Document XRn7r6Ed7wV4r2Rj5MEmNy9Dg

n11* y' - DEPARTMENT OF HEALTH. EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE CENTER FOR DISEASE CONTROL NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH U.S. POST OFFICE AND COURTHOUSE CINCINNATI, OHIO 45202 February 14, 1975 Dr. Lawrence H. Ballou Medical Director Firestone Tire and Rubber Company Akron, Ohio 44317 Dear Dr. Ballou: In answer to your questions, I can cite a 1974 experiment by Maltoni (experiment BT5)* in which two groups of 30 female Sprague-Dawley rats were treated with 6000 and 10,000 ppm vinyl chloride monomer respectively for 4 hours daily between the 12th and 18th day of pregnancy (i.e. for only one week). Both the adult animals and their offspring were followed for 75 weeks. As of August 1974 no tumors developed in the adults but 2 subcutaneous angiosarcomas developed in a total of 86 offspring: one deve-loped in a 24 week old male whose mother was exposed to 10,000 ppm 1 Ui".t--rtnN-.5 j 5i4 4-Un A I I u VliV W V I I Li I rl fiu a! ip u(r T Iv I W WVU Ijl l_L. II^UIN U I VI I ^IIIU t W ITllU JL mother was exposed to 6000 ppm for 1 week. These results, though not conclusive, do suggest that vinyl chloride does have a transplacental effect, and that fetuses may be more sensitive to it than are adults. Therefore I would agree that women of child bearing age should not be exposed to vinyl chloride. Sincerely, A-0 , Joseph S. Mallov, M.D. Division of Field Studies and Clinical Investigations Reference: Maltoni, Cesare and Lefemine, Giuseppe, "Carcinogenicity Bio-Assays of Vinyl Chloride: Current Results" Aug.31 ,1974. cc: J.Stender P.Falk J.Wagoner H.Blejer OCC 0741 IXOtPcSdl} ^ INTEROFFICE :IR. F. A. MAHL TO vUAL Zla'L. OrPOETURm- DATE FROM f::beuaey 19, 1975 DR. L. II. DA1LGU REFERRING TO LETTER OF SUBJECT Attached Is some correspondence relative to a problem that may come up between opposing views of EGCC and ODHA. Rather than write a full blown explanation to you, I will let you read these attachments -- then asl: your opinion* because I want to give Pottstovn and Perryville a concensus of Akron's thinking. LTTHmB:p,k Attach. MEDICAL DIRECTOR S1273 . . t4 ' OCC 0742