Document XODyex7vbN51RyqxKDKBV1Gay
FILE hb. j:^: .X a: -A: l:.:^? ID:HH:-:.IELL Ln& ra-.IOjLOaV
'.
AR226-2364
::02 :W 'aC-7
PmjE 1
DRAFT
^_
).
\ .
I j
\J
\
Proposal to Condiict a General Human Heatth and Environmental Effects
Fllak Analysis on C-8
W7 The purpose
environment
of this hom
project
is to to
evaluate
the
risks
to
human
health
and
lha
and
disposal
of
exposure C-fl during manufacture, C-8. The analysis Will be conducted in
transport,
product
uss;
semi-quantitativa
estimates
of
risks
so
that
exposures
a fashion that wdl provide yielding the hi'ghast risks
can be identified and recommendations on reducing these risks can be
adewvaelyotpheadt.wiRll is(akcsltfirtaotme fmutaunruefcaocmtuprea,ritsroannsspoofrtriasnksd product use will developed in
alternatives. conduclod in
The
project
will
bo
conducted
in
three
estimated tor potential C-8 parts. The first two will be
parallel, in which human health and ecological risks will b
ccohnatrraicbtuetreiztehdfl. hTinlhioBsfitnrailskpsarstowtilht adterveecloomp mcoenncdluatsiioonnss toonr roisxkpoaurea that
strategies and alternatives can be davaloped. months to complete
Tha project
management is estimated to take 12
from the Bme of initiation. The Exposure analyses listed
pbreeloswenwteildl raesqsuuirme ecoallFabebo.raIt.ion witf!uwipUpraoppprrioavtaelpdlaanttep.)ersonnel. (Tha dates
Scope:
I.
Human Health Risk
A. Hazard Identification
\
Tims Line
4/18/9^)
Esi. Cost($)
SOOO
Hazards to human health critical toxfcity flndpoints
will
ba
reviewed
and
summarized
in
this
section.
The
of relevance lo human health risk will ba identified and
potential dosimeters to be used for interepecies extrapolation of risk will bo discussed. The Haskell toxfcitysummary will be updated as part of this
task.
B. Dosa-Flesponsa Analysis
8/30/9^
cTohnodduocatien-groeponsB characteristics of 0-8 Wilt be evaluated.
43,200 This may include
benchmark dose analyses to identify no-obsarvod adverse effect levels
dwehvoerloopneedcebsassaeryd. oAn ptphreolpikreialytemdoodaienroieftaocrstiofonr. inTthearspecies extrapolation will atao bo
ba reviewed.
If
possible,
rudimentary
pharmacolcinetics physiologically-based
of
C-8
will
also
dapopseroraeclahteiosnwshillipbsewdieltvbeelodpeevdetloopfaecdiliintattheisinptehrasspeacies extrappohlaatrimonacoofkriinsekt.ioRsisks vs.
C. Exposure Analysis
Reasonable
exposure
scenarios
tor
C-8
will
ba
9/30/97 developed. This
are
16,000 likely to
airborne, durations
drinking of
water,
dermal,
and
other
oral
ingestion
pathways.
include Intake rates and
(rr>i> i". -i---ex-po-su- re will be developed. Masked will work with an aastnni*/* norcr>.^'
Tnhaaensueiidwatiamwdi!a!tbaaotnabcuolnacteedn.traMtinonntseoCf aCri-o8 m
tho
-a-f-fe--c-ted-..--mekd.^iwali(iawt.r',^
I> ^/lUVIUc*
water, soil).
expected upper data. The
confidence
limits
for
these
techniques exposures,
may be used to calculate depending the availability
of
cost associated wah this task includes only Haskell personnel time-
D. RisHCharactanzaiion
Risks
will
be
summarized
according
to
the
major
12/15/97 routes of exposure
16,000
(air.
dermal, other oral) tor each disposal). Tha risks will
C-8
application
(manufacture,
transport,
water, product use.
