Document XY7b3N0dxZrdgZb044rbpw6G
f/ionsc:tO INDUSTRIAL CHEMICALS COMPANY
.**-*! .
e , Kt 11 er - South Second Street - St, Louia
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TO
October 26# 1971 /
ALLEGED DIOXINS AND BENZOFURAN5 IN P G B '$ - INPUTS TOR REPORT
MSB 10*22-71 Memo to REK/WRR
:W. R. Richard General Offices
C, w. Rooa * Res. 1 T. M. Patrick * Ras. 1 M. W. Dietrich - Res. J, P. Mieure Re*. 2
E . S. Tucker * Ret. 2
The attached report! and summary data table for furan* cover Information in hand on the above subject.
Overall, we ihould be able to meet predicted regulatory agency maximum permissible levels of chlorodibenzofurana in our PCB/FC? produotfl. Data in hand ahov; that Aroclor 1247# 1254# 1260 and MCS 1016 contain no detectable (<2 ppm)* furana (or chlorodiberuop-dioxins). Aroclor 5442 contains no detectable (<3 ppm) furans.
The above position is based on the belief that higher levels would be permitted for furnns because of lower toxicity compared to dioxins. The data shown or. the confidential attachment from a European manufacturer shows that tetrachlorodibcnzo-p-dioxin has an acute toxicity to rabbits at least 30X that for tetrachlorodifcenzofuran. Regulatory agencies# including the ERA# are currently imposing 0.1 ppm max, for tetrachlorodibenzo-p-dioxin in 2#4,$*T end hexachlorophene. Or. thif basis a 2 ppm max, level should be acceptable for furana.
If we are required to pus the detection to 0.1 ppm, we will need to synthesize furans and develop more sensitive method*. This will be costly, and difficult technically# Specially for PCI product.
Baaed on experimental work in our own laboratories and in pert at the University of Utrocht -
Xnow
1. Monsanto Aroclor 1242, 1254# 1260 and MCS 1016 contain no detectable (<2 ppm) chlorodibenzofurans (I) or chlorodifcenrop-dioxipi (II) of the tyte below. Axoclor 5442 also contains no detectable (<5 ppm) chlorodibenzofurans or chlorodibenzop-dioxina.
ci i~s
Dr. W. R. Richard .
October 24, 1471 Page two
2. Competitive products - Prodelec and Bayer chlorinated biphenyl similar in composition to Aroctcr 1260 contain detectable furans (up to 30 ppm) and no dioxins (<2 ppm). Japanese product from Shiiuki similar to Aroclor 1242 contains no detectable (<2 ppm) furans or dioxins.
3. Rll the above PCb products contain chlorinated naphthalenes at ppm level. Aroclor S442 contains either chlorinated anthracene or phenanthrene.
Po^*t Know or Limited Information Only
1. Biodegradability of furana toxicity to bacteria may be a problem for biodegradation studies.
2. Photodegradation of furans .Work by the VSDA Indicates that photodegradation of dioxins under conditions in which water Is the solvent 18 probably extremely slow in the natural environment.
3. existence of furans (or dioxins) in the environment or as biological residues * Methodology normally applied to analysis of environ mental materials will not make this detection.
Questions for Medical
1. Toxicity of other impurities -
Chlorinated naphthalenes/ anthracene and/or phenanthren found in above commercial products?
,
2, Acuta'toxicity or teratogenic effects of chlorodibanzofurans
' relative to dioxins? Availability*of published data in the
public domain for reference purposes?
i
1
3* Based on the above - the odds that 2 ppm max. for chlorodlbenxofurans will be put on our products?
1 suggest that the only immediate analytical work would be to fi up furan data for remaining PCB/PCT products with existing metho olocy. Out'of this/ we should decide what minimum monitoring is needed to Insure that our manufacturing process produces no furans In our final products. Additional analytical method development work should be done only if lower detections are needed, based on Inputs such as adverse toxicity findings from others.
R. E. Keller STS 0 3 0 6 3 ,
db
b
QC/MS ANALYSIS PATA
TOXIC COMPONENTS IN PC B /PC T PROOPCTS
IABORATORY/PROPPCTS
Vos et al
University of Utrecht
Prodelec Phenoclor DP
(Composition gImi1er to
Aroclor 1260)
Bayer Clophen A60 Lot 912434 (Composition similar to
Aroclor 1260)
Monsanto Aroclor 1260 Lot AK-3
Applied Sciences Monsanto Industrial Chemicals Prodelec Phenoclor DP6
Prodelec Phenoclor t>?6
Bayer Clophen A60, Lot 931134 Kaneclor KC-300 Shltuki, July
1970 (Composition similar to Aroclor 1242)
Monsanto Aroclor 1242 Lot AX-255 Monsanto Aroclor 1254 Lot AK-38 Monsanto AroclOr 1260 Lot AK-3 Monsanto MCS 1016 Dru B Monsanto MCS 1016 KA-708 Monsanto Aroclor 5442 lot Al-9
CnLOROOIBENZOFURAHS FOUND
<4 Cl/nol
4 Cl/nol
----rcI/moT
m (<1 ppm)
Detected (1--20 ppm) Detected(1-20 ppm)
AH
1%^
HD Detected (1-20 ppm) Detected (-5 ppm)
ND (<1 ppa)
HD (<1 ppa)
ND (<1 ppm)
HD .(<2 ppm) ND t<2 ppm) ND (<2 ppm)
ND 2 ppm)
ND (<2 ppm) HD (<2 ppm) ND (<2 PP) ND <<2 ppm) ND (<2 ppm) NO (<5 P!0
Detected Detected Detected
HD f<2 ppm)
ND (<2 ppm) ND (<2 ppm) ND (<2 ppm) ND (<2 ppm) MD (<2 ppm) ND (<5 ppm)
Detected(15-30 ppn) Detected(15-30 ppm)
Detected
HD (<2 ppm)
ND (<2 ppa) HD (<2 ppm) ND (<2 ppm) ND1 (<2 ppm) ND (<2 ppm) ND <<5 ppm)
$TR 09653
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