Document Vnx0Kq0kk7mNeOYy2mQ47G0N

BiiMtital Hntene Digest September, 1956 *1188 A Stadr > Respiration to Pulmonary Abtaloi. H. Baatenter, H. Dcbolia, A. de Coster, and K. Englcnt. Arch, nulutiti profess. 16. 546-553 (1955). French. - la order to test the respiratory mine of tongs affected with asbeatosis nine cases were closely studied. The seven men aid two women had been exposed to asbestos dost, 1,000 to 2, 000 particles per cu. m.. for 18 to 30 years. The patients displayed definite symptoms of asbestos!* with troublesome cough and dyspnea, and all showed x-ray shadows like ground glass extending pver both Inngs. No tubercle bacilli were .found la any case. A definite reduction was found in vital capacity, but the maximum expiratory volume was satis factory. Breathing, however, was accelerated by- hyperventilation. At rest breathing waa sufficient and satisfactory, bat on exertion dyspnea appeared, varying considerably accord ing to the pathological lesions in the longs. These functional changes were in no way differ ent from those seen in other cases of pneumoconiosis. .Varying emphysema was found, bat no special strata was thrown upon the heart. -- Cond. from Bolt, Hyg. 1189 Asbestoslas Report of a Case. E. R. Wiese and W. E. B. Ball. Diseases of Chest 30. 229, 230 (Ang. 1956). The history- and autopsy findings in a fatal case of asbeatosis are reported. Conditions described include: absence of the middle lobe of the right lung; greatly, en larged heart; wider spread, sharply demarcated development of fibrosis; and degenera tion of collagen In^exteualve irregular fields. These and other conditions are described folly. Fine needles representing the original asbestos fibers were seen. Small asbestos bodies were seen in a few areas of focal fibrosU. although they had not appeared In the - sputum. 1190 New Viewpoints on Pulmonary Cancer in Asbestos Workers. H. BohllgandG. Jacob. Dent, matt. Wochschr. 81, 111-133 (Feb. 17. 1956). German. The following distinguishing features have-been attributed to Che long cancer (bat has been recognized as an occupational disease of asbestos workers: (1) increased Inci dence; (2) development at an early age; (3) dependence on duration of exposure to asbestos dust; (4) a latent period between onset of exposure and the appearance of the cancer; (5) the locaiirntioo; (6)the histological structure; and,(7) the mulUcentral origin. The authors discuss each of these points, and show that there is little clear evidence to support any of these assumptions, with exceptions noted. Women workers In the asbestos Industry have - lung cancer more often, and at an earlier age than do other women, but the same is not true of men. Malignant-growths of the pleura seem-to occur more often in asbestos workers than in other persons. The multicentral development is observed also in workers exposed to cobalt sad to chromates. The study of the pathogenesis Is still in the state of hypotheses, and the theory of mechanical pathogenesis Is given most consideration. Microtraumas sad asbestos bodies are always found in the pulmonary cancers of asbestos workers, but the authors feel thatThis Roe* not necessarily |mrvc^lic*iacctHulcnt4faewry> -NsyeitoeeMBd factors that speak against a purely mechanical pathogenesis of asbestos cancer, but they concede that the development of so-called asbestos warts proves the Irritating effect of asbestos on human tissues. -- Cond. from J. Am. Med. Assu. 1191 Nasal Penetration oi Particles ot Small Inertia In Experimental Animals. Gabrielle Asset, L. E, Googwer, and Stella Ryan. Arch. Ind. Health 13, 591-&0I (June 1936). Experiments were carried nut to determine the nasal penetration of particles of small inertia in dead rabbits, dogs, and guinea pigs. The beads of the animals, or the entire bodies, were exposed in a wind tunnel to an aerosol consisting of particles of 1.3 - microns with density of 1,2 g. per.ee. and moving at a rate of 2.5 mph. The concentra tions of the aeroaol entering the nasal passages and of that leaving the nasal passages were determined. It was found that there was a significant difference in nasal penetration be tween the guinea pigs, on the one band, and the rabbits and the dogs, on the other hand. Wind direction bad no influence on the nasal penetration ot droplets of low inertia. -- Authors* summary