Document XzN8e38mb47N0pZ3p5EkwO8vx

UCC CO VC RESEARCH INHALATION STUDY Bio -TEST J!GJxyuii&u6, Jnc. 1610 FRONTAGE ROAD NORTHBROOK, ILLINOIS 60062 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 IBT NO. 663-03222 K. OCT 0 6 1975 R N. WHEEL Etf, JR. UCC 003082 ucc 003083 9rujuM/iuiL BIO-TEST XcdyyuiJ^yius^, Sac. 1810 frontage road NORTHBROOK. ILLINOIS 60002 September 23, 1975 Dr. Milton Freifield Project Manager, Vinyl Chloride Research Manufacturing Chemists Association 1825 Ccnne cticut A venue, N. W. Washington, D. C. 20009 Dear Mr. Freifield: Re: IBT No. 663-03222 - Chronic Vapor Inhalation Toxicity Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters We are submitting herewith our laboratory report prepared in connection with the above study. Very truly yours, ^ tp . tip n Cm JCC:bp J. C. Calandra President UCC 003084 SudutituaL BI O - 7 S 5 T ;W 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 IBT NO. 663-03222 I. Introduction A chronic vapor inhalation toxicity study with Vinyl Chloride (Ethylene Derived) was initiated on September 10, 1973, and termi nated on September 10, 1974. Animals were then placed on observa tion. A summary of all data obtained through the twenty-third month is reported herein. UC-C 003085 StuLuiluaL B I O * T E S T Jafciatvun, Hue. 2 II. Summary Exposure of mice to Vinyl Chloride was terminated after 9 months of testing. At this time all surviving mice were placed under observation for the remainder of the investigation with the exception of the T-III group (2,500 ppm) which was sacrificed during the eleventh month. Rats and hamsters were exposed to Vinyl Chloride for 12 months before being placed under a non-treated observation period. Respectfully submitted, INDUSTRIAL BIO-TEST LABORATORIES, INC. Report prepared by: Dennis C. Lindberg, B . S . Assistant to the Manager Decatur Research Laboratories Report approved by: cjiz(*L fohn W. Goode, Ph.D. Inager Decatur Research Laboratories --- . -- - Florence K. Kinashita,/Ph.0T Technical Manager Toxicology ________ / M. L. Keplinge^/ Ph. 9^/ Manager, Toxicology Pg i mr 003086 9nindinial B I O T E S T JaionoioMU, Hue. 3 III. Body Weight Data The mean body weight data for albino rats, albino mice and hamsters are presented in Tables I, II and III, respectively. ucc 003087 B IO -TE S T A ucc 003088 lAIUJi I'tSi MA'I L.KJAI.: Vinyl QiluinJu (I.thy lute Ikjrivnl) Va,tot liitoLliim Tumcily Siuily AIUihj Hals, AJblm* Muc mil Iw.lil.n Jfamsict buhimary ul Me-du hotly WciyJils Albino Hals Muait hoily Wuiylila (grants) Mon1J1 Niimlicr. (*J II 1 2 1 4 5 6_ 2 1 1 JO M U 11 J4 It 16 17 IB 11 20 21 22 21 _ Chaii| 1U T1 1u 1 III 205 M.l 456 4*1* SW 5W 541 550 551 617 677 61 612 70* 711 761 7*2 m 7BI 01 *12 *21 717 *14 201 201 200 HI. U.0 151 44* is; 451 4*11 410 411 52b 522 521 545 541 5U0 554 567 567 567 565 576 511 651 5*5 6*1 5*1 627 640 661 621 67* 616 6*0 616 716 71* 704 740 721 712 764 764 754 7*6 76* 765 715 75* m 7*J 7*4 7*1 711 7*1 7BM 741 - 711 766 - 760 - 601 551 - Ik 11 r II T IN u.u 16* 171 Its /IS 212 242 240 275 274 2*9 2*7 211 217 102 IBJ 115 110 111 112 J2U 10* 11b 121 126 121 121 121 144 14* 142 146 156 167 15* 151 112 J57 16* J51 166 161 162 156 1*0 174 1*6 174 JIB )S4 111 17* 147 115 414 420 424 425 441 450 444 44B 4 71 461 45* 462 U, 1 Mil 491 4 72 45(1 - 511 4*1 4*4 - 527 411 414 - 520 507 - 527 4*0 - 557 4*4 117 116 l IV IH1* 251 2*2 2** 211 JI4 124 11* 14* 16] 161 1*4 NA 115 NA 111 421 -- - - Nu moii; animals reniaininy in yiotj|>. NA - lli 11 available. r 4a. , B IO -TE S T A ucc 003089 TAliJ.K H Ttiii MATtltlAlo Vinyl Cliluiide (liiJiyknc thrived) Utrwtu Va|mi lululiltui Tuicicily Study - Albino IbL, Albino Mice nnl Cd.lcn I Jam a ler* SuiiMhJiy of Body WelyltU - Albino Mice Sl- (ilOIJ|l Mean Body Weiylili (grams) Month Number; 0 1 2 3 4 5 6 7 B 9 10 a 12 13 14 15 lb W 14 19 20 21 22 23 Male IJC Ti T II T III IS 10 11 11 4L 4) 1b 52 4V 47 41 47 u 47 45 4b 44 M 43 II 19 19 43 44 12 47 47 47 41 44 49 44 41 50 44 - - _ Mi 50 It 42 41 42 45 o 44 4b 37 44 45 -.- __ 36 Jt 10 43 41 34 45 41 41 43 31 ' - - - - - F umb UC 29 32 n 35 36 15 11 17 41 40 37 40 40 40 41 42 40 U> 39 19 41 41 T 1 id )1 34 37 IV 34 10 41 40 10 42 41 42 43 44 19 34 _ . _ . 1 II 24 II 34 35 17 lb 30 it 44 19 30 40 17 14 40 31 14 . T ill ZB II 34 35 3b 37 37 14 37 39 27 ---- -- -- ____ _____ _ ____--------------------------------------. _ ._ - No mute animal* ri:immuii}| yioup Qlillgt _ _ - 12 _ _ - I Ul B IO -TE S T A ucc 003090 taiim: m TEST MATIlHJAI.: Vinyl CJikituli; (Klliylciiu Dirrivril) Chrome Vd|ju InlutMliuii 'I'ujOLity Slmly - Album RiU, Albino Mite iul t.ii |. tt Hiiuwuiy ul Mean llwly Wngliu UulUen Ibniblcu bex M-k- IVlIldl* -- ' ~ Mean Doily W*lylu (gras**) Cirtmii 0 1 2 ) 4 s 6 1 a 9 10 11 12 11Month Miiwbiei, a IS 16 U II 19 20 21 22 2) lie: Ti r ii l IN n 6ni to 9ft 90 ft9 a# no 101 9914 120 1)4 w 112290 119 91 no 121 IM UJ 122 120 112 IM 121 111 no i ii 126 122 US 141 lift 117 ns 1II2S9 IIS IIS 126 uIISa 114 12S IIS 121 110 1)1 121 126 12) 12ft 124 111210 12S 122 129 124 126 12* na 129 1n 11/ 111 1m nft 1)2 1)4 127 141 1J4 1J)I64 111 1)6 11) 140 1)7 - - 14) 14) - 146 IS* , - ut: TI T II r hi ft 78 74 69 104 9S 94 92 lea 102 99 100 lift 112 I0B 106 120 IIJ 107 lut> 121 111 106 104 124 122 H4 lit 126 no 1n1a2 12ft 126 m 10* ns I2S lift 107 l1i1f9t 112 10) n11o6 112 99 117 ua 109 101 m ns mI0S 122 117 116 109 in 121 )I7 112 US 122 122 v> MO I2S Ut na 124 122 - 112 1)4 1-2ft 121 112261 _ _ . . - . _ - -- - - -- -- . _ --.----------- ___ ___ - lii moi c animala >uimniii|j m |rou|i, Change n 19 . - . - t PndudiUai B I O T E $ T 2a&*tat#Ust, 7 IV. Mortality Data The cumulative monthly mortality data are presented in Tables IV through VI. The following is a summary of remaining animal groups: Species Sex Groups Remaining Rats Male Female UC. T-I UC. T-I Mice Female UC Hamsters Male UC, T-I From mortality data of the past 5 months of observation, the following estimations of death were obtained: Species Rats Mice Group and Sex UC-M UC-F T-I-M T-I-F UC-F Estimated Time of Death Months: 5 5 4 1 1 Hamsters UC-M T-I-M 5 3 ucc 003091 HtUwiisucil B I O - T E S T JaA&a&yustL, Hkh. 3 Month Number 1 2 4 5 6 7 8 9 10 11 12* 13 14 15 16 17 18 19 20 21 22 23 TABLE IV TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Rats Cumulative Number of Mortalities at End of Month UC T-I T -II T-III MF MF MF MF 000000 002010 A 1 A0lA 00 00 A 024130 1 "I 23516l 34 34616l 54 448262 65 4 5 9 3 10 5 10 8 4 6 10 4 11 5 16 15 5 7 11 7 12 9 24 28 7 8 13 9 14 19 34 52 13 14 19 16 21 37 58 66 16 17 23 24 26 50 73 83 19 21 26 30 33 63 85 86 21 23 28 37 