Document XyBXL3LLBmVk334Qj1YyZ3oy

May 30, 1980 FOLLOWING LETTER SEOT TO ATTACHED LIST CF GOVERNMENT AGENCIES Dear It is the policy of the Chemical Manufacturers Association to make pub licly available all final reports of research that it administers. In keeping with that policy, the following reports are enclosed: o "Chronic Vapor Inhalation Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters," 23-month status summary report submitted to CMA by IBT September 3, 1975; o "Vinyl Chloride Pathology Report," submitted by EPA to CMA Jan uary 9, 1979; o "Pathology Report on the Brains from Mice, Hamsters, and Rats Exposed to Vinyl Chloride in IBT Study 663-03222," by Dr. William Busey of EPL, submitted to CMA May 20, 1980; and o "Review and Audit of IBT No. 663-03222, Chronic Vapor Inhalation Toxicity Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters for the Manufacturing Chemists Association," by Dr. Bob West of Bob West Associates, submitted to CMA May 20, 1980. These reports all pertain to a vinyl chloride inhalation study conducted at Industry Bio-Test Laboratories (IBT). The brain tumors described in the histopathology reports are of the same type as those reported by Dr. Maltoni in animals exposed to a similar concentration, and are thus supportive of his findings. The results of the study, however, can be described in qualitative terms only, as tissue accountability was extremely low and Dr. West's audit revealed numerous inconsistencies in the conduct of the research. CMA 004581 2- - After reviewing the reports, CMA does not believe that the IBT data warrants further investigation. There is little cause to repeat the study at this time, as similar research has been conducted elsewhere. CMA will be nego tiating for a settlement with IBT in the near future. Sincerely, CRS:dtb Geraldine V. Cox, Ph.D. Vice President and Technical Director Enclosures CMA 004582 GOVERNMENT AGENCIES Send a copy of final research reports to the following: Honorable Eula Bingham (Dear Dr. Bingham) Assistant Secretary of Labor for Occupational Safety and Health Occupational Safety and Health Administration Labor Building 200 Constitution Avenue, N. W. Washington, D. C. 20210 (202) 523-6091 Honorable Susan B. King (Dear Chairmen King) Chairman Consumer Product Safety Commission 1111 18th Street, N. W. Washington, D. C. 20207 (202) 634-7740 Honorable Douglas M. Costle (Dear Mr. Costle) Administrator United States Environmental Protection Agency 401 M Street, S. W. Washington, D. C. 204 6 0 (202) 755-2700 Honorable Anthony Robbins (M.D. - Dear Dr. Robbins) Director National Institute for Occupational Safety and Health Parklawn Building Room 805 5600 Fishers Lane Rockville, Maryland 20852 (301) 443-1530 Honorable Jere E. Goyan (Dear Commissioner Goyan) Commissioner ' Food and Drug Administration Parklawn Building 5600 Fishers Lane Rockville, Maryland 20852 (301) 443-2410 Honorable Vincent T. DeVita, Director National Cancer Institute Building 3A, Room 11A52 9000 Rockville Pike Bethesda, Maryland 20014 (301) 496-5615 Jr. (Dear Dr. DeVita) 2/80 CMA 004583