Document XR7O20LRKjg8nMpwwYLOz4eBw

Dre Jula Gordon, Chsraiea The Cor.aifc.tea of the Progressive . Hair Bya Industry Roosb 5LQ5il S cot 42ad gfcreat KawYc-'rl;, nowYork 10017 Dajar Dr. Gordon: Se'hsv completed the revLawof tha oarporiicatifcei data and other aatcrlal subsaittad by you on September' JL,1965 in support of your request for pro visional lioting of lead eait hair colors, Via regret the iuortiinste delay in this reply. tfa have ccncludad that the data submitted ia inadequate to deeaoastgata , gafoty of lead ealt hair c-aiorg in general or of the particular prepare" t'ions tested. The work thus far carried out, rethor than desoastretins safety, raises certain questions which will require additional ` isivestigation. TLa 90 day rabbit intact skin study shews a trerIy tenfold increase la bone lead content for the high test level 3 against tha controls. The inference oust be caco that thcro Is absorption and partial ctorega of lead in the boaee. liowever, it ia cor. clear fresa the data cuL-aittsd whether the animals warn eulfcebiy restrained at all Ciwae during the study. There it therofera the possibility of ingestion frea self greening and licking of residual material off tha back In which case the results of tha study weald bo invalid. If ingestion by solf-girccaiog waa prevented, than the cniy conclusion Chat can be drawn is that there io significant penetration through tha intact skin. If this conclusion 13 valid, it would not bo in the public internet to lict load ealt hair colors. You have reported the leed content of urine acoples fresa 105 regular usare of cad cals hair coloring products. Ife do rot, foal that the urine load content clona ia a sufficiently relir.Ho indicacin of land absorption. f| Relatively recent reports in the liter aturo * PUS Publication #1440, j Hsxch 1966 for cxasplo >--have censad us Co recsese tha typo end estent 1 of studies which wo believe ere necessary for permanent listing. We : . i? bava -sii':' 'o-aeiv-aJ V:.* z -jy-tr. vv X ?>, i. O'- i ,!.: . ' : .. escth e seas e woald In -s/ru i hd ^SSTliT" *taatisTTho*:rf o r v tc- 'v o v ia ili-a a li- v : ..' I. . rr zi. t i :. i'ai.:.x r-norc. B0 b o lia v s r o a t t it # r ^ s Cha o l l c w i t v ; ls v * e Ci g s tio x ts shou.L ,c a v ^ llr - le b a f o r a l t e l o cea be. n ttn s id s ra c .w3 (<'.) A c s t t e s a i t o i i i c t t y 'fit/T!Ytf 5#"aStjai. -ila <?.;$ * jereus liOOVf. che:. Vr ::' '. il T."- vv> :... ir: <>0 .- ;, .'1:.<'.'- ' (2C T: .':, a .: :j a c r ;... ...;-.-.i 1: ; ;; . ' .' 8fe&c<#*iu r>i D r a i i i . 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