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ARM-OfFI 004635 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS POCKET NOS. 8EHQ-*** *-0373/0374 8EHQ-****-0394 8EHQ-****-6006 8EHQ-****-6012 888EEEHHHQQQ---************---666000111568 8EHQ-****-6019 8EHQ-****-6023 88EEHHQQ--********--I84652946 GQ436 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-373/374 SORTED by SUBMITTAL DATE DATE SUBMITTED (Date I-oggedAa HPA)ltcneil U> 11/19/80 8EHQ-1180-0373 S (11/24/80) 11/19/80 (11/24/80) 8EHQ-1180-0374S 2/20/81 (2/26/81) 2/20/81 (2/26/81) 8EHQ-0281-0374S 8EHQ-0281-0373S N-ethyl perfluoroctylsulfonamido ethanol Preliminary information from an ongoing teratology study N-ethyl perfluoroheptylsulfonamido ethanol FC-95 & FC-99 Potassium salt of perfluoro alkyl sulfonates Perfluoroalkyl Mixtures (FC95) Preliminary information from an ongoing teratology study 3M Technical Report regarding presence of fluorochemicals in the blood of some of 3M's plant employees. Final written report of the teratology study referenced in submission of 11/19/80 N-ethyl peril uoroctylsulfonamido ethanol Final written report of the teratology study referenced in submission of 11/19/80 N-ethyl perfluoroheptylsulfonamido ethanol 1. Protocol for Oral Teratology Study in Rats, 8/80 2. Preliminary memo report by 3M, 11/12/80 1. Protocols for Oral Teratology Study in Rats 2. Preliminary report, 3M memo, 11/12/80 3. 3M Technical report, "Analysis of Selected Decatur Employee Serum for sulfonic and Carboxylic Fluorochemicals," 10/04/79 1. Report No. 1609, "Oral Teratology Study of FC-95 in Rats," 2/18/81 1. Report No. 1610, "Oral Teratology Study of [subject chemical] in Rats," 2/18/81 6/15/81 (6/24/81) 3/22/82 (3/24/82) 5/15/84 8EHQ-0681-0374S 8EHQ-0681-0373S 8EHQ-03820373/374S Perfluoroalkyl Mixtures (FC-95) FC-143 ammonium carboxylate FM-3422 FC-95 8EHQ-0584-0374 perfluoroalkyl alcohol Response to EPA letter of 5/15/81 requesting additional information on perfluoroalkyl mixtures 1. Animal Toxicity Studies with Amonium Perfluorooctanoate, 8/80 Submission of studies on subject material per EPA request Information regarding teratology studies 1. Analysis of FM-3422 in serum and liver in rats from I.R.D.C. Study, 11/10/78 2. FM-3422, Ninety day subacute rhesus monkey toxicity study, 1/16/79 3. Special lens oral teratology study of T2999COC in Rats, 12/22/81 4. FC-95, Ninety day subacute rhesus monkey toxicity study, 12/18/78 5. Report removing FC-95 from "confidential" and placed in "non-confidential status, 3/18/82 6. Oral Teratology Study of T-2999CoC in Rabbits, 5/10/81 - 6/26/81 7. An Epidemiologic Mortality Study of Employees at the Chemolite Plant, 2/80_______________ 1. Internal 3M memo re: Teratology Studies on Perfluoroalkyl alcohol and Perfluoroalkyl______ 004637 SOUFMSUMBAMRIYSSION ENCLOSURES (5/23/84) 5/15/84 (5/23/84) 11/29/88 (12/5/88) 5/15/98 (5/21/98) 7/10/98 9/14/98 (9/18/98) 2/05/99 (3/12/99) perfluorooalkyl sulfonate FC-95 8EHQ-0584-0373 FM-3422/T-3352 perfluoroalkyl alcohol FC-95/T-3351 perfluoroalkyl sulfonate Information regarding teratology studies 8EHQ-1288-0373 8EHQ-0598-0373 (Follow-up on: 