Document XznaogRgZmY7gYe8jRdGR3KOw
pternyal CoCrreospoRndenRce. E.
W.
G. C.
Lamprecht McCormick
- 218-3 - 220-26-02
V. PAo.thParporkaogpad-a23-62-3268-37
R. L.
D.
Winter
- 236-28
AR226-0285
wo fom `Subject:
E.G. GORTNER - RIKER -218-3-3 To Re MATHISEN -COMMERCIAL CHEMICALS 23628 ANALYTICAL ANALYSES OF SUSPENSION OFFM-3924
-
3h
Cate: April 8, 1981
Reference: CCD. Analytical Method #G-29-0381
INTRODUCTION:
oil with suspended FM-3924 were receiveedboon_coMranrocihl,
Four 16,
samples of 1981 from E.
corn G.
Gortner.
The 924,
T-f2o9u9rs9aOmpCle2s-5Jmabge/lkegd/daPylacand
T-2999 4,
T-29909.25COmCg/2k5mgg/d/akyg/wdearye
FM-3 submitted
forsmagm/pmlles cwoenrceentrurnatiboynaofGFLMCm-e3t4h2od
! CfuOosCringusea minethaanroalt efexetdriancgtiosntudayn.d aTnheinternal standard.
GLC RESULTS:
Sample
Placebo Corn 0f1 7-2999 COC FM-3924 0.25 mg/kg/day 7-2999 COC FM-3924 2.5 mg/kg/day
72-529m9g9/kgC/OdCayFM-3924
MgM1 FM-3924 No FM-3924detected 0.0459 mg/ml FM-3924
0.4694 mg/m] FM-3924
5.136 mg/ml FM-3924
SUMMAR:Y
411 samples
were
within
108
of
target
and
shoved
gooc reproducibility.
tandards used show
ould disse maara showed sane crystalization, but after Sonification The
solubility
of FM-3924 was found to on at 0.5 mg/ml level.
be
low. It was
S found
that sonification several days
signs would
of saturati dissolve the
FM-3924
into
the
corn
oil.
But after
ifteewdoiunlgdstveu-dsyolcuobrinli0z1e1.. The crystalization could cause problems in the
d-- e Fe3m
TRU/he
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LL