40 75 94 89 23 25 31 45 46 87 100(4) 100 28 27 35 53 55 90 100 100 33 28 38 59 64 94 100 100 38 31 43 66 71 94 100 100 46 34 47 73 77 94 100 100 52 42 52 80 100(18) 100(4) 100 100 57 48 63 89 100 100 100 100 64 54 72 92 100 100 100 100 T-IV F 0 0 n 0 0 0 0 1 4 7 17 40 46 76 86 100(7) 100 100 100 100 100 100 100 * Includes 5 males and 5 females from each group excluding T-IV sacrificed for cytogenic study. () Indicates moribund or sick animals sacrificed. ucc 003092 9tujUutual B I O - T E S T jaLoMte*i*i, Sue. 9 Month Number 1 2 *5 1 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE V TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Mice UC M Cumulative Number of ]Mortalities at End of Month T-I T- n T-III F MF MF M F 00 0 00 000 0 0 0 3 000C 0 6 430 1 5 1 19 5 4 1 4 7 8 2 26 6 4 2 8 7 12 2 30 6 8 3 10 9 18 5 31 11 9 12 13 23 18 5 32 14 16 30 30 46 23 8 38 24 37 58 56 75 28 10 42 31 78 82 76 98 30 15 54 46 96 94 100 100 34 16 57 66 98 95 100 100 44 23 70 80 99 97 100 100 54 28 79 91 100 100 100 100 67 39 88 97 100 100 100 100 82 46 100 100 100 100 100 100 82 54 100 100 100 100 100 100 82 58 100 100 100 100 100 100 92 70 100 100 100 100 100 ' 100 100 77 100 100 100 100 100 100 100 81 100 100 100 100 100 100 100 89 100 100 100 100 100 100 100 92 100 100 100 100 100 100 JndnA&ual B I O T E S T J<i6tnatoAi*A, Sue. 10 Month Number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE VI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Golden Hamsters UC M Cumulative Number of Mortalities at End of Month T-I T-n T-III F MF MF M F 54447525 8 11 10 12 9 16 10 u 3 13 * X -f 12 13 x T K ^ 9 15 16 16 15 19 15 13 9 18 16 16 16 20 15 15 13 18 16 16 20 21 16 16 13 28 24 19 22 33 18 26 14 28 24 19 23 35 19 28 14 29 24 20 25 36 20 28 14 30 26 20 26 37 23 29 15 31 28 21 26 38 28 36 18 36 34 33 37 46 40 45 23 40 43 49 46 49 49 58 28 46 49 58 54 53 61 69 39 61 53 72 66 55 71 84 50 78 58 83 74 59 84 100(3) 57 81 61 85 76 66 86 100 62 85 62 86 77 75 88 100 65 90 68 89 79 84 92 100 71 96 73 95 86 89 100(5) 100 71 100(2) SO 100(3) 100(13) 100(7) 100 100 73 100 82 100 100 100 100 100 78 100 85 100 100 100 100 100 () Indicates moribund or sick animals sacrificed. ucc 003094 !)*uL*i&ual BIO T E S T ^*6 11 V. Hematologic Data Twenty-three month hematologic data are presented in Tables VII through X. UCC 003095 BIO -TEST ucc 003096 TABLE VII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Group Animal Number Total Leukocyte Count (thousands/mm-*) Test Month: 23 Erythrocyte Count (millions/mm 3) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 Untreated Control 1 4 5 7 15 17 18 19 22 27 28 '34 37 40 41 42 47 49 52 53 Mean 9.0 11.3 8.7 9.8 13.6 16.0 11.5 14.8 8.0 10.8 15.6 9.7 11.6 15.0 6.6 8.8 7.9 9.2 11.6 10.4 11.0 8.03 8.89 8.97 7.30 5.30 6.91 8.52 6.40 7.79 6.57 6.14 8.17 7.88 8.19 7.84 8.55 8.44 6.65 7.84 8.70 7.65 14.2 16.0 15.6 16.1 11.5 14.6 15.7 14.8 15.2 15.4 14.8 15.2 15.6 16.2 16.0 15.9 17.0 14.0 16.0 16.2 15.3 48 53 51 50 40 48 54 46 50 50 45 48 52 52 51 50 55 44 50 52 49 t\j Group T-l OCJ C '* Oo (O TABLE VII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Animal Number Total Leukocyte Count (t housands/mm 3 ) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 1 lemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test M nth: 23 201 207 209 212 214 222 223 225 226 in 228 '232 233 234 238 241 246 250 255 268 Mean 9.8 14.6 12.4 12.4 8.7 9.2 10.8 14.8 11.8 5.4 7.6 9.2 10.4 7.3 10.5 12.2 13.7 18.6 6.4 8.7 10.7 6.54 6.54 3.82 7.26 6.91 6.38 6.44 6.44 7.83 6.57 7.83 7.80 8.19 8.45 7.75 9.37 6.77 7.47 6.95 7.18 7.12 12.4 14.0 8.6 14.4 14.3 13.7 13.8 10.4 15.2 13.7 15.2 14.3 15.8 15.6 15.4 16.4 13.6 14.0 13.8 14.6 14.0 40 44 30 46 44 42 46 38 49 42 47 44 50 49 48 52 41 45 42 44 44 IP o m Ul u> TABLE VIII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rati. Group Animal Number Total Leukocyte Count (thousands/mm Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 Untreated Control c~ So (O O CO 102 105 107 108 111 112 113 117 118 119 121 123 124 125 127 130 131 132 133 134 Mean 13.0 9.1 7.8 15.3 8.3 15.6 10.3 3.6 6.1 11.1 9.0 14.4 10.8 6.1 5.8 20.0 5.0 5.9 8.1 7.0 9.6 5.02 6.78 6.38 7.15 5.29 4.49 5.49 7.26 5.80 5.43 6.10 4.90 6.25 7.27 7.10 2.69 7.18 7.60 6.54 7.30 6.10 12.0 14.9 13.2 14.6 10.4 9.1 12.2 14.6 12.0 12.2 13.6 10.0 13.2 14.8 14.0 5.7 14.6 14.4 13.5 14.4 12.7 40 48 42 46 34 30 38 46 38 38 42 35 40 46 43 22 46 45 42 45 40 o in A A rtW BIO -TEST 003099 Group T-l TABLE VIII continued TEST MATERIAL: Vinyl Chloride (Ethyle.iu Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rat:. Animal Number 315 322 326 337 352 354 363 Mean Total Leukocyte Count (thousands/inm^) Test Month: 23 9.6 6.4 24.6 9.0 28.4 14.9 5.9 14.4 Erythrocyte Count (millions/mm^) Test Month: 23 7.11 6.95 2.01 8.24 6.28 4.42 8.60 6.23 Hemoglobin Concentration (g/100 ml) Test Month: 23 13.2 13.6 4.4 13.8 10.8 8.8 13.5 11.2 Hematocrit Value (%) Test Month: 23 43 43 17 49 36 30 46 38 S O T 1531*018 Group Animal Number Untreated Con trul 17 28 40 T-l 250 TABLE IX TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Ring* Differential Leukocyte Count (number of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Number: Month Number: Month Number: Month Number: 23 23 23 23 Basophils Month Number: 23 52 41 52 0 0 0 10 0 52 37 0 1 0 11 0 40 48 1 0 0 10 0 11 79 0 0 0 * Several of the ring-form neutrophils were twisted like a figure 8. O' BIO -TEST Group Animal Number Untreated Control 108 112 117 130 T-I 326 352 354 TABLE X TEST MATERIAL: Vinyl Chloride (Ethylme Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Almno Mice and Golden Hamsters Hematologic Data - Female Ran. Ring* 7 14 7 11 Differential Leukocyte Count (numbi r of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Number: Month Number: Month Number: Month Number: 23 23 23 23 1 34 52 5 0 52 31 1 0 30 63 0 1 34 54 0 1 2 0 0 Basophils Month Number: 23 0 0 0 0 [ Vi * 11 0 35 53 1 0 0 13 0 31 54 1 1 0 90 32 57 2 0 0 * Several of the ring-form neutrophils were twisted like a figure 8. So 9*(L*Unial BIO-TEST JaintaitvtM, 9m. VI. Gross Pathology Tables XI, XII and XHI present suspected treatment-related tumors based on lessions found during gross necropsy. These lessions will be evaluated by histopathological examination to determine their true value. Tumor Key C ESC P PMA S SZ A = cannibalized = escaped = postmortem animal = valid evaluation precluded by postmortem autoiysis = sacrificed animal - sacrificed sxtramis - animal still alive ucc 003102 9*uL*it>tiaL B I O - T E S T JaiotafaM, $nc. 19 TABLE XI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Untreated 