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2/10/2017 Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds and Related Compounds National... Jump to main content National Center for Environmental Assessment Recent Additions | Contact Us Search: D All EPA This Area You are here: EPA Home Research & Development NCEA Home Dioxin Dioxin Reassessment. NAS Review Draft Draft Documents Go Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds National Academy Sciences (NAS) Review Draft You will need Adobe Acrobat Reader, available as a free download, to view the files on this page. See EPA's PDF page to learn more about PDF, and for a link to the free Acrobat Reader. Part I: Estimating Exposure to Dioxin-Like Compounds Part I: Estimating Exposure to Dioxin-Like Compounds Part II: Health Assessment of 2.3.7.8- Volume 1: Sources of Dioxin-Like Compounds in the United States Tetrachlorodibenzo-pDioxin (TCDD) and Table of Contents (PDF) (23 pp, 406KB) Related Compounds Chapter 1: Background and Summary (PDF) (55 pp, 2.52MB) Chapter 2: Mechanisms of Formation of Dioxin-Like Compounds During Combustion of Organic Materials (PDF) (39 pp, 337KB) Chapter 3: Combustion Sources of CDD/CDF: Waste Incineration (PDF) (91 pp, 1.96MB) Chapter 4: Combustion Sources of CDD/CDF: Power/Energy Generation (PDF) (70 pp, 1.68MB) Part III: Integrated Summary and Risk Characterization for 2.3.7.8Tetrachlorodibenzo-pDioxin (TCDD) and Related Compounds Chapter 5: Combustion Sources of CDD/CDF: Other High Temperature Sources (PDF) (44 pp, 1.11MB) Chapter 6: Combustion Sources of CDD/CDF: Minimally Controlled and Uncontrolled Combustion Sources (PDF) (26 pp, 410KB) Chapter 7: Metal Smelting and Refining Sources of CDD/CDF (PDF) (46 pp, 1.0MB) https://cfpub.epa.gov/ncea/iris_drafts/dioxin/nas-review/index.cfm#part1 1/3 2/10/2017 Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds and Related Compounds National... Chapter 8: Chemical Manufacturing and Processing Sources (PDF) (93 pp, 2.22MB) Chapter 9: Biological Sources of CDD/CDF (PDF) (7 pp, 73KB) Chapter 10: Photochemical Sources of CDD/CDF (PDF) (7 pp, 81KB) Chapter 11: Sources of Dioxin-Like PCBs (PDF) (52 pp, 1.22MB) Chapter 12: Reservoir Sources of CDD/CDF and Dioxin-Like PCBs (PDF) (34 pp, 587KB) Chapter 13: Ball Clay (PDF) (7 pp, 118KB) References (PDF) (64 pp, 346KB) Volume 2: Properties, Environmental Levels, and Background Exposures Table of Contents (PDF) (15 pp, 342KB) Chapter 1: Introduction (PDF) (37 pp, 254KB) Chapter 2: Physical and Chemical Properties and Fate (PDF) (114 pp, 1.25MB) Chapter 3: Levels of CDD, CDF, and PCB Congeners in Environmental Media and Food (PDF) (204 pp, 3.24MB) Chapter 4: Human Exposure to CDD, CDF, and PCB Congeners (PDF) (146 pp, 3.9MB) Chapter 5: Potentially Elevated Exposures (PDF) (68 pp, 1.15MB) Chapter 6: Temporal Trends (PDF) (54 pp, 739KB) Appendix A: Environmental Chemistry (PDF) (21 pp, 1.68MB) Appendix B: Environmental Concentrations (PDF) (300 pp, 7.0MB) Appendix C: Bioavailability of Dioxin (PDF) (23 pp, 134KB) Volume 3: Site-Specific Assessment Procedures Table of Contents (PDF) (15 pp, 216KB) Chapter 1: Introduction (PDF) (56 pp, 448KB) Chapter 2: Estimating Exposure and Risks (PDF) (49 pp, 355KB) Chapter 3: Evaluating Atmospheric Releases of Dioxin-Like Compounds From Combustion Sources (PDF) (83 pp, 1.55MB) Chapter 4: Estimating Exposure Media Concentrations (PDF) (148 pp, 1.9MB) Chapter 5: Demonstration of Methodology (PDF) (50 pp, 593KB) Chapter 6: User Considerations (PDF) (59 pp, 1.17MB) Chapter 7: Model Comparisons and Model Validations (PDF) (175 pp, 2.42MB) Chapter 8: Uncertainty (PDF) (54 pp, 421KB) Part II: Health Assessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds Chapter 1: Disposition and Pharmacokinetics (PDF) (114 pp, 1.33MB) Chapter 2: Mechanism(s) of Action (PDF) (48 pp, 250KB) Chapter 3: Acute. Subchronic, and Chronic Toxicity(PDF) (57 pp, 399KB) Chapter 4: Immunotoxicity (PDF) (54 pp, 375KB) Chapter 5: Developmental and Reproductive Toxicity (PDF) (134 pp, 882KB) Chapter 6: Carcinogenicity of TCDD in Animals (PDF) (62 pp, 534KB) Chapter 7: Epidemiology/ Human Data Part A: Cancer Effects (PDF) (103 pp, 967KB) Part B: Effects Other than Cancer (PDF) (215 pp, 2.75MB) Chapter 8: Dose-Response Modeling for 2378-TCDD (PDF) (128 pp, 2.39MB) Chapter 9: Toxicity Equivalence Factors (TEF) for Dioxin and Related Compounds(PDF) (64 pp, 428KB) https://cfpub.epa.gov/ncea/iris_drafts/dioxin/nas-review/index.cfm#part1 2/3 2/10/2017 Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds and Related Compounds National... Part III: Integrated Summary and Risk Characterization for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds Full Document (Table of Contents, all Chapters & Appendices) (PDF) (264 pp, 3.09MB) Table of Contents (PDF) (14 pp, 214KB) Chapter 1: Introduction (PDF) (23 pp, 311KB) Chapter 2: Effects Summary (PDF) (48 pp, 502KB) Chapter 3: Mechanisms and Mode of Dioxin Action (PDF) (15 pp, 165KB) Chapter 4: Exposure Characterization (PDF) (40 pp, 986KB) Chapter 5: Dose-Response Characterization (PDF) (42 pp, 712KB) Chapter 6: Risk Characterization (PDF) (34 pp, 226Kb ) Appendix A (PDF) (12 pp, 495KB) Glossary (PDF) (6 pp, 103KB) References (PDF) (30 pp, 278KB) ORD Home | Search EPA | Satisfaction Questionnaire Local Navigation NCEA Home Basic Information Risk Assessment Science Activities Publications Tools and Databases Guidelines Jobs EPA Home Privacy and Security Notice Contact Us Jump to main content https://cfpub.epa.gov/ncea/iris_drafts/dioxin/nas-review/index.cfm#part1 3/3