Document X5dmaDy37KedEkwQgazDpODJ

rtfisa Project LH It PftOraSAL TO INTERNATIONAL LEAD I1NC OftDAN IIATIC* TO* TVS CONTINUATION, THROUGH TtB YEAR 16, Of THE FINANCIAL SUPPORT Of THE PROGRAM OP RESEARCH IM THE EETTEMNO LABORATORY, IN THE CEPART1CMT OP ENVIROh'kENTAL HEALTH OP THE COLLEGE OP 1KDICINE OP THE UNIVERSITY OP CINCINNATI, ON THE PROJECT *KUMAR EXPOSURE TO PARTICULATE LEAD COMPOUNDS IE THE AIR UNDER EXPCRIkCNTAL CONDITIONS" Is Ui proposal Anted Aufutt It, IM, U sxperiaeatal prograa for ItST mi out It Bed. BlBCo that tin# and up to tk* pruaeat data, July IS, 1M7, tkli prograa ku beea pursued diligently. IM experlaeut a* described (iitput IS, ItSS) Ma beea eoeplated aod the reaulta have beea reported (July Itdd ud February 1BB7). Aaotber expert neat, uhiefe Yolloved logically froo tbe reaulta obtained previously, mi outlined for laltiatloa la early October ISM, aod u expected to cootlauo lato August of 1BSB. (TNIa experiment baa beea deacrlbed la tbe procreal report aad aeed not be detailed here.) la abort, la vice of tbe eaeeattally negative raapooao of tbe experlaeatal subjects to respiratory exposure to air coatslalac 10 olcrocruaa of lead per cubic aeter, tbe level of eoocentratloo 1 f lead la tbe aeu eaperloaat baa beea lac reived to BO alcrogrSM per cubic outer. IM too subjects aere kept oa tbe aaae expert n!il rr(lMfl until Jurw 19, 1SSY, at eblcb tlae they bad cos^leted a flnt period of JO eeeka of exposure to air coatslalac JO olcrotraaa of lead per cubic aeter (nblcb bad eateoded froo October 10, IBS* tbroucb February IB, IK?), aad a second period of If eeeka (eblcb Ad eateaded frco February BO, 1BST tbroucb June IB, 1BB7). During these teo periods, tbe tlae speal by each subject la tbe respiratory chaster aaoeated to >1 houra per evek (first period) sad Jl.B hours per seek (second period). Early la June, Just before tbe Coeeenceaeal eierclset of tbe University f Clsclaaatl, one sf tbe saperteestsl subjects reported that, having Leva assured of belaf aearded bis Master of Arts Decree at tbe Cossasnceaent, be Rad been (ranted scholarship at Yale University, for the onllsustteo of hit studies, tnd that hts faculty advisor had wr,sd kin i, in. < n, if be could puixlMr ' warnjj.i^p.iiiiiiijmi LIA12368 ....H i* hr>i<i m an tirftiwitffrHir mV liia..-iM'ir. ins-iiwimr MSn--I if an -erin'i 1 *U~ advantage of this somewhat unexpected opportunity to advance Ui career. It m, of course, situation tktt bad to bo lictd, iod could hardly ho dtilt with la aay othor manner thaa to tho advantage of thla graduate atudeat. The scholarship had boea granted (or a full year beginning September flrat of thla year. la order to obtain aa ouch benefit aa possible froo Subject g.h., sad - froo the coape re 11 re behavior of tho teo subjects, during tho brief period remaining, the second period of the exporlsent (Indicated above) eaa terminated at the end of It seeks, sad the third period eaa Initiated on June Id, 1M7. goth subjects ere dealt elth la this Banner, except that c m of then. Subject S.S. (ebo eoeld continue on Into tho next year), ess shifted to 43 hours of exposure per seek, bile the other. Subject I.K., changed to the rate of S3 boors of exposure per week. This eea does because Subject S.S. would remain but for 10 weeks, and the best use of his tine and effort during this period appeared to be that of (lading out whether the severity of tho exposure at the level of SO nlcrogrnne per cehls wetar for S3 hours per week would be such as to Induce aa; excretory response la so abort s ties as 10 weeks. Should tkls tarn out to be the case, a naans night well he provided of eapeditlng the course of the experlaent lavetvlag the other Sshject. (Or perhaps It night he best to terminate the experlneat St SO nlcrograae per cubic eater and go to 33 or 30 nlcrograae per cubic aster. The speeding wp of tkls eiperlaent should result in Inforwatloo that will determine whether S farther experlaent Is