Document X73d8gdn7V4b2dJggeXL3e8oy

BIO-MEDICAL RESEARCH DOCUMENT DESCRIPTION FORM Duplicate in all cards:--> 63 68 --------- 1 / i, year as-1961- 69 76 ^ ^ 0 n ej * File number [Right justify [Numeric only] Author(s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 20 21 pa 40 41 77 78 Sub-Index Code 60 61 62 ii 12 13 Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. ,, ,,,, 61 62 21 22 23 24 Source (Journal, Vol., Number, Pages, Date ) 12 .. __ / 'f f*> 61 62 31 32 Brief Summary 12 10 SUMMARY: 61 62 61 62 63 64 el (he results will be given in 1 1/2 years from now when a 5-year prospectrve study is completed. SUPPORTED BY Universitat Ulm funds n a. 0646, CEMP modifying effect of diet on upper ali mentary TRACT CANCER IN CHEWERS AND SMOKERS P,N. Notani, Cancer Research Inst.. Epidemiology Dry., Dr, Ernes! Borges Marg. cVo Tala Memorial Ctr., Bombay 400012, Maharashtra, India (D-IARC- 79-270) Tobacco chewing and smoking habits carry a high risk lor oral cancers, yet not an those who chew or smoke heavily get the disease. This indicates a role lor other lactors which may have a modifying effect on these risks. Preliminary analysis of existing rec ords indicated a reduction in oral cancer nsk in per sons with tobacco chewing and smoking habits who took eggs, meat or fish (Ind. J. Cancer, 13, 1976). it is intended to devise methods for collection of di etary information, confirm preliminary observations on oral cancer by a case-control study and extend the study io cover pharyngeal and esophageal can cers. SUPPORTED BY (No Supporting Organization Re ported) funds n.a 1.0647, B I LOPT OCCUPATIONAL DISTRIBUTION AMONG LUNG CANCER PATIENTS COMPARED TO THOSE WITH CHRONIC BRONCHITIS, BRONCHIAL ASTHMA AND SARCOIDOSIS IN BERNE M. Scherrer, University of Bern. Outpatient Clinic, Dept, of Internal Medicine, Fre/burgstrasse. CH3010 Bern 3012, Switzerland (D-IARC-79-531) it is believed that with a highly developed modern industry various carcinogenic substances are pro duced (synthetic materials, metals etc.). Inhalation of noxious materials at work may. therefore, be a fur ther cause of the development of lung cancer in addition to smoking. The distribution of different oc cupational groups among patients with lung cancer and selected pulmonary conditions is being studied in order to find out whether workers in the chemical, ynthetic or metal industry are more frequently af- acted than other occupational groups. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 1.0648, B I L0 PQ R T EPIDEMIOLOGY OF GASTRIC CANCER IN NEW FOUNDLAND C.J. Pfeilter, Memorial University of Newfoundland, School of Medicine, Laboratory of Investigative Gas troenterology, Health Science Complex, St. Johns. Newfoundland. Canada AlC 5S7 (D-IARC-7S-96) The purpose of this epidemiological investigation is to: (1) characterize the demographic and statistical pattern of gastric cancer in Newfoundland by region al analysis and international comparison, (2) deter mine high and low risk geographical regions and occupations of the male work force, (3) quantitatively study water trace element composition Irom highand low-nsk sectors, as well as other indicated envi ronmental, or geochemical facto's, (4) relate such findings to incidence of cancer of all sites combined and death attributable to all causes, and undertake, on a comparative basis, an analysis of occupational nsk and water trace element correlates with gastric cancer in the high and low risk areas of Iceland and Japan. Data from Newfoundland. Iceland and Japan will be analyzed in an identical lashion by stepwise, muitivanaie analysis. Statistical and chemical analyt ical work will be conducted in Canada. SUPPORTED BY (Np Supporting Organization Re ported) funds n.a. 1-0649, AU mutagenicity studies on new PESTICIDE FORMULATIONS AND FOR OCCUPATIONAL chemical EXPOSURE I Dinu, Academy of Medical Sciences. Inst of HySiene & Public Healfh. Dept, of