1 Control 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Days on Test 557 z w* *V 372 411 504 556 564 532 590 331 656 681 712 609 607 424 645 712 611 402 138 365 146 612 Mortality Data Liver Spleen Luna A P ? A A P A P PMA P PMA PMA PMA P A P A A A P P A P P P SE A A P PMA P P PMA A PMA PMA Skin Misc. v X X X X Kidney Ucc 003703 JuduittUal B I O - T E S T Due. 20 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 37 Control 38 continued 39 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 A 660 P 360 S A A A 667 SE 702 PMA 524 PMA 619 P A 703 P A 673 P 204 P A A 360 S 360 S 692 P A 641 P 347 PMA 463 PMA 272 P A 456 P A 572 P 581 P 511 P A 360 S 626 P 578 PMA A X X X X X Kidney ucc 003104 Mutkial BIO - T E S T Jabt*aio*iM, Hoc. 21 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Spleen Luna Skin Misc. Untreated 73 A Control 74 599 P continued 75 541 P 76 3 FMA 77 675 P X 78 A 79 A 80 A 81 A 82 685 P 83 603 P XX 84 360 s 85 699 P 86 595 p 87 587 p 88 713 PMA 89 384 P 90 302 P 91 706 PMA 92 507 P 93 415 P 94 409 P 95 384 P 96 591 P X 97 168 P 98 474 P 99 496 P 100 710 p X X X X ucc 003A05 UtttLitMaL B I O T E $ T JaiooaivUM, 9*e. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test T-I 201 202 462 203 146 204 668 205 361 206 642 207 208 701 209 210 536 211 189 212 213 703 214 215 145 216 568 217 599 218 718 219 529 220 101 221 541 222 223 721 224 668 225 226 227 228 229 675 230 74 231 719 232 233 234 235 324 236 645 Mortality Data Liver Spleen Luna A P PMA P s p A PMA A P P A P A P P P P P PMA P A P P A A A A P PMA P A A A PMA P X X X X X X X X Skin X Mis c. ucc 003106  Mtufaial B 1 O T G S T Jaivtat&uu. Due. 23 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test T-I 237 continued 238 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 136 A Xh 261 111 693 669 611 595 695 703 526 508 113 693 361 634 34 581 617 624 275 274 361 693 318 662 642 Mortality Data Liver Spleen Lung PMA A P P P P PMA P P A P P P A A P P P A S PMA PMA P P P PMA P S P P P A P X X X X X X X X X Skin X X X Misc. Thymus Kidney Kidney Kidney 270 99 C 271 534 P 272 640 P ucc X 003107 Kidney HttdttdUiaL B I O *T E S T Jaintofotiti, 24 TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. T-I 273 690 P continued 274 275 661 SE 504 p 276 158 PMA 277 388 P 278 569 P 279 361 S 280 383 P 281 585 P 282 A 283 204 P 284 670 P 285 A 286 665 SE 287 547 PMA 288 531 P 289 43 ESC 290 438 P 291 412 ESC 292 A 293 541 P 294 573 P 295 224 P 296 89 PMA 297 94 PMA 298 249 PMA 299 361 S 300 547 P UCC 003108 HMrftutniai BIO-TEST Jao*atwUst, 9*c. 25 TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number T-II 401 402 403 **04 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 Days on Test 495 505 626 3t>l 474 534 527 555 535 340 485 631 631 506 64 597 506 631 574 415 604 449 108 341 589 626 529 626 611 626 297 317 361 617 626 626 Mortality Data Liver P P o s p p SE P P PMA PMA S S P P P P S p p p PMA ' PMA P P S PMA S P S p PMA S P S S X X X X X X X X X X X X X X X X X X X X X X X X Lung Skin Misc. X Pancreas X X -Mesentery X X ucc X 003109 Thymus Mutirual B I O - T E S T JaivtaivUn, Jna. 26 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number T-II 437 continued 438 1*70 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 Days on Test 478 381 XT X 62o 134 616 451 535 626 576 449 482 501 507 532 626 626 502 452 626 466 526 361 577 333 575 485 626 465 239 547 395 361 224 626 244 Mortality Data Liver Spleen Lunjj P PX PMA SX PMA PMA P PMA S P PX X PX PX PX PMA SX SX PMA PX X SX P PMA SX PMA P XX PMA PMA SX X PX PMA P PX S ** P sX P Skin X Misc. UCC 003110 SctLtiiual B I O - T E S T JaC&icfcucC, Stic. 27 TABLE XI continued _____ TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 473 502 P continued 474 544 P rs L. -1 ' 476 229 P X X X 477 374 P X 478 196 PMA 479 590 PMA 480 231 PMA 481 525 P X 482 569 P X 483 596 P X 484 626 S 485 468 P 486 513 P X 487 223 PMA 488 223 PMA 489 361 S X 490 359 PMA 491 626 S 492 432 P 493 465 P X 494 612 P X 495 536 PMA 496 480 P X 497 446 P X 498 429 P 499 129 P X 500 480 P X X X X X Misc. Prostate Seminal vesii Lymph nodes UCC 003111 ShdudbiaL B I O - T E S T 9*c. 28 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-IH 601 355 SE 602 247 PMA p roo r> 604 402 P X X 605 366 P X 606 242 P 607 344 P X 608 384 P X X 609 361 S 610 439 P X 611 390 P 612 236 P XX Mesentery 613 394 P X 614 400 P X 615 411 P X 616 496 P 617 250 P X 618 498 s X 619 426 p X 620 470 p X 621 371 p X X 622 244 p X 623 292 ? X 624 362 SE X X 625 341 SE X XX 626 344 P X 627 353 P X 628 448 P X 629 389 P X X 630 424 P X 631 452 PMA 632 341 SE X X 633 341 P X 634 455 P X 635 177 P 636 392 P X ucc 003112 farfuitMal B I O T E 5 T 2aivuttv\iM, Sue. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-III 637 405 P continued 638 412 P '^1 c X X 640 -t59 P *\ 641 359 SE 642 208 PMA 643 293 P X 644 498 S X 645 340 P X 646 373 P 647 258 P 648 314 P 649 402 SE 650 318 PMA 651 372 SE X 652 386 P X 653 281 P 654 452 P 655 343 SE 656 428 *D X 657 148 P 658 427 PMA 659 453 P X 660 92 P 661 299 P X 662 339 P X 663 361 S X 664 373 SE 665 274 P 666 382 P X 667 383 SE X 668 361 S X 669 377 P X 670 366 P X 671 383 SE X 672 310 SE X Kidney X X Brain Brain * X Brain ucc 003113 StteLuiMaL B I O - T E S T daivtaLmom. Hue, 30 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-III 673 321 P X continued 674 335 PMA 675 552 5E 676 342 P X 677 297 SE 678 304 P 679 428 P X 680 273 PMA 681 314 P X 682 296 SE 683 338 P 684 359 P X 685 374 P X 686 360 P X 687 498 S X 688 443 P X 689 308 P X 690 393 PMA 691 413 P X 692 408 P 693 157 PMA 694 361 S X 695 455 P X 696 311 P 697 364 P X 698 383 P X 699 332 P 700 143 y X ucc 003114 UnduiiuaL BIO-TEST f/*L**t**imi 31 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Untreated 101 Control 102 1 (V3 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 Days on Mortality TestData Liver Spleen Lung 661 SE A 713 p 649 P A 360 S X A A 513 PMA 704 P A A A 573 P 673 P 386 SE A A A 619 p A 575 P A A A 563 PMA A 313 P 557 P A A A A A 492 PMA A Skin Misc. X X X X X X X X X ucc 003115 3*uL*tfMal B10 T E S T 2aJ&utitvui, 3m 32 TABLE XI continued -- TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Untreated 13? Control 138 continued 13? 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 Days on Test 504 463 612 619 718 452 360 113 715 71 704 656 596 652 360 357 691 616 499 544 129 607 296 698 272 Mortality Data Liver Spleen Luna A P A P A A P P A P A S A P P A P P P P A SE S P PMA P P P A PMA PMA P P PMA A .1 X Skin X X X X X X X X X Misc. ucc 003116 9h<(mfatal B I O T E S T JalavdanioA, 9hg. 33 TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Untreated 173 Control 174 continued 17? 