Document XO3QK0rKeLE0jneD1v1Y0e2DK

*0*0000 AS# \ - tfCDipf ^ ^>5 ,.-,- JHMs ***??' -S' ... ' . -j; y " : ' f \KTi^<^i^ &W -tf/\> v ,-S, -v-^ MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W WASHINGTON, 0, C. 20009 (202)483-6126 May 15, 1973 To: TECHNICAL TASK GROUP ON VINYL CHLORIDE RESEARCH Subject: Schedule and Agenda for Meeting on Monday, Mav 21. 1973 Gentlemen: The management representatives of the sponsors of the Vinyl Chloride Monomer Research Program have decided that it is best to discuss the vinyl chloride monomer problem with NIOSH, on the basis of publicly available data, with out delaying until the release of presently restricted data. They have asked the Technical Task Group to prepare their recommendations for the technical content and format of such a presentation. Enclosed herewith is the outline that has been pre pared by Dow. No prejudgment is offered in their proposal, but it will serve as a convenient basis for discussion at the meeting called for this purpose. The Technical Task Group will meet at 10:00 AM, Monday, May 21 in MCA's Conference Room (Room 404). If you or your alternate are unable to attend, we would appreciate your telephone report on your views before the time of the meeting. You are probably aware of the action of the Food and Drug Administration (as announced in the May 9 issue of the New York Times) suspending the approval of PVC bottles for packaging whisky. As of today (May 15), official notice of such action has not yet appeared in the Federal Register, so we have no firm information on the basis upon which this action has been taken. It is hoped that their data can be studied and evaluated before the meeting of our task group. Sincerely, KDJ:mb Attachment cc : Mr. A. C. Clark Kenneth D. Johnson, Ph.D. Assistant Technical Director Occupational Health RSV 0000402 OUTLINE OF PROPOSED PRESENTATION TO GOVERNMENT Presentation A. Government - Dr. M. ^Key, Director of NIOSK and others he may suggest as a resul.t or a preliminary contact to set up meeting. MCA - K. Johnson and/or G. Best of MCA. Industry: Technical Business Dow V. K. Rowe G. J. Williams Goodrich Shell 4 H. Kusnet^ A. Vittone or T. Nantz 1 UCC D. C. Dernehl What should be presented - A. U. S. companies represented by presentation. B. History of Toxicity Studies 1) Review of past toxicity studies 2) Past epidemiologic$al studies Acroosteolysis 3) Work reported by Viola 4) History of TLV's (lit.) C. Toxic Work in Progress 1) MCA toxicity studies 2) MCA epidemiological studies 3) Meaningfulness of work in progress. (What questions will be answered or go unanswered.) 4) Dow work in progress. RSV 0000403 D. Assessment of the whole problem - Review of vinyl chloride and PVC industry and hov; it relates to toxicity problem. 1) Production (U.S. and world) a) Volume - past, present, future b) Producers c) VJorkers exposed - number d) Exposure levels 2) Uses a) PVC i) ii) iii) iv) Producers Uses and volume of Number of workers Exposure levels each b) Copolymers i) ii) iii) Uses and volume of each Number of workers Exposure level c) Aerosol i) ii) iii) Volume and use Exposure level in use Estimated number of people d) Other i) Intermediates E. Recommendations for Action 1) Control a) Discontinue use in aerosols b) Lower TWA to 50 ppm (Reassess after work in progress is completed.) RSV 0000404 2) Future research a) Toxicity studies (additional) i) Establish dose response for carcinogenic action. This will require large numbers of test animals in order to be statistically valid. ii) Determine mechanism of action Investigate effect of high concentration of VC1 on (-3H). If (-SH) is reduced, then establish dose-response? then attempt to counter act by supplementation with (-SH). (If action is as hypothesized, then strength of a no-effect concept is markedly enhanced.) 3) Establish working contact at NIOSH Solicit NIOSH participation in whatever toxicology program is adopted. (Consultation, advice, support in whatever context seems more appropriate.) RSV 0000405