Food Hygiene/Toxiw|ogy. Sirada Bisenca Amzei 22. Bucharest. Roma nia New pesticide formulations were tested for rheir abihhr to damage hereditary material The main criteria of choice were Wide distribution, targe production and high chemical reactivity. The following test proce dures were used- induction ol reverse mutations His negative to His positive in S. tvphimunum auxetroph strains TA loo and TA 98 (Ames et at. method 1975) tor detection of mutagens; the clastogenic effects ol the tested substances were also established in some "in vitro' experiments on human lymphocytes cultures and 'in vivo' on bone marrow cells of rats. Eight of the tested substances showed genetic activityin at least one of the test systems used. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 1.0650^^ BLOPUV `REPRODUCTIVE OUTCOMES ASSOCIATED WITH PATERNAL EXPOSURE TO VINYL CHLO RIDE MONOMER P.A. Buffler, University of Texas, Medical Branch at Galveston, School ol Medicine, Dept ot Preventive Medicine & Community Health, 300 University Btvd.. Galveston, Texas 77550 The carcinogenic potential ol vinyl chloride has been described and, recently, vinyl chloride has been de scribed as a mutagen and a teratogen. Recognized fetal wastage has been established as an indicator ot mutagenic effects due to environmental or occu pational exposures. A cohort ot 249 men who had known exposure to vinyl chloride monomer (VCM) and who were currently married were identified from the work force of a major chemical company. A comparison group of non-exposed male employees wifh similar socioeconomic characlenstics were also identified. An interview methodology was developed to obtain complete reproductive histories from the wives ot the employees. Data for each pregnancy outcome will be correlated with the husband's work hislory. Only those pregnancies which occurred while the husband was exposed to VCM or within the subsequent three months will be considered 'at risk'. Data regarding other factors associated with preg nancy outcomes has also been collected. Analysis is near completion and has locused on fetal death, congenital defects, fertility rates and inlant mortality.) SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 1.0651, BI LOPT RADIOIMMUNOASSAY OF CEA AND AFP AS A SCREENING TEST IN THE SURVEY OF HEALTH OF WORKERS IN THE CHEMICAL INDUSTRY M.A. Ivanescu, Ministry of Chemical Industry, Labour Protection & Hygiene Centre. Radioimmunoassay Laboratory, 59 Pop de Basesti. Cod 73244, Bucha rest 3, Romania Selected groups of workers with exposure to vinyl chloride, benzene, chromium, ammo-compounds, and black carbon have been examined since 1975 by radioimmunoassay technics. The results are cor related with numerous laboratory and clinical data in order to evaluate the possibility Ot using RIA of serum or urine CEA and AFP as a screening test in the survey of health of groups of workers with occu pational cancer risk. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 1.0652, BOPT PRENATAL EVENTS AND CHILDHOOD CANCER At Munoz. Centre International de Recherche sur le Cancer, Interdisciplinary Programme & International Liaison, ISO Court Albert Thomas. 69372 Lyon Cedex 2. France (D-IARC-79-178) This programme uses material from established prospective studies to assess the rote ot prenatal events on the incidence of congenital malformations. The Oxford study was started in 1972; by December 1977 cohort of 18,000 had been assembled. The pregnancy records m this study contain information cn illnesses during pregnancy and on exposure to drugs and chemicals; two or more antenatal serum samples and one postnatal sample were collected (or each woman admitted to the study. The Hungar ian study dates from 1975 and now consists of the records ot 12.500 pregnant women. In this study also antenatal spectmens will be available, in addi tion to the pregnancy record. The children born to women (rom both these studi.es are being followed to identity those with congenital malformations or cancer. The occurrence ot these diseases will be correlated with specific intrauterine exposures re corded in the pregnancy records, and the serum specimens and controls will be used appropriately SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 1.0653, BCELPT EPIDEMIOLOGICAL FACTORS IN URINARY BLADDER CANCER W.E. Vahtensieck, Univ. Hospital Of Urology, Venusberg. 