17o 177 178 179 180 181 182 183 184 169 611 361 640 660 665 185 616 186 669 187 188 614 189 631 190 199 191 192 241 193 461 194 596 195 196 197 495 198 699 1*99 531 200 361 Mortality Data Liver Spleen Luna P A O A P SX P A PX A A SE P P A P P PMA A PMA PMA SE A A SE P P S X Skin X X X X X X X Misc. Adrenal gland Adrenal gland ' Adrenal gland UCC 0031 n 9neUuiunl B I O - T E S T Jfi&nNttonitt, jUc. 34 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. 301 460 P 302 652 SE X Adrenal gland 303 361 S :: 304 604 P X 305 569 P X 306 174 PMA 307 479 PMA 308 238 P X 309 651 P X XX 310 512 P X 311 555 P X 312 595 P X X 313 404 P X 314 516 P X 315 A 316 283 P 317 630 P X 318 247 P 319 41 PMA 320 388 P X 321 460 P X X 322 A 323 641 P X X 324 691 PMA X 325 522 P X 326 718 SE X 327 616 P X 328 451 P X X 329 614 P X X 330 413 P X 331 661 SE 332 617 P 333 621 P X 5 ucc x 003118 X 334 577 P X X 335 656 SE X Adrenal gland  SudminiaL B1 0 T E S T 3mc. 35 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mi ce and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number T-I 336 continued 337 223 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 Days on Test 524 1^*7 1i t 607 632 180 214 588 760 573 180 116 427 361 466 597 300 540 449 449 531 49 51 547 493 333 454 476 523 428 361 521 277 437 Mortality Data Liver Spleen Luna Skin P A p P P PMA P P PMA P PMA PMA P S P P A P A P PMA P O PMA PMA PMA P A PMA PMA P P P S PMA P P 7" X X X X X X X X *- X X X X X X X XX X X X X X Misc. Kidney ucc 00311Q "" HndMihial B I O T E S T Ja&vtatvtfM, Due. 36 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-I 373 continued 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 84 ' t) 542 642 381 198 494 419 361 656 513 519 337 356 654 400 283 584 127 556 387 576 593 346 361 703 532 591 Mortality Data Liver Spleen Lung PX p P SE P PMA P PMA S SE P P P PMA P PMA P PMA PMA PMA PMA P P PMA S P P P V X X X X X X X X Skin V X X X X X X X X X X X X Misc. Kidney Uterus Adrenal gla: HtvLubUal B I O - T E S T lahawievuti, % 37 TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 501 473 PMA 502 341 P X T*73 -t 71 ? 504 483 P 505 384 P X X 506 360 P X 507 438 P 508 433 PMA 509 327 PMA 510 395 PMA 511 626 SE X 512 348 P X 513 295 PMA 514 624 P X 515 377 P 516 377 P X 517 515 P 518 208 P 519 356 P 520 360 SE X X 521 143 P 522 626 S 523 480 P X 524 361 S X 525 466 PMA 526 392 P X 527 364 P X 528 471 PMA 529 515 PMA 530 420 P X 531 488 P 532 414 P X 533 389 P X 534 437 P X 535 238 PMA 536 509 P X 537 508 P X * X X XX X X X X X X X XX X Misc. Kidney 'iasenterv- ucc 0031 SmiuAtnial B I O T E S T $nc. 38 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats > Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-II 538 continued 539 5*0 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 377 316 !>5^ 341 281 306 356 487 428 373 396 303 361 336 335 427 500 461 399 626 496 393 321 314 222 314 452 402 626 366 429 361 443 417 363 416 Mortality Data Liver Soleen Lung PMA PMA PMA P P P P P P P P P S PMA P P P PMA P S PMA P P P P P P P S P P s P p p p X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. X Pancreas Thymus X X Kidney X X Adrenal gland X ucc 003122 Sttdu,itainl B I O * T E S T Ja&otatarttA. 9tie. 39 TABLE XI continued ___ TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Luna Skin T-II 574 continued 575 J* ' o 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 276 325 379 345 468 234 262 395 411 309 505 306 429 420 419 402 311 311 388 387 361 357 429 417 454 361 335 P P PMA P P PMA P P P P P P P P P PMA P PMA PMA S PMA P PMA .P S PMA X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Lymph nodes ucc 003123 PrtdttibtiaL B I O - T E 5 T 2akvs<%tc*<*4, }nc* 40 TABLE XI continued TEST- MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. t-iii 701 702 703 UT 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 728 729 730 731 732 733 734 735 736 366 262 185 373 443 373 346 375 306 240 333 303 261 405 312 353 361 383 405 224 211 317 374 296 438 321 303 361 381 443 319 361 334 82 361 316 P P c r.virt P P P PMA SE P P PMA P P P P S P P P P SE P P P P P S P P PMA S SE PMA S PMA X X X X X X X X X X X X X X X X X X X X X X X X Thymus X Salivary gland X ucc 003124 UnduA&uaL 3 I O T E S T $nc. 41 TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-III 737 378 PMA continued 738 295 P X 7w 4> / D V 740 362 SE X 741 311 P 742 361 S X 743 325 PMA 744 367 P X 745 351 PMA 746 368 SE X 747 235 P X 748 347 P X 749 379 P X 750 336 P X 751 82 PMA 752 82 PMA 753 377 P X 754 371 P X 755 277 P X 756 348 P X 757 374 P X 758 383 PMA 759 82 PMA 760 320 P X 761 354 SE X 762 256 P X 763 365 P X 764 290 P X 765 322 P 766 311 SE 767 326 SE X 768 311 P X 769 113 PMA 770 268 P X 771 286 P X 772 330 P X X X X Pancreas X X Thymus X X X Kidney - 3*uL*it?ual B I O * T E S T JahwtftvUii, 3*c. 42 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-III 773 314 P X continued 774 343 P ""S Z19 p 776 2 S 4 o X y X 777 365 p X 778 299 c ' 779 325 PMA 780 353 SE X 781 389 P X 782 322 P 783 303 SE X . 784 372 PMA 785 283 P X 786 113 PMA 787 113 PMA 788 113 PMA 789 324 P X 790 113 PMA 791 401 P X 792 339 P X 793 274 P X 794 271 P X 795 113 PMA 796 78 ESC 797 78 ESC 798 348 P X 799 78 ESC 800 78 ESC XX X Misc. Salivary glan Cervical lymj nodes Kidney ucc 003126 9rt*L*tf/uai BIO*TEST JaJnvutiyU*d, 2tta. 43 TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-IV 2401 2402 2404 2405 2406 2407 2408 2409 2410 2411 2412 2413 2414 2415 2416 2417 2418 2419 2420 2421 2422 2423 2424 2425 2426 2427 2428 2429 2430 2431 2432 2433 2434 2435 2436 379 35 511 345 411 405 310 398 434 268 473 349 434 496 261 498 346 351 352 398 498 342 379 434 498 489 457 366 382 297 372 429 311 264 342 484 P PMA PM A ? P P PMA P P P P P SE P PMA S P P P P S PMA PMA P S P P P P P PMA P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Mesentary X X X X X X X ucc 003127 X Pancreas Undndt/iial B I O T E S T Jnc, 44 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-IV 2437 continued 2438 385 306 Mortality Data Liver Soleen Lung PX SE Skin 2439 265 P X 2440 394 PMA 2441 306 P 2442 2443 381 473 P P X X 2444 352 P X 2445 385 PMA 2446 385 P 2447 2448 2449 340 325 370 P P P X XX X 2450 426 PMA X 2451 426 P X 2452 2453 365 331 PMA PMA 2454 423 P X 2455 220 PMA 2456 330 PMA 2457 392 P X X 2458 375 P X 2459 2460 387 365 P PMA X X 2461 498 S X X 2462 326 SE X X 2463 375 P X 2464 318 PMA 2465 411 P X X 2466 356 P X X 2467 2468 365 432 PMA D 2469 2470 424 361 P P X X X 2471 383 PMA 2472 414 P X Misc. Cervical lymph nones Lymph nodes ucc 003128 Sttdtidi/uaL B I O - T E S T Hhc. 45 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-IV 2473 continued 2474 2476 2477 2478 2479 2480 2481 2482 2483 2484 2485 2486 2487 2483 2489 2490 2491 2492 2493 2494 2495 2496 2497 2498 2499 2500 447 431 ,,2. 