Document XOJ7Lwm3YgxQ65dkxXp8E1w3K

July 1971 XYLAMINe production ano physiological measurements in subjects ingesting sodium cyclamate. ____ and A. A. B. Swan. Tax. AppZ. Pharmacol. 18! 535-541, March 1971 H. * ' ejects capable of metabolizing cyclamate to cyclohexyl amine ingested 5 g. sodium cyclamate 7 or 8 days. The conversion to cyclohexyl amine and consequent absorption was followed by i*1'^ urement of the amine in consecutive 24-hr urine samples. The maximum daily excretion of *** "^eXy1 amine in 5 subjects in a total of 69 volunteers ranged from 0.1 to 0.9% of the daily cfclal omh ate intake. It was concluded that no pharmacologically active concentrations of cyclohexyl amine eye reached in the tissues of these subjects capable of metabolizing cyclamate after daily ingestion **Jarge amounts of cyclamate for a week or more. --Cond. from Authors' abst. of INDUSTRIAL DUSTS' COMPLICATIONS OF ASBESTOS EXPOSURE. 0. R. Gracey, et al. Cheat 59: 77-81, Jan. 1971 nie patient described in this article developed a malignant pleural mesothelioma more than 25 years following brief employment In an asbestos processing plant. The authors discuss the relationship between asbestos exposure and neoplasm, the Intriguing subject of co-carcinogenesis and the potential hazard to urban dwellers from the Increasing Industrial usage of asbestos. Pleural and parenchymal fibrosis are conmon radiologic features of pulmonary asbestosls but are by no means unique this disorder. Similarly, pulmonary function abnormalities may Include the entire gamut of shyslologlc changes, depending upon the stage of the disease, complications and associated pathologic lesions. Unfortunately, no treatment is possible for this type of mesothelioma other than temporary palliation of the pleural effusion. --Cond. from text MORTALITY IN TOE CHRYSOTILE ASBESTOS MINES AND MILLS OF QUEBEC. J. C. McDonald, et al. Aroh. Environ, ftaitk 2H: 577-666,"June 1971 Of 11.788 persons bom between 1891 and 1920 employed in the Quebec asbestos mining Industry, 88.4% Mere traced. Of these 2,457 (23.6%) had died. Exposure indexes for each worker were calculated from job dust levels and duration of employment. The overall mortality was lower than expected for the population of Quebec but in the highest dust category, comprising 5% of the cohort, the age- standardized rate was 20% higher than in the other groups. Respiratory, cardiovascular, and malignant diseases In equal proportions accounted for the excess. There were 101 deaths from respiratory cancer including three from malignant mesothelioma, an estimated excess of about 15 deaths. The difference In rates for respiratory cancer between those maximally and minimally exposed was fivefold and, though perhaps exaggerated, was apparently determined by accumulated dust exposure and duration of employment. --Authors' abst. iiitor'a Sote: In view of questions raised in the past concerning the findings of the study conducted y IHf in 1957, it is extremely gratifying to note that the above study, which was more extensive and involved a longer period of observation, effectively confirms the conclusions reached in our study regarding pulmonary malignancy among chrysotile miners in Quebec. --O.C.B. PHYSICAL ASPECTS OF THE ENVIRONMENT ^OlSE HAZARD METER. J. H. Botsford. Am. Ind. Hyg. Assn. J. 32: 92-95, Feb. 1971 A noise hazard meter has been designed to evaluate a noisy environment in terms of the anticipated -enporary threshold shift (TTS). The instrument presents an electrical analog of the component the TTS. The noise hazard meter was tested with a group of normal individuals in a noisy *nviromrent. Encouraging results are reported and further studies are planned. --Author's abst. 19.