8EHQ-1180-0373 8EHQ-1180-0374 8EHQ-0381-0394) 8EHQ-0898-373S 8EHQ-0998-0373 (Follow-up on: 8EHQ-1180-0373 8EHQ-1180-0374 8EHQ-0381-0394) 8EHQ-0299-373 Fluorochemical FM-3924 N-ethyl perfluorooctanesulfonamido ethanol Perfluorooctane Sulfonate (PFOS) Perfluorooctane Sulfonate (PFOS) N-ethyl perfluorooctyl sulfonamido ethanol (N-EtFOSE) Perfluorooctane Sulfonate (PFOS) Perfluorooctane Sulfonate (PFOS) Submittal of report entitled "Two Year Oral (Diet) Toxicity/Carcinogenicity Study of Fluorochemical FM-3924 in Rats" Submission of information on PFOS relating to analysis of blood sera samples Summarizing status of 3M meeting request Preliminary results of two-generation rat reproduction studies Reports on chemistry and sera data sulfonate, 05/15/84 2. Internal 3M memo re: Teratology Study on Perfluoroalkyl Alcohol, 05/15/84 3. Internal 3M memo re: Teratology Study on FC-95, 05/16/84 4. Letter from Jefferson Medical College re: draft report of T3351, 12/7/83 5. Internal 3M memo re: Teratology Study on FC-95, 05/16/84 6. Rat Teratology Study, No. T-3351, Final Report, 12/19/83 1. Internal 3M memo re: Teratology Studies on Perfluoroalkyl alcohol and Perfluoroalkyl sulfonate, 5/15/84 2. Internal 3M memo re: Teratology Study on Perfluoroalkyl Alcohol, 05/15/84 3. Letter from Jefferson Medical College re: final report of T-3352, 05/14/84 4. Rat Teratology Study, No. T-3352, Final Report, 3/21/84 1. Two Year Oral (Diet) Toxicity/Carcinogenicity Study of Fluorochemical FM-3924 in Rats 1. The Science of Organic Fluorochemistry, 02/05/99 2. Perfluorooctane Sulfonate: Current Summary of Human Sera Health & Toxicology Data, 2 004638 SDUABTMEITTED NERPUEAFMEBREERNCE CSPURHBOESDMTUIACCNATCLE // (Date Logged As ili Received by hM H M IH M H i / 2/25/99 (3/11/99) 2/25/99 (3/11/99) 3/15/99 (3/23/99) 8EHQ-0399-373 8EHQ-0399-374 8EHQ-0399-374 Perfluorooctanesulfonate (FC-95) 2-(N-ethyl perfluoroctanesulfonamido)alcohol (FM-3422) Perfluorooctanesulfonate (FC-95) 2-(N-ethyl perfluoroctanesulfonamido)alcohol (FM-3422) Potassium Perfluorooctane Sulfonate 5/26/99 (6/4/99) 5/26/99 (6/7/99) 5/28/99 (06/04/99) 2/15/00 (02/22/00) 8EHQ-0699-373 (Follow-up on: 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-0381 -0394; 8EHQ-0598-373) 8EHQ-0699-373 (Follow-up on: 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-0381-0394; 8EHQ-0598-373) 8EHQ-0699-373 (Follow-up on: 8EHQ-1180-0373 8EHQ-1180-0374 8EHQ-0381-0394) 8EHQ-0200-0373 (Follow-up on: 8EHQ-0998-373; 8EHQ-0998-374; 8EHQ-0998-394) Sulfonyl-based fluorochemicals Sulfonate-based fluorochemicals Carboxylic-based fluorochemicals sulfonyl-based fluorochemicals N-Ethyl Perfluorooctyl Sulfonamido Ethanol (N-EtFOSE) Perfluorooctane Sulfonate (PFOS) M isT i Summary of rat teratology results 01/29/99 1. FC Rat Teratology Results, 02/10/99 Summary of rat teratology results 1. FC Rat Teratology Results, 02/10/99 Information on rat teratology Summarry of initial screening data regarding the distribution of PFOS in biota 1. Rat Teratology Study; T-3351 (Potassium Perfluorooctane Sulfonate); Final Report 2. Letter of 11/12/82 from Dr. Johnson at Thomas Jefferson University 