448 469 368 407 417 323 398 316 314 250 348 476 440 344 403 390 379 415 498 355 368 356 285 422 432 Mortality Data Liver Spleen Luna PX X PX * . fc pX PX PMA PMA PX PMA P P XX PMA SE P PX PX PMA PX PMA PMA PMA S PX PMA PMA SE P PX Skin X X X X X X Misc. Pancraac Mssen:ei-v Ovary Kidney Maser.tery ucc 003129 D^dui^ual B I O - T E S T ^alonatvuM, Hue. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc, Untreated Control 801 802 0o 804 805 806 807 808 809 810 811 812 813 814 815 816 817 818 819 320 821 822 323 824 825 826 827 328 829 830 831 832 833 834 835 560 429 z in L74 428 371 301 429 502 329 452 204 428 197 190 388 505 148 305 474 568 187 94 568 134 418 122 134 321 340 200 570 462 401 94 PMA PMA PMA PMA PMA PMA P P P P P PMA PMA PMA P P PMA PMA P PMA P P P P PMA PMA PMA PMA P PMA PMA PMA p P P ucc 003130 DtuLtAiniaL B I O T E S T 2a6o*atvuM, Jhc. 47 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated Control - - -- - ^J 836 837 s-'j 839 840 841 842 843 844 843 846 847 848 849 850 851 852 853 854 855 856 857 858 859 860 861 862 863 364 865 866 867 868 869 370 116 178 5C8 416 388 279 302 213 390 451 390 575 461 271 527 497 441 161 255 255 261 174 564 148 178 178 435 496 272 376 409 564 454 351 349 PMA P < >. PMA PMA PMA PMA PMA P PMA P P PMA SE PMA P P PMA PMA PMA P PMA PMA P P PMA PMA P PMA P P PMA P SE p Kidney X UCC 003131 Snduitnial B I O T E S T Sue. 48 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated Control 871 872 372 374 875 876 877 878 879 880 881 882 883 884 885 886 887 888 889 890 891 892 893 894 895 896 897 898 399 900 176 567 276 152 466 450 371 500 411 431 423 406 380 381 459 292 376 431 275 316 530 94 409 378 262 428 354 277 424 P FMA P PMA P P PMA P P P PMA P P P P P P P PMA P P PMA P P PMA P P PMA PMA ucc 003132 9*Miiinial BIO - T E S T Hue. 49 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin T-I 1001 149 P 1002 445 P 1003 392 PMA 1004 362 P 1005 492 P X 1006 421 P 1007 130 C 1008 309 PMA 1009 498 S X 1010 332 PMA 1011 79 C 1012 79 PMA 1013 85 C 1014 85 C 1015 85 C 1016 309 P 1017 378 P 1018 136 C 1019 92 C 1020 290 p 1021 121 c 1022 437 p 1023 1024 121 498 c s X 1025 498 s X 1026 367 PMA 1027 413 P 1028 137 P 1029 332 PMA 1030 498 S 1031 115 P 1032 346 P 1033 115 P 1034 173 PMA 1035 281 P X X X X X X Misc. Prostate Mesentery Mesenteric nodes ucc 003133 UndtatniaL BIO-TEST JafaafatM, Sue. 50 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 1036 continued 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070 407 150 373 196 265 205 275 377 378 123 145 247 149 498 243 389 121 196 118 196 149 145 85 121 346 165 271 121 104 498 121 332 286 434 121 P PMA P P P PMA PMA P P PMA PMA P P S PMA P P P PMA P P PMA C C P PMA PMA C PMA S P P P P C X X Mesenteric nodes X X X X X. X ucc 003134 UnduditiaL B I O - T E S T 2aio*aioMmt, Dttc. 51 TABLE XII continued ---- TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-I 1071 continued 1072 1073 1074 1075 1076 1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 446 316 294 377 386 386 401 311 319 437 406 362 448 498 432 406 407 407 275 410 267 332 380 293 369 432 386 353 446 365 Mortality Data Liver Spleen Luna P PMA PMA PMA P P P P P P P P PMA S P PMA P P P PMA P P P PMA P P P P P P X X X X X X X X X X X X X X X Skin Misc. Mesenteric nc Kidney Kidney - ucc 003135 Jtulu&isual B I O T E S T JabonahMM. Snc. 52 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Number Days on Test Mortality Data Liver Spleen Lung Skin 1201 1202 1203 1204 1205 1206 1207 1208 1209 1210 1211 1212 1213 1214 1215 1216 1217 1218 1219 1220 1221 1222 1223 1224 1225 1226 1227 1228 1229 1230 1231 1232 1233 1234 1235 320 277 324 225 274 296 254 291 275 309 286 331 351 331 322 359 293 318 272 291 226 285 291 225 269 374 299 295 284 310 276 311 290 297 308 P r P P P P P P P P SE P SE PMA P P SE P PMA P P P P P P PMA PMA P P P SE P P P X V A X X X X X X X X X X X X X X X X X X X X X X X X X X X X V X X X X X X X X X X X X X X X X X X' Misc. Mesentery Mesenteric node Kidney Lymph nodes ucc 003136 $Hdudt*lal BI O - T E S T JoionatvUl, Sue. 53 TABLE XII continued * TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-II 1236 continued 1237 1238 1239 1240 1241 1242 1243 1244 1245 1246 1247 1248 1249 1250 1251 1252 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1267 1268 1269 1270 348 340 317 268 292 143 368 303 302 310 389 268 288 300 340 290 258 258 271 282 264 401 292 303 304 287 313 383 244 299 276 249 180 302 303 Mortality Data Liver Spleen Lung P P P P P P P P P P P P PMA PMA P P P PMA P P P P P P PMA P P P P PMA P PMA P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X * X X Skin Misc. Kidney Mesenteric nodes ucc 003137 StvimifUal BIO-TEST JaionotaMU, *}t 54 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-II 1271 continued 1272 1273 1274 1275 . 1276 1277 1278 1279 1280 1281 1282 1283 1284 1285 1286 1287 1288 1289 1290 1291 1292 1293 1294 1295 1296 1297 1298 1299 1300 283 258 339 324 317 218 261 273 288 288 265 289 289 286 145 277 248 284 197 305 91 91 255 306 253 214 298 234 294 294 Mortality Data Liver Spleen Lung P PMA P P P P P PMA P PMA PMA P P P PMA P P P P P ESC ESC P P P SE PMA P PMA P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin X Misc. Lymph nodes Kidney Salivary glanc ucc 003138 UmLutteal B I O - T E S T 55 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number T-m 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410 1411 1412 1413 1414 1415 1416 1417 1418 1419 1420 1421 1422 1423 1424 1425 1426 1427 1428 1429 1430 1431 1432 1433 1434 1435 Days on Test 143 248 276 264 169 93 219 130 208 306 304 312 277 312 221 273 248 280 255 239 237 274 288 220 245 234 274 236 282 127 290 211 291 235 254 Mortality Data Liver Spleen Luna PMA P P P P C SE PMA P P P S PMA S PMA P SE P P P P P P P P P P P P PMA P P P P SE X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X Skin Misc. Mesentery ucc 003139 DttAtuUial BIO - T E S T JaboNiiMin, Dmc. 57 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Luna Skin Misc. T-IH 1471 continued 1472 1473 1474 1475 1476 1477 1478 1479 1480 1481 1482 1483 1484 1485 1486 1487 1488 1489 1490 1491 1492 1493 1494 1495 1496 1497 1498 1499 1500 243 240 241 263 260 302 265 198 226 250 260 287 283 231 224 312 266 276 236 229 148 230 306 194 241 312 325 262 221 224 PMA P P P