5300 Bonn. Nordrhem Westfalen. Federal Re public ol Germany (D-IARC-79-203) Information is being collectec from patients with uri nary bladder cancer on occupational exposure to carcinogenic factors, contributing geographical fac tors. eating habits with particular reference to sac charin and cyclamate. tobacco and alcohol con sumption, drug abuse and metabolic disorders SUPPORTED BY (No Supporting Organization Re ported) funds n a. 1.0654, B F LO P S DISCRIMINATION OF OCCUPATIONAL AND NON-OCCUPATIONAL MESOTHELIOMAS IN CLUDING ANALYSIS OF DUST PARTICLES AND ASBESTOS IN LUNG (A8BREV) H. Otto, Pathologisches Institut der Staedlisch. Klini- ken, Beurhausstr. 40, 4600 Dortmund, Federal Re public Ol Germany (D-IARC-79-205) At the Institute ot Pathology of the Clinic at Dort mund, the Hauptverband der Gewerblichen Berulsgenossenschaften has opened a central regis ter for ail cases of mesothelioma. The Berufsgenossenschaft will request lung material lor analysis from the surgeon. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 1.0655, E HORMONAL CONTRACEPTION AS A FACTOR IN GYNECOLOGICAL CANCER H. Radzuweit, Frauenklinik Bezirkskrankenhau, Thiemstrasse in, 75 Cottbus, German Democratic Republic (D-IARC-79-198) Prolonged intake of hormonal contraceptives as a possible cause of increased risk for a gynecological cancer has been discussed many times. Several studies contradict this relationship. Using data from patients with colon, corpus uteri and ovarian carcino ma this problem is again being analyzed lor the period 1978-85. All temale patients with carcinomas of these sites are being questioned about the period and the time they have taken contraceptives. Using controls, the frequency of intake of hormonal contra ceptives in the total female population of this region will be deduced SUPPORTED BY (No Supporting Organization Re ported) funds n a. 1.0656, BOPT CASE-CONTROL STUDY OF THE OCCUPATION AL AETIOLOGY OF CANCER OF THE URINARY BLADDER S.A Tola, Inst, of Occupational Health, Dept, ol Epi demiology & Biometry, Haartmaninkatu 1, SF00290 Helsinki 29. Finland (D-IARC-79-157) Some 278 cases of cancer of the urinary bladder were reported to the Finnish Cancer Registry during 1975-1976. The diagnosis will be confirmed in the respective hospitals and age-matched controls will be selected (rom the patients of those hospitals. Questionnaires with special emphasis on occupation al history will be sent to cases and controls. The analysis ol the data will locus on comparison of occupational histones. SUPPORTED BY (No Supporting Organization Re ported) funds n a 1.0657, LPQT EPIDEMIOLOGICAL STUDIES OF CANCER IN TWINS I V. RantasalO. Helsingin Yliopisto. Dept, of Public Health Sciences, Fabianinkatu 33. Sr00220 Helsinki. Finland (D-IARC-79-151) The study of twins can illuminate the relative role of different environmental factors in cancer aetiology. The Finish Twin Reoistry contains data on some 34,500 adult twins ol the same sex_Zygosity was determined by questionnaire in 1975. record linkage with the Finnish Cancer Registry lor cancer cases incident prior to 1975 has been earned Cut, Since data on zygosity (or many ot the cases in this retro spective study were not available, cancer incidence in twins and risk ot cancer among co-twins ot cancel cases was compared tor twins vs. non-twins using 7.332 singletons as controls The study will be con tinued lor several years until sufficient cases with 1*75 ' R&S 106312