3. Letter of 12/07/83 from Dr. Johnson at Thomas Jefferson University Summary of further studies regarding the presence of perfluorinated sulfonates and perfluorinated carboxylic acids in human sera 1. Chart: Sulfonate-based Fluorochemicals identified in Human Sera 2. Chart: Carboxylic acid-based Fluorochemicals identified in Human Sera Information regarding the manufacture, use, distribution and environmental release of FCs Fluorochemical Use, Distribution and Release Overview (Prepared by 3M 5/26/99) Final reports for the two-generation rat reproduction 1. Final Report, Protocol 418-009, Combined studies Oral (Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity Study of N-EtFOSE in Rats, Study No. 6316.5, 6/30/99 2. Final Report, Protocol 418-014, Oral 3 0 0 4 :6 3 9 ..*SER(dD*PUekaa*cAtBJet,eJ)i.vML'e.e..od.;IgJ.B>.Tg..*ey.Td...EA..'s.D'. ---i NERPUEAFMEBREERNC, E & CSPUHRBEOSMTDIACUNACCLET/^ '1 .SoUfMMARY ^ TP..;. , V^, -4 b-,A', ^ *- - 3/17/00 (3/20/00) 3/17/00 (3/20/00) 8EHQ-0300-0373 (Follow-up on: 8EHQ-1180-0373; 8EHQ-1180-0374) 8EHQ-0300-00373 (Follow-up on: 8EHQ-1180-0373; 8EHQ-1180-0374) Sulfonate-based Fluorochemicals Perfluoroalkyls Information on environmental fate and effects Response to EPA letter of 02/25/00 ENCLOSURES txS <v- (Gavage) Cross-Fostering Study of PFOS in Rats, Study No. T-6295.13, 7/23/99 3. Final Report, Protocol 418-008, Combined Oral (Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity Study of PFOS in Rats, Study No. 6295.9, 6/10/99 1. ` Sulfonated Perfluorochemicals in the Environment: Sources, Dispersion, Fate and Effects," 3M, 03/01/00 4 004640 DArE SUBMITTED (Dte Logged As Jtecetved 3/20/81 (3/27/81) 05/06/81 6/16/81 (6/25/81) 3/22/82 (3/24/82) 10/16/87 10/23/87 10/11/93 (10/20/93) Doc3kMet's8ETHSCQA-*8*(*e*)-F39L4UOROSOCRHTEEMDICbAy LSUSBUMBMITITSASILODNASTE REPEAFERENCE NUMBER CSPURHBOESDMTUIACCNATCLE/ 8EHQ-0381-0394S Perfluoroalkane carboxylic acids (Follow-up on 8EHQ-03810394C] 8EHQ-0681-0394S Corresponding ammonium carboxyiates Perfluoroalkane carboxylic acids Corresponding ammonium carboxyiates FC-143 (Perfluroalkane ammonium carboxylate mixture) 8EHQ-0382-0394 FC-143 (Ammonium Perfluorooctanoate) (Follow-up on 8EHQ-03810394S) (Follow-up on 8EHQ-03810394S) 8EHQ-1093-0394S FC-143 (Ammonium Perfluorooctanoate) FC-143 (Ammonium Perfluorooctanoate) Mixture of Ammonium Perfluorooctanoate Ammonium Perfluoroheptanoate Preliminary information from 3M report entitled "Oral Rangefinder Study of T-2998CoC in Pregnant Rats" Response to 04/07/81 EPA letter requesting substantiation of confidentiality claims 1. Additional letter stating report has CBI material, 3/20/81 2. Oral Rangefinder Study of T-2998CoC in Pregnant Rats, 2/24/81 3. Status Report re subject chemical, 4/27/81 Response to letter of 5/15/81 from EPA, which included request for additional information on 3M's TCSA 8(e) submission for perfluoroalkane ammonium carboxylate mixture. Sanitized (non-CBI) copies of studies provided at meeting with Terry O'Bryan on 3/12/82 at EPA Information on toxicity/carcinogenicity 1. Protocol for Oral Teratology Study of T2998CoC (FC-143) in Rats, 4/81 