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Copies +o: E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial .'-led I cine HASKELL LABORATORY REPORT NO. 672-77 Material Tested hhskell No. 11336 Sample Ready for Testing 6-23-77 0+hor Codes [iMat Or Ch EYE IRRITATION TEST IN RABBITS Procedure: One-tenth mllllll+er of the undiluted chemical was placed Into the right conjunc+Ival sac-of albino rabbits. After 20 seconds, one treated eye was washed with tap water for one minute. The treate other rabbit was not washed. Observations of the cornea. Iris and conjunctiva were made with a hand-si and "four hours, and at one, two, and three days; Fluor-1-strip stain and a blomlcroscope were used at after the day of treatment. Results; Dose O.I ml undI Iu+ed test material Treatment of Eyes Not washed O.I ml undI luted test material Washed Cornea None Ocular Effects Iris Conjunctiva None Redness: None SwelI Ing; Slight 1-4 hours Discharge: Mild 1-4 hours None None Redness: M!Id at 4 hours Swel I Ing: l.!one Discharge: Mild at 4 hour Company S.ni.xe<*. O AR226-2861 Summaryl^lBHlBproduced transient very mild conjunctivitis wl+h no corneal or Iri+ic effect when rabbit e^e. An eye wsed with the compound and promptly washed had transient minimal conjunctivitis w Irltic effect. Both eyes were normal within I day. Al' fiough only transient very mild to minimal ocular effects occurred as In the case of all chemicals, be avoided. Good hygienic practice would be to flush copiously with water in the event of any eye con material. Report No. 672-77 Date Issued: August 26, 1977 Report by: AY^o -^" iF^^-^6-___ Doris F. Edwards lexicologist Approved by: WT Morro Dermal an Section S.,,,, Company