Document XznREVX2y4k6yzYNw8aOmq28w

October 3. 1969 Dr. A. R. Glasgow Chief of Roforenee Standards Section Reeldue Chemistry Branch Division of Pesticides Pood end Drug Administration Washington. D. C. 20204 Dear Dr. Qlesgovi One pound samples of our Aroelors 1294 and 1260 arc being forwarded to you and to Nr. Vincent Sodlab at the Atlanta Toxicological Branch today. Perhaps it will be of interest to mention that In 1962 one of our consulting laboratories determined the oral LD50 In rata of Aroelor 1254 to be greater 10 grama per kilogram when administered undiluted wing four groups of mixed sex animals weighing between 200-250 grama and administered at doses of 7*94. 10*0, 12.6, and 15*8 respectively for the Individual groups. The oral LD50 was calculated as 11.9 gAg with limits of 10.47 to 13.45 g/kg. Zn the oase of Aroolor 1260. a 50* solution In oom oil developed data leading to a calculated LD50 of 10.0 gAg with lower and upper limits of 8.6 and 11.6 gAg. Z have enaloeed vummarlea of raeent data we have received from Industrial Bio-Teat Laboratories in . Chicago. The summaries indicate the 90-day interim results of two year ohronie feeding etudles to dogs of Aroelor 1254 and 1260. A aooond enclosure le the summery shoving the statue of three generation rat reproduction studies on these actaria Is begun la May. Vs also have underway two year oral studies In rats. We added 300 extra aninale to this study to allow sacrifice of soma animals at three months, six months end one year. DSW 019686 STLCOPCB4007619 Or* h> A* Olaagow October 3t 1969 Page Two A verbal report on the 90 day aaorifioee lndleatea that there were no aeaaurable effecte aa Indicated by the uaual paraaetere. A written Interim report will be reoelved when the alcro pathology hat been ooopleted* X have taken the liberty of aendlng a copy of thla letter to you to Mr* Sedlak in the Atlanta Branch. Ve will be lntereated in learning of the reaulta of your propoaed toxloologloal teating. Sincerely, Bluer P. Wheeler Manager* Environmental Health EPWtJu c.o. b.c. Jack 0* Early Vlnoent Sedlak R. E. Keller W. R. Richard DSW 019687 STLCOPCB4007620