'A1. An Assay of Cell Transformation and Cytotoxicity in C3H 10T Clomal Cell Line for the test chemical T-2942 CoC, 3/4/81 2. Oral Teratology Study of T-3141CoC in Rabbits, 2/23/82 3. Oral Teratology Study of T-2998CoC in Rats, 4/81 4. Ninety Day Subacute Rat Toxicity Study, FC143, 11/6/78 5. Ninety Day Subacute Rhesus Monkey Toxicity Study, FC-143, 11/10/78 1. "Two Year Oral (Diet) Toxicity/Carcinogenicity Study of Fluorochemical FC-143 in Rats" Confirms telephone conversations regarding prior submission with pages erroneously stamped as confidential Toxicity/Carcinogenicity Study 1. Table 1 - Tumor Incidence Values, 10/93 2. Table 2 - Summary of Hyperplasia/Neoplasia Lesion Incidence in the Liver, Pancreas and Testis, 10/93 Ammonium Perfluorohexanoate 004.641 SDUABTMEIT. TED; NERPUEAFMEBREERNCE (Date togged'As ' Received UvEPM 5/15/98 (5/21/98) 9/14/98 (9/18/98) 8EHQ-0598-0373 (Follow-up on: 8EHQ-1180-0373 8EHQ-1180-0374 8EHQ-0381-0394) 8EHQ-0998-0373 (Follow-up on: 8EHQ-1180-0373 8EHQ-1180-0374 8EHQ-0381-0394) CSPURHBOESDMTUIACCNATCLE/ Ammonium Perfluoropentanoate (or Ammonium Perfluoroalkyl carboxytates) Perfluorooctane Sulfonate (PFOS) N-ethyl perfluorooctyl suffonamido ethanol (N-EtFOSE) Perfluorooctane Sulfonate (PFOS) 5/26/99 (6/4/99) 5/26/99 (6/7/99) 5/28/99 (06/04/99) 2/15/00 (02/22/00) 8EHQ-0699-373 (Follow-up on: 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-0381-0394; 8EHQ-0598-373) 8EHQ-0699-373 (Follow-up on: 8EHQ-1180-373; 8EHQ-1180-374; 8EHQ-0381 -0394; 8EHQ-0598-373) 8EHQ-0699-373 (Follow-up on: 8EHQ-1180-0373 8EHQ-1180-0374 8EHQ-0381-0394) 8EHQ-0200-0373 (Follow-up on: 8EHQ-0998-373; 8EHQ-0998-374; 8EHQ-0998-394) Sulfonyl-based fluorochemicals Sulfonate-based fluorochemicals Carboxylic-based fluorochemicals Sulfonyl-based fluorochemicals N-Ethyl Perfluorooctyl Sulfonamido Ethanol (N-EtFOSE) Perfluorooctane Sulfonate (PFOS) SUMMARY OF SUBMISSION ENCLOSl'RES I Submission of information relating to analysis of blood sera samples "showing PFOS at very low (i.e., parts per billion ("ppb")) levels" Preliminary results of two-generation rat reproduction studies on the subject chemicals; provides summary of preliminary findings. Summary of initial screening data regarding the distribution of PFOS in biota Summary of further studies regarding human sera 1. Chart: Sulfonate-based Fluorochemicals identified in Human Sera 2. Chart: Carboxylic acid-based Fluorochemicals identified in Human Sera Information regarding the manufacture, use, distribution and environmental release of FCs "Fluorochemical Use, Distribution and Release Overview" (and attachments), Prepared by 3M 5/26/99 Final reports for the two-generation rat reproduction studies 1. Final Report, Protocol 418-009, Combined Oral (Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity Study of N-EtFOSE in Rats, Study No. 6316.5, 6/30/99 2. Final Report, Protocol 418-014, Oral (Gavage) Cross-Fostering Study of PFOS in Rats, Study 2 004642 DAI E SUBMI/T'T'ED *' EPA NRUEFMEBREERNCE (Date LoggedAs ? R uine d U\ FPA I CHEMICAL SPURBOSDTUACNTCE/ SOUFMSUMBAMRIYSSI,ON r & \, \ y i r s j w , *" y M *% ENCL' O SUy R%ES ^ HPAr ^ *f r ,f/s - ': f ; ; | | ' ' ". '''' No. T-6295.13, 7/23/99 3. Final Report, Protocol 418-008, Combined Oral (Gavage) Fertility, Developmental and Perinatai/Postnatal Reproduction Toxicity Study of PFOS in Rats, Study No. 6295.9, 6/10/99 3 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-6006 SORTED by SUBMITTAL DATE (7/29/92) 7/27/92 (1/12/94) 8EHQ-0792-6006A following: 63% N-(2hydroxyethyl)-N-methylperfluorooctane sulfonamide, 3% CAS #68555-76-0, 4% CAS #68555-75-9, 1% CAS 68555-74-8, and, 4% CAS #34454-97-2 Summary of "Study Design and Results: Acute Inhalation Toxicity Study in Rats (Final Report)" 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-6012 SORTED by SUBMITTAL DATE 7/27/92 (7/29/92) 8EHQ-0792-6012 99% 1-octane Oral toxicity, dermal irritation, eye irritation data sulfonamide 1,1,2,2,3,3,4,4,5,5,6,6,7, 7,8,8,8-heptadecafluoro N-methyl 1% water 1. Acute Oral Toxicity - Method, Summary, Pathology; Primary Dermal Irritation - Method, Summary; Primary Eye Irritation - Method, Summary; Sample T-3727, 5/7/85 < zb r mm2 ('7/29/92) 7/27/92 (1/12/94) Doc3kMet'8sETHSQC-A**8*(*e)-6F0L1U5 OROSCOHRETMEDICbAyLSUSUBBMMITISTSAILONDSATE "P----------------- ENCLOSURES 8EHQ-0792-6015 8EHQ-0792-6015A R&D sample with 0.23% fluoropolymer, 0.025% sulfonamides, C4-8-alkane, perfluoro, N-ethyl-n(hydroxyethyl), reaction products with 1,1'methylenebis[4isocyanatobenzene], and solvent mixture R&D sample with 0.23% fluoropolymer, 0.025% sulfonamides, C4-8-alkane, perfluoro, N-ethyl-n(hydroxyethyl), reaction products with 1,1'methylenebis[4isocyanatobenzene], and solvent mixture Acute inhalation toxicity data M W B-- < Summary of "Study Design and Results: Acute Inhalation Toxicity Study with Rats (Final Report)" 1. An Acute Inhalation Toxicity Study of T-3809 in the Rat, 7/11/86 004645 004646 SDUABTME ITTED {D*ie I-ogged As Iteeetred 7/27/92 (7/29/92) 3Ms TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-6016 SORTED by SUBMITTAL DATE REPEAFERENCE CHEMICAL substance/4 ^ 4 '^ wStm PRODUCT >A 8EHQ-0792-6016 68% Poly(oxy-1,2ethanediyl), a-[2-ethyl (heptadecafluorooctyl)su Ifonyl] amino] ethyl] -whydroxy- SUMMARY OF SUBMISSION iI' 'W~, ! Submittal of acute studies 3% poly(oxy-1,2ethanediyl), a-[2-ethyl (pentadecafluoroheptyl) sulfonyl] amino] ethyl] w-hydroxy- 5% poly(oxy-1,2ethanediyl), a-[2ethyl(tridecafluorohexyl) sulfonyl] amino] ethyl] w-hydroxy- 1. Acute Dermal Toxicity Study with T-3448 in Albino Rabbits, 01/27/84 2. Acute Dermal Toxicity Study in Rabbits, Sample T-4370, 12/06/89 3. Primary Skin Irritation Test with T-3448 in Albino Rabbits, 12/22/83 4. Acute Dermal toxicity Study with T-3448 in Albino Guinea Pigs, 03/15/84 5. Acute Dermal Toxicity (LD50) in Rabbits (sample T-3639), 09/19/84 6. Acute Dermal Toxicity Study in Rabbits (sample T-3649), 10/17/84 7. Memo on FC-170C Toxicity re oral report of guinea pig and rabbit dermal LDso from customer study, 08/17/83 1% poly(oxy-1,2ethanediyl), a-[2-ethyl (undecafluoropentyl) sulfony] amino] ethyl] w-hydroxy- 4% poly(oxy-1,2ethanediyl), a-[2-ethyl (nonafluorobutyl) sulfony] amino] ethyl] w-hydroxy- 12% poloyoxyethylene glycol 7/27/92 (1/12/94) 8EHQ-07926016A I <0.3% dioxane Surfactant or coating component <0.3% dioxane Summary of study designs and results for acute toxicity reports 004647 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-6018 SORTED by SUBMITTAL DATE DSUABTMEITTED (Dare Logged As Reu-ivedUvEPA) 7/27/92 (7/29/92) EPA NREUFMEI!