Document X5w5mbywkzbmZbBq1GbKKReK

R&S 106342 BIO-MEDICAL RESEARCH DOCUMENT DESCRIPTION FORM 63 68 69 76 r oqqim? Duplicate in all cards:--^ year as-1961- File number [Right justify [Numeric only] 7778 Uc--' | Sub-Index Code Author(s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 1 20 21 ________________40 41____________________________ 60 r'c.(jJ.u--jla --G,,----------- / &-/07T*/. &. UtnAA. fil- 61 62 Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms, separated from each other with comma-space. Avoid other punctuation; do not abbreviate. 12 61 62 21 0)n c_o^.d n id i 4- y \ o n~f rOd'f ion; t3rof (Jin y_ 1 'in CJJh /S (t_ 1 __ tjf /.ouj 22 23 24 Source (Journal, Vol., Number, Pages, Date ) 12____________________________________ ------------------ ,--x ,p.---/--s----r--*----J,-------f---t--'-7---?-- 61 62 31 32 ij 'fjRCS (Research on: Csneer; Pharmacology; Respiratory System; Social ar.d Occupational Medicine) 2, 13S2 '19741 ONCOGENICITY OF VINYL CHLORIDE AT LOW CONCENTRATIONS IN RATS AND RABBITS A. Capuro, P.L Viola and A. Bizotti. Regina Elena Institute for Cancer Research, Rome, Italy. Paper received; 10th May, 1974: amended 22nd July, 1974. 00QQ"5# R&S 106343 r?r/ In the past four years we have demonstrated (1,2) that rats exposed to a flow of air containing 30 000 p.p.m. (part per million) of vinyl chloride develop cutaneous tumors in 70"c of cases, ljng carcinomas in 20 ? of cases and. less TuNo /. (tri -scnniiy t>} nnytt fi/nrUc tn rat* cj `unctfnt { (Up Ji'Sf. Thtr iwwurs efifmrrd hcttwvn A atui IS months t*f treatment. frequently, osteochondromas. VC conc;r ::r !''n (p.p.rM io :o ao c->: coooc zooto Hisiotypcs S'cn squamous cell carcinoma Lunp adenxarctnom* U.cr anfioutconu Liver cholangioma Small irucitinc adenocarcinoma Tumors animais under treatment o" * 50 Cl 150 18 ISO I3'150 7.150 1r 45 14 12 <0.0005 9 S In order to ascenain'the degree of oncogenicity of vinyl chloride, experiments have been performed in which rats inhaled lower doses of this chemical. 1100 animals (3 month old Wistar Ar IRE male or female albino rats) were exposed for 4 hours a day, 5 days a week for 12 months to a flow of air con to 10 C-'C io i>y. to o:o tooco SLm squamous cell carcinoma Ltng jJi'rvjrcmoma L*nc aive :'ai carcinoma Medustiruc reticulosarcoma Li*vt angiosarcoma 34.;00 14 COO ; loo 8/COO 16-COO 17 7 1 < 0.00OS 4 8 taining 20 000, 10 000, 5000, 2000. 500 or 50 p.p.m. of vinyl chloride. With exception of the animals in the group exposed to the lowest dose (50 p.p.m.) all other experimental animais devel oped a high percentage of tumors. As reported in JC-CC 5CCO <*.v 5003 2001 COCO cooc coco 50? 5<x" Skin squamous ceil carcinoma Lun; adcnocartinoffu U*ef anpirurcoma Peritonea! ancmsarcoma Skin acanthoma Liver angiuurcunta Small intestine adenocarcinoma Lung adenocarcinoma Skin squamous carcinoma Li'er angivsarcoma CO'COO 4/COO IC'CCO c/coo 6*:oo to-coo 6/COO 8'C00 311250 4 150 10 2 < 0.0005 6 I 3 S 3 < 0.005 4 j <0.01 table 1, the neoplasms originated in different tissues and organs, with prevalence of the liver. It is worth emphasizing that even using lower concentrations, it was possible to confirm the oncogenicity of vinyl chloride which, under the experimental conditions employed, is to be con sidered a very hazardous compound and one of the most powerful carcinogens. \ C.T-rr:- h" _ - 0 C30 ocoo _ - * r tt;: .r-!ii; c-Jin-:! * Hie n -t cspoied to i C, *rre kept under the tame L\>nJi:ions for IS m;fti rjVf.* i j' r -- 10 io t 'XM.i'c/fec' .-rlr.njp ir r.r'v.f, P'C tu**tort appeared .V**vc**r * itnd If w-'tirr ' ' i \-y "ir n pcs T-TL t' v-'ar r*'::-cnr ,7 P* Sn-.o acar;rt>r\a L-TM.' iJc^-V^rcmona 1C -0 (' -3 ?? < 0.0005 li r. ; -i* 0 CO * V; * ri.-a-.-_.;, . ' t c?" sfd t 1C rt' kept u rJt*r i C'>r~itrinn* f *r /.' In a limited number of experiments utilizing other types of animals the appearance of tumors similar to those described in the rats was observed. These data, collected in table 2. indicate in particular that the rabbit, which is no: very susceptible to chemical carcinogens, displays high sensitivity to vinyl chloride. Even in this case, at the concentration of 10 000 p.p.m.. the hisiotypes reflect those obtained in ihe rats. We car. conclude that the carcinogenic el tec; ol vinyl chloride has been clearly confirmed by the present results, which also indicate that almost all tissues and organs are sensitive to ihis. carcinogen. 1. \ icla. P.L (I ""*0) Proc. 10th International Cancer Coneress. Houston, abstract 29 2. Viola. P.L. Bigotti. A. and Caputo. .V (Id'll Cancer Research, 31. 516