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FILE NAME Talc TALC DATE 1980 DOC TALC037 DOCUMENT DESCRIPTION Medical Records DEPARTMENT OF PATHOLOGY A. BARTON HEPBURN HOSPITAL OGDENSBURG NEW YORK 13669 26-80 Weir Frederick - Age - Dr. 1. Carthy - November 3 1980 | Clifton Hospital Star Lake New York -4- SKELETAL SYSTEM e A tumor is present within the first part of the brim The tumor has destroyed the bone in the sacrum immediately below the pelvic 7 downwards over the pelvic brim enters region so that as the finger is run in diameter and which is filled with an irregular cavity which is up to 2.5 cm necrotic diffluent tumor material The posterior layers of the sacrum appear intact upwards into the disc between the The tumor appears to be infiltrating bones sacrum and the 5th lumbar vertebrum Further = of thewe derceeansoetd ewxear me inweidthaindn s thehho eat d was not opened in this case as the relatives AUTOPSY FINDINGS FINDINGS ~ 2 Bronchial carcinoma 2. .Mkeitdansetyataincd stuamcorrumin lungs subcutaneous lymph nodes liver pancreas left a 3 Emphysema setee 4 Possible bronchopneumonia awaiting microscopic ea CAUSE OF DEATH or Bronchial carcinoma MICROSCOPIC APPEARANCES APPEARANCES and The myocardium is well inflammatory cell preserved infiltrate is shows no areas of fibrosis or necrosis Significant layers The endocardium not seen within the myocardium or the overlying pericardial is of normal thickness No tumor is seen in this section BRONCHUS : figures Sections taken from the bronchus serving the left that bronchus and spreading through the wall of upper lobe show carcinoma arising from made up of sheets of the structure in the form of thick layers or closely packed cells The tumor cells are small and elongated darkly staining nuclei which are display rounded eosinophilic or alightly foamy cytoplasm enclosed in small amounts of pale and mitotic Only moderate nuclear pleomorphism is evident are spindle although present are not numerous In Here and there throughout the section few areas the tumor cells of necrosis some infiltrated by lymphocytes and are seen small numbers of areas described in a previous biopsy specimen neutrophils 2079x80 The tumor is similar to that yee ao .26-80 Weir Frederick DEPARTMENT OF PATHOLOGY A. BARTON HEPBURN HOSPITAL OGDENSBURG NEW YORK 13660 Dr. J. Carthy - -5- 5a November 3 1980 LU . LU r Ad Conver . GGUARDUINGARDIGNUGARDGUARDIING NGGUARDING LABIO LABIO Conver Conver . In the sections taken from the tumorous pulmonary lobes marked interstitial fibrosis is a feature in many places In these regions the normal architecture is i obliterated and replaced by thick anastomosing fibrous trabeculae which enclose irregular cystic spaces The latter are lined by layers of columnar low large or columnar cells although in most instances the lining layers are now lost are infiltrated at many points by collections of lymphocytes and The fibrous layers deposits brownish and numbers of clusters of asbestos bodies also display the honeycomb pattern is pronounced the irregular In one section where lined by ciliated columnar epithelial cells branching dilated air spaces are This sometime called adenomatous proliferation of bronchioles is fairly widespread in the sections Asbestos bodies are noted within a few alveoli and a few of the terminal bronchioles The lung tissues are congested In a few alveoli clusters of pigment laden macrophages are noted Acute inflammatory change is not a feature granulomatous disease is not present In one of the sections tiny collections of tumor cells are noted are taken away from the main tumor mass.which is demonbsuttraastsetdatiend thtehebsreonscehcitailons sections of Special stains reveal much of the pigment within the lungs to be iron and course the asbestos bodies react positively with the iron stain Other show the presence of strands of smooth muscle within the thick fibrous trabecpurleapearaitniotnhse honeycombed areas PANCREAS: Sections confirm the presence of metastatic tumor within the pancreas and the tumor is si ar to that described above The island of normal pancreatic tissue seen shows aulytic changes but is otherwise preserved and shows no areas of necrosis or inflammation LIVER Likewise metastatic tumor within the liver are congested and edematous in appearance no fattoyr other degenerative changes is confirmed The surrounding liver tissues The liver cells are well preserved and show KIDNEYS Section from the left kidney shows the presence of metastatic tumor The enclosing kidney tissues are congested Glomerular disease is not in evidence and the cells lining the convoluted and collecting tubules although autolyzed show no other degenerative features There is partial fibrosis of the kidney tissues immediately immediately adjacent to the tumor deposits PLEURAE A pleural plaque is demonstrated in a section taken from the thoracic wall is made up of partially hyalinized laminated dense fibrous The plaque low connective tissue of cellularity The fibrofatty tissues adjacent to the plaque and also the skeletal muscle layers show a patchy infiltration by lymphocytes and plasma cells N \ 26-80 DEPARTMENT OF PATHOLOGY Age A. BARTON HEPBURN HOSPITAL OGDENSBURGOGDENSBURG NEW YORK 13669 Weir Frederick ~ Dr. J. Carthy - November 3 1980 06- TOPSY : FINDINGS 1. 2 3 4 5 Small call poorly differentiated differentiated differentiated carcinoma of lung Manedtastatic tumor in lungslungs subcutaneoussubcutaneous lymph nodes sacrum interstitial liver pancreas left kidney ACshrboensitcosiinsterstim tieal fibrosis of lungs with honeycombing Fibrosing alveolitis Pleural plaques a CAUSE OF DEATH Carcinoma of lung 1 Bronchial carcinoma ac St Joe -C Resources 10-26-81 Funds -c ie | < Hugh F. Frame M.D. Pathologist RECEIVED OCT 26 1981 GUATAN CLAS Dee : tare WN .