%& psiit \ f J 8EHQ-0792-6018 1-octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7, 7,8,8,8heptadecafluoro-comp. with 2,2'-iminobis fethanol] (1:1) Acute orai toxicity data tWES^IIU 1. Acute Oral Toxicity - Rats, Sample T-2185, 9/25/78 2. Acute Oral Toxicity - Rats, Sample T-2275, 7/12/78 00448 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-6019 SORTED by SUBMITTAL DATE 7/27/92 (7/29/92) 8EHQ-0792-6019 Average C8F17S03-K, potassium perfluoroaikyl sulfonate Acute inhalation toxicity data 1. An Acute Inhalation Toxicity Study of T-2306 CoC in the Rat, 12/31/79 004649 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-6023 SORTED by SUBMITTAL DATE 3M's TSCA 8(e) FLUOROCHEMICAL SUBMISSIONS Docket 8EHQ-****-8624 SORTED by SUBMITTAL DATE O o DATE SUBMITTED rltatc Logged As Received By ERA) 11/30/92 (12/7/92) EPA CHEMICAL REFERENCE SUBSTANCE/ NUMBE-R" W m PRODUCT SUMMARY i'J" OF SUBMISSION 8EHQ-1192-8624 Lithium perfluorooctane Acute oral and inhalation toxicity data in rats sulfonate 12/29/92 (1/5/93) 8EHQ-12928624S Supplemental Information on Lithium perfluorooctane sulfonate Toxicity and teratology studies in rats and rabbits ENCLOSURES 1. Lithium Perfluorooctane Sulfonate: Acute Peroral Toxicity Study in the Rat #91N0016, 6/23/92 2. Project No. 91-8379, An Acute Inhalation Study of Lithium Perfluorooctane Sulfonate in the Rat, Final Report, 5/26/92 1. Report Summary of 2-Week Peroral (gavage) Minimum Toxicity Screen (MTS) in Albino Rats 2. Summary letter on range-finding and definitive teratology study - rats 3. Summary letter on range-finding and definitive teratology study - rabbits 4. Summary of range-finder for 90-day feeding study SDUABTMEITTED ENRPUEAFMEBREERNCE (DateIoggcdA$ R cd (ve d B j^,m M A J(HtX 11/19/99 8EHQ-1199-14596 (11/23/99) 01/28/00 8EHQ-0200-14596 (02/08/00) Doc3kMet'8sETHSCQA-**8*(e*)-1F4L5U96OROSCOHRETMEDICbAyLSUSBUMBMITITSSAILODNAS TE SCPURHBOESDMTUIACCNATCLE/ SUMMARY -, ,4 - \ Ammonium Perfluorooctanoate Perfluorooctanoate Summary of 6-month primate feeding study Response to EPA request for description and results of 3M medical surveillance program 1. Gilliland FD, Mandel JS. Mortality among employees of a perfluorooctanoic acid production plant. J Occup Med 1993;35;:950-954. 2. Gilliland FD, Mandel JS. Serum perfluorooctanoic acid and hepatic enzymes, lipoproteins, and cholesterol: a study of occupationally exposed men. Am J Ind Med 1996;29:560-568. 3. Olsen GW, Gilliland FD, Burlew MM, Burris JM, Mandel JS, Mandel JH. An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid. J Occup Env Med 1998;40:614-622. 4. Olsen GW, Burris JM, Burlew MM, Mandel JH. 3M Final Report: An epidemiologic investigation of plasma cholecystokinin, hepatic function and serum perfluorooctanoic acid levels in production workers. St. Paul;3M Company. I 0046