Document XRq3r5wN3mq7rEyDVDpmXrVQR

Monsanto t hom % cnc ONl Medical, A2SC b April 9, 197^ E**CNCt TO Dr. R. E. Kelly A2SA Attached are the abstracts of articles, obtained from a recent TOXLINE search, dealing with the subacute and chronic toxicity of the following chemicals: 1) Acrylonitrile 2) Ethylene <3^' StyrenS^ 4) Vinyl Acetate 5) Vinyl Chloride Monomer - and FVC 6 Vinylidine Chloride No articles dealing with the toxicity of vinyl bromide were recovered. All available volumes (original to 1969 listings) of the FHS-149 monograph series have also been searched for reference . to relevant articles. Information was available on: Styrene (taken from PHS-149, original volume) Kennaway, E.L., 1930, Biochem. J. 24: 497-504 - skin painting of mice resulted in no tumors Styrene (taken from PHS-149, Vol. II) Wolf, M.A., Rowe, V.K., McCollister, D.D., Hollingsworth,R.L., and Oyen, I., 1956, Arch. Industr. Health 14: 387-398. a) Rats (M&F white) - ave. cone, of 9.3 mg/L. vapor inhialeSf for (105) 7 hr.exposures - 148 d. duration No tumors; conjunctivitis & rhinitis. b) Rats (M&F white) - ave. cone, of 6.0-6.3 mg/L. vapor for (139) 7 hr. exposures - 214 d. duration results - as above, no tumors. c) Rabbits (M&F)[ll ave. cone, of 3.0 mg/I., for 0.30} 7 hr. exposures and 12J ave. cone, of 6.0-6.3 mg/L. for (264) 7 hr. exposures No tumors. 0006384 bsb d) Rhesus Monkeys (M&F)- ave. cone, of 6*0-6.3 mg/L. for (264) 7 hr. exposures - 360 d. duration No tumors. . . . cont. RSV0033636 R. 1. Kelly April 9, 1974 Rage - 2 - el Guinea pigs - ave. cone, of 9.3 mg/L. for (9) 7 nr. exposures, or 6.0-6.3 mgA. for (139) 7 hr. exposures, or 3.0 mg/L. for (130) 7 hr. exposures No tumors Conjunctivitis & rhinitis in 2 higher levels. Vinyl Chloride Polymer (taken from PHS-149,Vol. 1) Oppenheimer, B.S., E. T. Oppenhelmer and A.P. Stout. 1952# Proc. Soc. Exper. Biol, is Med. 366-369. -45 Wistar rats - VCP film administered s.c. 44 alive at I89 d. - duration of experiment - >22 month -Results - 14 sarcomas; 12 fibrosarcomas; 1 llposarcoma; 1 unclasslf. malignancy 1st tumor appeared at 189 d. A*P att. Frederick R. Johannsen 0006385 BSB RSV0033637