PMA PMA PMA PMA PMA P PMA PMA P PMA PMA S PMA P PMA P PMA PMA PMA P PMA S PMA P P PMA X X X X X X X X X X X X X X X X X Mesentery Cervix X X X X XX - UCC 003140 Jnduit^ial BIO-TEST Hnc. 58 TABLE XII continued ----- TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. Untreated Conn-ol 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 428 308 345 266 266 390 522 511 511 641 564 616 435 313 564 405 664 325 508 392 571 364 202 579 702 647 511 665 547 669 367 392 511 PMA P P P P PMA P P PMA PMA A PMA P PMA PMA PMA PMA PMA PMA PMA P P PMA PMA PMA PMA PMA P P PMA P SE PMA A PMA IJCC 003141 $nAuit/ual B I O T E S T JaivtaioMM, One. 59 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. Untreated ConProl continued 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 99 209 427 271 582 326 492 511 374 572 511 666 579 709 321 471 440 423 579 551 432 209 371 315 486 672 578 714 450 574 322 575 P PMA D P PMA P P PMA P PMA PMA P PMA A. PMA PMA A P SE A P PMA PMA P PMA P P PMA PMA P PMA P P PMA P Uterus ucc x 003142 $nduit/ual B ( O - T E S T JaioMafou**, 3h&. 60 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. Untreated 971 Conorol 972 continued 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 569 449 500 508 526 408 416 526 300 572 405 374 434 500 579 372 667 504 573 452 522 429 94 547 598 666 662 577 439 467 P P PMA P PMA PMA PMA PMA P PMA PMA P PMA PMA P PMA PMA P PMA P PMA P P P PMA P PMA PMA PMA P X ucc 003U3 StuLainial B I O T E S T JaivtafotM. Umo. 61 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-I 1101 271 1102 435 1103 375 1104 307 1105 338 1106 329 1107 380 1108 359 1109 316 1110 192 1111 354 1112 498 1113 414 1114 368 1115 377 1116 402 1117 264 1118 262 1119 196 1120 374 1121 343 1122 423 1123 323 1124 333 1125 396 1126 249 1127 349 1128 354 1129 462 1130 308 1131 416 1132 329 1133 360 1134 85 1135 382 Mortality Data Liver Spleen Lung PMA P P P SE PMA P P P P P S P P P P PMA SE P P P P P P PMA PMA P P P PMA PMA P P C P X X X X X X X X X X X X X X X X X X X Skin X X X X X X X X X X X X X X X X X X Misc. Mesemery Kidney Kidney Mesenteric nodes Kidney Kidney Uterus Kidney UCC 003144 Httdutfaal B t O T E S T 2a&o*ato\i*t, 62 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number T-I 1136 continued 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 Days on Test 325 246 187 232 353 340 444 351 236 370 309 398 450 356 429 380 54 388 353 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 388 260 388 382 294 309 416 416 253 320 347 373 283 380 449 55 Mortality Data Liver P PMA P PMA P SE P P P P P P PMA P P P C P P X X X X X X X Spleen X Lung X X X X X PMA SE P P P P PMA PMA P P PMA P P P PMA C X X X X X X Skin X X X X X X X X X X X Mis c. Mesenteric nodes Mesenteric nodes Mesentery Mesentery Mesentery Mesenteric nodes Kidney Kidney Stomach Mesenteric nodes ucc 003145 HttduiUiaL B I O - T E S T 2dMit<yuM, 9mo. 63 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-I 1171 continued 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 55 304 416 355 319 218 428 341 320 341 290 342 295 397 373 284 295 355 343 339 261 305 308 309 247 323 416 123 498 202 Mortality Data Liver Spleen Lung C SE PMA P P PMA P P P P P P P P P PMA P PMA PMA P PMA PMA P P P P PMA PMA S P X X X X X X X X X X X X X X X X Skin X X X X X X X X X X X X Misc. Ovary Uterus Kidney Kidney Kidney, Cervix Uterus Mesenteric nodes Kidney ucc 003146 3*du4t/iiaL B I O - T E S T aJ*>\aioMM, Jnc. 64 TABLE Xll continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Group Animal Number Days on Test 1301 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1312 1313 1314 1315 1316 1317 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331 1332 1333 1334 1335 95 259 258 240 290 226 228 296 190 265 231 327 373 214 270 257 278 270 255 333 236 237 316 278 275 277 230 250 218 276 299 222 258 278 278 Mortality Data Liver Spleen Lung P P P P P P P P P P P PMA P PMA PMA P P P P P P P P P P P PMA P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X - X X Skin X X X X X Misc. Lymph nodes Mesenteric nodes ucc 003147 UnduAttUaL BIO-TEST 2a&o*ato*iu, 9c. 65 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 1336 continued 1337 1333 1339 1340 1341 1342 1343 1344 1345 1346 1347 1348 1349 1350 1351 1352 1353 1354 1355 1356 1357 1358 1359 1360 1361 1362 1363 1364 1365 1366 1367 1368 1369 1370 227 214 230 305 275 206 285 179 270 220 275 177 298 261 208 216 315 274 252 271 307 224 241 278 264 245 259 430 244 310 269 335 287 258 276 PMA PMA P PMA P P P PMA P P P P P P P P P P P P P P P P P PMA P P P P P P P P P *VV X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X XX X X XX X XX X XX ucc 003148 !)ndu4&ual B I 0 - T E S T Jg&toato'uad, Sue. 66 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 1371 continued 1372 1373 1374 1375 1376 1377 1378 1379 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 1390 1391 1392 1393 1394 1395 1396 1397 1398 1399 1400 293 316 250 322 322 262 316 234 256 369 278 205 232 275 176 217 340 273 295 251 256 183 272 297 329 498 277 498 212 448 P P ? PMA PMA P P P P P P P P P PMA P P P P PMA P P P P PMA S P S P PMA X X X X X X X X X X X X X X X X X X X X X X X X XX X Kidney X X X X Kidney X X X X XX ucc 003149 JntLaiMal B I O - T E S T One. 67 TABLE XU continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-UI 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 1522 1523 1524 1525 1526 1527 1528 1529 1530 1531 1532 1533 1534 1535 205 225 258 221 206 157 294 229 220 258 272 215 284 283 295 256 302 293 312 263 275 312 222 277 312 312 256 252 265 276 195 179 228 222 210 Mortality Data Liver Spleen Luna P P P P P PMA P SE P P PMA P P P P SE PMA PMA S P P S P P S S SE P P P P P P SE P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin X X X X X X X Misc. Mesentery ucc 003150 ^MtLtdiUal B I O T E S T JaUtaittM, 9*c. 68 TABLE XII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Luna Skin T-IH 1536 continued 1537 1538 1539 1540 1541 1542 1543 1544 1545 1546 1547 1548 1549 1550 1551 1552 1553 1554 1555 1556 1557 1558 1559 1560 1561 1562 1563 1564 276 263 178 227 232 247 253 208 208 312 208 276 263 276 260 282 295 269 267 224 254 278 273 261 275 294 180 235 298 P PMA P P P P P SE S s p p p p PMA PMA P P PMA P SE P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX XX X XX X X X X X X XX 1565 1566 1567 1568 1569 1570 206 240 220 309 191 312 P PMA P P P S X X X X X "X X XX X Misc. Mesentery Ovary Kidney HOC 0031 Ureter Mesentery Ovary 3ttdmfaai BIO - T E S T 2a&a*at*i<u, Sac. 69 TABLE XU continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-III 1571 continued 1572 1573 1574 1575 