Document X2ZKDkBQqmaBqVvvK1DzEjqJ
Copies +o:
E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial .'-led I cine
HASKELL LABORATORY REPORT NO. 672-77
Material Tested
hhskell No.
11336
Sample Ready
for Testing
6-23-77
0+hor Codes
[iMat
Or
Ch
EYE IRRITATION TEST IN RABBITS
Procedure: One-tenth mllllll+er of the undiluted chemical was placed Into the right conjunc+Ival sac-of albino rabbits. After 20 seconds, one treated eye was washed with tap water for one minute. The treate other rabbit was not washed. Observations of the cornea. Iris and conjunctiva were made with a hand-si and "four hours, and at one, two, and three days; Fluor-1-strip stain and a blomlcroscope were used at after the day of treatment.
Results;
Dose
O.I ml undI Iu+ed test material
Treatment of Eyes
Not washed
O.I ml
undI luted test material
Washed
Cornea None
Ocular Effects
Iris
Conjunctiva
None
Redness: None
SwelI Ing; Slight 1-4 hours
Discharge: Mild 1-4 hours
None
None
Redness: M!Id at 4 hours
Swel I Ing: l.!one
Discharge: Mild at 4 hour
Company S.ni.xe<*. O
AR226-2861
Summaryl^lBHlBproduced transient very mild conjunctivitis wl+h no corneal or Iri+ic effect when
rabbit e^e. An eye wsed with the compound and promptly washed had transient minimal conjunctivitis w
Irltic effect. Both eyes were normal within I day.
Al' fiough only transient very mild to minimal ocular effects occurred as In the case of all chemicals,
be avoided. Good hygienic practice would be to flush copiously with water in the event of any eye con material.
Report No. 672-77 Date Issued: August 26, 1977
Report by:
AY^o -^" iF^^-^6-___
Doris F. Edwards lexicologist
Approved by:
WT
Morro
Dermal an
Section
S.,,,,
Company