Document XRo0gk3ymgBEO9DkggJ1jN12K
BIBLIOGRAPHY
1. Tabershaw/Cooper Associates, Inc., "Evaluation of Mortality in B.F.Goodrich Workers", 5/17/74 (report for B.F.Goodrich Company).
2. Tabershaw/Cooper Associates, Inc., "Epidemiological Study of Vinyl Chloride Workers", 5/3/74 (report for Manufacturing Chemists Association).
3. Johnson, M. N., to Fairlie, A. M., Private Communication. 4. Wyatt, R. H. et.al., "An Epidemiologic Study of Blood Screening Tests and
Illness Histories Among Chemical Workers Involved in the Manufacture of Polyvinyl Chloride", Department of Community Medicine, College of Medicine, University of Kentucky, Louisville, Kentucky, May, 1974. 5. Dutka, A. F., to Strassburg, R. W., "Correlation of Blood Test Results to Vinyl Chloride", B.F.Goodrich Chemical Company Correspondence, 6/21/74. 6. Wilcox, W. J., "Health Records Study", B.F.Goodrich Chemical Company Correspondence, 6/24/74. 7. Wilcox, W. J., "Health Records Study", B.F.Goodrich Chemical Company Correspondence, 6/27/74. 8. Wilcox, W. J., "Health Records Study", B.F.Goodrich Chemical Company Correspondence, 5/9/74. 9. Bowles, R. L., Fairlie, A. M., and Schaap, J. C., "Indices for Work History and Chemical Exposure", B.F.Goodrich Chemical Company Correspondence, 7/15/74. 10. Fairlie, A. M., "Description of Variables Used in Health Records Study", B.F.Goodrich Chemical Company Correspondence, 6/6/75.
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TABLE 1. - MOST SIGNIFICANT VARIABLES AFFECTING EACH LIVER FUNCTION TEST
Test
1. Total Bilirubin
Variable Do No Smoke Cigarettes Do Smoke Cigarettes
Average .63 .55
2. Alkaline Phosphatase
Do Smoke Cigarettes Do Not Smoke Cigarettes
68 62
3. GGTP
> 1 Drink per Day C 1 Drink per Day
42 18
4. SGOT
Do Have Liver Problems Do Not Have Liver Problems
40 27
5. a. SGPT b. SGPT
Any E> 3 VC1 No E? 3 VC1 Dizzy from VC1 Not Dizzy from VC1
32 26 32 27
6. LDH
None
No. Employees 350 417
417 350
33 191
14 753
163 59
137 85
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TABLE 2. - PROPORTIONATE STUDY OF ABNORMAL BLOOD TESTS
A Comparison of the Numbers of Abnormal Employee Blood Tests When Classified by Chemical Exposure and Personal History Variables
Variable
Had
TOTAL BILIRUBIN flTests>1.0/out of total Total % with abnormal Bilirubin = 5%
Smoke Cigarettes
12/417 (3%)
Did not Have 24/350 (7%)
ALKALINE PHOSPHATASE //Tests> 85/out of total Total % with abnormal A.P. = 12%
Gall Bladder Trouble Smoke Cigarettes
8/27 (30%) 62/417 (15%)
85/740 (11%) 31/350 ( 9%)
GGTP y/Tests > 37/out of total Total % with abnormal GGTP 10%
Alcohol:* 1 drink per day Liver Problems Any E = 5 VC12
12/33 (36%) 4/7 (57%) 3/7 (43%)
11/191 (6%) 19/217 (9%) 20/217 (9%)
Liver Problems
SGOT //Tests > 40/out of total Total % with abnormal SGOT = 7%
7/14 (50%)
47/753 (6%)
SGPT //Tests > 25/out of total Total % with abnormal SGPT = 64%
Any E23 caprylyl peroxide 52/58 (90%)
Dizzy from VCM
101/137 (74%)
AnyE>3VCM
115/163(71%)
89/164 (54%) 40/85 (47%) 26/59 (44%)
LDH -- No Trends
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TABLI 3. BLOOD ABNORMALITY RATING BY CANNONICAL CORRELATION-
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TABLE 4. - LIST OF SELECTED CHEMICALS
acrylic acid acrylamides-acrylamide, methyl, n-octyl, nMA acrylonitrile acetylene acrylates-ethyl, methyl-methyl-meth, 2 ethyl hexyl,
n-butyl Bisphenol A Butadiene caprylyl chloride (actually caprylyl peroxide in this study) chlorinated solvents-carbon tetrachloride, chloroform,
trichloroethylene, EDC chloro ethyl vinyl ether diethyl maleate mecuric chloride methanol phenol PVC dust toluene vinyl chloride vinylidene chloride vinyl acetate
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