Document Xgq7gMGpVQLEaE0vOMVMVr4B

Oetobs* 3. 1969 Dr. A. R. Olasgew Chief of Reference Standards Section Residue Chemistry Braneh Division of Pesticides food and Drue Administration Washington. P. 0. 20204 Dear Sr. Olaagovi One pound staples of our Aroolors 12)4 and 1260 are being forwarded to you and to Nr. Vincent Sedla* at the Atlanta Toxicological Branch today. Perhaps it will be of interest to asntion that in 1963 one of our oonsulting laboratories determined the oral LD50 in rats of Aroolor 1254 to be greater than 10 grass per kilogram shea administered undiluted using four groups of nixed sex anisala weighing between 200-250 grass and sdmlnlstarsd at doses of 7*94, 10.0. 12.6, and 15*8 respectively for the individual groups. The oral LP50 was calculated as 11.9 gAg with Units of 10.47 to 13.45 gAg* In the oaae of Aroolor 1260. a 50)1 solution in com oil developed data leading to a calculated LD50 of 10.0 gAg with lower and upper Halts of 8.6 and 11.6 gAg. X have enclosed summarlss of recent data we have received fros Industrial Bio-Teat Laboratories In . Chisago. Ths summarlss indioats ths 90-day intsris rssfclts of two ysar chronic feeding studies to dogs of Aroolor 1254 and 1260. A second enclosure is the ausssry showing the status of thrss gsnsrstloo rst reproduction studios on those starts Is begun in Nsy. V# slso have underway two year oral studios in rats. Vs sddsd 300 extra sniasls to this study to allow aacriflcs of sons sniasls at thrss months, six months and one year. DSW 018477 STLCOPCB4005021 Or. A* R. Olasgow October 3* 1969 Page Two A verbal report on the 90 day aaorlfloea indicate that there were no measurable effects as indicated by the usual parameters. A written interim report will be received when the micro pathology ha been completed. Z have taken the liberty of sending a copy of thi latter to you to Nr. Sedlak in the Atlanta Branch. Ve will be interested in learning of the results of your proposed toxicological testing. Sincerely. Elmer p. Vheeler Manager. Environmental Health EPVtJU c.o. Jack 0. Early Vlnoent Sedlak b.c. R. E. Keller W. R. Richard DSW 018478 STLCOPCB4005022