause of excess employee mortality due to stomach cancer, as well as a need to review the full Epidemiological Study Report. In the discussion which followed a number of suggestions were proposed, some of which follow; Where possible, death certificates as the source of "cause of death" should be verified by checking medical records of the deceased* With regard to the lung cancer, smoking histories should be developed and used to adjust the SMR. m For stomach cancer, should check clinical and medical histories to get clues on specific type of cancer* Newark Cancer Registry should be reviewed for changes in mortality data. BETTER THINGS FOR BETTER LIVING . . . THROUGH CHEMISTRY DUP040011007 i ~ R. H. Akins, et aI -2 July 3.6, 1:976 Early warning screening tests are not available at this time. There is a need to review as .thoroughly as possible the work histories of the employees who died from stomach cancer. There.: is need for a; rech.ie.ek of the .non-exposed popu lation for lack of incidence of stomach cancer. After rhe related discussion, a proposal was solicited from Drs. Louria and Clemente on a thorough epidemiological type study of the Newark Plant. Dr. Louria indicated an interest in engaging in such a study and indicated a preliminary contact would be made with us in several days, and if such a study was engaged in that a proposal might be developed within several weeks. Attached to Drs. Douria's and Clemente1s copy of this letter is the Epidemiological Report as submitted to OSHA. RMS/jew R. Mi. SALEMI RECEIVED JUL1 9 1976 -Ha s k e l l ; l a b o r a t o r y DUP040011008 DU PONT SEMINAR PARTICIPANTS JULY 111, 1976 ROBERT H. AKINS OBLESTiNO: OLEIpNIEj t4,D, CHARGES j HELY j :M:,D, BRUCE W. KAARH 5 M,D. JOSEPH D: LOJEWSKI DONALD LOU.RTA, M..D. RICHARD M. LUCKRING ROBERT F..MITCHELL JAMES P. MORGAN DR. SIDNEY PELL CHARLES F. RHEINHARDT, M.D DR. ROBERT M. SALEMI DR. WILLIAM S,, .STRUVE DR, JOHN A. ZAPP - PLANT MANAGER - NEWARK - DIRECTOR?l UNITED' HOSPITAL Of "'NEWARK ' - PLANT PHYSICIAN - NEWARK - ASSISTANT MEDICAL DIRECTOR ' ' WILMINGTON fit PRODUCTION MANAGER - COLORS y WILMINGTON ~ - PROFESSOR, CHAIRMAN DEPARTMENT , OF PREVENTIVE MEDICINE AND COMMUNITY HEALTH - PROJECT. & ENVIRONMENTAL MANAGER - EMPLOYEE RELATIONS SUPERINTENDENT NEWARK - INDUSTRIAL HYGENlS.T - HASKELL LABORATORY - BIOSTATTST..ICIAH ~ WILMINGTON - DIRECTOR HASKELL LABORATORY - PROJECT & ENVIRONMENTAL MANAGER - MANAGER - COLORS RESEARCH AND DEVELOPMENT - DIRECTOR HASKELL LABORATORY - RETIRED 27682-01 DUP040011009 DP PQNT USE ONLY C- LEAD CHROMATE AND ZINC CHROMATE PRODUCT RISK (TOXICITY) At present, "there exists moderate but inconclusive evidence that zinc chromate is a human and experimental carcino- , gen; there is less evidence linking lead chromate to human / cancer .and slight evidence experimentally"1 (1) . There is no. evidence that either chemical will pose a carcinogenic hazard from .isolated acute exposures by the oral, inhalant, or percutan eous routes.. Both chromates have been classified as suspect carcinogens by Du Pont. , Specific environmental data on these two chemicals are lacking. The most suitable general guide available (2) states'*.,., it appears that the following concentrations of chromium, triva lent or hexavalent:, will not interfere with the specified bene ficia1 us es: a. Domestic water supply ....... *0,05 mg/1 b. Stock and wildlife watering ------------------, 5.0 mg/l cF r s h life 1.0 nig/1 Other aquatic life 05 mg/l REFERENCES 1. J. F. Morgan, '".Background of consideration of carcinogenicity pf lead chromate and zinc chromate pigments," memorandum dated April 14, .197.5" (BL File C-01522) . J. E, McKee and H. W, Wolf ., eds., Water Quality Criteria, 2nd ed,,. The Resources Agency of California, State Water Quality Control Board, Sacramento, California 1963, pp. 163-166, (A later edition, Water Quality Criteria 1972 (EPA) supports the repommended drinking water level of .0.05 mg/l with additional literature references - see p, 62) .^ RRM/mdc ^ ^ e -g ^-7/77 ?/'*// ^ DUP040011010