1576 1577 1578 1579 1580 1581 1582 1583 1584 1585 1586 1587 1588 1589 1590 1591 1592 1593 1594 1595 1596 1597 265 257 255 194 221 243 212 250 269 273 259 290 272 299 295 239 239 197 264 248 226 113 202 240 236 118 240 1598 1599 1600 190 268 264 Mormlity Data Liver Spleen Lung P P SE P P P SE SE P PMA PMA P P P. PMA PMA P P PMA P P PMA P P PMA PMA P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X PX SE X X P XX X Skin X X X X Misc. Salivary glands UCC 003152 Jttdiuhial BI O - T E S T laionatviii*, Hmc. 70 TABLE XHI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Cross Tumor Observations in Male Hamsters Animal Group Number Days on Test Untreated 1601 Control 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 1613 1614 1615 1616 1617 1618 1619 1620 1621 1622 1623 1624 1625 1626 1627 1628 1629 1630 1631 1632 1633 1634 1635 447 591 591 452 529 492 596 565 591 64 8 697 46 649 536 698 107 107 44 186 151 83 51 96 54 Mortality Data Liver Spleen Luna A PMA P P P PMA P SE P A P A A PMA A A C P C A A P P A P A PMA PMA PMA PMA PMA PMA C PMA C Skin Misc. ucc 003153 juduilnMil BIO-TEST 9hc. 71 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Untreated 1636 Control 1637 continued 1638 1639 1640 1641 1642 1643 1644 1645 1646 1647 1648 1649 1650 1651 1652 1653 1654 1655 1656 1657 1658 1659 1660 1661 1662 1663 1664 1665 1666 1667 1668 1669 1670 Days on Mortality TestData Liver Spleen Lung 99 PMA 99 PMA 136 PMA 207 PMA 199 PMA 199 PMA 40 PMA 66 PMA 123 PMA 123 PMA 88 PMA 201 PMA 177 PMA 157 PMA 541 P 363 PMA 157 PMA A 395 P 61 PMA 2C 169 P 688 P 2c 14 PMA A 524 P 591 P 55 PMA 14 C 363 P 11 C 576 P 519 PMA 708 P Skin Misc. ucc 003154 HnJj4ii\ial B I O T E S T JaionaiMiti, Sue. 72 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1671 Control 1672 continued 1673 1674 1675 1676 1677 1678 1679 1680 1681 1682 1683 1684 1685 1686 1687 1688 1689 1690 1691 1692 1693 1694 1695 1696 1697 1698 1699 1700 695 243 701 686 479 593 436 575 325 511 651 246 108 108 529 430 530 467 319 503 121 303 P P A A A P P PMA P P A P A A PMA P P PMA PMA PMA P P A P P PMA P P A PMA ucc 003155 HmJMihial B I O - T E S T JaktaioM*, Sue. 73 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin 1801 1802 1803 1804 1805 1806 1807 1808 1809 1810 1811 1812 1813 1814 1815 1816 1817 1818 1819 1820 1821 1822 1823 1824 1825 1826 1827 1828 1829 1830 1831 1832 1833 1834 1835 1836 666 61 59 35 44 382 371 589 100 100 533 575 622 631 137 191 148 100 65 164 111 175 607 523 51 375 649 607 377 108 108 108 108 A A P C c p PMA P P P PMA PMA P P P P PMA PMA PMA PMA PMA PMA PMA PMA P PMA C PMA P A P PMA PMA PMA PMA PMA X X. X X X - Misc Kidney Lymph nodes Kidney Kidney Kidney ucc 003156 SttdMi&tial BIO T E S T Smc. 74 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-I 1837 continued 1838 1839 1840 1841 1842 1843 1844 1845 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1868 1869 1870 1871 1872 614 108 4 696 386 14 64 420 373 635 47 47 47 572 574 531 72 248 77 94 109 141 196 101 632 206 206 206 206 312 570 202 55 P PMA A C A PMA P C PMA PMA PMA P PMA PMA C P P P C PMA PMA PMA PMA PMA P PMA S PMA PMA PMA PMA P PMA A PMA PMA X X X X X Misc. Kidney ucc 003157 DndM&tMal B I -TEST 2aJ>o*ai&\iM, 9mg. 75 TABLE XIll continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-I 1873 64 PMA continued 1874 24 C 1875 485 P X 1876 29 C 1877 460 P XX 1878 684 P 1879 A 1880 684 P 1881 A 1882 711 P X 1883 611 P X 1884 A 1885 A 1886 279 P 1887 555 P 1888 597 P X 1889 616 P X 1890 A 1891 45 C 1892 45 C 1893 576 P 1894 587 P 1895 310 SE 1896 A 1897 289 PMA 1898 A 1899 1900 347 PMA A Misc Kidney Kidney ucc 003158 9nAuAhUal B I O T E S T % 76 TABLE XIII continued ___ TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 2034 2035 2036 107 36 298 201 101 162 86 95 113 48 24 6 109 48 424 632 100 203 40 186 129 83 61 111 100 100 100 100 100 594 100 100 632 632 590 589 PMA PMA PMA P PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA S PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA S S P P Misc. ucc 003159 DwLuAbual BIO T E S T /*a-- 77 TABLE XIH continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-U 2037 continued 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 2052 2053 2054 2055 2056 2057 2058 2059 2060 2061 2062 2063 2064 2065 2066 2067 2068 2069 2070 2071 2072 632 90 370 238 208 225 107 64 238 85 288 486 46 249 415 561 532 632 244 576 588 9 10 41 33 9 12 221 221 7 10 632 171 391 108 108 S C P P PMA PX PMA PMA P C PMA P C P PX P P S P P P c PMA PMA PMA C PMA PMA PMA C C S P P XXX PMA PMA Misc \lss t Kidney ucc 003160 Undtuhial B I O T E $ T Ja&oaafoiiei, One. 78 TABLE Xlll continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rata. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 2073 continued 2074 2075 2076 2077 2078 2079 2080 2081 2082 2083 2084 2085 2086 2087 2088 2089 2090 2091 2092 2093 2094 2095 2096 2097 2098 2099 2100 632 469 44 632 7 632 101 101 127 632 93 632 107 100 44 158 44 590 582 632 632 9 388 32 528 535 632 99 C PMA PMA PMA P S C S PMA PMA PMA PMA PMA P P S s c p c P p s p XX XX XX x X XX X Misc. Kidney UCC 003161 !}t*duii/Uai BIO-TEST Utte. 79 TABLE XIU continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-III 2201 2202 2203 2204 2205 2206 2207 2208 2209 2210 2211 2212 2213 2214 2215 2216 2217 2218 2219 2220 2221 2222 2223 2224 2225 2226 2227 2228 2229 2230 2231 2232 2233 2234 2235 348 54 405 192 219 434 231 101 206 417 350 108 367 422 582 179 552 422 219 196 386 346 346 346 496 365 100 305 330 441 377 189 422 340 16 P C P PMA P P PMA P PMA P P PMA PMA P P P P PMA PMA P PMA P PMA PMA P SE P PMA P P P P P P C X X X X X X X X X X X X X X XX X X X - Misc. Pancreas Thymus IJCC 003162 iai B I O - T E S T !aUnat<yiiu, Jke, 80 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test T-UI 2236 continued 2237 2238 2239 2240 2241 2242 2243 2244 224S 2246 2247 2248 2249 2250 2251 2252 2253 2254 2255 2256 2257 2258 2259 2260 2261 2262 2263 2264 2265 2266 2267 2268 2269 2270 339 591 529 478 270 517 590 591 100 477 484 139 404 147 373 46 137 149 278 295 361 395 547 591 591 508 46 408 474 270 373 372 39 176 351 Mortality Data Liver Spleen Lung P S P PMA PMA P P PMA PMA P P PMA P PMA P C P P P P PMA P PMA S S SE C P PMA PMA P PMA C PMA P X X X X X X X X X X X X X X X X X X X * Skin Misc. Kidney ucc 003163 Sniutthial BIO-TEST Ja&tnnfaM, Une. 81 TABLE XXII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Skin T-IH 2271 continued 2272 2273 2274 2275 2276 2277 2278 2279 2280 2281 2282 2283 2284 2285 2286 2287 2288 2289 2290 2291 2292 2293 2294 2295 2296 2297 2298 2299 2300 324 54 338 411 591 569 323 155 85 85 85 64 