required, sad at what level.) There It Utile doubt that this procedure Is the beat aeane of obtalnlsg the naalnum yield of Information froo this ssperlaent. It Is mot feeslbl# to introduce s mew subject Into the reglaea, without obtaining preliminary data during s "normal" (ceotrol) period, and s delay In the progress of the experlaent for tbit purpose would not be warranted, be 0 shall lake ad,.. w of 1 v, .1* thwrafnrw, to Iftlw a inm i h i 111 ii m TWWff LIA12369 'PPW m mmA -3- It mh likely that on* b *v aubject (or ptriupi t*o) tksuld b* obtain** for prtllilMrji obeervetlone, u toon th* outcoa* of the experlnental *ork of tki Mat too aoatbi caa W eetebllahed - 1 .*., uhoa the aaalpMi of ip*clatu obtained fro* Subject a.g, ahal 1 bar* b**a completed aad th* reiulta examined, tb* reiulta *111 b* |lna cartful coni Id*rd loo aad reported to tbe apooaora *lth recn--emit t loot for tbe further dealga of tbe expert seat. Pro* tbe budgetary polat of vie*, ft doe* not aeea vlae, at thla tine, to recommend grota ebagea during tbe next flacal year. During tbe laat four nontba of IHT, tbe expenditure* to be nade for tbe coapenaallom of tbe experimental subject*, for allowance* for food, aad other purpoaea, aa **11 a* tbe coat of analytical tenricea, *111 be diminished. Whether they *111 be halved, by virtu* of tbe loaa of on* of t*o (object> for thla entire period *111 depend upon the outcome of preeent observation*. It ***** unlikely that tuch a decreate la exp*milturct *111 eontlaue through 1IU (or through that portico of It ublcb caa no* be recognlaed aa aeceaaary to complete the preaent oaperlneat). Jud *bat 111 be r*gulr*d to achieve the goal aet for the** experiment* la aot evident at thla tin*. The principal laveatlgatur 1* not *nduly concerned about the detail* I of tbe budget M long a* It 1* adequate, and I* not at all dltturbed by th* pro*pect that prudeat planning at thla polat la thla *ork nay reault la reduced expenditure* and an uneapended balance of fund* at tbe end of IH7, HI* concern It, rather, for tbe gathering of the Wet and not! ueefwl tnforoatlon la tW aborted poealbla period of Mao. la vie* of IW crucial aatur* of Ike eaperlaental objective, both for * **! la purpn** end for lb* future, It I* recoenonded that the budget for IMS W nalntatned at the level of IIIS7, It la lag-lbt*, In dealing vlth in o * xt*e r laent al pri>gr*n of *M<h IV I. gull* unpreiMr f .Me, f f. t miawni LIA12370 i i>ii'il^iiiiil4lltf1^:'...-^w;,-^-.f.-t^, 4- tktt It ku ittirtd upon u uncharted area of exploration), to deeerlb* tho detail* of tho noxt experlnent. The (act la that ao clue has boon obtained la our prior Investigations or la any oooblaatloo o( (told Investigation* that have hooa aado, aa to tho exact level o( the cooceetratloo of lead la the air vhlch la required to 1educe a aeaaureable excretory reapooae (erlaary) la a normal, healthy aaa, under ooodltlooa Intended to approach thoee that obtain la the general ataoaphere of a coaenoilty. Modi epeculatloa haa boon Indulged la, and much atatlatlcal aaalpulatloo of data froe various aouroea haa yielded certain dubloua laferencea cooceralag the physiological effect of the difference# that exlet betueea the lead content of the ataoaphere la different arena e.g., urban and rural, but ao factual information haa been obtained under controlled condition*, be ebould be prepared, therefore, to eeek, at the earliest possible ties, a definitive ansmer te tbla question, la a crucial, terminal experiment. it 1* our opinion that this point in this Investigation Is near at hand, and that ue should not he handicapped by e shortage of funds at this tine. It Is suggested that * verbal report of the finding* of these eapertaent* night eel 1 he ande to represent at Ives of the sponsors toeerd the end of 1M7, as a basis for the consideration of e proposed design for the continuation of the experlnental uorh at a definite rate of expenditure during ISM. This should