Document Xm92NyyoapqgBXwV5XZ3Ve5B

FOR DU POUT USE ONLY AR226-2889 Copies Co E. I. du Font de Nemoura and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, Newark, Delaware 19711 Study Initiated/Completed 7/15/80 - 8/8/80 Haterial-Subrnltted by ipt. Jackson Lab ACUTE ORAL TEST IN RATS Procedure; The test material, as an aqueous solution, was administered by intragastric intubation to young adult male ChR-CD rats in single doses, 1 rat per dose level. Survivors were weighed and observed over a 14-day recovery period and then sacrificed. Results: Dose (ag/kg) 25,000*** 17,000*** 11,000 2,250 670 Solution Z 62 62 62 15 15 Mortality** S-14 d. S-14 d. S-14 d. S-14 d. S-14 d. Lethal Dose > 25,000 ng/kg Clinical Signs: ng/kg. Slight weight loss for 1 day after dosing at 17,000 and 25,000 Company Sanitized. Does not contain TSCA CBI verylo3to5ici':y when administered orally in sing] ale ChR-CD* rats; ICB Lethal Dose is greater than 25,000 og/kg of body weight, the maximum feasible dose. Slight Initial weight loss at the 2 highest dose levels was the only clinical sign observed. ** S - ( ) d. " Sacrificed ( ) days after dosing. *** Administered as a divided dose, 2 portions 15 minutes apart. Report by: ff H. Lonrtie Hinckle Technician Approved by: C^.J^-f. Gerald L. Kennedy Chief, Acute Investigations Section LH:jrg Study Director: 0. L. Daahiell Uate Issued: August 13. 1980 Report No. 617-80 'Company Sanitized. Doss not contain TSCA CSS