Document XRnv9jKzGaV4nL6rkoxwBZXRB

ABDOO134407 TABLE 8-1 Cancer Data Sheet for Derivation of qj* Compound: Chloroethene Reference: Haltonl et al., 1980, 1981 Species, Strain, Sex: Rat, Sprague-Dawley, M,F combined Body weight: 0.35 kg (assumed) length of exposure (le) 365 days Length of experiment (Le) * up to 1029 days Lifespan of animal (L) - 1029 days Tumor site and type: Liver angiosarcoma Route, vehicle: Inhalation, air \ v. ./ Experimental1 Qoses or Exposures 'X i / ppm- enr S' am 10 /?r/r 25 13TIS 50 fin 100 i3T2 150 er2 200 250 500 2500 6000 10,000 30,000 mg/m# 25.6 63.9 127.8 255.6 383.4 511.2 639.0 1278.1 6390.5 15337.4 25562.3 76687.1 Controls Transformed Oosea (mg/kg/day) 0.344 0.860 1.719 038 5.158 6.878 8.596 17.19 86.97 206.3 343.9 1031.6 0.0 Incidence No. Responding/No. Tested or Examined 1/119 5/120 1/60 1/120 6/119 12/120 3/59 6/60 13/60 13/59 7/60 18/60 0/363 . b*-*' ,5 .0 1 - .o . .o S :o!' . 0$ .on .j* . 0* .7 Unadjusted qi* from study 5.0381387x10'* (mg/kg/day)_lb Human qj* - 2.95x10"* (mg/kg/day)"* ^ ' 1"* ' r" aD-0.223 mVday x 4/24 x 5/7 x (C]xO.5*0.35 x 365/1029 bThe unadjusted qy* was derived from the dose-response data up to doses of 1.719 mg/kg/day. The goodness of fit hypothesis was rejected for the data at >3.438 mg/kg/day. i. 0707p -87- f ' 09/17/85