85 64 385 286 26 360 330 448 438 438 326 359 591 211 285 38 155 99 P C P P s PMA SE PMA ESC ESC ESC ESC ESC ESC P P C P PMA P PMA P PMA PMA S PMA PMA C PMA PMA X X X X X X Misc. Kidney Mesentery ucc 003164 Jn<Lui^iaL B I O - T E S T 2aio*abrtal, Hue. 82 TABLE XIII continued -- TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1701 Control 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 1724 1725 1726 1727 1728 1729 1730 1731 1732 1733 1734 1735 632 632 23 43 414 426 559 108 95 137 95 7 7 68 104 116 137 505 591 629 495 130 589 404 91 131 128 410 127 127 454 23 70 104 271 S S PMA P P P PMA PMA PMA PMA C PMA PMA PMA P PMA P P P P PMA P P PMA PMA PMA PMA PMA PMA P PMA C PMA PMA X Kidney UCC 003165 fadttitnial BI O - T E S T JaAtHnttHfri, Httc. 83 TABLE Xlll continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1736 Control 1737 continued 1738 1739 1740 1741 1742 1743 1744 1745 1746 1747 1748 1749 1750 1751 1752 1753 1754 1755 1756 1757 1758 1759 1760 1761 1762 1763 1764 1765 1766 1767 1768 1769 1770 1771 1772 411 103 411 97 611 168 351 79 415 52 54 592 530 118 186 65 30 233 53 194 373 59 595 208 147 147 89 307 53 582 541 567 575 47 367 116 116 PMA PMA PMA PMA P PMA PMA C P C c P P PMA P PMA c PMA c PMA PMA PMA P PMA PMA PMA PMA PMA C PMA P P P C PMA PMA PMA X X Ovary ucc 003166 3wtMifaial BIO-TEST JaionaivttM, One. 84 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Untreated 1773 Control 1774 continued 1775 1776 1777 1778 1779 1780 1781 1782 1783 1784 1785 1786 1787 1788 1789 1790 1791 1792 1793 1794 1795 1796 1797 1798 1799 1800 193 198 249 267 283 114 190 362 340 314 38 200 587 27 341 43 571 464 193 435 14 400 542 536 506 539 547 531 P P P PMA PMA PMA PMA PMA PMA PMA C P P PMA PMA C P P PMA P C PMA P P P P P PMA X ,X Misc. UCC 003167 3*<hutMal B I O T E $ T 2aie*at*MU, 3tie. 85 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-I 1901 104 PMA 1902 187 PMA 1903 188 PMA 1904 141 PMA 1905 394 PMA 1906 153 PMA 1907 200 PMA 1908 57 PMA 1909 84 PMA 1910 200 P 1911 113 PMA 1912 201 P 1913 108 PMA 1914 120 PMA 1915 131 PMA 1916 164 PMA 1917 580 P 1918 49 PMA 1919 49 PMA 1920 131 PMA 1921 106 PMA 1922 311 P 1923 119 PMA 1924 119 PMA 1925 119 PMA 1926 133 PMA 1927 61 PMA 1928 52 PMA 1929 127 PMA 1930 572 P 1931 578 P 1932 94 PMA 1933 81 PMA 1934 74 PMA 1935 126 PMA 1936 191 PMA X Misc. Kidney UCC 003168 Jndtut/Uai B I O T E S T Ja&ottUtvUat, Dmc. 86 TABLE X1U continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-I 1937 continued 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 191 180 185 6o 473 553 417 54 493 435 451 608 47 53 83 467 476 313 47 51 59 578 632 544 632 40 56 86 174 33 31 107 178 592 397 411 Mortality Data Liver Spleen Luna PMA PMA PMA PMA P P PMA C P P P P c c PMA P PMA PMA C PMA C P S P S ESC PMA C PMA C C PMA PMA P PMA P X X X X X X - Skin Misc. Ovaries ucc 003169 9t*dttiUial BIO-TEST JabcHinttMii, % 87 TABLE XU1 continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-I 1973 continued 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 524 14 467 31 371 487 86 577 581 494 424 542 94 128 207 193 65 389 55 488 493 24 191 632 33 144 603 88 P C P C P P PMA P P P P P PMA PMA PMA PMA PMA PMA C P P C P S PMA PMA P ESC X X Misc. Ovaries Ovaries ucc 003170 BIO-TEST Jaiotatvuui. 9*c, 88 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. 2101 2102 2103 2104 2105 2106 2107 2108 2109 2110 2111 2112 2113 2114 2115 2116 2117 2118 2119 2120 2121 2122 2123 2124 2125 2126 2127 2128 2129 2130 2131 2132 2133 2134 2135 2136 602 9 486 545 476 553 451 392 514 578 570 336 52 476 632 529 52 632 87 60 39 509 632 39 446 221 562 576 286 513 129 495 173 208 447 413 P C P P PMA P P P P P P PMA C P S P C s c c ESC PMA S ESC P P P P P P PMA P PMA P P PMA X X X X X X X X Kidney Kidney X Mesent* X X X Cervix X ucc 003171 -- JtvLtiiteal B I 0 T E $ T Jafaa&nitt, }ne. 89 TABLE Xlll continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-II 2137 continued 2138 2139 2140 2141 2142 2143 2144 2145 2146 2147 2148 2149 2150 2151 2152 2153 2154 2155 2156 2157 29 47 359 29 39 522 68 36 36 522 104 603 46 628 426 307 632 614 207 542 632 2158 2159 2160 2161 2162 2163 2164 2165 2166 2167 2168 2169 2170 2171 2172 564 614 473 96 96 96 534 541 200 485 196 468 632 409 383 Mortality Data Liver Spleen Lung C C PMA C C P C c c p PMA P C P P PMA S P P P S X X X X X P P PMA ' PMA PMA PMA PMA P P P P P S P P X X - Skin X X X X X Misc. - Thymus Ovaries ucc 003172 JuduitMal B I O - T E S T Jao*afo**M, 2me, 90 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-H 2173 continued 2174 2175 2176 2177 2178 2179 2180 2181 2182 2183 2184 2185 2186 2187 2188 2189 2190 2191 2192 2193 2194 2195 2196 2197 2198 2199 2200 456 489 541 466 462 492 53 566 570 9 514 520 202 470 261 212 194 245 541 536 29 193 508 625 596 632 558 547 Mortality Data Liver Spleen Luna P P P PX SE X X P C P P c p XX p PMA P PMA PMA P PMA PX X P C PMA SE X PX P S XX P XX PX Skin X X X X Misc. Kidney Cervix Ovaries UCC 003173 3"Judicial B I O - T E S T 2a&\ateHi*i> 3m 91 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin______ Misc T-IH 2301 2302 2303 2304 2305 2306 230? 2308 2309 2310 2311 2312 2313 2314 2315 2316 2317 2318 2319 2320 2321 2322 2323 2324 2325 2326 2327 2328 2329 2330 2331 2332 2333 2334 2335 9 74 149 591 320 309 314 304 201 118 206 201 390 64 247 300 318 315 249 207 360 381 403 361 350 498 390 354 448 354 398 498 496 411 89 C PMA C S P PMA PMA C C PMA PMA P PMA PMA PMA PMA P PMA PMA PMA PMA PMA P P P S P P P P PMA S P PMA C X X X X X X X X X X X X ucc 0031^4 9ndiut\iaL BIO - T E S T 3* 92 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-HI 2336 continued 2337 2338 2339 2340 2341 2342 2343 2344 234S 2346 2347 2348 2349 2350 2351 2352 2353 2354 2355 2356 2357 2358 2359 2360 2361 2362 2363 2364 2365 2366 2367 2368 2369 2370 442 405 399 87 409 490 219 286 403 332 419 403 8 41 54 96 118 244 359 8 353 48 385 207 352 96 100 96 96 96 96 305 439 591 407 Mortality Data Liver Spleen Luna PX PMA PX C PX P PMA P PX PMA PMA PMA C PMA C PMA PMA PMA P XXX C SE X C PX PMA PX X PMA PMA PMA PMA PMA PMA PMA PMA PX PMA Skin Misc. - Stomach ucc 003175 J/vLutual B I O T E S T Jaiotafaiti, Drnc. 93 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-HI 2371 continued 2372 2373 2374 2375 2376 2377 2378 2379 2380 2381 2382 2383 2384 2385 2386 2387 2388 2389 2390 2391 2392 2393 2394 2395 2396 2397 2398 2399 2400 367 383 390 379 61 68 53 264 207 49 38 279 279 306 378 387 364 207 194 325 38 364 29 243 361 29 41 84 397 208 PMA PMA PMA PMA PMA PMA C PMA PMA PMA ESC PMA PMA PMA P P PMA PMA PMA P C P C P PMA C C PMA PMA PMA X X X X Misc. UCC 003^