Document XRY980gN092jOxbwxQ7ndmg1K

it M / it' 1 t i -T PLAINTIFF'S EXHIBIT m EDITORIALS li or. M. A. 25. !9<< THE-J O U RNAL' O F T H E AMERICAN ,MEDICAL ASSOCIATION pitch, tar, soot, paraffin oil, anthracene oil, creosote, aromatic amino compounds (aniline, naphthylamine,.-it benzidine), benzene,; ultraviolet rays, roentgen rays,^? radioactive materials and substances from certain para-H^ff 535 North Dearborn Street Chicaco 10, III. sitic worms. Approximately 8,000 to 9,000 cases of C*bU Addm* "Medic, Chietfo" occupational cancer appear to have been placed on record, the majority during the last two to three dec Subscription price Eifht dollar* per annum in advance Ades, during which the sources of occupational cancer. - ' 'were mostly discovered. These figures, however, do "? ',C\ Pleatf tend in promptly notice of change of oddreis, giving both oti end im; aJteoyt ttale whether the change it temporary or permanent. Sack notice ikonld mention oil janrnalt received from thit office. Important information regarding contribution! trill be found on teeond advertiting page following reading matter. not reflect the actual incidence of industrial cancer, as} ! the cause of many cases of this type is not properly - recognized or their occurrence is not recorded. ; ! Environmental cancer may involve many organs and -., SATURDAY, NOVEMBER 25, 1944 tissues, notably the skin, lip, tongue, cheek, oral cavity,'-...'.: nasal sinuses, larynx, bronchi, lung, liver, kidney, ureter,;^ ; ENVIRONMENTAL CANCER ......... ' , Environmental cancer is cancer due to prolonged contact with some canccrigenic agent in t!ie environ ment.' The relationship of a previous exposure to such an agent and the cancer often appearing many years later is frequently overlooked or not understood. Envi ronmental cancers can be divided into four main groups according to the type of exposure: ' First are the cancers caused by agents in the normal environment. Representative of this group is cancer due to the continued ingestion of arsenic in drinking water and foodstuffs in certain regions, the solar cancers of the skin in dry and sunny regions,', as in our Mid western and Southwestern states, the bladder cancers in people in places like Egypt with endemic schisto somiasis, and possibly also lung cancers due to inhalation cf road dust containing canccrigenic tar. The second group of'environmental cancer results from certain habits (habitual cancer), as for example cancer of the, lip and mouth in,smokers, cancer^of the oral lining in betel and tobacco chcwcrs, and cancer of the abdominal skin in kangri users. Tlic third group comprises cancer resulting from use,of certain medicinal agents (medici nal cancers), e.'gi" cancer, of. the skin after arsenical medication _ and exposure^ to roentgen rays_ and radioactive substances. The fourth, which is the largest and'most important group,1 is represented by occupa tional cancer elicited by exposure to chemical and. physical agents in the course of regular occupations.1 The agents known or suspected to cause occupational cancer are arsenic, chromates, nickel carbonyl, radium, bladder, connective tissue, bone and hemopoietic tissues,^.? Tlic site of the cancer depends on the type of the'v- canccrigenic agent and the kind of exposure. The sex ratio is determined mainly by the exposure to the `v- various canccrigenic agents. It is for this reason that.-v the male sex is predominantly affected by occupational^ cancer, but osteogenic sarcoma occurs in women work-"!? ing in luminous dial factories. Undoubtedly the rapid? increase in the employment of women in hazardous^ industries will be followed by an increase of occupa--. tional cancer in women. .-.V's The public health importance of industrial cancer.^ an* undoubtedly will increase not only with respect to th$3|' number of workers, male and female, exposed to indus^i trial canccrigenic agents but also with respect to theU-! variety of plants and oi>crations in question. Public^ health authorities will wish to institute effective technical . .. .. .... .. . --, and sanitary supervision of such establishments as weiP as medical control of the workers, present as well as^ jiast. Practitioners and cancer clinics, in addition bull industrial physicians, will aid greatly in meeting tW^f iLb jfrlike M cast situation by close study of the occupational history of * all patients coming to them with precancerous and ;;.' cancerous lesions. It is mainly in this way thatthe^: industrial origin of cancer can be established andtne sources of occupational forms discovered. The benefits^ from such efforts will be not only the early detectiofS^ The and improved prognosis of cases of occupational cancers but also the prevention of industrial cancer by;/t||- elimination of exposures to cancerigenic agents. Indus-isS: trial cancer is largely preventable by proper technical.'.-; measures. - : .... pr with mesothorium, asbestos, crude and processed mineral oils, 1. Clemintcn, Jf.: Cancer ai<l Occupation in Denmark, 19JS 1939,. Copenhagen, Nyt Norditk Fortag Arnold Ilujck, 19-11. Davis, E.: Chemi cal Carcinogenesis. Drugs, Dyes. Remedies and Cosmetics with Particular Reference to Bladder Tumors, J. Urol. 40:14, 1943. Gross, E.: Das Carcinom vora Standpunkt des Gewcrbctoxikologen, Ztscbr. f. angew. Chem. 53: 368, 1940. Ifucper, W. C.: Occupational Tumors and Allied Diseases, Springfield, 111., Charles C Thomas, 1943, p. 896; Cancer in Its Relation to Oceupation and Environment, Bull. Am. Soc. Control of Cancer 25:6, 1943. Warren, S.: Minimal Criteria Required to Prove Causation of Traumatic or Occupational Neoplasms, Ann. Surg. 117: S85, 1943. Organized investigation of environmental and esp^r! cially occupational cancers is a promising approach.to?V the study of fundamental problems of human caacetv.-_ because these cancers are the counterpart of expfih'.fr mental cancer in animals. Environmental cancers ptf*-;-mit a scientific analysis of cancerigenic agents and.of^ , local and general reactions induced by them in humaftK; beings. ' 'Vifft fflvoh Jfeye: Ascar