2
concentrations to the be characterized by comparing the likely exposure
N
to as a Margin of Expodsoufiree-.reTshpaoncshaarraeclatetiroiznaslhtoipn. wTilhl tperomveitdheotdheisrgieeknmeraanllaygreefrewrriethd S3
o
EID092861
EID092861
;+;'-' t::- Qy- rJ. "K 1^1 '.^."^fi.JL LH& TCKI'-'CLGGV
502 ?56 5207
DRAFT
information the highest
that risk.
wit help The
Identify
the
operations
and
exposure
pathways
thai
made
of
potential
characterizations will als'o enable risks posad by C-8 alternatives.
future
comparisons
present to ba
(I
Ecological Effects
/ \ A. Hazard identification
Tima Una
Ear. Cofit($)
Hazards 10 key environmanta! summarized in this
haaltn
indicator
species
wBI
tie
reviewed
and
tha currant (Iteraturasescetaiorcnh. , Tchhreocnriictisctaul dtoiexsicity endpoints will be identified. BaKed on
undertaken.
Avian
reproduction
and
avian
In aquatic food-chain
species
will
need
to
ba
assessment; PK data and
however E Fata
this
may
be
extrapolated
using
accumulation will need mammalian toxicology
part of this task.
Information.
The
Haskell
toxicity
summary
will
be
and PBupdated as
1.) Hazard Assessment
/
2.) T(Teshtiisng (Fish ELS and Daphnid Chronic)
9/16/87 a/15/sr
$lb.w0
iB with statte renewal and analytical) 3.) Avian (if needed)
)
$80.000
8/15/87
580.000
B. Exposure Analysis
'q
'
Reasonable exposure enulronmonta!
scenarios
tor
C-fl
win
be
developed
For
the
higher
respective
exposure disposal sites
areas and a
at the three customer
manufacturing
sites,
including
their
will be developed.
Haskell
will
work
with
site. Intako an assigned
rates and peraon(s)
durefa'ons
of
exposure
ahnedlpwcahsatreacdtiesrpizoesatlhese exposure pathways for manufacturing, trfarnosmpothrta, pplraondtuscitte to
concentrations
of
operations. Tha G-8 in the affected
business media
wilt
provide
Haskell
with
data
on
use,
tabulated. confidence
Monte Carlo limits tor
techniques
may
be
(air. water, soil). used to calculate
These data expected
will
be
these
exposures.
depending
or
the
availability
of
upper data. The
cost
associated with this task includes only Hashe!} personnel time.
1.) Exposure Assessment-Washington
2.) Exposure Assessment - Dordrecht
Works 6/15 8/15/E
3.) Exposure Assessment - Shimlzu 4.) Exposure Assessment - Customer
fl/15/5
10/tS
D- Risk Characterization
RISKS will bo summarized (water, soil. air) for
according
to
the
major
media
of
environmental
disposal).
Tha
each C-8 application (manufacture, nslo will be characterized by
transport,
product
exposure use,
Environmental (PNEC). This
Concentrations
(PEC)
to
the
comparing the likely Predicted No Effect
Predicted
method characterization will
fs
generally
referred
to
as
Hazard
Concentratiri""Quotient. The
t1h11e0
operations
and
provide the risk manager exposure pathwa-y.s.,,.._,,-.
w.i.t.hn
IiniiifuoirimnaailKioinn
tinhat
will
help
iidentify
,,ch--ara--cte- rizat-ionswill posed by - -...,,.-.....
TMalsoou
eennaabQlies
that pnreosfnen>t .the.-hig--hae-t--risk.
fluiture comparisons to be
T-- he
C-8 alternatives.
made of potentiafl risks
,
12/15_/.9_7/
16,000
III. Recommendations on Risk Management Strategies and AHematii
This section ecotogbal
will
evaluate
collectively
the
risks
12/15/8A fdentHled to human
4800
hoalth
which
receptora. Based On these operations could be targeted to
analysas,
raRommandatfons
will
and ba made
as
to
most cost effective manner.
This
will
ensure risks are appropriately ba a vary subjective
managed
in
the
require tome intaraaction with the appropriate poopte frometxheercbiussein(neasrsr.ative) and will
ESD092S62
Fm;
S ^
EID092862