triable the group cone*med, at the beginning of 1*41, to antlcipst# tho actual rate of expend!ture and to nshe provltloo for ay alteration, hopefully, some redoctloo la the rate, thst nay neat elth approval. VItb these factors la olnd, a budget eooperable to that submitted la the proposal for 1HT, la appended hereto. Is this budget, the aseueptien 1* nsde, ellbout official-advice, thst the continued support of the C. I. Kbit* Health fere I re, *| the ssme financial level, otll be authorised In uveher, 1*47, ehen II 1# up for conafdereiion OT... immm"wi >.i,-i^uiujapil ii j l h b%ii; ,j ||, LIA12371 fflPf nailitri l ii ii.n1 ftilfc^iTii - lunar bontina>p<Ud aa tba Mol for Itpandl t uro te ba Moda ia IMI IPM for NrMcMl (ioelotflnc (rUp baoafita) for iMiMti, food alloaaaeaa, ata. for Ovorfeead (proportional abaro of ooat of oparatinf tba laboratory) for Oaotiagooclaa TO,000 0,100 90, *M T,TOO |m,soo froo lataraatiooal load Hoc Raaaarcb Organimation froo Aaaricaa patrolman laatltata froo Dim Croat Af-OOOflOa U,000 >1,000 >,#00*a $1M,>00 Application for raaaaal of Croat to ba coot Ida rod ia DottObar 1M7 * tMladiac orarbaad 1# iM? ' ttfMtfl V x / / /* K^rt A. --/ f_________________________ MMl^nfirvitl|ter w N-f LIA12372 IMIPPPW turn WOJKT Stt--urt Iaaue Datai Aufuat X967 rancr WO. LH-75 TTTH Bunaa fccpoaura to Particulate Lead Coapoade la the Air under bperlaestel Condition! rCTYlOUB nacrririCATIOW La-75 lwu Kxpoeure to Anblant Air CooeeatintUM of fertlculato U*1 oamucTQW cniverelty of Cincinnati cuwaarr coanucr 4aauar7 1, 1967 to December Jl, 1967. $75,000 ixxao 1577556 t il 1377560 ontn> $55755o m 85,000 ATX TOTAL 15575& CWUIATIY BWBB (to July 31, 1967) $161,850 1966 WOT08O cm COTKACT PMC1 $73,000 1968 AUTHOMZATlOn 19t>7 A Prior"Author!tatlane Ourcanlttod 1966 Propoeed Authrolutloo Unde*Lenated ftraenrch Authorlaatloa 1966 Propoeed or Contract Price 37,500 1757555 ($37,500 IUROi $37,500 TIL) WAMOTT ATPUCATIOltt Direct to geaoUna additive, and Indirectly to Boat other uaea ot load. OBJECT TO To dataralna the aajtLnun ceaceotrvt too of lnorfanlc lead la the ataoa* pnara that can be lahaled coetlauoualy throughout a llfatlaa by aorael, healthy paraona without daaonalratly pro<relve ercuaulatioae of land la their body Uiiu*. The reeulta will ba uaad la the dofaoaa of tha paollae additive aartat. WBtAwm e t y t iv \. C-irr*r.t r.tatua Two tub^a:ti bare completed 80 waaka of expoeure to air COO- taiatne it ilcrjfmw of land par cubic aatar and a second period of 16 waaka. Tha third period will ba 1 Lai tad Vo 10 waaka, dua to tha unavailability to par* tlelpata lor-gar la tha experLarat of ooa of tha aubjecie. Tba rata of expoeure par waak baa baan treatly Increased. 8 Projected pesesrch Tha if*adIre up of thla experiment should result In iaforention that will datanalne whether n furthar axparlnaat la required, and at what lavel, 3 Vi*'r* t->ad * 7v<tr* * froa 1/1/6) to Pebn*ry 1967, ctn. Last report ",-r1 V furled 7/ > 1 />A to p>> rvuiry 1 V>7. b. rr-;-l . ncKXUL TO DTIOTUTlOSUt UAD tt*C OITJUIlZATIOn POD TW cote :x Uricn, wvxr.x t v t t u j i *ts, or rxx pnuirui dupronr o p t k i Wu.KkM or fBUkrj in m UTTrj>:< uroKArcinr, m t k i ;rr*wrxnrr or OYimnaccAL k j j u t k o p t h cruji.i or w c mc ix i o p t k i lajvtusrn Of ciiriXkATi, cn t k i tyrjm --h u t o k t .'j k i t o p w c ic l l a t i u a d c o b* ItXSIB u t k i All tar. cmiWOCAl. COKOITlOna.' (dated July 16, 1967). C a Hurt fX4># ./. m. Jl lUiMI nenii H i ' . s* U-75 DUO PNOJKT SUMMIT ptf* tvo ntmonxm arrow r Hlot product loo - not AppUetblo 2. CoMiacr X*alutloc - not Applicable J. LLemalat ActlmUa - sot applicable Patenti - not applicable 5. KbUetlku . XUHO - MM %. Drvaiopaeot aeeoelatlone - mm Mxmoac DcgrivK i. itn Ocala Ifclaiala world 2. Application* and Harfcet Toluae * Oae m gaeollae 3. 8If of Harfcet PfeaSlag - 230,000 tone of Utl la 04> Md 51,000 tM 1a fturope. k. Cctytltlw Threat Chanpe reflalac UetMlfiJti to illalmu lMl additive*.