Document XzkbOgGkrya83yreDKRQmVepJ

July 18, 1975 Dr. J.C. Calandra ..... Industrial BIO-TEST Laboratories 1810 Frontage Rd Northbrook, 111, 60062 A\ / VA J ret AROCLOR 2-year Rat Feeding Studies Dear Joei The attached tabl^nsummarizes a comparison of the 3 revised AROCLOR reports 1254, 1260). In 2 instances, the previous conclusion of "slightly tumorlgenic" was changed to "does not appear to u caroinogoulc", The latter phrase is preferable, Mav we request that the AROCLOR 1254 report be amended to say "does net appear to be carcinogenic". The number of hepatomas reported for AROCLORS 1260 and 1242 have been interchanged. This appears to have arisen from con fusion regarding the numbering of the animals. The original reports show tumors in animals with numbers in the 100-300 range for AROCLOR 1260 and in the 500 to 800 range for AROCLOR 1242. This leads me to conclude that the numbering scheme shown in the .. second set of reports is correct. With AROCLOR 1254 confusion is compounded. The original report showed tumors in animals with numbers in the units to teens, but the revised report: shows animal numbers ranging from 4o to 1000. Can this be straightened out? I was unable to reconcile the differences in the animal numbers between the first supplemental report and the original reports, I had Inquired as to the changes in the numbers. A3 I recall; I was told that the sections had been renumbered when the new slides were made and that a key relating to the sets of numbers DSW 020441 STLCOPCB4008370 Dr, J.C, Calandra July 18, 1975 Page - 2 would be supplied. This has not been done. It may* not be necessary for AROCLORS 126o and 1242, but AROCLOR 1254 remains unresolved. Insofar as I can see, the remainder of the reportB appear acceptable. Kindest personal regards. Sincerely, George J, Levinskas, PhD Mgr,, Environmental Assessment and Toxicology /bkp att, cc: Dr. George Roush, Jr., M.D. DSW 020442 STLCOPCB4008371 Product Supplemental Report #1 (mailed) AR0C.TiOR126.O_ conclusion slightly turaorigenlc hepatomas 3 range of test animal nos: p. 9 600 to 800 p, 10 1000 series p. 11 70 to 100 p. 12 500 to 600 p. 2-3 600 to 700 700 series Supplemental Report #2 (JCC delivered does not appear carcinogenic -7 100 to 300 800 to 900 lotto 40 80 to 200 200 to 300 200 to 300 AROCLOR 12 $4 conclusion .-- hepatomas slightly - turaorigenlc 6 slightly tumorIgenic 6 AROCLOR 1242 conclusion slightly turaorigenlc does not appear carcinogenic hepatomas 7 3 range of test animal nos, as In report #2 as in report #1 for AROCLOR 1260 AROCLOR 1260 OSW 020443 STLCOPCB4008372