Document Xzp6M4OmD6wy8ZKqMqbpvpLJK

.July 11, 1935 Dp * Graham Edgar Ethyl 'Gasoline Corporation Chrysler Building How York City How York Boar Dr* Edgari Ploase accept my thanks for your letter of July 8til and for the critical examination of our paper which no discussed over the telephone# 1 think you "brought out a very useful question and on to which I have been so close over a period of many months that I did not even take nob of it. X enclose herewith a bit of discussion which, X believe, covers the point and clarifies the Issue. There is still some slight question as bo whether the findings on garage workers A M, and W. B. could be explained from the basis of physiological variation. X do not believe that that is the proper explanation and since X do not so believe, I choose not even to mention the point. In comparison with the other data of this article, the findings on A,M. are definitely out of line and one would need to show that a normal individual studied in this same manner could give similar results in order to conclude that these represent normal findings. X think my paragraph In discussion indicates the possibility of error particularly in the collection- of samples .on-'a large- number of individuals without stressing it too much. Persons who have had any experience with that manner of working will realise the difficulties, while those who have not had experience will never know how difficult it is to obtain and handle several hundred samples without contamination her and there. With regard to your other question as to the absence of any significant findings in the feces, X believe the discussion of the paper is reasonably adequate* The presence of lead in the feces under con ditions of exposure is dependant in large measure upon the collection of particulate lead in the upper respiratory tract, a portion of which is subsequently swallowed. In the present instance there is little reason to believe that significant amountsoof load should suffer this fate, and N20476 2 Dr Graham Edgar nifleant exposure can be found in the feces* I have not stressed the point unduly in the paper but it is quite obvious from the data that the actual lead absorption was very minute indeed* There is just one other point which I believe it is worth while to mention,* and that has to do with my statement that the lead excretion Of the two long employed garage mechanics has been normal* If you will note the text carefully you will see that X have taken the trouble to say that It is above the normal values found in persons studied by similar methods* That may not seem to you or to others to be an important reservations but I think It is* Actually as you will realise this is not an altogether finished subject* We shall probably have occasion to study other filling station raon and other garage mechanics from time to time, and X hope eventually to put the finishing touches on this work by studying the lead content of the tissues of men of this type* Thus far no such tissues have been available to me*- 'hut I think in time these data will be obtainable* With klndjest personal regards.* Cordially yours. RAKsis RobeJtnrr^ehoeT'^MTD. P*S* I enclose herewith certain pages on which slight changes have been made so that you can put these in your copy, and have the paper in the form in which It will finally appoar* RAK* KE 0015478