Document XR5zwzV60337KVRZ3o2QegMvG

R&S 026763 Abstracts of Papers for the Fifteenth Annual Meeting of the Society ofToxicology. Atlanta, Georgia March 14-18, 1976 3. Cole of [uC]t`in'.l Chloride rdlox'irtc Inhalation E\pott.re at Puts. P. C, WvTsN.snr, O. It. McCuw-sx. K. O. M adriu and I'. J. Gniur-e. Toxicology Research l.ahoiaiory. T he I)ow Gnomical Comr-m\. Midland. Michigan. The ob's-enve of the present study was to determine the rate of inhaled fuO|\ii:s| chloride (,JC-VC) to Ji't'ent'ii exposure con-'en'.rat'.rsn.v in rais. Male r-,ts "ere cxpv.ed u> 10 or 1()(X) ppm p'CJvr for 6 hr and die routes and rate, o; chinu-adici'. of ,JC act.v itv were followed for 7? !,t after to-tr.iitatinn of exposure. Boilowh'.g c'rosute lo 10 pp.n Vi.', urinate 'V activity arttl expired VC comprised 6S a .id 21',,. rcsp.vtneo. or ihc icvnviieJ r.uh oacinits. Alter exposuic to JO'.W ppm VC, iltc p-opornon of lire radioactivity in i!,c uin.e devicased while that expired at VC increased, representing 56 and 12.,. rc'pvcuvclv. T he paitern (if pulmonary elimination of VC per sc was described by similar inonoesponential processes following 10 or 1000 ppm with respective half-lives of 20.-1 and 22.4 nun. fhe elumnaiion of "C in the urine was described by a bicxponemial pioccss: ihc half-lit vs for the initial phase ofcscrciion wcic 4,6 and 4.1 hr following 10 and 1000 ppm. respectively. T he pcreeni.ip.e of the iccoseied i*C remaining in the carcass after 72 hr was 14 and I 5 "..at ihc respective low and hu h exposure levels. The HC remaining in the (issues was composed primarilv of nonvol.mle mei.tbohtes Ol VC inihcr lhan VC per sc. The urinary 1JC was separated by hieh-prc"iire liquid chromalograpfiy into Ihrce major mciabolitc.s corresponding to .\-a.civl-.S'-iZ-lodroxyeihylicysicine, thiodiglyeohc acid, ami a third umdcntiiied metabolite. Tb.e proportions of die urinary metabolites were not markedly influenced by the exposttie magnitude. The fate ol inhaled [<JC]VC was shown to be dosc-dcpcndenl and this is consistent with previous studies on the fate of VC following ingestion. / 144. SniH/rv Irritation Catartl hy the Decnntpo'itioii PrcP.ucts of Po/ri rtvl Chhni.'.e. Citxlii S. Bxttr.ow, Vvrs Alvkii and Makv.vnvc f?. Stocc. Dep.iiimeiii <if CJccunjiio:i.il Health, Graduate School of Public Health. University of P.tuburgh. PitisUurgh, Pernio Ivaniu. The evaluation of potciati.illy ipxic gases lias come to be iccngm/cd as one ,n the stilient features of fire toxicity .This s'ud>' was undertaken to quant itaie il-.e vie vice of sens, >i y irritation to the upper respiratory tract of mice to the decomposition products of ihrce diil'vreui I'oi tivalalions (A, }1, and C) of polyvinyl chloride fPVO. J'clymcr A contained a pl.istieie.-r. polymer B contained a plasticizci and lire retardant, and polymer C contained neither plaxtici."-i nor lire retardant. Groups of thiee tv) four male Swiss-Webster mice were expo ted to the den 'inposition products of appro.sim.ucly 50-60 mg of each polymer. The the: mogravimeti ie analysis of each polymer demonstrated that two distinct weight loss fractions occurred duiing me de composition process. By varying the dilution air through the exposure chamber a range of exposing concentrations was obtained for each weight loss fraction. Dosc-rc;poii'e curves were plotted by utilizing the percentage decrease in respiratory talc during cadi exposure as ipc r,-i;vin>' parameter. Ire result': shower: that m terms of -or;. ;n italic.'. I'VC-A > i'VC-ii > I'vC-C tor the tusi weight loss traction. Similar comparisons wcic m.i.le for the second weight loss fractions. Based o;i this work and previous studies of sensory lunation iu Olivet .liil'pino chemicals, piedictions of ciualiiati'c and uuatiiitativc human icsponses to sensoiy irritants such as the decomposition, products of J'VC are possible. iSupponcd under Research Grant No. 5-S005 from the National Bureau of Standard-.i *>*.*, *.;*.*