Document X7Drq2XqmGn5Req8QaKgQm9mB
V
<
Mr. Theodore R. Torkelson, Dow Chem. Co., Midland, Mich.
Feb* U, 1966
<
I would very much appreciate your comments on those of D. Lester.
H E Stokingar
R&S 131905
'(,. -_ - K.--V- .-
'. ..
' **,
- ...
' .`.
,'' ,
.`.i
m "a. CJ
RUTGi-RS THE STATE UNIVERSITY
-.- ^
stvcs-s
Sr-3 MVNJWSCS. NT JI3Air ("?>
feoroary * , !,ipco.
D ". !- erber: S;;i; ;Vf
u. ;.. r ,;:* ic
jcruics
iC'.h irc-auway
C ir.oir.nati , -hio 4^201
'' f -
.'j \TMt- *.-fj :* 1 i .: "*
. hear. 3r; St&kirq-srp.= *
*- * -.. I .0* I
k.^ >-* '
j should !ika to offer ccrrsents ^d-out-proposed revisions of the
Threshold Ucalt Values for tnree expounds which ora to be acted upon-
the r.r.xt o'eetirq of the ACSIH.'
The ccnocunc'-, su? J, i-dlcMc-rs`.b-y-ha (CH-Ci-C J.?} , J .E-dicaloreEhy sere
` -V-^y; - *> tv** - f* ^ >-
- *>-_
Vk tM* *h.<*'.tV1-
(C!Cr;CHvO 3-is virsyl cotoride V-h?:, t *=.C i) it i i* ^-.-"pCatsC to raise
the 7LV frra iv.- i.-i'i 2;i e -n-to
for Cirzz >o c.rpoc-nd?.
.T3 ! ow r the r tv rren :3tv' ->.<". to >') ; ci-i for vi. .-;' uh !or;b?,,
To the i'-st of tcrf -v'-c vSehp;, -.: - .-nr?, no ~-zrs recent hsca on
tie texicofopy of v iny i
j ,`r i d i i ~ c * ..lot
; o. i .'
.no }o:;c j
pepei; based on this c;it r*c=sat evi
! cro ccc* rs rccson Xo
!^.-.'?r the TtV fo- v i rv i - r> I or i c-j . T -. rhs ccntr*r~:y th. oroeasal to
re;: the TtV ;o;
.jrr*;*S
-. ;; y ; t - -. *. eteeii-...
c; ;p. j o;;.e <1
. Voch I, -d:ch;cr^ t'rt5 and
I i-;rh c-rcetny Jer-? y fco ?,*.pe-c t to tO`fav*f d
tet:city thci
;1 i emor lie * . / '
I ho f ''. r o':)
'ao;y rpro sb--".*."-! oo; 11 e - eo; *ir * ' U i tr 4 V . ) V-T I ( V 4 r a 3
*,'- : :o-i:o iri ror
*- J
--
141 .V> 4`^w-f f- -l- Vr-- -J
. j ? j t -.: r-:
l y,
: ..cl; nj.-,'., ':. t ` /{ .; --' ... ;'... . r
'..:v '. :::.*. tr^o. .
R&S 131906
'n toe ir-5p<r.-*u air rn-^ r--. :M inc
--it rat ii-"*
c -r.;! H t i no
L-
itr--haVfr'fci,
,
rCTi'i i *! 11 `
C* '
Or. nerbert Stokincer
_ *> --
February J
bleed will Pa 'ess (by o wide margin) for vinyl chloride than for
either of the ether cc-pccnds. If, r-r>r these emoourds, si<n35er
concentrations in the bicop also rwy be exnected to give similar
effects, then tnese effects will be ; =$5 for vinyl chloride at equal
concentrations of these materials ,'n the Inspired air. That this Is
. actually the cose io borne out by the fact that th-2 toxicity of both
i, 1 -dlchiorocthn<r end 1,2~3ichlorcetw,y lene are rn?ortediy greater
then for vinyl chloride (sea ?. A. rJtty, yo>, 2, Toxicology J?62}r
concentrations of the order of 16,070 -pci for ***-3 hours ore lstha-4;:
chronic exposure to 16<>05.73CO ?p;n of the cis Iscnsr of I,2'dichloro-
ethylene leads to loss of n.'-mtlto, decrease cf body weight
pathological changes In lungs, liver a-.d kidney.*. 'Of* tho b-tbsr.Kmal,. '
exposure to 50.GCD
of vinyl chloride for 8 hours per day for J3
days give nc indication of l;thalct*/, r:r did expo-sore to 1C?,CC9
ppr for 16 hours resuit in r-vjth; r.o tc'-icity wes noted vrhen a $2
day, B hour per oy exposure to I3,CC7 p,.n was rode.
fir
Thus, both t^e acute end the chronic features of the *tox5co\egy
of the dichloro- compounds indicate a g->-oter toxicity chan for vinyl
chloric, What justification can there the ip6S TLVc? .
therefore, for reve-jirg -
Thi cm scat 1 ini to fer, tr.e three co--rvmds set n h -it in e g rr
v>1t-> the evidence;' thase lirits *re in
order pf
hoping
sn'rtt of the coroncnds, * h :% era con <.?- ? - ; with f ; chlorine U-^ir.p
wfl, ibove all, :hcv taka oct '.rt r-f vrt-*-. ; r,r?--r - ' 'rc>r tPx.roic-v,
w1
y... ...i .w - `>4
--- a
` 'hi
- . f'
1 I